Clinical trials: Bowel Disease
Constipation in Postnatal Women, Constipation
Combined Effects of Whole Body Vibration and Abdominal Binders on Outcome Measures of Constipation in Postnatal Women
Constipation is a prevalent issue among postnatal women, often resulting in significant discomfort and reduced quality of life. Traditional treatments like dietary adjustments and laxatives frequently provide only temporary…
- Trial name
- NCT06877871
- Testing
- WBV utilizes mechanical vibrations to excite muscle, nerves. Abdominal binders are to help patients who have suffered abdominal trauma to stabilize core muscles, reduce pain, and improve mobility
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Intestinal Behçet's Disease
A Study of Adalimumab in Japanese Subjects With Intestinal Behçet's Disease
To investigate efficacy, safety and pharmacokinetics of adalimumab subcutaneous (sc) for Japanese subjects with intestinal Behçet's disease who are refractory to conventional therapies.
- Trial name
- NCT01243671
- Testing
- Adalimumab
- Where
- 12 sites in Japan
- Volunteers
- 20 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Familial Adenomatous Polyposis
Trial of Eflornithine Plus Sulindac in Patients With Familial Adenomatous Polyposis (FAP)
The purpose of this randomized, double-blind, Phase III trial is to determine if the combination of eflornithine plus sulindac is superior to sulindac or eflornithine as single agents in delaying time to the first occurrence of…
- Trial name
- NCT01483144
- Testing
- Eflornithine, Sulindac 150 MG
- Where
- 17 sites in United States, Belgium and 5 more
- Volunteers
- 171 people
- Sponsor
- Cancer Prevention Pharmaceuticals, Inc.
Colorectal Cancer
A Phase II Study of Bevacizumab, Irinotecan and Capecitabine in Patients With Previously Untreated Metastatic Colorectal Cancer
Bevacizumab has recently been shown to improve survival when combined with chemotherapy in patients with previously untreated metastatic colorectal cancer.
- Trial name
- NCT00483834
- Testing
- Bevacizumab, Irinotecan, Capecitabine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Rectal Cancer
Monitoring by Microdialysis of Postoperative Complications After Proctectomy
The aim of this study is to monitor by microdialysis the postoperative outcomes in order to identify anastomotic leaks after rectal surgery.
- Trial name
- MTM-COLON-II (NCT01999634)
- Testing
- cma microdialysis catheter placement
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Crohn's Disease
The Challenge Study: A Dietary Personalization Protocol for Patients With Crohn's Disease and Deep Remission
The Challenge study is a prospective, open label, pilot trial in patients in deep remission on dietary maintenance therapy. The purpose of this study is to determine whether they can consume some of the products that were…
- Trial name
- NCT02930564
- Testing
- CDED + milk fat and gluten
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Wolfson Medical Center
Colorectal Carcinoma
A Clinic-wide Intervention (Primary Care-GI Connect) for Improving Rates of Colonoscopy After Abnormal Fecal Immunochemical Test Result in Patients at Federally Qualified Health Centers
This clinical trial evaluates a clinic-wide intervention called Primary Care-Gastrointestinal (GI) Connect for improving follow-up colonoscopy rates in patients at a Federally Qualified Health Center (FQHC) who have an abnormal…
- Trial name
- NCT06568016
- Testing
- Best Practice, Communication Intervention, Coordination
- Where
- 2 sites in United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Ulcerative Colitis (UC), Crohn's Disease
Stopping PPI Therapy in Inactive IBD
To investigate the feasibility of proton pump inhibitor (PPI) withdrawal in inflammatory bowel disease (IBD); the data collected will provide valuable information to inform a future multi-centre randomised controlled trial.
- Trial name
- STOP-IT (NCT07691138)
- Testing
- Continue PPI Therapy, Withdraw PPI Therapy
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Nottingham
Appendicitis
Complex and Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX)
This prospective trial will randomize patients who have had an appendectomy to two different durations of antibiotic therapy depending on the status of the appendicitis.
- Trial name
- CASA-RELAX (NCT05838248)
- Testing
- antibiotic duration
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of Louisville
Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma
Short-term Starvation vs. Normal Diet Before Chemotherapy of Solid Tumors
Recent pre-clinical data provide strong evidence that short-term starvation before the administration of cytostatic drugs for the chemotherapy of solid tumors leads to significantly higher efficacy and lower toxicity levels.
- Conditions
- Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma, Colorectal Cancer, Gastric Cancer
- Trial name
- NCT02607826
- Testing
- Starvation
- Volunteers
- 298 people
- Sponsor
- University Hospital Tuebingen
Colorectal Cancer
Screening and Systematic Follow-up for Cardiopulmonary Comorbidity in Patients Having Surgery for Colorectal Cancer
More than one third of patients with colorectal cancer (CRC) suffer from comorbidity such as heart and lung diseases. This comorbidity markedly impairs survival after surgical treatment owing to increased mortality within the…
- Trial name
- NCT02328365
- Testing
- Structured medical follow-up after operation
- Where
- Denmark
- Volunteers
- 202 people
- Sponsor
- Vejle Hospital
Colorectal Cancer
Promoting Colorectal Cancer Screening in Rural Colorado
This community based participatory research study involves multicomponent educational interventions. Telephone interviews and focus groups of persons who are residents of the High Plains region of Colorado will be conducted.
- Trial name
- NCT00137592
- Testing
- small media, group education (multicomponent)
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Inflammatory Bowel Disease, Inflammatory Bowel Disease (IBD)
Automated Clinical Pathway for Inflammatory Bowel Disease Care
Pragmatic randomized controlled trial to evaluate the effect of an electronic medical record-based tool on improving on-time follow up and its effects on inflammatory bowel disease outcomes
- Trial name
- NCT07167836
- Testing
- Electronic medical record-based care pathway
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Anal Dysplasia, Human Papillomavirus
The HPV-SAVE Study Team: HPV Screening and Vaccine Evaluation in Men Who Have Sex With Men
Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Infection by certain high-risk oncogenic types of HPV (HR-HPV) is the major cause of several cancers in men, notably squamous cell carcinoma…
- Conditions
- Anal Dysplasia, Human Papillomavirus, Anal Cancer
- Trial name
- HPV-SAVE (NCT02503111)
- Testing
- The Hyfrecator ® 2000 Electrosurgical System, Observation Alone
- Where
- 4 sites in Canada
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Type 2 Diabetes
Efficacy of Acarbose on Intestinal Microbiome and Incretins of Type 2 Diabetes
This study is aimed to investigate the effect of acarbose on intestinal microbiome and incretins, therefore to explore the new pathways or new targets to treat type 2 diabetes.
- Trial name
- NCT01758471
- Testing
- Glipizide, Acarbose
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Anal Fissure, Microbial Colonization
Microbiota in Chronic Anal Fissure and Its Association With Prognosis
In this study, we will try to answer the following questions: 1. What are the salient features of the microbiota in chronic anal fissure? 2. Are these features associated with prognosis and response to therapy? 3.
- Trial name
- NCT05405634
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lasse Krogsbøll
Colonoscopy Preparation
Macrogole Versus Sodium Picosulfate in Bowel Cleansing for Colonoscopy in Pediatric Inflammatory Bowel Disease
Children hospitalized at the Department of Pediatric Gastroenterology and Nutrition at the Medical University of Warsaw with suspected or confirmed inflammatory bowel disease (IBD) will be invited to participate in the study.
- Trial name
- NCT07786363
- Testing
- polyethylene glycol (PEG 4000) (Forlax ®), Citrafleet®
- Where
- Poland
- Volunteers
- 125 people
- Sponsor
- Medical University of Warsaw
Lynch Syndrome
NBI Versus Indigo Carmine During Colonoscopy in Lynch Syndrome
This study compares two colonoscopy techniques (with Narrow Band Imaging versus with indigo carmine chromoendoscopy) in patients having Lynch Syndrome
- Trial name
- LYNCH-CHROMO (NCT02570516)
- Testing
- Colonoscopy
- Where
- 7 sites in France
- Volunteers
- 141 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Cancer
A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Metastatic Colorectal Cancer (Morpheus-CRC)
A phase Ib/II, open-label, multicenter, randomized study designed to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of immunotherapy-based treatment combinations in patients with metastatic…
- Trial name
- NCT03555149
- Testing
- Regorafenib, Atezolizumab, Imprime PGG
- Where
- 15 sites in United States, Australia and 3 more
- Volunteers
- 96 people
- Sponsor
- Hoffmann-La Roche
Crohn's Disease
Wireless Capsule Endoscopy in Small-Bowel Crohn's Disease
The purpose of this study is to determine the best role for capsule endoscopy in diagnosing Crohn's disease.
- Trial name
- NCT00178438
- Testing
- Capsule Endoscopy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Rochester