Clinical trials: Bowel Functions
Malnutrition, Diarrhea
WASH Benefits Kenya
The purpose of this study is to measure the independent and combined effects of interventions that improve sanitation, water quality, handwashing, and nutrition on child health and development in the first years of life.
- Conditions
- Malnutrition, Diarrhea, Child Development
- Trial name
- WASHB-Kenya (NCT01704105)
- Testing
- Water Quality, Sanitation, Handwashing
- Where
- Kenya
- Volunteers
- 8,246 people, healthy volunteers welcome
- Sponsor
- Innovations for Poverty Action
Refractory Constipation, Fecal Incontinence in Children
The Role of Anorectal Manometry in Pediatric Chronic Refractory Constipation
This research protocol outlines a two-year descriptive cross-sectional study to investigate the role of high-resolution anorectal manometry (HRAM) in children aged 4-18 years with chronic refractory constipation.The study plans…
- Trial name
- NCT07291661
- Testing
- High resolution anorectal manometry using a multiuse water perfused catheter
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Assiut University
Splinter of Gum
The Effect of Gum Chewing on Bowel Function After Cesarean Section
This study is a randomised controlled trial that included 150 pregnant women undergoing cesarean in Sisli Ethal Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey.
- Trial name
- NCT02497794
- Testing
- chew gum
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Non Celiac Wheat Sensitivity, IBS (Irritable Bowel Syndrome)
NCWS or IBS/FD in Relatives of CD Patients
Over 50% of non-celiac wheat sensitivity (NCWS) patients are HLA DQ2/DQ8 positive and often have a Celiac Disease (CD) family history.
- Conditions
- Non Celiac Wheat Sensitivity, IBS (Irritable Bowel Syndrome), Functional Dyspepsia, Celiac Disease
- Trial name
- NCT07584473
- Testing
- Wheat-Free Diet
- Where
- 2 sites in Italy
- Volunteers
- 600 people
- Sponsor
- University of Palermo
Irritable Bowel Syndrome
Effect of Probiotic Supplement on Bowel Function
The purpose of this study is to analyse the effect of probiotic supplement on symptoms of irritable bowel syndrome.
- Trial name
- IBS2 (NCT01475929)
- Testing
- Probiotic supplement
- Where
- Finland
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Danisco
Radiation Exposure
Radiofrequency in Anal Incontinence: Randomized Clinical Trials
Anal incontinence (AI) is used to englobe the involuntary loss of both fecal material and gases, which can help to improve quality of life.
- Trial name
- NCT03147729
- Testing
- Radiofrequency non ablation
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Escola Bahiana de Medicina e Saude Publica
Irritable Bowel Syndrome
Ethosuximide to Treat IBS
Abdominal pain remains the most deleterious symptom for patients with irritable bowel syndrome (IBS) and is causing a significant alteration of their quality of life.
- Trial name
- IBSET (NCT02973542)
- Testing
- Ethosuximide
- Where
- France
- Volunteers
- 162 people
- Sponsor
- University Hospital, Clermont-Ferrand
Irritable Bowel Syndrome, Digestive System Diseases
Efficacy of a Multi-strain Probiotic in the Treatment of Irritable Bowel Syndrome (IBS)
The Canadian College of Naturopathic Medicine is conducting a research study on Irritable Bowel Syndrome (IBS), a common condition in North America.
- Conditions
- Irritable Bowel Syndrome, Digestive System Diseases, Colonic Diseases, Functional, Colitis, Mucous
- Trial name
- NCT01176227
- Testing
- Kyodophilus multi-strain probiotic capsules
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- The Canadian College of Naturopathic Medicine
Small Intestinal Bacterial Overgrowth, Irritable Bowel Syndrome
SIBO, Immune Activation, and FGIDs in Children
PURPOSE: This study will evaluate the relationships between small intestinal bacterial overgrowth (SIBO), immune activation, inflammation, and symptoms in pediatric abdominal pain-related functional gastrointestinal disorders…
- Conditions
- Small Intestinal Bacterial Overgrowth, Irritable Bowel Syndrome, Functional Dyspepsia, Functional Abdominal Pain
- Trial name
- SIBO (NCT02872961)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- The University of Texas Health Science Center, Houston
Abdominal Surgery by Laparotomy
Hot Compress Application in Open Abdominal Surgery
This study aims to evaluate the effect of hot compress application to the intestines during abdominal surgery on postoperative nausea-vomiting and bowel function.
- Trial name
- HotCompress (NCT06888154)
- Testing
- compress application with heated saline
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Arterial Hypertension, Atherosclerosis Occlusive Disease
Gut Microbiota in Chronic Noncommunicable Diseases
It is an observational study in patients with chronic noncommunicable diseases (i.e. cardiovascular diseases, diabetes mellitus, non-alcoholic fatty liver disease, chronic obstructive pulmonary disease and asthma ) and control…
- Conditions
- Arterial Hypertension, Atherosclerosis Occlusive Disease, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction
- Trial name
- NCT04820556
- Where
- 2 sites in Russia
- Volunteers
- 1,084 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Anal Fistula Surgery, Anal Fistula
Recurrence and Anal Fistula Patient Reported Outcomes Trial
Perianal fistulas are a chronic anorectal condition associated with significant morbidity, including pain, persistent discharge, infection, and impaired continence, all of which can substantially affect patients' quality of life.
- Conditions
- Anal Fistula Surgery, Anal Fistula, Perianal Fistula
- Trial name
- RAPPORT (NCT07477496)
- Testing
- Perianal fistula surgical repair
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Upper Respiratory Tract Infection, Gut Microbiota
The Effect of Synbiotics on the Upper Respiratory Tract Infection
Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections. However, clinical trials of synbiotics, one of the microbiota-targeted intervention, in this regard is few.
- Conditions
- Upper Respiratory Tract Infection, Gut Microbiota, Immune Function
- Trial name
- NCT04960878
- Testing
- Synbiotic
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Oxidative Stress, Healthy
A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance
This is a prospective, randomized, placebo controlled, double-blind study to assess the effects of a postbiotic blend on exercise induced oxidative stress markers and exercise performance in healthy adult.
- Conditions
- Oxidative Stress, Healthy, Exercise-induced Muscle Damage, Exercise-induced Muscle Soreness
- Trial name
- PBE (NCT06795425)
- Testing
- Postbiotic Active Lifestyle Blend
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Infantile Colic, Constipation - Functional
Bowel And Bladder Function in Infant Toilet Training
The overall purpose is to assess whether assisted infant toilet training during the first year of life can prevent functional gastrointestinal and urinary tract disorders up to 4 year of age.
- Conditions
- Infantile Colic, Constipation - Functional, Bladder Dysfunction, Toilet Training
- Trial name
- BABITT (NCT04082689)
- Testing
- Assisted Infant Toilet Training
- Where
- 6 sites in Sweden
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- Dalarna County Council, Sweden
Non Small Cell Lung Cancer, Advanced Solid Tumor
Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC
This is a First-in-Human Phase IA/IB/II open label dose escalation study of intravenous (IV) administration of ONC-392, a humanized anti-CTLA4 IgG1 monoclonal antibody, as single agent and in combination with pembrolizumab in…
- Conditions
- Non Small Cell Lung Cancer, Advanced Solid Tumor, Metastatic Melanoma, Metastatic Head and Neck Carcinoma
- Trial name
- PRESERVE-001 (NCT04140526)
- Testing
- ONC-392, Pembrolizumab, Docetaxel
- Where
- 37 sites in United States, Australia
- Volunteers
- 733 people
- Sponsor
- OncoC4, Inc.
Hirschsprung Disease
Scintigraphic Defecography for Evaluation of Functional Outcome in an Adult Hirschsprung Population
This study aims to investigate long term outcomes of surgical intervention for Hirschsprung's disease and to explore the relation between scintigraphic defecography, type of surgery performed and symptoms as evaluated by a…
- Trial name
- NCT04957667
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- University of Southern Denmark
Lactose Intolerance, Adult Type, Intestinal Permability
Lactose Intolerance and Intestinal Permability
"This study evaluates the interplay between lactose intolerance, intestinal barrier function (zonulin), and intestinal inflammation (fecal calprotectin) in adults, aiming to clarify their independent contributions to symptom…
- Conditions
- Lactose Intolerance, Adult Type, Intestinal Permability, IBS (Irritable Bowel Syndrome)
- Trial name
- LI (NCT07424898)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Bezmialem Vakif University
Irritable Bowel Syndrome
The Effect of the Low FODMAP Diet and Dietary Oligofructose on Gastrointestinal Form, Function and Microbiota
Some carbohydrates, complex sugars, which are found in grains, fruit and vegetables, cannot be digested by humans. When eaten they pass through the small bowel to the large bowel, or colon.
- Trial name
- FOG (NCT02259465)
- Testing
- low FODMAP diet, Oligofructose, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Obesity, Metabolic Syndrome
Investigating the Possible Link Between Habitual Diet, Physical Activity, Sleeping Patterns, Obesity Status and Age With Gut Bacterial Composition, Gut Barrier Function, Metabolic Endotoxemia, Systemic Inflammation and Glycaemic Control.
In the UK, 25% of the adults are affected by metabolic syndrome (NHS, 2016). Metabolic syndrome is a cluster of different conditions including: hyperglycaemia, insulin resistance hypertriglyceridemia, dyslipidaemia and…
- Conditions
- Obesity, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT03864107
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Loughborough University
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