Clinical trials: Bowel Functions
Irritable Bowel Syndrome
Mindfulness for Irritable Bowel Syndrome
This study investigates the effectiveness of a 6 week mindfulness intervention in reducing symptoms of Irritable Bowel Syndrome (IBS). All Participants will receive treatment.
- Trial name
- MIBS (NCT02794376)
- Testing
- Mindfulness Based Cognitive Therapy (MBCT), Waiting Period
- Volunteers
- 67 people
- Sponsor
- University of Oxford
Irritable Bowel Syndrome
Pathophysiological Effects of Persistently Colonized Microbiome on Irritable Bowel Syndrome
The goal of this clinical trial is to explore the pathophysiological effects of the persistently colonized microbiome in irritable bowel syndrome (IBS) patients.
- Trial name
- IBS (NCT06013410)
- Testing
- colonoscopy
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Healthy
SwissGut - The Healthy Swiss Microbiome
Objective: This study is designed to address the complex interplay between the gut microbiome, environmental factors, and inflammatory diseases, with a specific emphasis on serving as a healthy cohort for several related…
- Trial name
- SwissGut (NCT06191224)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Benjamin Misselwitz
Anal Fistula Surgery, Anal Fistula
Recurrence and Anal Fistula Patient Reported Outcomes Trial
Perianal fistulas are a chronic anorectal condition associated with significant morbidity, including pain, persistent discharge, infection, and impaired continence, all of which can substantially affect patients' quality of life.
- Conditions
- Anal Fistula Surgery, Anal Fistula, Perianal Fistula
- Trial name
- RAPPORT (NCT07477496)
- Testing
- Perianal fistula surgical repair
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Obesity
Incretin Physiology and Beta-cell Function Before and After Weight-loss
To evaluate the impact of laparoscopic adjustable gastric banding (LAGB) on beta-cell function, insulin sensitivity, incretin function, postprandial secretion of incretin hormones (glucagon-like peptide-1 (GLP-1) and…
- Trial name
- NCT00625040
- Testing
- Oral glucose tolerance test (OGTT), isoglycemic iv. clamp, liquid meal test, gastric emptying rate
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Irritable Bowel Syndrome (IBS)
Probiotic Mixture (L. Rhamnosus GG and L. Plantarum 299V) In Pediatric Irritable Bowel Syndrome
What is this study about? This clinical study aims to investigate whether a specific combination of probiotics-Lactobacillus rhamnosus GG and Lactobacillus plantarum 299V-can help children and adolescents with Irritable Bowel…
- Trial name
- PRIME (NCT07125625)
- Testing
- Experimental arm: probiotic
- Where
- 3 sites in Italy
- Volunteers
- 124 people
- Sponsor
- University of Bari
Anal Carcinoma, Cervical Carcinoma
Changes in Pelvic Health, Sexual Function, and Quality of Life in Women With Pelvic Cancer Undergoing Radiation Therapy
This study investigates changes in physical measures of pelvic health and patient-reported outcomes of sexual function, intimate relationship, and quality of life over time in women undergoing radiation therapy for pelvic cancer.
- Conditions
- Anal Carcinoma, Cervical Carcinoma, Endometrial Carcinoma, Malignant Pelvic Neoplasm
- Trial name
- GEORGIA (NCT04713618)
- Testing
- Pelvic Examination, Survey
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Irritable Bowel Syndrome
1H-19F Gastrointestinal MRI in Health and IBS
The aim of this project is to demonstrate and validate the ionizing radiation free and non invasive assessment of small intestinal anatomy, content and function in healthy and disease by a newly developed combined proton (1H) and…
- Trial name
- NCT01347918
- Testing
- 19F capsule, sterculia
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Irritable Bowel Syndrome
Diagnostic Strategies in Patients Suspected of Irritable Bowel Syndrome
The purpose of this study is to determine whether a clinical diagnosis of irritable bowel syndrome based on patient reported symptoms and a few blood tests is safe, and to determine whether a clinical diagnosis is as good for the…
- Trial name
- NCT00659763
- Testing
- Exclusion diagnosis, Clinical diagnosis
- Where
- Denmark
- Volunteers
- 149 people
- Sponsor
- Zealand University Hospital
Chronic Obstructive Pulmonary Disease
Characteristics of Intestinal Microbiome in the Progression of Early COPD
This study is aiming at explore the characteristics of intestinal microbiome during the early progression of COPD, the correlation between the changes of intestinal microbiome and the severity and risk of acute exacerbation of…
- Trial name
- NCT04876833
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Colorectal Cancer, Quality Improvement
ERAS (Enhanced Recovery After Surgery) Protocol Implementation in Piedmont Region for Colorectal Cancer Surgery
The study assesses the impact on quality of care of implementing the ERAS (Enhanced Recovery After Surgery) protocol for colorectal cancer surgery in the network of public hospitals in the Regione Piemonte (North-West Italy).
- Conditions
- Colorectal Cancer, Quality Improvement, Perioperative Care, Recovery of Function
- Trial name
- ERAS-Colon (NCT04037787)
- Testing
- ERAS protocol
- Where
- Italy
- Volunteers
- 2,397 people
- Sponsor
- Ospedale Santa Croce-Carle Cuneo
Cardiometabolic Health, Gastro-intestinal Wellbeing
Effects of Wholegrains on Children's Health (KORN)
KORN investigates the effects of wholegrain oat and rye intake on health and cognitive wellbeing in children with overweight.
- Conditions
- Cardiometabolic Health, Gastro-intestinal Wellbeing, Cognitive Function, Overweight
- Trial name
- NCT04430465
- Testing
- Grain products high in wholegrains from oat and rye, Grain products low in wholegrains
- Where
- Denmark
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
IBS, IBS - Irritable Bowel Syndrome
Effect of Tenapanor on the Metagenomics and Metabolomics of Patients With Irritable Bowel Syndrome With Constipation
The aim of this study is to better understand how tenapanor affects the metagenomics and metabolomics of patients with irritable bowel syndrome with constipation (IBS-C). Tenapanor is the newest FDA-approved agent for IBS-C.
- Trial name
- NCT05995899
- Testing
- Tenapanor
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Kyle Staller, MD, MPH
Irritable Bowel Syndrome
An Intervention Study Using HMOs to Improve IBS Symptoms
There is now strong evidence implicating the human gut microbiota in many gastrointestinal diseases, including irritable bowel syndrome (IBS).
- Trial name
- GUT-HEAL-IBS (NCT06281600)
- Testing
- Human milk oligosaccharide
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Glenn Gibson
Irritable Bowel Syndrome
Study of LX1031 in Subjects With Non-Constipating Irritable Bowel Syndrome
The purpose of the study is to evaluate the safety, tolerability, and effectiveness of LX1031 versus a placebo control in subjects with non-constipating irritable bowel syndrome.
- Trial name
- NCT00813098
- Testing
- LX1031 High Dose, LX1031 Low Dose
- Where
- 36 sites in United States
- Volunteers
- 155 people
- Sponsor
- Lexicon Pharmaceuticals
COPD, Pulmonary Hypertension
Vasoactive Intestinal Peptide in COPD
This study, a new immunomodulatory therapy of COPD with vasoactive intestinal peptide (VIP) was evaluated. Based on preliminary unpublished clinical and experimental results, the course of disease under VIP treatment and the…
- Trial name
- VIPCOPD (NCT00464932)
- Testing
- Vasoactive Intestinal Peptide (VIP)
- Volunteers
- 34 people
- Sponsor
- Medical University of Vienna
Irritable Bowel Syndrome (IBS)
Efficacy and Safety of Dietary Supplementation of Diamine Oxidase to Improve Symptoms in Patients With IBS
This project is a single center, randomized, controlled clinical trial evaluating the effects of DAO enzyme dietary supplement on symptoms of irritable bowel syndrome.
- Trial name
- NCT06139744
- Testing
- DAO supplement
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Bladder Cancer, Ileus
Use of Pedometer Following Radical Cystectomy
This is a study to evaluate whether use of a pedometer following radical cystectomy decreases post-operative narcotic use and time to return of bowel function.
- Conditions
- Bladder Cancer, Ileus, Narcotic Use
- Trial name
- NCT04305730
- Testing
- Use of a pedometer following surgery, Standard of care
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Benaroya Research Institute
IBS - Irritable Bowel Syndrome, Obesity
The Effect of a Probiotic Mixture in Obese Patients With Irritable Bowel Syndrome
The objective of the current study is to evaluate the effect of a probiotic mixture on the adequate relief and faecal microbiota in obese patients with irritable bowel syndrome
- Trial name
- NCT04760353
- Testing
- Probiotic mixture (OMNi-BiOTiC STRESS)
- Where
- 2 sites in Croatia
- Volunteers
- 80 people
- Sponsor
- University Hospital Rijeka
Calcific Aortic Valve Disease, Inflammation
Impact of TAVI on the Gut Microbiota and Its Metabolites
Aortic stenosis is a common heart valve disease in older adults. It occurs when the aortic valve becomes narrowed, making it harder for blood to flow from the heart to the rest of the body.
- Conditions
- Calcific Aortic Valve Disease, Inflammation, Dysbiosis, TAVI
- Trial name
- Swiss-GUT-TAVI (NCT07565077)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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