Clinical trials: Bowel Functions
Gastrointestinal Microbiome (Focus), Gastrointestinal Symptoms
The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight
The study is a single-center, randomized, double-blind, placebo-controlled study in middle-aged to elderly adults with excessive body weight. The study includes an 8-week intervention period followed by a 2-week follow-up period.
- Trial name
- myBIOM (NCT07453823)
- Testing
- Synbiotic
- Where
- Ireland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chr Hansen - part of Novonesis
Colorectal Cancer
Robotic vs Laparoscopic D3-D4 Lymphadenectomy for Colorectal Cancer
Approximately one third of patients with colorectal cancer are diagnosed as locally advanced stage with metastasis to N3 - N4 lymph nodes requiring a D3 - D4 lymphadenectomy.
- Trial name
- NCT05961423
- Testing
- Robotic surgery
- Where
- Taiwan
- Volunteers
- 286 people
- Sponsor
- National Taiwan University Hospital
Healthy
Dietary Fiber, Microbiota and Cognitive Function in Healthy Adults
Dietary fiber is well-known for its many health benefits, including the support of gastrointestinal, metabolic, and mental health.
- Trial name
- FOCUS (NCT04951674)
- Testing
- High fiber diet, Control diet
- Where
- Ireland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University College Cork
IBS - Irritable Bowel Syndrome, Functional Gastrointestinal Disorders
Effect of a Diet Without Non-caloric Sweeteners on Gastrointestinal Symptoms in Patients With IBS and Dyspepsia
Digestive Functional Disorders (DFD), represent 50% of medical check ups, the symptoms interfere with patients quality of life and generate high health costs.
- Trial name
- IBS (NCT04129762)
- Testing
- Diet without NCS, Diet with NCS
- Where
- Mexico
- Volunteers
- 140 people
- Sponsor
- Hospital General de Mexico
Irritable Bowel Syndrome
The Effect of Serotonergic Modulation on Intestinal Permeability and Visceral Hypersensitivity in Healthy Individuals and Irritable Bowel Syndrome (IBS) Patients
Serotonin, 5-hydroxytryptamin (5-HT), plays an important role in regulating the gastrointestinal functions. In this study we will modulate the serotonin system with acute tryptophan depletion (ATD) and administration of…
- Trial name
- NCT00731003
- Testing
- Oxitriptan, Acute tryptophan depletion, Amino acid drink with tryptophan
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Anus Cancer, Fecal Incontinence
Function Following Laser for Anal Intraepithelial Neoplasia (FLAN)
High-grade squamous intraepithelial lesions (HSIL) and anal cancer are rising in incidence and at highest risk are HIV positive men who have sex with men (MSM).
- Conditions
- Anus Cancer, Fecal Incontinence, Anal Intraepithelial Neoplasia, Post Operative Pain
- Trial name
- FLAN (NCT04109573)
- Testing
- high resolution anal manometry
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Homerton University Hospital NHS Foundation Trust
Right-sided Colon Cancer
RISE Ileocecal Valve Functional Reconstruction
The traditional surgical treatment for right-sided colon cancer involves the removal of an important structure, the ileocecal valve, which includes the ileocecal valve.
- Trial name
- NCT07167420
- Testing
- RISE (Revolute Insert Side-End ileocecal valve reconstruction)
- Volunteers
- 188 people
- Sponsor
- Army Medical University, China
Irritable Bowel Syndrome
Subsensory Sacral Nerve Stimulation for Irritable Bowel Syndrome
Sacral nerve stimulation (SNS) has become a well-established treatment for patients with fecal incontinence since 1995. The mechanism of action of SNS is still not fully understood but recent studies have shown changes in both…
- Trial name
- NCT01948973
- Testing
- Subsensory, OFF, Suprasensory
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- University of Aarhus
Campylobacter Infections, Irritable Bowel Syndrome
Campylobacter Enteritis and Post-Infective Bowel Dysfunction (PI-BD): Role of Antibiotics and Microbiota
The principal research objective is to determine the impact of antibiotic use on the risk of developing long term bowel symptoms after infection with the germ Campylobacter.
- Trial name
- CERAMIC (NCT02040922)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome, GI Disorders
GUT LINK: A Study of a Care Pathway Across Primary and GI Specialty Care
It can be challenging for Primary Healthcare Providers (PHCPs) to differentiate between IBS and more serious illnesses involving the GI tract, such as Crohn's disease, ulcerative colitis, or cancer.
- Trial name
- NCT05725954
- Testing
- GUT LINK SmartPath
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Michael Stewart
Healthy, IBS - Irritable Bowel Syndrome
Microbiome Sampling in GI Disease With a Focus on Small Intestinal Microbial Assessment
GI disorders are influenced by the gut microbiome. To date, sampling of the small intestine in GI disorders has been limited. The investigators plan to sample the small intestinal contents during endoscopy for research purposes.
- Conditions
- Healthy, IBS - Irritable Bowel Syndrome, Inflammatory Bowel Diseases
- Trial name
- NCT06066866
- Testing
- endoscopic sampling of luminal fluid
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Stanford University
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female
Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (Reactive Hyperemia)
- Trial name
- NCT06735651
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgia State University
Bowel; Functional Syndrome
Postoperative Bowel Function After SPS by Different Reconstruction Methods
Colorectal cancer is one of the most common malignant tumors in the world. Surgery is still the main treatment for rectal cancer.
- Trial name
- NCT03669237
- Testing
- different reconstruction methods
- Where
- China
- Volunteers
- 200 people
- Sponsor
- YE Yingjiang
Sarcopenia
Role of the Gut Microbiome on Lean Mass and Physical Function in Older Adults
The investigators recently published significant associations between circulating gut bacteria-related metabolites with lean and skeletal muscle mass and with measures of physical function in older adults, evidence that suggests…
- Trial name
- NCT02811445
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Tufts University
Irritable Bowel Syndrome
Brain Imaging and Pain in Irritable Bowel Syndrome
This study examines the mechanisms, including brain imaging of placebo analgesia
- Trial name
- NCT00065754
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
Anorexia Nervosa
Fecal Microbiota Transplantation in Females With Anorexia Nervosa
The goal of this clinical trial is to learn whether fecal microbiota transplantation (FMT) can change the gut microbiome and improve health outcomes in females with anorexia nervosa.
- Trial name
- AN-SHIFT (NCT07877675)
- Testing
- Fecal Microbiota Transplantation Capsule
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Andreas Munk Petersen
Irritable Bowel Syndrome
Exploratory Study on Dosage of Qizhi Weitong Granules in the Treatment of Irritable Bowel Syndrome （IBS)
The purpose of this study are as follows: 1) To evaluate the efficacy and safety of Qizhi Weitong granules in the treatment of diarrhea-type irritable bowel syndrome (IBS-D);2) To explore the dosage of Qizhi Weitong Granulesin…
- Trial name
- NCT05113888
- Testing
- Qizhi weitong granules(High）, Qizhi weitong granules(Low）
- Volunteers
- 120 people
- Sponsor
- China Resources Sanjiu Medical & Pharmaceutical Co., Ltd.
Colorectal Cancer
Effect of Multimodal Prehabilitation After Colorectal Cancer Surgery
The process of enhancing an individual's functional capacity to optimize physiologic reserves before an operation to withstand the stress of surgery has been coined prehabilitation.
- Trial name
- NCT05854394
- Testing
- Multimodal prehabilitation management Multimodal prehabilitation management
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiamen University
Irritable Bowel Syndrome
Effect of Curcumin on Gut Microbiota in IBS
To evaluate the effect of curcumin food supplement on gut microbiota of children with irritable bowel syndrome (IBS) and to review any correlation between the changes in the microbiota with symptoms.
- Trial name
- NCT03568513
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medical College of Wisconsin
Intestinal and Lmmune Function Lmproved
Investigating the Efficacy of Probiotics in Enhancing Gastrointestinal and Immunological Health
Evaluate the effectiveness and safety of Ligilactobacillus salivarius LS97 as a food supplement compared to a placebo in improving intestinal and immune functions in healthy adults.
- Trial name
- NCT06886724
- Testing
- Probiotic
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
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