Clinical trials: Bowel Functions
Crohn's Disease, Peri-anal Fistulas
Investigation of Sexual Function in Crohn's Disease Patients With Perianal Fistulas
Objective: The aim of this study is to investigate whether Crohn's Disease patients with peri-anal fistulas will suffer from sexual dysfunction in an attempt to help us identify Crohn's Disease patients that would benefit from…
- Conditions
- Crohn's Disease, Peri-anal Fistulas, Sexual Dysfunction
- Trial name
- NCT01635543
- Where
- Canada
- Sponsor
- University of British Columbia
Irritable Bowel Syndrome
Faecal Microbiota Transplantation (FMT) in Patients With IBSmechanism(s) of Action
Two hundrad patients are randomized to either 90 g transplant, 90 g transplant twice with 1week interval into the distal small intestine via working channel of a gastroscope, or to 90 g transplant into the coecum of the colon via…
- Trial name
- NCT04236843
- Testing
- Feces
- Where
- Norway
- Volunteers
- 186 people
- Sponsor
- Helse Fonna
Irritable Bowel Syndrome
A Study of YM060 in Diarrhea-predominant Irritable Bowel Syndrome (d-IBS)
This study will examine the efficacy, safety and tolerability of different oral dose of YM060, 5-HT3 receptor antagonist, in patients with d-IBS.
- Trial name
- NCT00189813
- Testing
- YM060
- Where
- 45 sites in Bulgaria, Czechia and 6 more
- Volunteers
- 691 people
- Sponsor
- Astellas Pharma Inc
Irritable Bowel Syndrome With Diarrhea
Effect of FODMAPs on Mucosal Inflammation in IBS Patients
OBJECTIVE: To gain mechanistic insights, we will compare effects of low fermentable oligosaccharides, disaccharides and monosaccharides and polyols (FODMAP) and high FODMAP diets on symptoms and colonic protease expression in…
- Trial name
- NCT03221790
- Testing
- Low FODMAP Diet followed by a High FODMAP Diet
- Volunteers
- 20 people
- Sponsor
- Queen's University
Anal Carcinoma, Cervical Carcinoma
Changes in Pelvic Health, Sexual Function, and Quality of Life in Women With Pelvic Cancer Undergoing Radiation Therapy
This study investigates changes in physical measures of pelvic health and patient-reported outcomes of sexual function, intimate relationship, and quality of life over time in women undergoing radiation therapy for pelvic cancer.
- Conditions
- Anal Carcinoma, Cervical Carcinoma, Endometrial Carcinoma, Malignant Pelvic Neoplasm
- Trial name
- GEORGIA (NCT04713618)
- Testing
- Pelvic Examination, Survey
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Obesity
Incretin Physiology and Beta-cell Function Before and After Weight-loss
To evaluate the impact of laparoscopic adjustable gastric banding (LAGB) on beta-cell function, insulin sensitivity, incretin function, postprandial secretion of incretin hormones (glucagon-like peptide-1 (GLP-1) and…
- Trial name
- NCT00625040
- Testing
- Oral glucose tolerance test (OGTT), isoglycemic iv. clamp, liquid meal test, gastric emptying rate
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Colorectal Cancer
Surgical Prehabilitation of Cancer Patients Undergoing Colorectal Resection.
Psychological distress is common among adults newly diagnosed with cancer and those awaiting cancer treatment(s). Although preoperative psychological distress has been shown to be associated with poorer physical health and…
- Trial name
- NCT04248647
- Testing
- Multimodal prehabilitation
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Functional Constipation
Multistrain Probiotic for Functional Constipation
Subjects will be screened and will enter a placebo-only 2-week run-in period during which constipation symptoms will be evaluated and any disallowed products (e.g. probiotics) must be discontinued.
- Trial name
- NCT01618617
- Testing
- High dose Multistrain probiotic, 100 billion cfu/day, Low dose Multistrain probiotic, 15 billion cfu/day
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Renew Life Formulas Inc
Bowel Function Dissatisfaction
Impact of a Dried Vegetable on Bowel Function and Gut Microbiota
A randomized, placebo-controlled, parallel, double-blind trial with three intervention arms and a period of four intervention-weeks that assesses the intake of different dosages of a complex fiber product on bowel function via…
- Trial name
- HappYFiber (NCT05473793)
- Testing
- Dried chicory root particles
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Healthy
Effect of Brazilian Fruits Peel on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study was to investigate how Brazilian fruits peel affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective…
- Trial name
- BRASIL-MET (NCT02245906)
- Testing
- Control drink, Brazilian fruit peel flour, Negative control drink
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lund University
Irritable Bowel Syndrome (IBS)
Genetic Determinism of Epithelial Barrier Defects in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) profoundly affects the quality of life. Mucosal micro-inflammation, epithelial permeability disorder and proteases activity increase have been demonstrated in the patients' gastrointestinal tract.
- Trial name
- PROTIBS (NCT02841878)
- Testing
- Analysis on colorectal biopsy
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Nice
Irritable Bowel Syndrome
Saccharomyces Cerevisiae for Irritable Bowel Syndrome
This study is designed to see the response of saccharomyces cerevisiae for symptomatic improvement of patients with IBS
- Trial name
- IBS (NCT05149599)
- Testing
- Saccharomyces cerevisiae
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Ziauddin University
Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS) Treatment With H1-receptor Antagonists
Purpose: To evaluate the efficiency of Irritable Bowel Syndrome (IBS) patients treatment with the H1-receptor antagonist ebastine. Design: Double blind randomized placebo controlled trial.
- Trial name
- NCT01144832
- Testing
- ebastine
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- KU Leuven
Irritable Bowel Syndrome, Sexual Dysfunction
Visceral Sensitivity in Women With BS and Sexual Dysfunction
This study aims to compare visceral rectal sensitivity and quality of life of 40 Irritable Bowel Syndrome women, with (20) and without sexual dysfunction (20).
- Trial name
- IBS (NCT04716738)
- Testing
- Blood analyses and coprological
- Volunteers
- 20 people
- Sponsor
- Hospital General de Mexico
Rectal Cancer, Ileostomy; Functional Disturbance
Trial Evaluating the Tailored Versus the Systematic Use of Defunctioning Stoma After Total Mesorectal Excision for Rectal Cancer (GRECCAR17)
GRECCAR 17 will be the first prospective and randomized trial to assess a tailored policy in the use of defunctioning stoma after TME according to the personalized risk of anastomotic leakage.
- Trial name
- GRECCAR17 (NCT05233787)
- Testing
- Tailored use of defunctioning stoma after TME, Systematic use of defunctioning stoma
- Where
- 28 sites in France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Bordeaux
Irritable Bowel Syndrome, Gluten Sensitivity
Reduced Content of Gluten Diet on Patients With Irritable Bowel Syndrome (Pro.Ali.Fun.)
This study aim to manufacture bread and pasta with an reduced content of gluten and to assess the impact of reducing the daily intake of gluten by 50% in irritable bowel syndrome (IBS) patients.
- Trial name
- PROALIFUN (NCT03638544)
- Testing
- Reduced gluten bread and Pasta compared o normal gluten bread and Pasta
- Volunteers
- 20 people
- Sponsor
- University of Bari
Cognition, Affect (Mental Function)
PRECOG Pilot Project
This pilot study aims to investigate the chronic effects of a prebiotic blend on cognitive, affective and gut microbiome outcomes in healthy adults aged 60-75 years.
- Conditions
- Cognition, Affect (Mental Function), Gut Microbiome
- Trial name
- NCT06911957
- Testing
- Prebiotic blend
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Reading
Irritable Bowel Syndrome, Constipation
Efficacy and Safety of YKP10811 in Subjects With Irritable Bowel Syndrome With Constipation
This trial is to investigate efficacy and safety of YKP10811 in Subjects With Irritable Bowel Syndrome With Constipation. The difference of responder rate between test group (10, 20 and 40mg) and placebo will be evaluated.
- Trial name
- YKP (NCT02082457)
- Testing
- YKP10811 5mg, YKP10811 20mg
- Where
- South Korea
- Volunteers
- 273 people
- Sponsor
- SK Chemicals Co., Ltd.
Bowel Disease, Liver Diseases
The Impact of an Epidural Anesthetic on the Consumption of Sevoflurane in Major Abdominal Surgery
Major abdominal surgery - like non-laparoscopic bowel resection, liver, gastric, or pancreas surgery - is performed under general anesthesia.
- Conditions
- Bowel Disease, Liver Diseases, Pancreas Disease, Anesthesia; Functional
- Trial name
- NCT04021264
- Testing
- Ropivacaine-Sufentanil, Dextrose 5
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Irritable Bowel Syndrome (IBS)
Physical Activity in IBS - a Long Term Follow up
Increased physical activity has in the investigators recent study been shown to improve symptoms in irritable bowel syndrome (IBS).
- Trial name
- IBS (NCT01774695)
- Testing
- Increased physical activity
- Where
- Sweden
- Volunteers
- 39 people
- Sponsor
- Sahlgrenska University Hospital