Clinical trials: Bowel Functions
Metabolic Syndrome
Canola Oil Multicentre Intervention Trial
The purpose of the study is to examine how the consumption of different dietary oil varieties affects a broad range of metabolic responses that are important in the development of cardiovascular diseases.
- Trial name
- COMIT (NCT01351012)
- Testing
- Corn and safflower oil, Canola oil, High oleic acid canola oil
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- University of Manitoba
Irritable Bowel Syndrome, Obesity
Response of Irritable Bowel Syndrome to Abdominal Fat Reduction
The purpose of the study is to find out the response of Irritable Bowel Syndrome (IBS) to abdominal fat reduction in central obese patients using: application of High Intensity Focused Ultrasound (cavitation) on the abdominal…
- Conditions
- Irritable Bowel Syndrome, Obesity, Abdominal Obesity
- Trial name
- NCT05879692
- Testing
- focused ultrasound, Low Caloric Diet (LCD) and a low (FODMAPs) diet, aerobic exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Irritable Bowel Syndrome, Abdominal Bloating
Galactol® Enzyme Supplement for Post-Prandial Abdominal Bloating in Irritable Bowel Syndrome
This multicenter, randomized, controlled clinical trial aims to evaluate the efficacy and safety of a dietary supplement containing a combination of digestive enzymes (alpha-galactosidase, beta-galactosidase, and…
- Trial name
- NCT07465562
- Testing
- Galactol®, High-FODMAP Exclusion Diet
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Spinal Cord Injuries, Neurogenic Bowel
Exoskeleton Neurogenic Bowel Dysfunction Study
The purpose of the study is to assess the effects of exoskeleton training on neurogenic bowel disorders in spinal cord injury/ disease.
- Trial name
- NCT05176327
- Testing
- Exoskeleton training with Ekso NR
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- The University of Hong Kong
Non-celiac Gluten Sensitivity, Irritable Bowel Syndrome
Identification of Gluten Sensitivity in Irritable Bowel Syndrome
The aim of our study will be to establish in how many subjects with gastrointestinal symptoms and previous diagnosis of irritable bowel syndrome (IBS), the clinical picture is attributable to non celiac gluten sensitivity (NCGS)…
- Trial name
- IBS-NCGS (NCT04017585)
- Testing
- diet containing gluten
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Bari
Postoperative Constipation, Pelvic Organ Prolapse Vaginal Surgery
Impact of Defecation Posture on Ease of First Bowel Movement Following Posterior Repair
This study will determine if defecation posture, when using a defecation posture modification device (DPMD), improves ease with first bowel movement following pelvic reconstructive surgery, specifically posterior repair.
- Conditions
- Postoperative Constipation, Pelvic Organ Prolapse Vaginal Surgery, Defecation Function
- Trial name
- NCT06253689
- Testing
- Defecation Posture Modification Device
- Where
- 3 sites in United States
- Volunteers
- 160 people
- Sponsor
- TriHealth Inc.
Intestinal Diseases, Irritable Bowel Syndrome
Biomarkers for Intestinal Permeability in Patients With Constipation
Our overall objective with this study is firstly to provide a comprehensive assessment of intestinal permeability, mucosal barrier function using existing biomarkers and secondly to explore novel biomarkers for measuring…
- Conditions
- Intestinal Diseases, Irritable Bowel Syndrome, Constipation
- Trial name
- NCT02246647
- Testing
- Permeability measurement, Esophagogastroduodenoscopy, Flexible sigmoidoscopy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Rectal Cancer
A Randomized Controlled Clinical Trial Comparing Oncological Results and Functional Recovery Between Laparoscopic and Open Method for the Treatment of Advanced Rectal Cancer After Concurrent Chemoradiation Therapy (CCRT)
This is a three-year research project. The major aims of this study are to:(1) compare the functional recovery and oncologic results in patients with advance rectal cancer treated by either traditional open or laparoscopic…
- Trial name
- NCT00601549
- Testing
- Laparoscopic surgery, Traditional open surgery
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
Irritable Bowel Syndrome
Diarrhea Predominant Irritable Bowel Syndrome in Females
Clinical Trial with TRN-002 in Women with Irritable Bowel Syndrome (IBS) The purpose of this study is to investigate the safety and effectiveness of a new investigational drug in women for the treatment of diarrhea-predominant…
- Trial name
- NCT00461526
- Testing
- crofelemer
- Where
- 43 sites in United States
- Volunteers
- 240 people
- Sponsor
- Bausch Health Americas, Inc.
Healthy
Lacticaseibacillus Rhamnosus GG Pili Study
The aim of this study was to investigate the host-microbe interaction effects of various Lacticaseibacillus rhamnosus GG strains, with different binding capacities to the mucus in the small intestine, in healthy individuals
- Trial name
- NCT05461443
- Testing
- Probiotic
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Metabolic Dysfunction-Associated Steatotic Liver Disease, Non Celiac Wheat Sensitivity
Liver Steatosis and Fibrosis in Non-Celiac Wheat Sensitivity Patients: a Prospective Study
Hypothesizing an intestinal barrier impairment as a common pathophysiological substrate of both Non Celiac Wheat Sensitivity (NCWS) and Metabolic Dysfunction-Associated Steatotic Liver Disease (MAFLD), in a retrospective cohort…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Non Celiac Wheat Sensitivity, Irritable Bowel Syndrome, Functional Dyspepsia
- Trial name
- NCT07750535
- Testing
- Prevalence and severity of liver steatosis and fibrosis,
- Where
- 2 sites in Italy
- Volunteers
- 250 people
- Sponsor
- University of Palermo
Irritable Bowel Syndrome, IBS
Study of Bacteria on Mood and Bowel Symptoms in Patients With Irritable Bowel Syndrome
The purpose of this study is to determine whether probiotic bacterium Bifidobacterium longum (B. longum) can improve mood and bowel symptoms in patients with Irritable bowel syndrome (IBS).
- Trial name
- NCT01276626
- Testing
- Bifidobacterium longum, Maltodextrin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Société des Produits Nestlé (SPN)
Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome
Autonomic Reactivity and Personalized Neurostimulation
Disorders of gut-brain interaction (DGBI) affect up to 25% of U.S. children. Patients often suffer from disabling, multisystem comorbidities that suggest a common root (sleep disturbances, fatigue, anxiety, etc).
- Conditions
- Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome, Functional Dyspepsia, Dysautonomia
- Trial name
- NCT06863207
- Testing
- Percutaneous electrical nerve field stimulation, Hypnotherapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Rectal Neoplasms, Low Anterior Resection Syndrome
Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer
The goal of this study is to compare the postoperative anal function of patients with ultra-low rectal cancer after Parks operation (colon anal anastomosis) and Bacon operation (colon anal pull-out anastomosis), which may provide…
- Conditions
- Rectal Neoplasms, Low Anterior Resection Syndrome, Anastomotic Leak, Quality of Life
- Trial name
- NCT05943444
- Testing
- Parks technique, Bacon technique
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Healthy Adult
Effect of Bifidobacterium Animalis Subsp. Lactis Bi66 Supplementation on Gut Function in Healthy Adults
The goal of this clinical trial is to learn the effect of Bifidobacterium animalis subsp. lactis Bi66 supplementation on gut function in healthy adults. The main questions it aims to answer are: 1.
- Trial name
- NCT06740500
- Testing
- Probiotic
- Where
- China
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Irritable Bowel Syndrome, Colitis, Ulcerative
Advanced Metagenomic Analysis of Human Colonic Microbiota in Patients With Chronic GI Disorders
This clinical trial hypothesize that Gut Microbiota (bacteria, viruses, fungi)play a major role in the occurrence and progression of many chronic gastrointestinal diseases like Irritable Bowel Syndrome, Inflammatory Bowel…
- Conditions
- Irritable Bowel Syndrome, Colitis, Ulcerative, Crohn Disease, Colonic Neoplasms
- Trial name
- NCT01099111
- Where
- Saudi Arabia
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- King Fahad Medical City
Neutropenic Enterocolitis
Profile Fecal Analysis of Neutropenic Enterocolitis
A prospective, single-center, cohort study to allow collecting observations of patients receiving induction chemotherapy for primary Acute Myeloid Leukemia (AML), collecting biological samples(including fecal samples for…
- Trial name
- PROFANE (NCT04438278)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
IBS - Irritable Bowel Syndrome
Microbiota, Metabolome and Nutrition: an 'Artificially Intelligent' Way to Personalized Nutrition
Intervention: (Weeks 1-2, Visit 3-4) - Starting from the second week after the date of consent, patients with IBS will be randomized 1:1 into two groups.
- Trial name
- PN-AI-21 (NCT06420843)
- Testing
- FOODMAP
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Istituto Clinico Humanitas
Pain, Postoperative, Postoperative Ileus
Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery
Title: Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery: A Multicenter, Randomized, Controlled Trial The goal of this clinical trial is to evaluate the effectiveness and safety of tegileridine…
- Trial name
- NCT07412223
- Testing
- Tegileridine, Morphine
- Where
- 3 sites in China
- Volunteers
- 152 people
- Sponsor
- Xiangya Hospital of Central South University
Obesity, Body Weight
Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
This study, at the Western Human Nutrition Research Center (WHNRC), will focus on whether or not achieving and maintaining a healthy body weight is the most important health promoting recommendation of the Dietary Guidelines for…
- Trial name
- DGA4ME (NCT04293224)
- Testing
- DGA Mediterranean diet pattern, energy balance, DGA Mediterranean diet pattern, negative energy balance, TAD diet pattern, negative energy balance
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
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