Clinical trials: Bowel Functions
Irritable Colon
Study to Assess the Effect Of Alosetron On Mucosal Blood Flow
This study will look at colonic mucosal blood flow in subjects who have taken alosetron vs placebo and healthy volunteers vs diarrhea-predominant Irritable Bowel Syndrome (d-IBS) patients.
- Trial name
- NCT00370032
- Testing
- alosetron
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Functional Constipation
The Effect of Probiotics on Constipation, and Intestinal Microflora in Children With Functional Constipation
To compare the differences of fecal microflora between constipated and non-constipated healthy children, and evaluate the efficacy of probiotics in reducing symptoms of constipation and the influence of intestinal microflora in…
- Trial name
- NCT03054805
- Testing
- Magnesium Oxide, MIYAIRI-BM
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Irritable Bowel Syndrome
Efficacy and Safety of IBS Digital Behavioral Treatment
A Randomized, Double-Blind, Comparator-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Two Self-administered behavioral treatments for Adult Subjects with Symptomatic Irritable Bowel Syndrome (IBS).
- Trial name
- EASITx (NCT04133519)
- Testing
- Arm 1 - Active behavioral Treatment Arm (Regulora; Gut-Directed Hypnotherapy Software as a Medical Device - SaMD), Arm 2 - Active Comparator behavioral treatment arm (MR-1; Muscle Relaxation, Software as a Medical Device - SaMD)
- Where
- United States
- Volunteers
- 378 people
- Sponsor
- metaMe Health
Ulcerative Colitis
Melatonin and Ulcerative Colitis: A Pilot Clinical Trial
Ulcerative colitis is an inflammatory bowel disease that afflicts up to one million people in the U.S. Symptoms include rectal urgency, bloody diarrhea, moderate to severe abdominal pain, fever, and fatigue.
- Trial name
- NCT00790478
- Testing
- Melatonin
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Emory University
IBS - Irritable Bowel Syndrome
Irritable Bowel Syndrome and Control Volunteers: Diet Challenge
The purpose of this study is to study the relationship between the bile acids, short chain fatty acids and bacteria within the intestines.
- Trial name
- NCT03983434
- Testing
- Inulin
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University
Urinary Bladder, Neurogenic, Blood Pressure
Recovery of Bladder and Sexual Function After Human Spinal Cord Injury
This study will incorporate critical cross viscero-visceral intersystem interactions to investigate in a controlled laboratory setting the extent, severity, and frequency of occurrence of autonomic dysreflexia with respect to…
- Conditions
- Urinary Bladder, Neurogenic, Blood Pressure, Autonomic Dysreflexia, Bowel Incontinence
- Trial name
- NCT04193709
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Louisville
Irritable Bowel Syndrome
Acceptability and Efficacy of the Zemedy App for Irritable Bowel Syndrome
The purpose of this research is to assess if a new self-help app for IBS is an acceptable and effective intervention for improving the overall quality of life in patients with Irritable Bowel Syndrome.
- Trial name
- NCT04170686
- Testing
- Zemedy App for Irritable Bowel Syndrome
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- University of Pennsylvania
Head and Neck Cancer, Synbiotics
Impact of Symbiotic Administration on Intestinal Function of Head and Neck Patients Surgically Treated
The purpose of this study is to determine whether the symbiotic use in patients with head and neck cancer impact on intestinal function after surgical treatment.
- Conditions
- Head and Neck Cancer, Synbiotics, Nutrition Therapy
- Trial name
- NCT02654652
- Testing
- Symbiotic, Maltodextrin
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Irritable Bowel Syndrome With Diarrhea
52-Week Efficacy and Safety Study of Ibodutant in Women With Irritable Bowel Syndrome With Diarrhea (IBS-D)
Irritable Bowel Syndrome with diarrhoea (IBS-D) is a functional gastrointestinal disorder characterised by chronic or recurrent abdominal pain or discomfort and diarrhoea.
- Trial name
- IRIS-4 (NCT02120027)
- Testing
- Ibodutant 10 mg
- Where
- 139 sites in United States, Czechia and 7 more
- Volunteers
- 558 people
- Sponsor
- Menarini Group
Irritable Bowel Syndrome
Olorinab in Irritable Bowel Syndrome With Predominant Constipation (IBS-C) and Irritable Bowel Syndrome With Predominant Diarrhea (IBS-D)
The purpose of this study is to determine whether olorinab is a safe and effective treatment for abdominal pain in participants with irritable bowel syndrome (IBS).
- Trial name
- CAPTIVATE (NCT04043455)
- Testing
- Olorinab
- Where
- 69 sites in United States
- Volunteers
- 273 people
- Sponsor
- Arena Pharmaceuticals
Major Depression, Irritable Bowel Syndrome
Open Trial of Duloxetine in Outpatients With Irritable Bowel Syndrome Symptoms and Co-Morbid Major Depression
This study will evaluate the efficacy of duloxetine in reducing depressive symptoms, abdominal pain, and other symptoms of Irritable Bowel Syndrome (IRS) in a population of outpatients with Major Depressive Disorder MDD and…
- Trial name
- IBS-MDD (NCT01754493)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- New York State Psychiatric Institute
Irritable Bowel Syndrome
Evaluation of the Efficacy and Safety of Lubiprostone in Adults With Mixed or Unsubtyped Irritable Bowel Syndrome
A study of the efficacy and safety of Lubiprostone in subjects diagnosed with IBS-M/IBS-U.
- Trial name
- NCT02544152
- Testing
- Lubiprostone
- Where
- 16 sites in United States
- Volunteers
- 71 people
- Sponsor
- Sucampo Pharma Americas, LLC
Type 1 Diabetes
The Effect of Gluten-free Diet on New Onset Type 1 Diabetes (T1D)
The primary aim of this pilot study is to test whether gluten-free diet (GFD) instituted in children shortly after onset of Type 1 Diabetes (T1D) can decelerate the decline in beta cell function as compared to age matched…
- Trial name
- NCT02867436
- Testing
- Gluten-free diet
- Where
- 2 sites in Czechia
- Volunteers
- 45 people
- Sponsor
- University Hospital, Motol
Crohn's Disease
A Long-term Active Treatment Study of Mongersen (GED-0301) in Subjects With Crohn's Disease
The purpose of this study is to assess long-term safety data of GED-0301 for a period of up to 208 weeks in adult subjects (i.e., ≥ 18 years of age) who participated in the core Phase 3 GED-0301-CD-002 and GED-0301-CD-003 studies…
- Trial name
- NCT02641392
- Testing
- GED-0301
- Where
- 231 sites in United States, Australia and 29 more
- Volunteers
- 310 people
- Sponsor
- Celgene
Type 2 Diabetes, Obesity
EndoBarrier in Obese Subjects With Type 2 Diabetes Mellitus
The aim of the study is to explore short and longer-term effects of the Endobarrier™ implantation on insulin resistance and beta-cell function assessed by repeated Botnia clamps.
- Trial name
- NCT02769728
- Testing
- EndoBarrier
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Graz
Irritable Bowel Syndrome, Diarrhea
Does Welchol (Colesevelam Hydrochloride) Improve Colonic Transit in Diarrhea-predominant Irritable Bowel Syndrome (D-IBS)?
Our hypothesis is that the medication approved for treatment of high blood cholesterol levels, Colesevelam HCl (WELCHOL), decreases colonic transit and permeability in patients with diarrhea due to irritable bowel syndrome.
- Trial name
- welchol (NCT00911612)
- Testing
- Colesevelam
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Spinal Cord Injury, Constipation
Utility of an Animated Bowel Biofeedback Training Routine to Improve Bowel Function in Individuals With SCI
An injury to the spinal cord results in a number of secondary medical problems, including the inability to voluntarily control the bowels.
- Conditions
- Spinal Cord Injury, Constipation, Fecal Incontinence, Neurogenic Bowel
- Trial name
- NCT02406859
- Testing
- Bowel Biofeedback, Anorectal Manometry
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Fecal Incontinence, Irritable Bowel Syndrome With Diarrhea
The Role of Fiber in the Prevention and Treatment of Fecal Incontinence
The purpose of this study is to determine the effect of fiber supplementation on the fecal metagenome and metabolome in relation to symptoms and anorectal physiology in post-menopausal women with irritable bowel syndrome with…
- Trial name
- NCT04806386
- Testing
- Psyllium
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder
Efficacy of Vivomixx on Behaviour and Gut Function in Autism Spectrum Disorder
The purpose of this study is to assess the effects of 3 months supplementation with the multi strain probiotic Vivomixx on the overall function, aberrant behaviours and frequency of gastrointestinal symptoms in children with…
- Trial name
- VIVO-ASD (NCT03369431)
- Testing
- Vivomixx
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- University College, London
Obstructed Defecation Syndrome, Rectocele
Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM
The stapled transanal rectal resection (STARR procedure) is an effective treatment for obstructed defecation syndrome (ODS) caused by intussusception and rectocele.
- Conditions
- Obstructed Defecation Syndrome, Rectocele, Intussusception, SNS
- Trial name
- STARR (NCT00673400)
- Testing
- Stapled transanal rectum resection
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Cantonal Hospital of St. Gallen