Clinical trials: Bowel Perforated
Perforated Appendicitis
The Effect of Gum Chewing on Postoperative Ileus
The purpose of this study is to see if chewing gum after surgery for perforated appendicitis will shorten the time of intestinal dysfunction.
- Trial name
- NCT00879294
- Testing
- Motion sickness wristband, Chewing Gum
- Where
- United States
- Sponsor
- Wake Forest University
Peptic Ulcer Perforation
Fast-track Surgery for Perforated Peptic Ulcers
The concept of "enhanced recovery after surgery" has become increasingly popular in elective abdominal surgeries. Yet, the role of this concept has not been described in emergency procedures.
- Trial name
- NCT01620671
- Testing
- Surgical repair of perforated peptic ulcer
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Perforated Appendicitis, Covid19
Frequency of Perforated Appendicitis in Times of COVID-19
Appendicitis is one of the most common clinical conditions in general surgery. The diagnosis is usually made from clinical examination, imaging (sonography or CT) and laboratory parameters.
- Trial name
- NCT04472052
- Testing
- appendectomy
- Where
- Germany
- Volunteers
- 143 people
- Sponsor
- University Hospital Tuebingen
Gastric Fistula
Endoscopic Treatment of Intestinal Fistulas and Perforations
Background: T-shaped tissue anchors have promise to close incisions and perforations of the intestines securely. The closure of perforations, gastro-gastric, or intestinal fistulas usually requires invasive open or laparoscopic…
- Trial name
- NCT00835458
- Testing
- gastro-gastric fistula closure
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Legacy Health System
Perforated Appendicitis
Irrigation Versus No Irrigation for Perforated Appendicitis
The purpose is to quantify the effect of irrigation during laparoscopic appendectomy for perforated appendicitis.
- Trial name
- NCT00854815
- Testing
- Irrigation, No Irrigation
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Children's Mercy Hospital Kansas City
Peptic Ulcers
Risk Factors Affecting Mortality in Perforated Peptic Ulcer
Perforation is one of the most severe and life-threatening complications of peptic ulcer disease. This study aims to evaluate the risk factors associated with postoperative morbidity and mortality in patients undergoing surgery…
- Trial name
- NCT07050199
- Testing
- Emergency laparotomy
- Where
- Nepal
- Volunteers
- 85 people
- Sponsor
- Maharajgunj Medical Campus
Intestinal Anastomotic Leak, Intestinal Perforations
Endosponge Vacuum Therapy (E-VAC) Registry of Intestinal Anastomotic Leaks and Perforations
The purpose of this registry is to collect data on the clinical use of endoluminal vacuum (E-Vac) therapy to treat both upper and lower intestinal leaks and perforations.
- Trial name
- NCT02477930
- Testing
- No interventions are done
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Baylor Research Institute
Laparotomy, Peritonitis
Standardized Perioperative Management of Patients Operated With Acute Abdominal Surgery in a High-risk Emergency Setting
The objective of the study is to handle patients with the need for an acute laparotomy according to a standardised perioperative protocol and to document the measurement as they are performed (i.e.
- Conditions
- Laparotomy, Peritonitis, Ileus, Perforated Bowel
- Trial name
- SMASH (NCT03549624)
- Testing
- Standardised protocol for the perioperative management in patients in need of an acute laparotomy
- Where
- Sweden
- Volunteers
- 1,435 people
- Sponsor
- Sahlgrenska University Hospital
Patent Ductus Arteriosus, Surgery
Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus
The primary goal of the trial is to compare two different Patent Ductus Arteriosus (PDA) treatment approaches: 1) an "early treatment" approach or 2) a "conservative" approach.
- Conditions
- Patent Ductus Arteriosus, Surgery, Necrotizing Enterocolitis, Intestinal Perforation
- Trial name
- PDA:TOLERATE (NCT01958320)
- Testing
- pharmacologic treatment of the PDA, no pharmacologic treatment of the PDA, NSAID
- Where
- 18 sites in United States, Sweden and 2 more
- Volunteers
- 202 people
- Sponsor
- University of California, San Francisco
Appendicitis
Perforated Appendicitis With Delayed Presentation
There is no consensus among pediatric surgeons regarding the optimal treatment for children with complicated appendicitis with delayed diagnosis.
- Trial name
- NCT01068288
- Testing
- Laparoscopic or open appendectomy, Expectant Management
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- The Hospital for Sick Children
Enterostomy
Mucous Fistula Refeeding Reduces the Time From Enterostomy Closure to Full Enteral Feeds ("MUC-FIRE" Trial)
The primary objective of this study is to demonstrate that mucous fistula refeeding between enterostomy creation and enterostomy closure reduces the time to full enteral feeds after enterostomy closure compared to standard of…
- Trial name
- MUC-FIRE (NCT03469609)
- Testing
- mucous fistula refeeding
- Where
- 17 sites in Austria, Germany and 1 more
- Volunteers
- 120 people
- Sponsor
- University of Leipzig
Perforated Peptic Ulcer
Open vs Laparoscopic Repair of Perforated Peptic Ulcer
comparison between outcomes of both open and laparoscopic repair of perforated peptic ulcer
- Trial name
- NCT05767320
- Testing
- open repair(exploration), abdominal laparoscopy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Emergency Laparotomy, Intestinal Obstruction
Tissue Perfusion During Emergency Laparotomy
This study is investigating the effect of intraoperative Noradrenaline on cardiac preload and stroke volume, after initial fluid resuscitation, in order to assess whether there is a masked preload responsiveness and ultimately…
- Conditions
- Emergency Laparotomy, Intestinal Obstruction, Perforated Viscus
- Trial name
- NCT04403425
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Colon Neoplasm, Rectum Neoplasm
Ultrasound Guided Transversus Abdominis Plane(TAP) Block in Intensive Care Unit
The Transversus Abdominis Block (TAP) block is known to be an effective means of reducing patient pain after abdominal surgery. In the meantime, the general TAP block has been studied in patients who were in the recovery room and…
- Conditions
- Colon Neoplasm, Rectum Neoplasm, Perforated Colon, Perforated Bowel
- Trial name
- NCT03198338
- Testing
- 0.25% Bupivacaine, 0.5mL/kg, Normal Saline, Ultrasound
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Seoul National University Bundang Hospital
Emergency Surgery
Is TIme From adMission to surgEry an Independent Prognostic Factor for Survival of Patients With Gastro-intestinal Perforation Associated With Septic Shock: (TIME) An Italian Intersocietary Retrospective and Prospective Observational Trial
Gastro-intestinal perforation is a condition that can become life-threatening in case of appearance of systemic symptoms, sepsis-related peripheral hypoperfusion and single or multiple organ failure needing a prompt intervention…
- Trial name
- TIME (NCT04811755)
- Testing
- Surgical timing from ED admission to surgery
- Volunteers
- 3,276 people
- Sponsor
- San Luigi Gonzaga Hospital
Surgery, Emergencies
Laparoscopic Versus Open Repair of Peptic Ulcer Perforation
Although laparoscopic repair (LR) of perforated peptic ulcers (PPUs) has long been accepted, clinical evidence comparing LR versus open repair (OR) remains lacking.
- Conditions
- Surgery, Emergencies, Peptic Ulcer Perforation
- Trial name
- LOREPUP (NCT04447170)
- Testing
- Simple repair or Graham technique
- Where
- 13 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Gianluca Costa
Perforated Appendicitis
Prospective Randomized Evaluation of Antibiotic Regimen Following Appendectomy for Perforated Appendicitis
The purpose of this study is to compare traditional triple antibiotic therapy against dual single day dosing antibiotic therapy in the management of perforated appendicitis in children.
- Trial name
- NCT00195923
- Testing
- Ampicillin, gentamicin, clindamycin, flagyl, ceftazidime
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's Mercy Hospital Kansas City
Perforated Appendicitis
Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis
The proposed study will investigate whether antibiotic irrigation using a gentamicin/clindamycin solution during laparoscopic appendectomy is superior in preventing postoperative wound infections and IAA in perforated…
- Trial name
- PA protocol (NCT04039750)
- Testing
- antibiotic rinse with suction, suction only
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Prisma Health-Upstate
Colorectal Neoplasms, Perforation of Rectum
Outcomes of Perforation After Colorectal Endoscopic Submucosal Dissection
Endoscopic resection of superficial colorectal neoplasms decrease risk of colorectal cancer. En bloc resection is necessary for large superficial lesions with risk of superficial submucosal cancer and is advised if feasible for…
- Conditions
- Colorectal Neoplasms, Perforation of Rectum, Perforation Colon
- Trial name
- NCT05728710
- Testing
- Endoscopic submucosal dissection
- Where
- 13 sites in Belgium, France
- Volunteers
- 350 people
- Sponsor
- Central Hospital, Nancy, France
Acute Appendicitis, Acute Cholecystitis
Web-based International Register of Emergency Surgery and Trauma
The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a…
- Conditions
- Acute Appendicitis, Acute Cholecystitis, Acute Diverticulitis, Post-operative Complications
- Trial name
- WIRES-T (NCT03643718)
- Testing
- Emergency General Surgery
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII