Clinical trials: Bowel Symptoms
Depression, Thyroid Cancer
Ganoderma Spores Modulate the Gut-Brain Axis
This study aims to investigate whether Sporoderm-removed Ganoderma lucidum spore powder (RGLS) ameliorates depression in thyroid cancer patients through gut-brain axis modulation, and to elucidate the underlying microbial and…
- Trial name
- NCT07524777
- Testing
- Sporoderm-removed Ganoderma lucidum spore powder (RGLS)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ling Zhiqiang
Bladder Cancer, Breast Cancer
Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer
RATIONALE: Physician-initiated smoking cessation strategies may be effective in getting early-stage cancer patients to quit smoking.
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Head and Neck Cancer
- Trial name
- NCT00002520
- Testing
- nicotine, Usual Care
- Where
- United States
- Volunteers
- 434 people
- Sponsor
- Eastern Cooperative Oncology Group
Lifestyle Risk Reduction, Weight Changes, Body
STI.VI. Study: How to Improve Lifestyles in Screening Contexts
The main study objective is to determine the feasibility and impact (effectiveness) of intervention models for lifestyle changing (diet and physical activity) on health outcomes.
- Conditions
- Lifestyle Risk Reduction, Weight Changes, Body, Breast Cancer, Colorectal Cancer
- Trial name
- STIVI (NCT03118882)
- Testing
- Diet group, Physical activity group, Physical activity and diet group
- Where
- Italy
- Volunteers
- 1,270 people
- Sponsor
- Centro di Riferimento per l'Epidemiologia e la Prev. Oncologica Piemonte
Irritable Bowel Syndrome With Diarrhea
12-Week Efficacy and Safety Study of Ibodutant in Women With Irritable Bowel Syndrome With Diarrhea (IBS-D)
Irritable Bowel Syndrome with diarrhoea (IBS-D) is a functional gastrointestinal disorder characterised by chronic or recurrent abdominal pain or discomfort and diarrhoea.
- Trial name
- IRIS-3 (NCT02107196)
- Testing
- Ibodutant 10 mg
- Where
- 127 sites in United States, Bulgaria and 9 more
- Volunteers
- 535 people
- Sponsor
- Menarini Group
Recurrent Rectal Cancer
Induction Chemotherapy for Locally Recurrent Rectal Cancer
This is a multicentre, open-label, parallel arms, phase IIII study that randomises patients with locally recurrent rectal cancer in a 1:1 ratio to receive either induction chemotherapy followed by neoadjuvant chemoradiotherapy…
- Trial name
- PelvEx II (NCT04389086)
- Testing
- Combination drug, Chemoradiotherapy, Surgery locally recurrent rectal cancer
- Where
- 14 sites in Belgium, Netherlands and 3 more
- Volunteers
- 364 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Clostridium Difficile Infection
PROSPECTIVE STUDY OF PREDISPOSING FACTORS OF REFRACTARY Clostridium Difficile INFECTION. INFLUENCE OF THE GUT MICROBIOMA
A higher frequency of recurrences in the University Hospital of Cabueñes (HUCAB) than in other hospitals in our area, including Central University Hospital of Asturias (HUCA) has been found.
- Trial name
- NCT04259931
- Testing
- microbiome analysis
- Volunteers
- 50 people
- Sponsor
- Hospital Universitario de Cabuenes
Obesity, Childhood
Combining Prebiotic and Diet/Physical Activity Educational Program Effects on Body Composition and Intestinal Microbiota in Children
The purpose of this study was to determine the feasibility, acceptability, and initial efficacy of combining prebiotic (Beneo Synergy 1) and calcium treatment with Project FUN (an online nutrition and physical activity program)…
- Trial name
- NCT05671731
- Testing
- Beneo Synergy 1, Project FUN
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Marquette University
Liver Fibrosis, Liver Cirrhosis
Influence of Probiotics Administration Before Liver Resection in Liver Disease
Surgical resection is one of the curative treatment modalities for HCC. Limits are postoperative septic and liver functional complications related to an increase in bacterial translocation and systemic endotoxemia.
- Conditions
- Liver Fibrosis, Liver Cirrhosis, Permeability; Increased, Hepatocellular Carcinoma
- Trial name
- LIPROCES (NCT02021253)
- Testing
- Probiotic
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Rouen
Constipation
Dietary Supplementation Effects on Bowel Movement Frequency and Intestinal Biological Markers in Seniors Presenting Slowed Intestinal Transit
This randomized, double-blind, controlled clinical trial among healthy volunteers with infrequent bowel movements but not severe constipation evaluate the effects of a supplementation in "symbiotic" on intestinal transit of…
- Trial name
- NCT04304170
- Testing
- VES002
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- CEN Biotech
Colon Polyp, Artificial Intelligence
Colonic Polyp Size Measurement With Artificial Intelligence
Primary objective of the study is to evaluate if the novel virtual polyp sizing tool accuracy in determining the size class of polyps among diminutive (0-5 mm), small (6-9 mm) and large (10 mm and above).
- Trial name
- NCT06073405
- Testing
- Colonic Polyp Measurement Assessment Via Artificial Intelligence
- Where
- Italy
- Volunteers
- 225 people
- Sponsor
- University of Roma La Sapienza
Colorectal Cancer, Adenoma Colon
Real-time Computer-Aided Detection of Colonic Adenomas With NEC WISE VISION® Endoscopy
This is a prospective, multicenter, randomized study to evaluate the clinical performance of a novel CADe device, WISE VISION® Endoscopy System, in patients undergoing high-definition white light (HDWL) colonoscopy for screening…
- Conditions
- Colorectal Cancer, Adenoma Colon, Polyp of Colon
- Trial name
- COLOWISE (NCT05611151)
- Testing
- Computer Aided Detection (CADe)
- Where
- 5 sites in United States, Germany and 2 more
- Volunteers
- 830 people
- Sponsor
- NEC Corporation
Short Bowel Syndrome
The Use of DPP-4 Inhibitors in Short Bowel Syndrome
The inhibition of Dipeptidyl peptidase-4 should increase the concentration of glucagone-like peptide 1 and 2, and the increase of the latter should increase the absorptive capacity of the intestine.
- Trial name
- DPP-4 (NCT02653131)
- Testing
- Dipeptidyl peptidase-4 inhibitor
- Where
- Poland
- Volunteers
- 8 people
- Sponsor
- Stanley Dudrick's Memorial Hospital
Celiac Disease
Probiotic Blend for Celiac Disease
The objective of the study is to develop a probiotic product (B. longum CCT 1934; B. lactis CCT 7858; L. rhamnosus CCT 7863; S. thermophilus ATCC 19258) to reduce the symptoms caused by celiac disease and concomitantly improve…
- Trial name
- NCT05646823
- Testing
- Probiotic blend
- Where
- Brazil
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Inflammatory Bowel Diseases
Effects of Prednisolone and Infliximab on the Regulation of Urea Synthesis in Active Inflammatory Bowel Disease
Loss of total mass of muscles (catabolism) is a serious clinical problem in patients with active inflammatory bowel disease (IBD).
- Trial name
- NCT00955123
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Colorectal Neoplasm, Metastasis
Adjuvant HIPEC to Prevent Colorectal Peritoneal Metastases in High-risk Patients
The prognosis of peritoneal metastases from colorectal cancer has recently improved with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC).
- Trial name
- NCT02575859
- Testing
- adjuvant HIPEC, surgery
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Colon Cancer Stage I, Colon Cancer
Predictors of Disease Recurrence After Curative Surgery for Stage I Colon Cancer
Patients with stage I (pT1-2 N0 M0) colon cancer (CC) accounts for 15-20% of colonic neoplasia. Stage I CC is mostly cured with surgical resection, consequently, adjuvant chemotherapy is never considered for this subset of…
- Trial name
- CORE1 (NCT05726188)
- Testing
- Colonic resection
- Where
- 24 sites in France, Italy
- Volunteers
- 2,000 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Dyspepsia, Malabsorption Syndrome
Evaluation of Topical Lidocaine Spray as Adjuvant to Upper Gastrointestinal Endoscopy in Children
There is some controversy in the medical literature regarding the effectiveness of topical lidocaine in children as an adjuvant drug to upper gastrointestinal endoscopy.
- Conditions
- Dyspepsia, Malabsorption Syndrome, Gastroesophageal Reflux Disease, Abdominal Pain
- Trial name
- NCT00521703
- Testing
- Lidocaine, Tannic acid
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Infantil Cândido Fontoura
Fracture of Hip, Ileus
Peripheral Perfusion Index in Acute Surgical Patients
Introduction Perioperative haemodynamic instability is associated with postoperative morbidity and mortality. Macrocirculatory parameters, such as the conventionally obtained mean arterial blood pressure and cardiac output, may…
- Conditions
- Fracture of Hip, Ileus, Perforated Viscus, Anastomotic Leak
- Trial name
- NCT03757442
- Where
- Denmark
- Volunteers
- 1,338 people
- Sponsor
- Hvidovre University Hospital
Colonic Polyp
Injured Submucosal Arteries After CSP for 10-19 mm Nonpedunculated Colorectal Polyps.
Cold polypectomy has the advantages of simple operation, less time-consuming and fewer complications. Guidelines have recommended cold snare polypectomy (CSP) to resect small polyps sized <9 mm.
- Trial name
- NCT05930041
- Testing
- Experimental CSP, Active Comparator HS-EMR
- Where
- Japan
- Volunteers
- 124 people
- Sponsor
- Showa Inan General Hospital
Infection Due to ESBL Escherichia Coli
Fosfomycin Versus Meropenem or Ceftriaxone in Bacteriemic Infections Caused by Multidrug Resistance in E.Coli
Enterobacterieaceae (and specially Escherichia coli) showing resistance due to multidrug-resistant Escherichia coli, plasmid mediated AmpC or quinolone resistance caused by chromosomal mechanisms have spread worldwide during the…
- Trial name
- FOREST (NCT02142751)
- Testing
- Fosfomycin sodium intravenous, Meropenem intravenous, Ceftriaxone intravenous
- Where
- 22 sites in Spain
- Volunteers
- 161 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla