Clinical trials: Bra
Depressive Disorder
Paxil CR Bioequivalence Study Brazil
The study is prospective, open, randomized, crossover in steady state and the volunteers received multiple doses of the drug test and reference (two periods of drug administration).
- Trial name
- NCT01316926
- Testing
- Test formulation, Reference formulation
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Non-small Cell Lung Carcinoma
Use of [18]F-FDG on PET/CT as an Alternative Non-invasive Method for Staging of Lung Cancer
To evaluate the diagnostic accuracy of the 18Fluor-fluorodeoxyglucose ([18F]FDG) in the Positron Emission Tomography/Computed Tomography (PET/CT) as compared to mediastinoscopy for staging of non-small cel lung carcinoma.
- Trial name
- NCT02664792
- Testing
- Use of [18f]FDG - PET/CT for the diagnosis and staging of non-small cell lung carcinoma
- Where
- Brazil
- Volunteers
- 108 people
- Sponsor
- Latin American Cooperative Oncology Group
Child Development
Evaluation of the Home Visiting Pilot Program on Early Childhood Outcomes in Fortaleza Brazil
This is a cluster-randomized study of a home visiting program targeting mothers of children 0 to 2.5 years of age with the objective of improving global child development.
- Trial name
- NCT02718287
- Testing
- Home visiting intervention PCCSF (220 clusters), Home visiting without PCCSF (220 clusters)
- Volunteers
- 2,520 people
- Sponsor
- Inter-American Development Bank
Diseases of the Nervous System, Other Specified Viral Diseases
COVID-19 Neurological Disease: A Prospective Study
Background: Recent reports increasingly recognize neurological manifestations in COVID-19 patients. However, the full spectrum of the disease and risk factors are not well understood.
- Trial name
- NCT04672590
- Testing
- Primary exposure is hypoxia (no intervention)
- Where
- 5 sites in Brazil, India and 1 more
- Volunteers
- 1,017 people
- Sponsor
- University of Liverpool
Vaccine-induced Thrombotic Thrombocytopenia Syndrome, Guillain-Barre Syndrome
Gene Sequencing as a Strategy for Identifying Genetic Factors Associated With Serious Adverse Events After Covid-19 Vaccines in Use in Brazil
This protocol proposes to investigate genetic factors that may be involved in the pathogenesis of adverse events of interest with selected covid-19 vaccines: vaccine-induced immune thrombotic thrombocytopenia, and neurological…
- Conditions
- Vaccine-induced Thrombotic Thrombocytopenia Syndrome, Guillain-Barre Syndrome, Acute Disseminated Encephalomyelitis, Transverse Myelitis
- Trial name
- NCT05630313
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
COVID-19
Immunogenicity and Safety of Fractional Booster Dose of COVID-19 Vaccines Available for Use in Pakistan/Brazil: A Phase 4 Dose-optimizing Trial
Since the emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen in late 2019, millions of people around the world have fallen ill and died from coronavirus disease 2019 (COVID-19), with…
- Trial name
- NCT05343871
- Testing
- Sinovac, AZD1222, BNT162b2
- Where
- 2 sites in Brazil, Pakistan
- Volunteers
- 2,354 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
COVID-19
Effectiveness of the Oxford-AstraZeneca COVID-19 Vaccine as a 2nd Booster, the REFORCO-Brazil Study
This study will address specific questions concerning the additional protection of the AZ COVID-19 vaccine as a second booster dose in preventing severe COVID-19 outcomes (hospitalisation, ICU admission etc) and will provide data…
- Trial name
- REFORCO-B (NCT05697705)
- Testing
- ChAdOx1 nCOV-19 vaccine (Vaxzeria), BNT162b2 (Pfizer), Ad26.COV2.S (Janssen)
- Where
- Brazil
- Volunteers
- 188,814,085 people
- Sponsor
- AstraZeneca
Mastodynia
A Breast Support Intervention for Women With Breast Pain
The purpose of this study is to assess whether prescribing a bra to participants results in an improvement in the Patient Global Impression of Change (PGIC) compared to participants who receive standard care alone.
- Trial name
- NCT02515253
- Testing
- Bra prescription, Standard Care
- Where
- 2 sites in United Kingdom
- Volunteers
- 33 people
- Sponsor
- University of Portsmouth
COVID-19, ARDS
Long-term Impact of COVID-19 Among COVID-19 Patients With Acute Respiratory Distress Syndrome in Brazil
The present multicenter prospective observational study aims to assess the long-term effects of COVID-19 on patients with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- NCT05225194
- Testing
- COVID-19, ARDS
- Volunteers
- 318 people
- Sponsor
- Hospital Moinhos de Vento
Tuberculosis
A Real-world Study of Tuberculosis Incidence in AS, PsA, or PsO Patients Treated With Secukinumab in Brazil
This was a retrospective observational study that relied on data extracted from patient's chart review at the participating centers.
- Trial name
- ToBeReal (NCT06715254)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Novartis Pharmaceuticals
Smoking Cessation, Brachial Flow Mediated Dilatation
Smoking Cessation in a Cohort HIV+ Rio de Janeiro, Brazil.
The study was carried out within a large, urban prospective cohort of PLHIV at the Instituto Nacional de Infectologia Evandro Chagas (INI).
- Conditions
- Smoking Cessation, Brachial Flow Mediated Dilatation, Nicotine Replacement Therapy
- Trial name
- NCT05873738
- Testing
- Nicotine replacement
- Where
- Brazil
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Instituto Fernandes Figueira
Physical Activity
Evaluation Study of Interventions for Physical Activity Promotion in Primary Health Care in Brazil.
To verify changes in physical activity levels, metabolic markers, and physical fitness as results of two physical activity interventions within the Brazilian public health system (primary health care).
- Trial name
- PACTIVEM (NCT01852981)
- Testing
- Lifestyle counseling, Supervised exercise
- Where
- 2 sites in Brazil
- Volunteers
- 157 people
- Sponsor
- University of Sao Paulo
Lung Neoplasms, KRAS Gene Mutation
Frequency of EGFR and KRAS Mutations and Clinical-prognostic Correlation in Brazilian Lung Cancer Patients
The assessment of the type and frequency of EGFR and KRAS mutations in lung cancer patients, as well as clinical-prognostic correlation, are crucial in the era of targeted therapies.
- Conditions
- Lung Neoplasms, KRAS Gene Mutation, EGFR Gene Mutation
- Trial name
- NCT03171636
- Where
- Brazil
- Volunteers
- 130 people
- Sponsor
- Hospital Erasto Gaertner
Parenting
Video Interaction Project in Brazil
Early exposure to poverty is associated with adverse impacts on long-term educational achievement. Support of positive parenting is a key strategy to prevent emergence of socioeconomic disparities in child development.
- Trial name
- NCT05198739
- Testing
- Video Interaction Project (VIP) program
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Thirst in Intensive Care Unit (ICU) Practice
Thirst Translation and RCT
To translate the SEDE-E (Extubated) and SEDE-T(tracheotomized) protocols-Chinese version and validate it with an RCT trial
- Trial name
- SEDE (NCT07157917)
- Testing
- Protocol based, Control
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University
Diffuse Glioma, IDH-mutant Gliomas
Epidemiological Profile of Patients With IDH-Mutant Diffuse Gliomas Diagnosed From 2021 in Brazil
This is a real-world, retrospective, non-interventional, single-arm, multi-center Brazilian study that will include patients diagnosed with IDH-mutant diffuse glioma in Brazil from 2021.
- Trial name
- BRIGHT (NCT07789678)
- Where
- 12 sites in Brazil
- Volunteers
- 350 people
- Sponsor
- Latin American Cooperative Oncology Group
Medication Adherence
Non-adherence to Immunosuppressives in Kidney Transplantation in Brazil Multicenter Study
The purpose of the study are: 1. To estimate the prevalence of non-adherence to immunosuppressants, and to other treatment-related aspects (smoking cessation, alcohol consumption, physical activity, and appointment keeping), in…
- Trial name
- ADHEREBRAZIL (NCT02066935)
- Testing
- kidney transplant patient
- Where
- Brazil
- Volunteers
- 1,105 people
- Sponsor
- Fundação Instituto Mineiro de Estudo Pesquisa Em Nefrologi
Atrial Fibrillation
Therapeutic Equivalence Between Branded and Generic WARFArin Tablets in Brazil
The purpose of this study is to assess whether the switch from branded to generic warfarin or between different generic warfarin tablets may cause fluctuation in the results of coagulation tests (International Normalized Rate…
- Trial name
- WARFA (NCT02017197)
- Testing
- Marevan®, generic warfarin #1, generic warfarin #2
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of São Paulo
Ovarian Cancer
Observational, Bi-directional (Prospective and Retrospective) Study for Patients With Newly Diagnosed Ovarian Cancer Stages IA to IVB, or Persistent or Recurrent Disease From January 2021; Irrespective of Histology
The findings from this study have the potential to serve as a foundation for evaluating the current practices related to surgical procedures, systemic therapies, hyperthermic intraperitoneal chemotherapy, and referrals to…
- Trial name
- OLIVIA (NCT07167433)
- Where
- 14 sites in Brazil
- Volunteers
- 256 people
- Sponsor
- AstraZeneca
Diabetes (DM), Cardio Vascular Disease
Nut Consumption and Prevention of Non-communicable Diseases: A Global Individual Participant Data Meta-analysis
The relationship between nut consumption and the risk of developing non-communicable diseases (NCDs) has been a subject of growing interest.
- Conditions
- Diabetes (DM), Cardio Vascular Disease, Cancer, Dementia
- Trial name
- NUTPOOL (NCT07205978)
- Where
- 2 sites in Denmark, Spain
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili