Clinical trials: Bra, open to volunteers
Chronic Pain, Depression Disorders
Analysis of the Therapeutic and Clinical Profile of Cannabinoid Treatments: A Real-World Study
What is the purpose of this study? The use of medicinal cannabis has grown significantly in Brazil. However, because many patients use these products through "compassionate use" (when traditional treatments haven't worked), there…
- Conditions
- Chronic Pain, Depression Disorders, Anxiety Disorders, Quality of Life
- Trial name
- CANAREAL (NCT07362407)
- Testing
- Participants are followed while using cannabis-based products (such as CBD or THC oils, extracts, or isolates) as prescribed by their own physicians for therapeutic purposes.
- Where
- Brazil
- Volunteers
- 384 people
- Sponsor
- Santa Catarina Federal University
Solid Tumor, Metastatic Solid Tumor
Validation of the G8 Screening Tool for Prognostic Assessment of Frailty and Early Mortality in Elderly Individuals With Cancer: Prospective Cohort Study in Brazil
This is a prospective observational cohort study including 250 individuals aged 70 years or older newly diagnosed with solid tumors.
- Conditions
- Solid Tumor, Metastatic Solid Tumor, Recurrent Solid Tumor
- Trial name
- CORALINE (NCT07773285)
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- Latin American Cooperative Oncology Group
Thirst in Intensive Care Unit (ICU) Practice
Thirst Translation and RCT
To translate the SEDE-E (Extubated) and SEDE-T(tracheotomized) protocols-Chinese version and validate it with an RCT trial
- Trial name
- SEDE (NCT07157917)
- Testing
- Protocol based, Control
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University
Hepatitis C
Safety and Efficacy of Decentralized HCV Treatment vs Standard-of-Care in Rio de Janeiro (Brazil)
Up to 650,000 people in Brazil are living with chronic hepatitis c virus (HCV) infection. Hepatitis C is a silent disease, and up to 20% of cases can progress to liver cirrhosis and its complications.
- Trial name
- HCVPCL05/20 (NCT06306300)
- Testing
- Specialist - Epclusa 400Mg-100Mg Tablet, Non- specialist - Epclusa 400Mg-100Mg Tablet, HCV Self-Testing kit (Ora-Quick HCV ST or Wond-Foo HCV ST)
- Where
- 2 sites in Brazil
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
COPD (Chronic Obstructive Pulmonary Disease)
Real-World Effectiveness of a Triple Combination BDP/FF/GB Extrafine in a Single Pressurised Metered Dose Inhaler in Brazilian COPD Patients
This multicenter, retrospective-prospective, cohort study aims to evaluate the effectiveness and safety of Extra-fine Beclometasone Diproprionate/Formoterol Fumarate/Glycopyrronium Bromide (EF-BDP/FF/GB) therapy in adults with…
- Trial name
- RETRIBUTE (NCT07406048)
- Testing
- BDP/FF/GB (100ug/6ug/12.5ug)
- Where
- Brazil
- Volunteers
- 396 people
- Sponsor
- Chiesi Farmaceutica Ltda.
Diffuse Glioma, IDH-mutant Gliomas
Epidemiological Profile of Patients With IDH-Mutant Diffuse Gliomas Diagnosed From 2021 in Brazil
This is a real-world, retrospective, non-interventional, single-arm, multi-center Brazilian study that will include patients diagnosed with IDH-mutant diffuse glioma in Brazil from 2021.
- Trial name
- BRIGHT (NCT07789678)
- Where
- 12 sites in Brazil
- Volunteers
- 350 people
- Sponsor
- Latin American Cooperative Oncology Group
Cancer, Latin America and the Caribbean Code Against Cancer (LAC Code)
Feasibility Study to Actively Disseminate the Latin America and the Caribbean Code Against Cancer in Primary Healthcare Centers
Phase II non-randomized four-arm study (before/after pragmatic trial) that will test 2 different implementation strategies either combined or separately for the dissemination of the Latin America and the Caribbean Code Against…
- Trial name
- FLACC-Brazil (NCT06965608)
- Testing
- WhatsApp-Based Cancer Prevention Messaging, Online Cancer Prevention Workshop for Healthcare Professionals, Combined WhatsApp Messaging and Online Workshop
- Where
- Brazil
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
Control Group, Mexico-based NSS FOPL
NSS Grocery Store Brazil
The purpose of this study is to assess the impact of non-sugar sweeteners (NSS) front-of-package labels (FOPL) on Brazilian parents' food and beverage selections for their children. The study includes three arms: 1.
- Conditions
- Control Group, Mexico-based NSS FOPL, Brazil-based NSS FOPL
- Trial name
- NCT07249008
- Testing
- Experimental : Mexico-based NSS FOPL, Experimental : Brazil-based NSS FOPL
- Where
- United States
- Volunteers
- 1,068 people, healthy volunteers welcome
- Sponsor
- George Washington University
Diffuse Large B-cell Lymphoma, Acute Lymphoblastic Leukemia
Effectiveness and Safety of Tisagenlecleucel Therapy in Brazilian Patients With B-lymphocyte Malignancies
This will be a multicenter, national, non-interventional, prospective cohort study
- Conditions
- Diffuse Large B-cell Lymphoma, Acute Lymphoblastic Leukemia, Follicular Lymphoma
- Trial name
- NCT05541341
- Testing
- tisagenlecleucel
- Where
- 7 sites in Brazil
- Volunteers
- 200 people
- Sponsor
- Novartis Pharmaceuticals
Pre-Exposure Prophylaxis (PrEP), HIV
Peer-led Community-based PrEP Delivery Among Youth in Brazil
The goal of this project is to conduct a series of studies to refine, test, and understand experiences with a peer-led community-based intervention in which youth will be integrated into health care teams and trained to deliver…
- Trial name
- COMPrEP (NCT06661356)
- Testing
- COMPrEP
- Where
- 2 sites in Brazil
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hepatocellular Carcinoma, Liver Cirrhosis
Prospective Evaluation of Hepatocellular Carcinoma Surveillance in At-Risk Patients (Screening HCC)
This prospective multicenter observational study evaluates the performance of a structured hepatocellular carcinoma (HCC) surveillance program in patients at increased risk of developing liver cancer.
- Conditions
- Hepatocellular Carcinoma, Liver Cirrhosis, Chronic Hepatitis B, Metabolic Dysfunction-Associated Steatotic Liver Disease
- Trial name
- Screening HCC (NCT07764835)
- Volunteers
- 300 people
- Sponsor
- D'Or Institute for Research and Education
Contact With or Exposure to Human Immunodeficiency Virus
ImPrEP LEN Brasil: Twice-Yearly Lenacapavir for HIV Prevention
The goal of this study is to learn how well long-acting lenacapavir works to prevent human immunodeficiency virus (HIV) infection in people at higher risk of getting HIV in Brazil.
- Trial name
- ImPrEP LEN (NCT07497594)
- Testing
- Lenacapavir long-acting, Tenofovi-Emtricitabine (TDF/FTC) tablet
- Where
- 8 sites in Brazil
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Parkinson Disease
PARKINSON BRASIL - Database on Motor and Non-Motor Aspects of Parkinson's Disease in Brazil
This is an observational, cross-sectional study with a control group, with the general objective of developing and evaluating a national database, unprecedented in Brazil, containing clinical, epidemiological, motor, and…
- Trial name
- NCT06536348
- Where
- 5 sites in Brazil
- Volunteers
- 958 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Chikungunya Virus Infection
Observational Study to Assess the Effectiveness of VLA1553 Vaccine in Preventing Chikungunya During a Pilot Vaccination Strategy in Brazil
This is an observational, non-interventional, test-negative case-control (TNCC) study to estimate the vaccine effectiveness of VLA1553 against Chikungunya virus in a real-world setting.
- Trial name
- NCT07347002
- Testing
- Live-attenuated CHIKV vaccine VLA1553
- Where
- 3 sites in Brazil
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Intrinsic Capacity, Frailty
Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults
The ICOPE Brazil study aims to understand aging trajectories in Brazil, especially healthy aging trends based on intrinsic capacity, a collective of mental and physical capacities one may have to maintain their functional ability…
- Conditions
- Intrinsic Capacity, Frailty, Aging, Healthy Aging
- Trial name
- ICOPE-BR (NCT06968702)
- Volunteers
- 3,838 people
- Sponsor
- University of Sao Paulo
Breast Cancer Patients
Breast Cancer BRAs Study (Breast Cancer Biomechanics of Radiotherapy And Surgery)
This study, delivered by Portsmouth Hospitals University NHS Trust in conjunction with the Research Group in Breast Health at the University of Portsmouth [1], aims to assess whether it is possible to test breast biomechanics in…
- Trial name
- NCT07135960
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Socioemotional Development, Cognitive Ability
Early Institutionalization Intervention Impact Project
The purpose of this study is to determine the effects of early intervention (placement into foster care, and a caregiving training) on physical, cognitive, social and brain development and psychiatric symptomatology in children…
- Conditions
- Socioemotional Development, Cognitive Ability, Behavioral and Neural Patterns of Attention, Brain Function
- Trial name
- EI-3 (NCT04165746)
- Testing
- Foster Care, Caregiving Intervention
- Where
- Brazil
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
COPD (Chronic Obstructive Pulmonary Disease)
Prospective and Multicentric Cohort Study of Severe and Very Severe Chronic Obstructive Pulmonary Disease (COPD) in Brazil (SCOPe).
Chronic obstructive pulmonary disease (COPD) is prevalent (8-20%) and is one of the leading causes of mortality. In 2019 according to WHO it was the third highest cause of death worldwide.
- Trial name
- SCOPe (NCT06724315)
- Where
- Brazil
- Volunteers
- 693 people
- Sponsor
- Hospital Israelita Albert Einstein
Respiratory Syncytial Virus (RSV), Maternal Immunization
TARSILA Real-World Evidence Study
The overall objective of Tarsila Study is to estimate the real-world vaccine effectiveness of maternal RSVpreF immunization during pregnancy in Brazil against medically attended (inpatient and outpatient) respiratory syncytial…
- Conditions
- Respiratory Syncytial Virus (RSV), Maternal Immunization, Acute Respiratory Illness (ARI), Lower Respiratory Tract Disease
- Trial name
- TARSILA (NCT07445763)
- Testing
- respiratory syncytial virus bivalent prefusion F vaccine
- Volunteers
- 5,000 people
- Sponsor
- Inova Medical
Congenital Syphilis
Evaluation of Antimicrobial Prophylaxis to Prevent Syphilis in Pregnancy in Patients at Risk in Rio de Janeiro, Brazil
The goal of this clinical trial is to learn if benzathine penicillin works to prevent maternal syphilis. It will also learn about the safety of benzathine penicillin.
- Trial name
- PRESERvE (NCT07189208)
- Testing
- Benzathine penicillin 2.4 million units, Counseling and intensified testing.
- Where
- 4 sites in Brazil
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles