Clinical trials: Bra, active
Non-squamous Non-Small Cell Lung Cancer
RACE-2L: Real-World Assessment of Clinical Practice and Outcomes in Non-squamous NSCLC After Failure of Platinum-based Chemotherapy in Brazil
The study will be implemented as a retrospective, noninterventional medical record review of patients from routine practice settings who have been diagnosed with a/m non-squamous NSCLC with or without AGA and received at least 1…
- Trial name
- RACE-2L (NCT06491862)
- Where
- 11 sites in Brazil
- Volunteers
- 250 people
- Sponsor
- AstraZeneca
Congenital Syphilis
Evaluation of Antimicrobial Prophylaxis to Prevent Syphilis in Pregnancy in Patients at Risk in Rio de Janeiro, Brazil
The goal of this clinical trial is to learn if benzathine penicillin works to prevent maternal syphilis. It will also learn about the safety of benzathine penicillin.
- Trial name
- PRESERvE (NCT07189208)
- Testing
- Benzathine penicillin 2.4 million units, Counseling and intensified testing.
- Where
- 4 sites in Brazil
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Mitral Valve Disease
EXPLORE MRace (BR): Early Feasibility Experience of Posterior Leaflet Restoration to Reduce Mitral Regurgitation Using the MRace Implant
An early feasibility study to evaluate the safety and feasibility of the MRace Implant and Delivery System to treat severe mitral regurgitation and to gather preliminary data on its performance thereby providing guidance for…
- Trial name
- EXPLORE MRace (NCT06113354)
- Testing
- Transcatheter mitral valve repair (MRace Implant and Delivery System)
- Where
- 2 sites in Brazil
- Volunteers
- 10 people
- Sponsor
- Polares Medical SA
Control Group, Mexico-based NSS FOPL
NSS Grocery Store Brazil
The purpose of this study is to assess the impact of non-sugar sweeteners (NSS) front-of-package labels (FOPL) on Brazilian parents' food and beverage selections for their children. The study includes three arms: 1.
- Conditions
- Control Group, Mexico-based NSS FOPL, Brazil-based NSS FOPL
- Trial name
- NCT07249008
- Testing
- Experimental : Mexico-based NSS FOPL, Experimental : Brazil-based NSS FOPL
- Where
- United States
- Volunteers
- 1,068 people, healthy volunteers welcome
- Sponsor
- George Washington University
Hepatocellular Carcinoma, Liver Cirrhosis
Prospective Evaluation of Hepatocellular Carcinoma Surveillance in At-Risk Patients (Screening HCC)
This prospective multicenter observational study evaluates the performance of a structured hepatocellular carcinoma (HCC) surveillance program in patients at increased risk of developing liver cancer.
- Conditions
- Hepatocellular Carcinoma, Liver Cirrhosis, Chronic Hepatitis B, Metabolic Dysfunction-Associated Steatotic Liver Disease
- Trial name
- Screening HCC (NCT07764835)
- Volunteers
- 300 people
- Sponsor
- D'Or Institute for Research and Education
Socioemotional Development, Cognitive Ability
Early Institutionalization Intervention Impact Project
The purpose of this study is to determine the effects of early intervention (placement into foster care, and a caregiving training) on physical, cognitive, social and brain development and psychiatric symptomatology in children…
- Conditions
- Socioemotional Development, Cognitive Ability, Behavioral and Neural Patterns of Attention, Brain Function
- Trial name
- EI-3 (NCT04165746)
- Testing
- Foster Care, Caregiving Intervention
- Where
- Brazil
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Thirst in Intensive Care Unit (ICU) Practice
Thirst Translation and RCT
To translate the SEDE-E (Extubated) and SEDE-T(tracheotomized) protocols-Chinese version and validate it with an RCT trial
- Trial name
- SEDE (NCT07157917)
- Testing
- Protocol based, Control
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University
Chikungunya Virus Infection
VLA1553-403 Pregnancy Surveillance Study
This post-marketing, observational study evaluates pregnancy and infant outcomes up to 12 weeks after delivery among women who received the chikungunya vaccine (VLA1553) during pregnancy or within 30 days before their last…
- Trial name
- NCT07414524
- Testing
- Live-attenuated CHIKV vaccine VLA1553, Vaccine(s) approved for use during pregnancy by the MoH
- Where
- 3 sites in Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
COPD (Chronic Obstructive Pulmonary Disease)
Prospective and Multicentric Cohort Study of Severe and Very Severe Chronic Obstructive Pulmonary Disease (COPD) in Brazil (SCOPe).
Chronic obstructive pulmonary disease (COPD) is prevalent (8-20%) and is one of the leading causes of mortality. In 2019 according to WHO it was the third highest cause of death worldwide.
- Trial name
- SCOPe (NCT06724315)
- Where
- Brazil
- Volunteers
- 693 people
- Sponsor
- Hospital Israelita Albert Einstein
Diabete Type 2
A Bridging Study of Efsubaglutide Alfa in Healthy Adults in Brazil
This is a Phase I, randomized, double-blind, placebo-controlled, single-dose study in healthy adult participants in Brazil to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of…
- Trial name
- BRIDGE-BR (NCT07518121)
- Testing
- Efsubaglutide Alfa Injection
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shanghai Yinnuo Pharmaceutical Technology Co., Ltd.
Postoperative Pain, Postoperative Complications
Protocol for Accelerated Recovery in Patients Undergoing Thoracic Surgical Procedures (PROSM). Study Randomized Comparative Between the Adoption of the Proposed Guidelines and the Traditional Method Currently Used in the Institution
Introduction: Aiming at reducing costs and optimizing the use of these financial resources, several postoperative recovery protocols have emerged that aim to reduce the length of hospital stay by accelerating surgical…
- Conditions
- Postoperative Pain, Postoperative Complications, Postoperative Nausea, Lung Cancer
- Trial name
- PROSM (NCT03271749)
- Testing
- PROSM guidelines for preoperative, anesthesia and postoperative care for lung resections
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Igor Renato Louro Bruno de Abreu
Solid Tumor, Metastatic Solid Tumor
Validation of the G8 Screening Tool for Prognostic Assessment of Frailty and Early Mortality in Elderly Individuals With Cancer: Prospective Cohort Study in Brazil
This is a prospective observational cohort study including 250 individuals aged 70 years or older newly diagnosed with solid tumors.
- Conditions
- Solid Tumor, Metastatic Solid Tumor, Recurrent Solid Tumor
- Trial name
- CORALINE (NCT07773285)
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- Latin American Cooperative Oncology Group
Chikungunya Virus Infection
Assessment of Chikungunya Virus Seroprevalence Before VLA1553 Vaccination in the Municipalities Selected for Participation in the VLA1553 Pilot Vaccination Strategy in Brazil
This is a cross-sectional serosurvey using household cluster sampling conducted before the VLA1553 pilot vaccination strategy will be implemented in about 10 municipalities in Brazil.
- Trial name
- NCT07163845
- Testing
- Live-attenuated CHIKV vaccine VLA1553
- Where
- 4 sites in Brazil
- Volunteers
- 5,354 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Chikungunya Virus Infection
Prospective Safety Cohort Study After VLA1553 Vaccination in Municipalities Selected for Participation in the VLA1553 Pilot Vaccination Strategy in Brazil
This is an observational study with primary data collection, which will combine a prospective safety cohort study and an SCRI study.
- Trial name
- NCT07254702
- Testing
- Live-attenuated CHIKV vaccine VLA1553
- Where
- 3 sites in Brazil
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Chronic Kidney Diseases, Hemodialysis Complication
Clinical Outcomes of Hemodialysis in Brazil (COHEBRA): a Prospective Cohort Study
Introduction: Chronic kidney disease (CKD) is characterized by progressive decrease in glomerular filtration rate (GFR), eventually reaching the end-stage renal disease (ESRD) requiring renal replacement therapy (RRT).
- Trial name
- COHEBRA (NCT05273424)
- Where
- Brazil
- Volunteers
- 500 people
- Sponsor
- Catholic University of Pelotas
Wound Healing Disorder, Post-Surgical Complication
NovoX®Cup as Primary Dressing After Breast Reduction
Breast reduction is one of the most frequently performed plastic surgeries. Studies have shown that breast reduction surgery significantly improves the patients' suffering and leads to a better health-related quality of…
- Conditions
- Wound Healing Disorder, Post-Surgical Complication, Mammaplasty
- Trial name
- NCT06420323
- Testing
- Treatment with NovoX® Cup, Treatment with Omnistrip®
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- MOSS S.p.A.
Monkeypox, MPOX
Observational, Prospective, Cohort Study of Mpox Infection in Brazil (NETPOX)
The study is a prospective cohort that evaluates the clinical and immune-metabolic variables that may be linked to the risk and severity of the infection or even hospitalization or death in patients infected with the Mpox virus…
- Trial name
- NCT05784038
- Testing
- Viral genomic, Untargeted Metabolomics
- Where
- 3 sites in Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital Israelita Albert Einstein
Geriatric Assessment, Geriatric Oncology
Geriatric Oncology Care in Brazil: Remote Geriatric Assessment-Driven Interventions With Supportive Care
The goal of this clinical trial is to determine whether a telehealth-delivered, geriatric assessment-guided supportive care program (GAIN-S) can improve health outcomes in older adults (age 65 and above) with solid tumors who are…
- Conditions
- Geriatric Assessment, Geriatric Oncology, Quality of Life, Functional Decline
- Trial name
- GAIN-S (NCT07084454)
- Testing
- GAIN-S Multidisciplinary Telehealth Intervention, Standard Oncology Care
- Where
- Brazil
- Volunteers
- 350 people
- Sponsor
- Cristiane Decat Bergerot, PhD
Post-Acute COVID-19 Syndrome
Incidence, Associated Factors, and Burden of Post COVID-19 Condition in Brazil
This is a national retrospective cohort study with internet-based recruitment which intends to enroll 1,694 adult patients with COVID-19 diagnosis during the SARS-CoV-2 omicron wave in Brazil.
- Trial name
- NCT05822193
- Testing
- Multiple exposures
- Where
- Brazil
- Volunteers
- 1,694 people, healthy volunteers welcome
- Sponsor
- Inova Medical
Diffuse Large B-cell Lymphoma, Acute Lymphoblastic Leukemia
Effectiveness and Safety of Tisagenlecleucel Therapy in Brazilian Patients With B-lymphocyte Malignancies
This will be a multicenter, national, non-interventional, prospective cohort study
- Conditions
- Diffuse Large B-cell Lymphoma, Acute Lymphoblastic Leukemia, Follicular Lymphoma
- Trial name
- NCT05541341
- Testing
- tisagenlecleucel
- Where
- 7 sites in Brazil
- Volunteers
- 200 people
- Sponsor
- Novartis Pharmaceuticals