Clinical trials: Brain Activity
Attention Deficit Hyperactivity Disorder (ADHD), Impulsive Aggression
Exploratory fMRI Study on the Treatment for Impulsive Aggression in Children With ADHD
The purpose of this study was to evaluate the effect of 4-week SPN-810 treatment on brain functioning in patients aged 8-12 years with ADHD and associated feature of impulsive aggression (IA).
- Trial name
- NCT03638466
- Testing
- Functional Magnetic Resonance Imaging (fMRI), Magnetic Resonance Spectroscopy (MRS), Point Subtraction Aggression Paradigm (PSAP) Task
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Infantile Spasms
A Randomized, Controlled Trial of Ganaxolone in Patients With Infantile Spasms
The study consists of cohorts where participants are randomized, in a 2:1 ratio, to 1 of 2 sequences, A and B. In each cohort, Sequence A, comprised of participants, who will receive ascending doses of ganaxolone and ascending…
- Trial name
- NCT00441896
- Testing
- Ganaxolone
- Where
- 15 sites in United States
- Volunteers
- 57 people
- Sponsor
- Marinus Pharmaceuticals
Hemiplegic Cerebral Palsy
Adapted Physical Activities in Hemiplegic Cerebral Palsy
The rehabilitation process is critical for people with disabilities, and it appears reasonable to predict that adaptive physical activity will become an important instrument for holistic development in a human rights perspective…
- Trial name
- NCT06459505
- Testing
- Routine or standard Physical Therapy, Adapted Physical Activity
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Riphah International University
Stroke
A Caregiver-Assisted Rehabilitation With Strategy Training (CAR-ST) for Stroke Patients
The goal of this randomized controlled trial is to examine if involving the caregivers in the strategy training (i.e. caregiver-assisted rehabilitation with strategy training, CAR-ST) works to improve activity functions in…
- Trial name
- CAR-ST (NCT06754566)
- Testing
- Caregiver-Assisted Rehabilitation with Strategy Training, Strategy Training, Education
- Where
- 5 sites in Taiwan
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Parkinson's Disease
Exercise Interventions in Parkinson's Disease
This study sets out to determine the effect of exercise performed over a longer period of time (6 months), delivered using community facilities, on motor and non motor symptoms, health and well being in people with Parkinson's…
- Trial name
- NCT01439022
- Testing
- Exercise Programme, Hand Writing programme
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- Oxford Brookes University
Nicotine Dependence
Brain Activity and Smoking Cessation
In the current study, the investigators propose to test: (1) whether brain activation and connectivity in a resting state, assessed by ASL perfusion MRI, BOLD fMRI, and diffusion tensor imaging (DTI) predicts smoking relapse, and…
- Trial name
- NCT01186055
- Testing
- Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Heart Failure
A Physical Activity Program for People With Heart Failure
STEP-IN is a research study that examines the effects of a physical activity program designed to increase the daily steps and cadence of patients with heart failure, compared to standard medical care, on functional capacity and…
- Trial name
- STEP-IN (NCT07204834)
- Testing
- Physical Activity
- Where
- 4 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Universidad de Granada
Stroke, Ischemic, Proprioceptive Disorders
Effects of Sensory Stimulation Versus Sensorimotor Therapy on Spasticity, Motor Function and Daily Activities in Stroke
To compare effects of exteroceptive and proprioceptive sensory stimulation versus sensorimotor therapy on spasticity, motor function and activities of daily living in patients with stroke
- Conditions
- Stroke, Ischemic, Proprioceptive Disorders, Sensory Defect
- Trial name
- NCT06459349
- Testing
- exteroceptive and proprioceptive sensory stimulation training, sensorimotor therapy group
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Mild Gastrointestinal Symptoms in Healthy Adults, Low-grade Chronic Inflammation
Fungal Fiber for Gut Health
This study compares effects of plant based fiber vs fungi based fiber on clinical outcomes related to gut function (immunity, emotions, stress) and explores the role of gut microbiome structure and function on individual…
- Conditions
- Mild Gastrointestinal Symptoms in Healthy Adults, Low-grade Chronic Inflammation, Stress, Gut Health
- Trial name
- FUN4GUT (NCT06404749)
- Testing
- fungal fiber, inulin
- Where
- Argentina
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Future Biome SA
Stroke, Stroke Rehabilitaion
Comparative Effects of Mirror Therapy and Cognitive Orientation to Daily Occupational Performance in Stroke: A Randomized Controlled Trial
This study aims to compare the effectiveness of three rehabilitation approaches in individuals with stroke: mirror therapy (MT), cognitive orientation to daily occupational performance (CO-OP), and conventional occupational…
- Trial name
- NCT07546864
- Testing
- Mirror Therapy, Cognitive Orientation to Daily Occupational Performance (CO-OP), Conventional Occupational Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Hacettepe University
Prion Disease
PRION-1: Quinacrine for Human Prion Disease
PRION-1 aims to assess the activity and safety of Quinacrine (Mepacrine hydrochloride) in human prion disease. It also aims to establish an appropriate framework for the clinical assessment of therapeutic options for human prion…
- Trial name
- NCT00104663
- Testing
- Quinacrine
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Medical Research Council
Healthy Aging, Cognitive Benefits
Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults
The goal of this clinical trial is to learn whether a single session of high-intensity interval exercise (HIIT) affects cognitive performance and brain activity in older adults, and whether cardiorespiratory fitness influences…
- Conditions
- Healthy Aging, Cognitive Benefits, Cardio Respiratory Fitness, Brain Activity
- Trial name
- ExBrain (NCT07727577)
- Testing
- High-Intensity Interval Training
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Colby-Sawyer College
Stroke, Chronic Stroke Patients
RESPARK - Brain Q for Chronic Stroke
This trial tests a promising new intervention to promote post-stroke neural reorganization and functional recovery. The Q Therapeutic (BQ 3.0) is a wearable medical system that produces and delivers non-invasive…
- Conditions
- Stroke, Chronic Stroke Patients, Cerebrovascular Accident (CVA)
- Trial name
- NCT07095920
- Testing
- Device: Q Therapeutic System (BQ 3.0) - Active
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Parkinson Disease, Epilepsy
Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement
The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range.
- Trial name
- BAG-OSMOV (NCT06241924)
- Testing
- High Resolution Electroencephalogram (EEG-HR), Stereo-electro-encephalography (SEEG)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Cerebral Palsy
Effects of "Telerehabılıtatıon Based Structured Home Program Implementatıons" Chıldren With Cerebral Palsy
The aim of the study is to examine the effectiveness of Telerehabilitation Based Structured Home Program Implementations on functional status, activity and participation in preschool children with Cerebral Palsy.
- Trial name
- (EoTBHPCP) (NCT04807790)
- Testing
- Telerehabilitation based structured home program applications
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Hacettepe University
Parkinson Disease
An Exploratory Study Investigating Safety, Tolerability and Pharmacokinetics of Ascending Doses of Lu AE04621 in Parkinson Disease Patients
To evaluate the safety, tolerability, pharmacokinetics, and efficacy of the Lu AE04621 and metabolite after ascending oral doses of Lu AE04621 in patients with Parkinson's Disease.
- Trial name
- NCT02649608
- Testing
- 0.04 mg Lu AE04621, 0.08 mg Lu AE04621, 0.2 mg Lu AE04621
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- H. Lundbeck A/S
Parkinson's Disease, Physical Exercise
Research on the Effect and Mechanism of Aerobic Exercise on PD
This trial is expected to recruit patients with primary Parkinson's disease and give them four consecutive weeks of aerobic exercise to observe its effect on Parkinson's disease and explore its mechanism
- Trial name
- NCT04651140
- Testing
- aerobic exercise
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Alzheimer Disease, Dementia
Efficacy Study of MPC-7869 to Treat Patients With Alzheimer's
The purpose of the study is to evaluate the change in cognitive ability and activities of daily living in patients with Alzheimer's disease (AD) as measured by specific evaluations during 18 months of dosing.
- Trial name
- NCT00105547
- Testing
- MPC-7869
- Where
- 132 sites in United States
- Volunteers
- 1,600 people
- Sponsor
- Myrexis Inc.
Chronic Musculoskeletal Pain, Tennis Elbow
A Neurofeedback Treatment for Chronic Musculoskeletal Pain
This study evaluates the effects of a novel neurofeedback treatment on pain specific brainwaves in adults. Chronic pain patients enrolled in this study will be randomized into a treatment group and a sham group.
- Conditions
- Chronic Musculoskeletal Pain, Tennis Elbow, Musculoskeletal Pain, Lateral Epicondylitis
- Trial name
- NCT03863847
- Testing
- Neurofeedback
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Aalborg University
Cluster Headache
A Close Examination of Patient Experiences in Cluster Headache Clinical Research
Historically, participation in clinical studies is highly skewed towards particular demographic groups of people. This research will invite several participants to gather a wide range of information on clinical trial experiences…
- Trial name
- NCT05978258
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.