Clinical trials: Brain Activity, open to volunteers
Ischemic Stroke, Acute, Active Malignancies
A Trial of Edaravone Dexborneol in Acute Ischemic Stroke With Active Malignancy
This multicenter randomized controlled trial aims to evaluate the efficacy and safety of edaravone dexborneol injection in patients with acute ischemic stroke (AIS) complicated by active malignancies.
- Trial name
- PRECISE AM (NCT07091994)
- Testing
- edaravone dexborneol injection, Standard therapeutic protocol
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Frailty, Dementia
Multicomponent Exercise Program on Physical Function, Cognition and Falls Risk Among Older Adults Living in Nursing Homes (MOVE4CARE)
Can a multicomponent exercise program significantly improve physical and cognitive function and reduce fall rates among nursing home residents? To address this question, the present study aims to compare the effectiveness of a…
- Trial name
- MOVE4CARE (NCT07392944)
- Testing
- Multicomponent exercise intervention, stretching and relaxation program
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Neurological Diseases or Conditions
Measuring Single Neuron Activity in the Brain
The SUNAN (Single Unit Neurophysiological Architecture of the Neocortex) study aims to understand how individual brain cells called neurons interact and communicate, and how the neurons can be affected in neurological disease.
- Trial name
- SUNAN (NCT06763471)
- Testing
- Neuropixels recording intraoperatively during planned neurosurgery
- Volunteers
- 50 people
- Sponsor
- University College, London
Safety, Tolerability
A Clinical Study of GenSci134 in Healthy Adults and Adult Growth Hormone Deficiency(AGHD)
To check how safe and well-tolerated a single subcutaneous injection of GenSc134 is in healthy male volunteers， a multiple-doses subcutaneous injection of GenSc134 is in healthy volunteers，a single subcutaneous injection of…
- Conditions
- Safety, Tolerability, Adult Growth Hormone Deficiency
- Trial name
- NCT07016802
- Testing
- GenSci134, Recombinant Human Growth Hormone Injection (Norditropin®)
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Hypoxemic Acute Respiratory Failure
Effects of Nasal Ventilation on Cerebral and Pulmonary Function in Orally Intubated Patients
The passage of air through the nasal cavity generates rhythmic oscillations transmitted by the olfactory bulb to the brain, which induces cerebral activation in functional areas and is associated with better cognitive performance…
- Trial name
- VENTINA (NCT06438302)
- Testing
- EEG activity measurement
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Palsy (CP)
Leveraging Extended Reality Exergaming and Telehealth to Improve Physical Activity and Health in Children With Disabilities
This phase II RCT evaluates the efficacy of a telehealth-delivered extended reality (XR) exergaming intervention on physical activity, cardiometabolic health, and physical fitness in physically inactive children with cerebral…
- Trial name
- NCT07564934
- Testing
- Extended Reality Exergaming
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Alabama at Birmingham
Stroke, Inspiratory Muscle Training
Inspiratory and Trunk Muscle Activity During IMT on Stable and Unstable Surfaces in Stroke Patients
This study aims to investigate the differences in muscle recruitment of the diaphragm (assessed using ultrasound), the sternocleidomastoid (SCM) and trunk muscles (both measured via surface electromyography (sEMG)), during loaded…
- Conditions
- Stroke, Inspiratory Muscle Training, Diaphragm, Sternocleidomastoid Muscles
- Trial name
- NCT06877338
- Testing
- Loaded breathing on stable and unstable surfaces
- Volunteers
- 24 people
- Sponsor
- Hong Kong Metropolitan University
Depressive Symptoms, Sleep Disturbance
Effects of Exercise Intervention on Sleep Quality and Emotional Problems in College Students With Depressive Symptoms
This exploratory randomized controlled trial aims to investigate the immediate and long-term effects of exercise on sleep quality, emotional problems, executive function, and neurophysiological characteristics in college students…
- Trial name
- NCT07738809
- Testing
- Archery Exercise, Non-exercise Control
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Capital University of Physical Education and Sports, China
Chronic Subdural Hematoma, Surgical Procedures, Operative
A National Study Examining the Most Effective Drainage Method After Burr Hole Evacuation of Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease. The main treatment is neurosurgical evacuation and subsequent hematoma drainage.
- Conditions
- Chronic Subdural Hematoma, Surgical Procedures, Operative, Recurrence, Mortality
- Trial name
- SUPERDURA (NCT06621407)
- Testing
- 24 hours active subperiostal drainage, 24 hours passive subdural drainage
- Where
- 4 sites in Denmark
- Volunteers
- 354 people
- Sponsor
- Aalborg University Hospital
fMRI Research, Transcranial Magnetic Stimilation
The Relationships Between Neural Correlates of Effort Perception and Physical Activity Engagement
Objectives and research hypothesis Physical inactivity is a major health concern that has been linked to a variety of chronic diseases, including obesity, diabetes, cancer, cardiovascular diseases, and mental disorders.
- Conditions
- fMRI Research, Transcranial Magnetic Stimilation, EEG Brain Oscillations, Motor Task
- Trial name
- EffortLESS (NCT06691490)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Aging, Alzheimer Disease
Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention
Due to the increasing incidence of dementia and the lack of causal treatment, non-pharmacological interventions represent an attractive and effective therapeutic strategy of neurodegenerative diseases, such as Alzheimer's…
- Conditions
- Aging, Alzheimer Disease, Life Style, Healthy, Exercise
- Trial name
- LIBRA-NET (NCT06986096)
- Testing
- Aerobic-strength training and nutritional counseling, Cognitive training and stretching.
- Where
- Slovakia
- Volunteers
- 40 people
- Sponsor
- Slovak Academy of Sciences
Parkinson Disease (PD)
Passive Versus Active Music Therapy Parkinson's Disease
The purpose of this pilot study is to identify the effects of active versus passive music therapy on functional ability and psychophysiological responses to goal-directed exercise in people with Parkinson's disease.
- Trial name
- NCT07661524
- Testing
- Passive music therapy, Active music therapy
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Alabama at Birmingham
Brain Concussion, Mild Traumatic Brain Injury
Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) often causes persistent motor and cognitive deficits in children resulting in functional limitations.
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Motor Disorders, Cognitive Impairment
- Trial name
- CI-tDCS (NCT05762796)
- Testing
- tDCS in Youth with mild traumatic brain injury
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Neurocysticercosis
Assessment of Combined Praziquantel and Albendazole vs Albendazole Alone to Treat Active Parenchymal Neurocysticercosis
The goal of this clinical trial is to compare the combination albendazole and praziquantel versus albendazole alone in patients affected by neurocysticercosis.
- Trial name
- NeuroSolve (NCT06376396)
- Testing
- albendazole and praziquantel, Albendazole
- Volunteers
- 300 people
- Sponsor
- R-Evolution Worldwide S.r.l. Impresa Sociale
Cerebral Palsy (CP), Motor Disability
Complex Rehabilitation Technology Enabled Physical Activity for Children With Motor Delays Via Telehealth in Natural Environments
The primary goal of CP-MOVES is to evaluate 1) the preliminary efficacy of a telehealth-delivered, parent coaching intervention in the use of adaptive standers, on physical activity, sleep, and endurance in young children with…
- Conditions
- Cerebral Palsy (CP), Motor Disability, Motor Delay
- Trial name
- CP-MOVES (NCT07252713)
- Testing
- Stander Use
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ohio State University
Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene
Evaluation of Impaired Mobility in Chronic Illness Constitution of a Cohort
Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern.
- Conditions
- Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene, Parkinson Disease, Chronic Obstructive Pulmonary Disease, Unspecified
- Trial name
- EVALMOB (NCT04375280)
- Testing
- Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ventilation Therapy; Complications
Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN)
The communication between the lungs and the brain has drawn a lot of attention recently. Animal studies have shown that the breathing cycle is coupled with brain activity, showing that the greater the volume of air delivered to…
- Trial name
- BATMAN (NCT06142773)
- Testing
- Tidal Volume set on ventilator
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Suicidal Ideation Active, Depression Disorders
Personalized TACS to Reduce Rumination in Patients with Active Suicidal Ideation
The goal of this clinical trial is to determine whether modulating default mode network (DMN) alpha connectivity using transcranial alternating current stimulation (tACS) can reduce rumination and, in turn, mitigate feelings of…
- Trial name
- Alpha-MOD (NCT06832124)
- Testing
- alpha-tACS
- Volunteers
- 50 people
- Sponsor
- Sebastian Olbrich
Colorectal Cancer, Older Adults (60 - 85 Years Old)
Chemo Brain Prehab Project
Colorectal cancer is 37% higher in the North West than the national average and is treated by chemotherapy, including fluorouracil, capecitabine, and oxaliplatin.
- Conditions
- Colorectal Cancer, Older Adults (60 - 85 Years Old), Physically Inactive, Chemotherapy
- Trial name
- CHEMOBRAIN (NCT07341217)
- Testing
- Exercise Prehabilitation, Multivitamins, Standard Care (in control arm)
- Where
- 4 sites in United Kingdom
- Volunteers
- 86 people
- Sponsor
- Dr. Chris Gaffney
Intestinal Disorder, Inflammatory Bowel Diseases
Effect of Acupuncture on Mild to Moderate Active Crohn's Disease
To observe the clinical effect of acupuncture on Crohn's disease (CD) and its influence on brain function activity and the TRY-KYN metabolism level, and to screen the brain image markers of acupuncture on CD
- Conditions
- Intestinal Disorder, Inflammatory Bowel Diseases, Crohn Disease
- Trial name
- NCT04187820
- Testing
- acupuncture
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian