Clinical trials: Brain Activity
Parkinson Disease
Pharmacologically Active Constituents of Chocolate and Their Symptomatic Effects in Patients With Idiopathic Parkinson's Disease
This study evaluates plasma concentrations of pharmacologically active constituents of chocolate and their effects on motor and non-motor symptoms of Parkinson's disease.
- Trial name
- Choc-PD (NCT02275884)
- Testing
- Dark chocolate (85% cocoa), White chocolate (0% cocoa)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technische Universität Dresden
Cerebrovascular Accident, Stroke
Spastic Cocontractions and Limitation of Active Movements Before and After Treatment During Injection of Botulinum Toxin
Following a stroke , 55% of the patients do not recover any traction of the upper limb and 30% a residual motricity not allowing a functional grip.
- Trial name
- NCT03453008
- Testing
- elbow extension, electromyography
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Toulouse
Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease
A Study to Assess the Efficacy and Safety of AXS-05 in Subjects With Alzheimer's Disease Agitation
This trial was a multi-center, double-blind, placebo-controlled, randomized study to evaluate the efficacy and safety of AXS-05 compared to placebo for the treatment of agitation associated with Alzheimer's disease.
- Conditions
- Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease, Agitation
- Trial name
- ADVANCE-2 (NCT05557409)
- Testing
- AXS-05
- Where
- 55 sites in United States, Puerto Rico
- Volunteers
- 408 people
- Sponsor
- Axsome Therapeutics, Inc.
Congenital Disorders, Cerebral Desaturation
International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery
The goal of this observational study is to determine the incidence of perioperative cerebral desaturation in neonates undergoing surgery for congenital malformations. The main questions it aims to answer are: 1.
- Conditions
- Congenital Disorders, Cerebral Desaturation, Neonatal Surgery
- Trial name
- NCT05673499
- Testing
- NIRS/EEG monitoring
- Where
- 15 sites in United States, Australia and 5 more
- Volunteers
- 900 people
- Sponsor
- Children's Hospital of Philadelphia
Balance Control
Impact of Physical Activities on Balance in Patient With Strabismic Amblyopia
The aim of this study is to determine the effect of physical activities on balance in patient with amblyopia after strabismus surgery.
- Trial name
- NCT06758063
- Testing
- exercises therapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Amany Refaat Mohamed Abdel Wahid
Stroke, Upper Limb Hypertonia
An Algorithm for Prognosis of Upper Limb Paresis in Patients With Subacute Stroke
Aim study 1:Assess the accuracy of PREP2 when applied in a subacute rehabilitation setting. Aim study 2: Prediction of real life UL use. Method: A prospective cohort study.
- Conditions
- Stroke, Upper Limb Hypertonia, Physical Activity
- Trial name
- NCT03632499
- Testing
- rehabilitation
- Where
- Denmark
- Volunteers
- 103 people
- Sponsor
- University of Aarhus
Epilepsy
Hybrid Micro-macro Electrodes in Patients With Epilepsy
The aim of the MicroEPI study is to know whether it is possible to use safely a medical device (a micro-electrode) that allows recording the activity of neurons in the human brain.
- Trial name
- MicroEPI (NCT05335187)
- Testing
- micro-macro electrode implantation
- Where
- 2 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- Pierre Mégevand
Parkinson Disease, Prodromal Stage
Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity
α-Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are the second most common neurodegenerative diseases.
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases
- Trial name
- ALPHA-FIT (NCT07324330)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- Germany
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Heart Attack, Cardiac Arrest
Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys
Based on limited published epidemiological data, up to an alarming 1 in 50 surgical inpatients die within 30 postoperative days.
- Conditions
- Heart Attack, Cardiac Arrest, Congestive Heart Failure, Atrial Fibrillation
- Trial name
- SATISFY-SOS (NCT02032030)
- Where
- United States
- Volunteers
- 73,952 people
- Sponsor
- Washington University School of Medicine
Parkinson Disease 10
The Effects of Exercise in Parkinson's Disease
Parkinson's disease is caused by a reduction of dopamine causing motor deficits. The investigators are studying how exercise can help PD patients by increasing dopamine release in an area of the brain that coordinates movement…
- Trial name
- PET (NCT01835652)
- Testing
- Active Exercise, Passive Exercise
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Pacific Parkinson's Research Centre
Phenylketonuria
Effect of Different Meal Types Given Before Exercise on Plasma Amino Acid Levels and Metabolic Control Parameters in Classical Phenylketonuria Patients Undergoing Aerobic and Resistance Exercises
This study will be the first in the literature to evaluate the relationship between aerobic and resistance exercises, plasma amino acid levels, metabolic control of patients, and the metabolic response to exercise with different…
- Trial name
- NCT07526909
- Testing
- Aerobic Exercise, Resistance Exercise, Water
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Hacettepe University
Brain Metastasis, Radiation Therapy
18F-FLUC PET/MR in Patients With Brain Mets
The goal of this clinical trial is to use new imaging methods to help in finding out whether the imaging shows that there is a tumor in people with a brain metastasis.
- Conditions
- Brain Metastasis, Radiation Therapy, Immunotherapy, Active
- Trial name
- NCT06159335
- Testing
- F-Fluciclovine radiotracer
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Wisconsin, Madison
Visual Impairment, Stroke
Re-Orchestration of Interregional Oscillatory Activity to Promote Visual Recovery
This project assesses the effect of bifocal cross-frequency transcranial alternating current stimulation (tACS) combined with visual training to improve visual recovery and orchestrated oscillatory activity in stroke patients…
- Conditions
- Visual Impairment, Stroke, Parkinson Disease
- Trial name
- R4V (NCT05220449)
- Testing
- Cross-frequency dual-site tACS
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Parkinson's Disease
Exercise Targeting Cognitive Impairment in Parkinson's Disease
The aim of this application is to compare and elucidate the effects of skill-based versus aerobic exercise versus control on mild cognitive impairment (MCI) of the executive function (EF) subtype in Parkinson's disease (PD); we…
- Trial name
- NCT02267785
- Testing
- Skill-Based Exercise, Aerobic Exercise, Social Contact
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Southern California
Sedentary Behaviour, Stroke
Effectiveness of the RISE Intervention
Study aim: Primarily, to investigate the effectiveness of the RISE blended behaviour change intervention in people with a first stroke to prevent major adverse cardiovascular events (i.e., recurrent stroke or TIA, acute coronary…
- Trial name
- RISE (NCT06124248)
- Testing
- RISE intervention
- Where
- 21 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Traumatic Brain Injury (TBI), Agitated Behaviour
Modified Environment for Agitation in Patients With TBI
This study examines the effect of an intervention consisting of dynamic circadian light and sound therapy, as well as systematic information on sleep pattern, agitated behavior and functioning level.
- Trial name
- ABS (NCT02524067)
- Testing
- Multifactorial circadian concept
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Diplegic Cerebral Palsy
Individualized Comprehensive Home-Centred Activity Based Therapy for Children With Diplegic Cerebral Palsy
Activity based therapy is gaining interest for rehabilitation of children with cerebral palsy (CP). A home-based comprehensive programme structured on the principles of activity based therapy seems to hold promise in the field of…
- Trial name
- NCT02412007
- Testing
- Individualized comprehensive home centred activity based programme
- Where
- India
- Volunteers
- 59 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Stroke, Stroke Rehabilitaion
Comparative Effects of Mirror Therapy and Cognitive Orientation to Daily Occupational Performance in Stroke: A Randomized Controlled Trial
This study aims to compare the effectiveness of three rehabilitation approaches in individuals with stroke: mirror therapy (MT), cognitive orientation to daily occupational performance (CO-OP), and conventional occupational…
- Trial name
- NCT07546864
- Testing
- Mirror Therapy, Cognitive Orientation to Daily Occupational Performance (CO-OP), Conventional Occupational Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Hacettepe University
Fabry Disease
A Co-designed Physical Activity Intervention in Fabry Disease
Currently, treatments for Fabry disease are pharmacological and predominantly focus on the physical symptoms of the disease. In the general population and individuals with disabilities, increasing physical activity levels and…
- Trial name
- NCT06257901
- Testing
- Interviews/Focus groups/Participatory workshops
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Brunel University
Healthy
Investigating the Efficacy of Brain Octane® Oil on Cognition, Coordination, Reaction Time and Measurements of Physical Performance in Recreationally Active Adults
This is a randomized, double-blind, placebo-controlled, parallel study investigating the efficacy of Brain Octane® Oil on cognition, coordination, reaction time and measurements of physical performance in recreationally active…
- Trial name
- NCT04095728
- Testing
- Brain Octane Oil
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bulletproof 360, Inc.
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