Clinical trials: Brain Activity
Schizophrenia
Effect of Repetitive Transcranial Magnetic Stimulation on Resting State Brain Activity in Schizophrenia
This study compares the efficacy of low and high frequency repetitive transcranial magnetic stimulation (rTMS) as a means of treating subjects with schizophrenia. Magnetic pulses delivered over the scalp cause brain activity.
- Trial name
- NCT01620086
- Testing
- Active Repetitive Transcranial Magnetic Stimulation 1 Hz, Active Repetitive Transcranial Magnetic Stimulation 10 Hz, Active control site Repetitive Transcranial Magnetic Stimulation at 1Hz
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Brain Concussion
Active Injury Management (AIM) After Pediatric Concussion
The proposed interventions of this study will determine the ideal discharge recommendations related to activity
- Trial name
- AIM (NCT03869970)
- Testing
- REST, ACTIVITY, mHEALTH
- Where
- 2 sites in United States
- Volunteers
- 237 people
- Sponsor
- Medical College of Wisconsin
Physical Exercise, Cerebrovascular Function
Exercise and Brain Vascular Function
Cognitive performance is negatively related to an impaired glucose metabolism, possibly due to impairments in brain vascular function.
- Conditions
- Physical Exercise, Cerebrovascular Function, Cerebral Blood Flow, Glucose Metabolism
- Trial name
- NCT03272061
- Testing
- Aerobic-based exercise program
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Adult Growth Hormone Deficiency, Growth Hormone Disorder
A Trial to Compare the Safety of Once Weekly Dosing of Somapacitan With Daily Norditropin® FlexPro® for 26 Weeks in Previously Human Growth Hormone Treated Adults With Growth Hormone Deficiency
This trial is conducted in Europe and Asia. The aim of the trial is to compare the safety of once weekly dosing of somapacitan (administered with an investigational pen) with daily Norditropin® FlexPro® (somatropin delivered…
- Trial name
- REAL 2 (NCT02382939)
- Testing
- somapacitan, somatropin
- Where
- 28 sites in Denmark, France and 4 more
- Volunteers
- 92 people
- Sponsor
- Novo Nordisk A/S
Dementia
Paired Integrative Exercise Program for People With Dementia and Caregivers
Preventing Loss of Independence through Exercise (PLIÉ) is a unique, multimodal movement program for people with dementia (affected individuals) that is taught by trained instructors and combines physical, mental and social…
- Trial name
- Paired PLIÉ (NCT02729311)
- Testing
- Paired PLIÉ Program, Waitlist control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Stroke
Aerobic Exercise in Patients With Stroke
The purpose of this study is to compare aerobic training to exergame training in people with chronic mild/moderate stroke. The objectives of this study are two-fold: 1) To evaluate the effects of a home-based aerobic exercise…
- Trial name
- NCT05429255
- Testing
- Aerobic Exercise, Exergame Training
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Columbia University
Acute Brain Injury, Traumatic Brain Injury
Connectivity and Neural Signatures of Consciousness in Unresponsive States
The CONSCIUS study is a prospective, interventional study including patients with acute brain injury and impaired consciousness implanted with intracranial electrodes.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Consciousness Disorders, Seizures
- Trial name
- CONSCIUS (NCT06426615)
- Testing
- Intracranial electrodes
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson's Disease
Evaluating the Influence of Externally vs. Internally Focused Exercise on Rehabilitation in Parkinson's Disease
The purpose of this study is to evaluate the underlying mechanism and influence of externally vs. internally focused exercise on rehabilitation in Parkinson's disease.
- Trial name
- DT-PDSAFEx (NCT02476240)
- Testing
- Parkinson's disease Sensory Attention Focused Exercise
- Volunteers
- 65 people
- Sponsor
- Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Alzheimer´s Disease
Follow-up Study to Assess Safety and Clinical Activity of Continued AFFITOPE® AD02 Vaccinations of Patients Who Participated in AFF006
This is a follow-up study to assess safety and clinical activity of continued AFFITOPE® AD02 vaccinations in patients with Alzheimer's disease.
- Trial name
- NCT02008513
- Testing
- AFFITOPE® AD02
- Where
- 27 sites in Austria, Croatia and 4 more
- Volunteers
- 194 people
- Sponsor
- Affiris AG
Brain Metastases
EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active
To learn if consolidative stereotactic radiosurgery (cSRS) can help to control central nervous system (CNS) disease in patients who have brain metastases and have a partial response or stable brain metastases after systemic…
- Trial name
- NCT06649058
- Testing
- Systemic Therapy, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 316 people
- Sponsor
- M.D. Anderson Cancer Center
Cervicogenic Headache
The Effects of a Specific Exercise Program on Subjects With Cervicogenic Headache
This study explores with the use of MSK Ultrasound imaging if the obliquus capitis minor and the rectus capitis major can be contracted with specific exercises.
- Trial name
- NCT05500378
- Testing
- Head extension and rotation movement
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Florida Gulf Coast University
Sedentary Lifestyle
Exercise Effects on Brain Health and Learning From Minutes to Months
Given the accelerating growth of older adults worldwide and the decline in cognitive function with aging, therapeutics that remediate age-related cognitive decline are needed more than ever.
- Trial name
- EXTEND (NCT03114150)
- Testing
- Cardiorespiratory fitness training, Functional fitness training
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Michelle W. Voss
Stroke
Efficacy of Bilateral Stimulation With Task-oriented Training in Improving Lower Limb Motor Functions in Patients With Stroke
This proposed study aims to compare the effects of unilateral and bilateral transcutaneous electrical nerve stimulation (TENS). It will compare the effectiveness of bilateral TENS + task-oriented training (TOT) with unilateral…
- Trial name
- RCT (NCT02152813)
- Testing
- TENS and Task-orientated training
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke, Chronic Stroke Patients
RESPARK - Brain Q for Chronic Stroke
This trial tests a promising new intervention to promote post-stroke neural reorganization and functional recovery. The Q Therapeutic (BQ 3.0) is a wearable medical system that produces and delivers non-invasive…
- Conditions
- Stroke, Chronic Stroke Patients, Cerebrovascular Accident (CVA)
- Trial name
- NCT07095920
- Testing
- Device: Q Therapeutic System (BQ 3.0) - Active
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Alzheimer Disease
A Multinational, Multi-center, Randomized, Double-blind, Active Comparator, Phase III Clinical Trial to Evaluate the Efficacy and Safety of Donepezil Transdermal Patch in Patients With Alzheimer's Disease
The objective of this study is to evaluate the efficacy and safety of donepezil transdermal patch in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT03197740
- Testing
- Donepezil patch, aricept Tab
- Where
- South Korea
- Volunteers
- 399 people
- Sponsor
- Icure Pharmaceutical Inc.
Cerebral Palsy
Robot-assisted Hand Rehabilitation for Children With Cerebral Palsy: a Pilot Study
Objective: To investigate the effects of robot-assisted hand rehabilitation with a Gloreha device on hand function and the participation of ADL for children with cerebral palsy(CP).
- Trial name
- NCT03490591
- Testing
- Robot-assisted hand rehabilitation
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Physical Activity
Effects of Brain Breaks on Educational Achievement in School Settings: The Break4Brain Project
A total of 600 children between 10 and 12 years of age will be randomized among two experimental conditions: physical activity interacting with a video (n = 300), and sedentary activity (n = 300).
- Trial name
- NCT06319833
- Testing
- Physical activity interacting with a video
- Where
- Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Alzheimer's Disease, Vascular Dementia
Personalized Music Therapy and Agitation in Dementia
Symptoms of agitation include abuse or aggressive behaviour toward self or others, appropriate behaviour performed with inappropriate frequency, or behaviours that are inappropriate according to social standards.
- Trial name
- NCT02147652
- Testing
- Personalized music
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Hemiplegic Cerebral Palsy
Electromyography Biofeedback Training Versus Mirror Therapy on Muscle Activity, Range of Motion and Function of Upper Limb in Children With Hemiplegia
One of the main motor control issues in hemiplegic CP is spasticity, which affects the flexor muscles of the upper limb. This spasticity causes the limb to adopt a flexed posture, limiting the range of motion and contributing to…
- Trial name
- NCT07818616
- Testing
- Neurotrac Simplex electromyography biofeedback device, Mirror, a designed physical therapy program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Active Melanoma Brain Metastases
Phase II Study of Cobimetinib in Combination With Vemurafenib in Active Melanoma Brain Metastases
The purpose of this study is to evaluate the effectiveness of the combination of vemurafenib with cobimetinib in patients with active melanoma brain metastases.
- Trial name
- CoBRIM-B (NCT02230306)
- Testing
- Cobimetinib, Vemurafenib
- Where
- 6 sites in United States
- Volunteers
- 5 people
- Sponsor
- Melissa Burgess, MD
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