Clinical trials: Brain Activity
Chronic Insomnia, Sleep Deprivation
Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia
This clinical trial aims to evaluate the safety and efficacy of PROSOMNIA Sleep Therapy (PSTx) for individuals suffering from chronic insomnia, sleep deprivation, and REM sleep disorders.
- Conditions
- Chronic Insomnia, Sleep Deprivation, REM Behavior Disorder, REM Sleep Behavior Disorder
- Trial name
- PSHW (NCT06644573)
- Testing
- PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nyree Penn
Cerebral Palsy (CP)
Scooter Board Activities on Neck Control and Dysphagia in Children With Cerebral Palsy
This study is a randomized control trial exploring the therapeutic effects of scooter board activities on neck control and dysphagia in children with cerebral palsy (CP).
- Trial name
- NCT06477224
- Testing
- Scooter Board Activities, Routine Physical Therapy
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Sedentary Behavior, Physical Inactivity
Promoting Physical Activity in Older Hispanic/Latino(a) Adults
In this randomized controlled trial, study staff will randomize 130 Hispanic/Latino adults without dementia and over age 55 from Southern California and from Kaiser Permanente Washington (State) to either the culturally adapted…
- Conditions
- Sedentary Behavior, Physical Inactivity, Alzheimer Disease, Protection Against
- Trial name
- NCT06362824
- Testing
- De Pie Intervention, Active Comparison Group: Healthy Actions And Lifestyles To Avoid Dementia (HALT-AD)
- Where
- 2 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Stroke, Exercise
The Influence of Exercise on Neuroplasticity and Motor Learning After Stroke
Participants will complete 11 sessions. These include screening, 5 sessions where exercise or rest (according to group assignment) are paired with practice of a motor task, MRI and Transcranial Magnetic Stimulation (TMS) before…
- Conditions
- Stroke, Exercise, Rest
- Trial name
- EX-ML3 (NCT02980796)
- Testing
- Exercise, Practice
- Where
- Canada
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Post-Hemorrhagic Hydrocephalus
Cerebral Perfusion, Oxygenation, Electrical Activity
The specific aim of the research proposal in preterm infants with IVH and PHH who require placement of an Omaya reservoir or a shunt is to determine if decreasing ventricular volume improves, middle cerebral artery flow, cerebral…
- Trial name
- NCT00747682
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Phenylketonuria, PKU
Moderate Intensity Exercise and Phenylketonuria
Phenylketonuria (PKU), an inherited genetic disorder, can cause irreversible brain damage, declined executive function, and autistic tendencies unless a phenylalanine (Phe) restricted diet is consistently maintained throughout…
- Trial name
- NCT01904708
- Testing
- Acute Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Oregon Health and Science University
Dementia
Decoding Death and Dying in People With Dementia by Digital Thanotyping
How can healthcare professionals recognize that a person with dementia is at the end of life? When people are dying, their physical, mental, and social abilities are gradually declining.
- Trial name
- 5-D (NCT06437132)
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 270 people
- Sponsor
- University of Bergen
Parkinson's Disease
Effectiveness of an Active Lifestyle Promotion Program for Patients With Parkinson's Disease
Patients with Parkinson's disease (PD) are heavily inclined towards a sedentary lifestyle. This is caused by a combination of physical impairments and cognitive dysfunction.
- Trial name
- ParkFit (NCT00748488)
- Testing
- Physical therapy aimed to move safely, Physical Therapy aimed to improve Physical Activity
- Where
- 32 sites in Netherlands
- Volunteers
- 700 people
- Sponsor
- Radboud University Medical Center
Mild Traumatic Brain Injury
Pro-2-Cool Device Clinical Study
This study is being conducted to quantify the clinical safety and efficacy of head and neck cooling when applied up to 8 days after mild traumatic brain injury (mTBI) among adolescents participating in sporting activities.
- Trial name
- NCT03511339
- Testing
- TecTraum device
- Where
- 5 sites in United States
- Volunteers
- 174 people
- Sponsor
- TecTraum Inc.
Parkinson Disease
Exercise Neuroprotection in Parkinson's Disease
The purpose of this study is to explore the relationships of exercise on inflammation in the body of older adults and people with Parkinson's disease (PD).
- Trial name
- PDex (NCT05854524)
- Testing
- Aerobic exercise
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Obsessive-Compulsive Disorder, Cognition Disorders
Physical Exercise in OCD: Treatment Efficacy, Additive Benefits to CBT, and Cognitive Correlates of Change
Obsessive compulsive disorder (OCD) is a severe and debilitating anxiety disorder afflicting 2% of the population. Cognitive behavioural therapy (CBT) is considered first line psychological treatment for OCD, but there are a…
- Trial name
- NCT02136953
- Testing
- Exercise, Cognitive Behavioural Therapy (CBT)
- Where
- 3 sites in Canada
- Volunteers
- 125 people
- Sponsor
- Sunnybrook Health Sciences Centre
Alzheimer Disease, Lewy Body Disease
Epileptic Activity in Patients With Alzheimer's Disease and Lewy Body Dementia
In the current study, the investigators will examine the extent of subclinical epileptic activity in patients with Alzheimer's disease and patients with Lewy body dementia as compared to healthy elderly controls.
- Conditions
- Alzheimer Disease, Lewy Body Disease, Epilepsy
- Trial name
- AD-LBD-EPI (NCT04436341)
- Where
- 2 sites in Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Danish Dementia Research Centre
Anti-Neutrophil Cytoplasm Antibodies (ANCA) Associated Vasculitis
Iptacopan in Patients With ANCA Associated Vasculitis
The purpose of this study is to evaluate the efficacy and safety of iptacopan compared to standard of care (SOC) to induce and maintain remission in study participants with active granulomatosis with polyangiitis (GPA) or…
- Trial name
- NCT06388941
- Testing
- Iptacopan, Rituximab
- Where
- 40 sites in United States, Argentina and 13 more
- Volunteers
- 84 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson Disease
Feasibility of the AHA Exergame System in Parkinson's Disease Patients
Background: Parkinson's disease (PD) remains a progressive disease associated with a high level of disability. Due to the physical and cognitive impairments, fatigue and apathy, patients frequently experience a decrease in their…
- Trial name
- NCT03891069
- Testing
- AHA Exergame System
- Where
- Portugal
- Volunteers
- 10 people
- Sponsor
- Campus Neurológico Sénior
Epilepsy
Comparing The Effect On Cognition Of Adjunctive Therapy With Zonisamide Versus Sodium Valproate
Zonisamide (Zonegran) and sodium valproate (Epilim) are both medicines approved to treat epilepsy. The purpose of this study is to find out the extent to which zonisamide may affect memory and concentration, compared to sodium…
- Trial name
- NCT00713622
- Testing
- Zonisamide, Sodium valproate
- Where
- 2 sites in Austria, Finland
- Volunteers
- 2 people
- Sponsor
- Eisai Limited
Traumas, Brain, Alzheimer Disease
The COACH Project: Combined Online Assistance for Caregiver Health
This study evaluates the effect of a physical exercise + caregiver skills training on feelings of burden, mood, and biological markers of inflammation in persons who provide care for Veterans with a TBI or dementia.
- Conditions
- Traumas, Brain, Alzheimer Disease, Dementia, Head Injury
- Trial name
- COACH (NCT03123224)
- Testing
- Combined Aerobic and Resistance Exercise + Caregiver Skills Training, Stretching Balance and Flexibility + Caregiver Skills Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Stroke
Adaptive Physical Activity for Chronic Stroke
This study will compare the Adaptive Physical Activity program (APA) to a less vigorous group exercise program, (Sittercise) to see if APA leads to greater improvements in walking endurance, quality of life, and participation in…
- Trial name
- APA-Stroke (NCT00773370)
- Testing
- APA-Stroke, Sittercise
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- VA Office of Research and Development
Cognitive Decline, Cognitive Impairment
Effects of Cognitive Intervention on Cognition, Mobility and Brain Electrocortical Activity
Within this project the investigators tested the effectiveness of 2-month of computerized cognitive training (CCT) on CogniFit online platform on 77 older adults, which were randomly divided into intervention and control group.
- Conditions
- Cognitive Decline, Cognitive Impairment, Aging, Motor Coordination or Function
- Trial name
- GIBKOP (NCT03860441)
- Testing
- Computerized cognitive training
- Where
- Slovenia
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Advanced Parkinson's Disease
Clinical Study for Adaptive Deep Brain Stimulation (aDBS)Controlled by Intracerebral Activity in Parkinson's Disease
Despite its therapeutic effectiveness in Parkinson's disease (PD) the current deep brain stimulation (DBS) strategy could achieve an even better clinical result by adapting to patient's condition.
- Trial name
- ADBS (NCT02154724)
- Testing
- aDBS, DBS
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Epilepsy
Trial to Evaluate the Effect of Eslicarbazepine Acetate on Cardiac Repolarization
A randomized, double-blind, placebo-controlled and open label active-controlled, 4 period crossover trial to evaluate the effect of eslicarbazepine acetate on cardiac repolarization in healthy adult men and women
- Trial name
- NCT02283788
- Testing
- BIA 2-093, Moxifloxacin
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.