Clinical trials: Brain Age
Age-related Cognitive Decline, Alzheimer's Disease and Related Dementias
Preventing Alzheimer's With Cognitive Training
Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia.
- Trial name
- PACT (NCT03848312)
- Testing
- Cognitive Training, Computerized Cognitive Stimulation
- Where
- 7 sites in United States
- Volunteers
- 7,600 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Premature Birth, Extremely Low Birth Weight
DCS Study in Extremely Premature Newborns
The researchers are attempting to improve the cerebral monitoring of extremely low gestational age (ELGA) infants, such that in the future, real-time monitoring will be possible, to aid clinicians in management of these infants.
- Conditions
- Premature Birth, Extremely Low Birth Weight, Infant, Small for Gestational Age, Intracerebral Hemorrhage
- Trial name
- NCT04367181
- Testing
- Diffuse Correlation Spectroscopy (DCS), Amplitude Integrated Electroencephalography (aEEG)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Maria Angela Franceschini
Encephalopathy, Cerebral Palsy
Initiating Pediatric Palliative Care in ACT Group 4
Due to the wide range of diagnoses encountered in pediatric palliative care, the Association for Children's Palliative Care (ACT) and the Royal College of Paediatrics and Child Health (RCPCH) have developed a classification of…
- Conditions
- Encephalopathy, Cerebral Palsy, Cerebral Malformation, Traumatic Head Injury
- Trial name
- StartSPP (NCT06273267)
- Testing
- Collection of data from the patient's medical file
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Palsy (CP)
Association Between Extremity Muscle Strength and Functional Outcomes in Children With Cerebral Palsy
The aim of this study was to evaluate whether upper and lower extremity muscle strength is a factor in activity, participation and quality of life parameters in school-age children with CP and to reveal the difference in upper…
- Trial name
- NCT07448207
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Pediatric Epileptic Syndrome, Partial-onset Seizures
A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood Epilepsy
The purpose of the study is to evaluate the efficacy of perampanel as measured by the 50 percent (%) responder rate during the maintenance period of the core study for seizure frequency in participants with pediatric epileptic…
- Trial name
- NCT04015141
- Testing
- Perampanel Oral Suspension, Perampanel Tablet
- Where
- 35 sites in United States, Belgium and 4 more
- Volunteers
- 100 people
- Sponsor
- Eisai Inc.
Aged 65 Years or Older, Cognitive Decline
The Effect of Occupational Activities and Finger Exercise Program on Hand Grip Strength and Activities of Daily Living in Elderly Individuals With Dementia: Randomized Controlled Trial
As people age, cognitive functions, muscle mass, and hand strength tend to decrease. Reduced hand grip strength in the elderly can make it harder for them to perform daily tasks such as buttoning clothes, pulling zippers, or…
- Conditions
- Aged 65 Years or Older, Cognitive Decline, Dementia
- Trial name
- NCT07033338
- Testing
- Occupational Activities and Finger Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Emel Dogan
Amblyopia
5 Years of Eye Screening for ARF in Children Aged <3 Years in Flanders
Researchers will investigate the distribution and evolution of amblyopia risk factors and other refractive errors in children younger than 3 years of age.
- Trial name
- NCT05612568
- Where
- Belgium
- Volunteers
- 250,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Adult Day Programs, Continuing Care
Assessing the Impact of DAy Programs on Individuals Living with Dementia and Their Family/friend Caregivers
This study seeks to understand the effects of adult day programs on older adults, especially those with dementia, and their caregivers.
- Conditions
- Adult Day Programs, Continuing Care, Old Age; Dementia, Family/Friend Caregivers
- Trial name
- NCT06496945
- Testing
- Adult day program use, Other community care (non-attendees)
- Where
- 4 sites in Canada
- Volunteers
- 3,000 people
- Sponsor
- York University
Old Age; Dementia
Tango for Older People With Dementia
Cognitive impairment (CI) is the leading cause of loss of autonomy and has a huge impact on physical performance and quality of life (QOL) in older people.
- Trial name
- NCT05744011
- Testing
- Tango intervention, Adapted Physical Activity
- Where
- 2 sites in France
- Volunteers
- 124 people
- Sponsor
- University of Burgundy
Drug Resistant Epilepsy
Comparison Between Efficacy of Daily and Intermittent Low Glycemic Index Therapy Diet
Drug resistant epilepsy constitutes about one third of all children diagnosed with epilepsy. Although ketogenic diet is being used for drug resistant epilepsy for almost hundred years, its restrictiveness and adverse effects…
- Trial name
- NCT03464487
- Testing
- Low Glycemic Index Therapy Diet
- Where
- India
- Volunteers
- 110 people
- Sponsor
- All India Institute of Medical Sciences
Behavior and Behavior Mechanisms
Impact of Another Person's Presence on Brain and Behavioral Performance
In a recent study, investigators provided the first neuroscientific data on social facilitation. This neuroimaging study, performed in the macaque monkey, shows a marked improvement in performance in a simple task when a congener…
- Trial name
- SOFEE (NCT03453216)
- Testing
- neuropsychological tests
- Where
- France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus
Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH)
In all the Western populations, the annual incidence of subarachnoid hemorrhage (SAH) increase with age. In patients older than 70 years, the occurrence of SAH exposes them to high risk of morbidity and a poor quality of life.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus, Cerebral Vasospasm
- Trial name
- FASHE (NCT00692744)
- Where
- 2 sites in France
- Volunteers
- 353 people
- Sponsor
- University Hospital, Rouen
Congestive Heart Failure
Safety and Efficacy Study of Carvedilol to Treat Children With Congestive Heart Failure
The purpose of this study is to determine whether a new medicine, called carvedilol, improves symptoms and heart function in children who have congestive heart failure (diminished function of their heart muscle that pumps blood…
- Trial name
- NCT00052026
- Testing
- carvedilol
- Where
- 21 sites in United States
- Volunteers
- 161 people
- Sponsor
- Shaddy, Robert, M.D.
Periodic Limb Movement Disorder, Cerebral Small Vessel Diseases
Periodic Limb Movement Syndrome in Patients With Cerebral Small Vessel Disease.
Patients from 60 to 75 years old diagnosed with cerebral small vessel disease with no history of symptomatic stroke, brain tumor, traumatic brain injury, seizures and neurodegenerative or mental disorder will undergo overnight…
- Conditions
- Periodic Limb Movement Disorder, Cerebral Small Vessel Diseases, Cognitive Dysfunction
- Trial name
- NCT04569643
- Testing
- Actigraphy, Cardiorespiratory monitoring, Neuroimaging
- Where
- Russia
- Volunteers
- 76 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Stroke
Alteplase Treatment in Elderly Acute Ischaemic Stroke (AIS) Patients
The objective of this study is to find out if Chinese Acute Ischaemic Stroke (AIS) patients older than 80 years benefit from intravenous (IV) Recombinant Tissue Plasminogen Activator (rt-PA) treatment within 4.5 hours of symptom…
- Trial name
- NCT05401149
- Testing
- rt-PA
- Where
- China
- Volunteers
- 3,058 people
- Sponsor
- Boehringer Ingelheim
Alzheimer's Disease
Dose Response Study of Aerobic Exercise in Older Adults
This is a randomized, 26-week study of supervised exercise assessing three doses of exercise in sedentary individuals 65 years of age and over with age-related cognitive changes.
- Trial name
- NCT01129115
- Testing
- Nonexercise control group, Aerobic Exercise Group 1, Aerobic Exercise Group 2
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Jeff Burns, MD
Dementia, Cognition Disorders in Old Age
Neuropsychological Assessment Of The Oldest-Old Population.(NEUROPSIC-GR)
Neuropsychological tests currently considered to evaluate the cognitive performance of the oldest-old population (more than 80 years) are not adapted to this group population.
- Trial name
- NEUROPSIC-GR (NCT05481749)
- Where
- 6 sites in Spain
- Volunteers
- 113 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Cerebral Palsy
Orthosis to Improve Trunk Control in Infants Age 6-18 Months
The purpose of this study is to determine the impact of the SPIO® Core-MAX® Expedition orthosis on an infant's head, trunk and upper limb function.
- Trial name
- NCT06027580
- Testing
- SPIO® Core-MAX® Expedition thoracolumbosacral orthosis, Standard Care Therapy option
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical College of Wisconsin
Tick Borne Encephalitis (TBE)
Burden of Tick-borne Encephalitis and Cost-effectiveness of Vaccination in the Czech Republic
This observational study follows children and adults who were hospitalized with tick-borne encephalitis (TBE) in the Czech Republic.
- Trial name
- ENCZECH (NCT07274046)
- Testing
- No intervention
- Where
- 4 sites in Czechia
- Volunteers
- 209 people
- Sponsor
- Charles University, Czech Republic
Elderly Individuals Aged 60 Years or Older, Mild Cognitive Impairment (MCI)
THE EFFECTS OF GAMBIR CATECHIN (UNCARIA GAMBIR ROXB) SUPPLEMENTATION ON COGNITIVE FUNCTION, EXPRESSION OF APP, MAPT, BDNF, IL-10, TGF-Β GENES, AND PLASMA MDA LEVELS IN THE ELDERLY.
Objective The primary objective of this clinical trial is to investigate the effects of gambir catechin administration on cognitive function, the expression of amyloid precursor protein (APP), microtubule-associated protein tau…
- Trial name
- NCT06604390
- Testing
- catechin extracts (health food), plasebo
- Where
- 2 sites in Fiji, Indonesia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Rahmi Novita Yusuf