Clinical trials: Brain Aging, open to volunteers
Gait Disorders, Neurologic, Atypical Parkinson Disease
Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills.
- Conditions
- Gait Disorders, Neurologic, Atypical Parkinson Disease, fNIRS, Aging
- Trial name
- NCT06906276
- Testing
- Assessment of brain activity with fNIRS and behavioural assessments (motor, motor-cognitive and cognitive) during three complex walking conditions.
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Healthy Aging
Study Evaluating the Effect of Humiome® Post LB on Stress, Anxiety, and Cognition in Aging Adults
To assess the effect of 3 months of daily consumption of a postbiotic (inactivated lactic acid bacteria) Humiome® Post LB on stress measured by the Depression Anxiety Stress Scale-21 (DASS-21) adjusted on baseline in study…
- Trial name
- AnexLB (NCT07110896)
- Testing
- Humiome Post LB (Postbiotic)
- Where
- 3 sites in France, Germany
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Primary Progressive Aphasia
Stimulating the Aging Brain Using Brain and Sensory Stimulation
The goal of this project is to investigate whether transcranial electrical stimulation and sensory stimulation affect language outcomes in individuals with primary progressive aphasia (PPA).
- Trial name
- StAB (NCT07650188)
- Testing
- tACS or multisensory stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Alzheimer Disease
- Trial name
- MESO7 (NCT07202494)
- Testing
- Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging)
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Aging, Alzheimer Disease
Exercise to Improve Brain Health in Older African Americans
The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans.
- Conditions
- Aging, Alzheimer Disease, Healthy Aging, Cognitive Change
- Trial name
- NCT05597124
- Testing
- Cardio-Dance Fitness, Strength, Flexibility & Balance
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Aging, Cognition Improvement
Westlake Aging Cohort (WeAC)
The Westlake Ageing Cohort (WeAC) is a longitudinal cohort study conducted in Hangzhou, Zhejiang Province, China. The investigators aim to enroll 2,800 participants aged 55 years and older for long-term follow-up.
- Conditions
- Aging, Cognition Improvement, Cognition Disorders, Cognition
- Trial name
- NCT07373444
- Where
- 2 sites in China
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Westlake University
Healthy Aging, Middle-aged and Older Adults
Peanut Butter and Brain Health
Healthy foods, including peanuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Trial name
- NCT07774546
- Testing
- Peanut butter
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Penn State University
Multiple Sclerosis
BrainAgeMS - a Comparative Study of Brain Aging in Healthy and Patients With Multiple Sclerosis
The purpose of this study is to investigate new quantitative MRI-sequences for assessment of age-specific data for the prediction of brain aging.
- Trial name
- BrainAgeMS (NCT06221631)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Aging, Alzheimer Disease
The Nightlight Falls Prevention Study
This project will test the effectiveness of a novel intervention consisting of unobtrusive, low-intensity, horizontal and vertical lights that outline the bathroom or entry way doorframe in residents' rooms and provide visual…
- Conditions
- Aging, Alzheimer Disease, Dementia Alzheimers, Dementia of Alzheimer Type
- Trial name
- NCT05973448
- Testing
- Novel Lighting Condition, Control Lighting Condition
- Where
- United States
- Volunteers
- 335 people
- Sponsor
- University of North Carolina, Chapel Hill
Aging
Evaluation of Electroencephalographic Biomarkers in Physiological Aging
Aging is the inevitable biological process that results in a progressive structural and functional decline from the cellular level to whole body function.
- Trial name
- AGE-MARK (NCT06824285)
- Where
- Italy
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Dementia, Parkinsonism
DaTSCAN Imaging in Aging and Neurodegenerative Disease
The investigators propose using DaTscan in patients with REM sleep behavior disorder (RBD), mild cognitive impairment (MCI), Parkinson's disease (PD), dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and other…
- Conditions
- Dementia, Parkinsonism, Mild Cognitive Impairment, REM Sleep Behavior Disorder
- Trial name
- NCT01453127
- Testing
- I-123 Ioflupane solution injection prior to SPECT scan (DaTscan), Single photon emission computed tomography (SPECT) scan
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Insomnia, Cognition
The Impact of Brief Behavioral Treatment for Insomnia Versus Brief Mindfulness Treatment on Cognition and Sleep Health in Adults (Age 50+) With HIV
The goal of this clinical trial is to examine the effects of a telephone-delivered Brief Behavioral Treatment Insomnia (BBTI) versus a Brief Mindfulness Treatment (BMT) on cognitive and sleep outcomes in older adults with HIV.
- Conditions
- Insomnia, Cognition, Aging, HIV
- Trial name
- NCT07272863
- Testing
- BBTI, BMT
- Where
- 2 sites in United States
- Volunteers
- 214 people
- Sponsor
- University of Alabama, Tuscaloosa
Cushing Syndrome, Adrenal Insufficiency
Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders
This is a multicentric, prospective, intervention study on circadian genes expression in peripheral blood mononuclear cells as biomarkers of circadian rhythm derangement in patients affected by alterations of endogenous…
- Conditions
- Cushing Syndrome, Adrenal Insufficiency, Cushing Disease, Addison Disease
- Trial name
- CHROnOS (NCT04374721)
- Testing
- circadian gene expression evaluation
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Mild Cognitive Impairment (MCI), Healthy Aging
cMIND AI Web Tool Usability Study (Hong Kong)
This study is testing a new web-based tool that uses artificial intelligence (AI) to help older adults in Hong Kong check how healthy their Cantonese-style meals are for brain health.
- Conditions
- Mild Cognitive Impairment (MCI), Healthy Aging, Nutrition
- Trial name
- NCT07735013
- Testing
- Web-Based AI Dietary Assessment System
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hong Kong Metropolitan University
Aphasia, Stroke
ReadMap: Reading in Stroke Alexia and Typical Aging
Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for…
- Conditions
- Aphasia, Stroke, Alexia
- Trial name
- ReadMap (NCT06700005)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Aging, Dementia
Feasibility of A Smartphone Application Intervention in Community Settings: A Pretest-Posttest Pilot Study
The objective of this project is to test the feasibility of using a smartphone app in a community setting through collaborating with community-based organizations.
- Conditions
- Aging, Dementia, Cognitive Decline
- Trial name
- NCT07313540
- Testing
- utmbHealthyBrain Smartphone App
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Aging, Inflammation
Macrophage/Monocyte Driven Inflammation and Anesthetic Sensitivity in Aging
The goal of this observational study is to determine whether macrophage/monocyte mediated inflammatory signaling contributes to reduced anesthetic requirements in older adults undergoing major abdominal surgery.
- Conditions
- Aging, Inflammation, Blood-Brain Barrier Permeability, Anesthesia Brain Monitor
- Trial name
- MACRO-AGE (NCT07372417)
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- University of Chile
Aging, Noninvasive Brain Stimulation
Memory Enhancement in Aging With Optimal Dosing
This project optimizes high-resolution transcranial Alternating Current Stimulation (tACS) to improve memory in healthy older adults, advancing drug-free approaches for Alzheimer's disease and related dementia (ADRD).
- Conditions
- Aging, Noninvasive Brain Stimulation, Memory
- Trial name
- NCT07461584
- Testing
- 1-day patterned tACS, 3-day patterned tACS, 5-day patterned tACS
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Aging, Sensory Deficit
Walking Sensation Study
The primary objective of this new line of research is to test whether augmenting sensory information from the legs, using Walkasins sensory neuroprosthesis, can enhance performance of a complex walking task in older adults with…
- Trial name
- NCT06975423
- Testing
- Active lower-limb neuroprosthesis, Inactive lower-limb neuroprosthesis
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida