Clinical trials: Brain Aneurysms
Intracranial Aneurysms, Flow Diverter
Surface-Modified Flow Diverter for Intracranial Aneurysms: Assessment of Ischemic and Clinical Outcomes
Flow diverters (FDs) have become a mainstay of endovascular therapy for unruptured intracranial aneurysms (UIAs), yet their implantation carries an inherent risk of ischemic complications.
- Trial name
- PRISMATIC (NCT07674004)
- Testing
- LFD, PED Shield
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Henan Provincial People's Hospital
Subarachnoid Hemorrhage, Aneurysmal, Subarachnoid Hemorrhage
Remote Ischemic Preconditioning in Subarachnoid Hemorrhage
Rupture of brain aneurysms is a common cause of death and disability, accounting for as many as 10% of stroke cases in the United States.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Subarachnoid Hemorrhage, Cerebral Vasospasm, Intracranial Aneurysm
- Trial name
- RIPC-SAH (NCT01158508)
- Testing
- Remote ischemic preconditioning
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Aneurysm Cerebral, Endovascular Procedures
Optimal Duration of Dual Antiplatelet Therapy After Stent-assisted Coiling
Comparison of duration of dual antiplatelet therapy after stent-assisted coiling of unruptured intracranial aneurysms
- Trial name
- NCT05257824
- Testing
- Aspirin 100mg, Clopidogrel 75mg
- Where
- 8 sites in South Korea
- Volunteers
- 528 people
- Sponsor
- Seoul National University Bundang Hospital
Acute Ischemic Stroke, Intracranial Arterial Stenosis
Post-Market Active Surveillance and Health Economic Evaluation of Cerebrovascular Diagnostic and Therapeutic Devices
The research focuses on "post-market active surveillance and health economic evaluation of non-pharmacological therapies and innovative cerebrovascular diagnostic and therapeutic devices".
- Conditions
- Acute Ischemic Stroke, Intracranial Arterial Stenosis, Extracranial Arterial Stenosis, Intracranial Aneurysms
- Trial name
- NCT07828379
- Testing
- Endovascular Treatment for Acute Ischemic Stroke
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Intracranial Aneurysm
French eCLIPs™ Efficacy and Safety Investigation
The objective of this study is to demonstrate the safety and efficacy of the eCLIPs™ products for the treatment of bifurcation aneurysms.
- Trial name
- EESIS-Fr (NCT05330897)
- Testing
- Implantation of an eCLIPs™ device, eCLIPs™ Electrolytic Bifurcation Systems
- Where
- 28 sites in France
- Volunteers
- 119 people
- Sponsor
- Evasc Medical Systems Corp.
Unruptured Intracranial Aneurysm, Intracranial Aneurysm
Surveillance Versus Treatment of Unruptured Intracranial Aneurysms of Fortuitous Discovery
The goal of this clinical trial is to determine whether a watchful waiting strategy with imaging surveillance is superior to immediate aneurysm treatment in adults with incidentally discovered unruptured intracranial aneurysms…
- Trial name
- STAF (NCT07817511)
- Testing
- Clinical and imaging surveillance, Endovascular or neurosurgical aneurysm treatment
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aneurysmal Subarachnoid Hemorrhage
Cervical Spinal Cord Stimulation for the Prevention of Cerebral Vasospasm
The study investigates safety, feasibility and effectiveness of cervical spinal cord stimulation (SCS) in prevention of cerebral arterial vasospasm following aneurysmal subarachnoid hemorrhage (aSAH).
- Trial name
- NCT00766844
- Testing
- spinal cord stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Konstantin V. Slavin
Aortic Aneurysm, Aortic Dissection
Clinical Investigation of Clinical Safety and Performance of the SP-GRIPFLOW, Selective Cerebral Perfusion Catheter When Used for Cerebral Perfusion During Aortic Arch Repair
The purpose of this study is to determine if the SP-GRIPFLOW catheter (the catheter designed by Fuji Systems) is safe and how well it functions.
- Conditions
- Aortic Aneurysm, Aortic Dissection, Aortic Arch Aneurysm, Aortic Arch; Aneurysm, Dissecting
- Trial name
- NCT05421130
- Testing
- Selective Cerebral Perfusion Catheter
- Where
- 5 sites in Germany, Netherlands
- Volunteers
- 149 people
- Sponsor
- Fuji Systems Corporation
Intracranial Aneurysm
Aneurysmal Subarachnoid Hemorrhage and Superior Mesenteric Artery Flow Study
The purpose of this research study is to determine if the diameter and flow of the superior mesenteric artery in patients with aneurysmal subarachnoid hemorrhage undergoing hypertensive therapy for cerebral artery vasospasm are…
- Trial name
- NCT02684500
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Florida
Brain Neoplasms, Intracranial Aneurysm
Efficiency of Two Glucose Sampling Protocols for Maintenance of Euglycemia
What is the efficacy and safety of q 30 minutes vs. q 1hour glucose sampling and intervention for an intensive insulin protocol to achieve and maintain euglycemia in non-diabetic patients undergoing craniotomy? The investigators…
- Trial name
- NCT00993057
- Testing
- Insulin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Northwestern University
Aneurysm Cerebral
Kaneka Endovascular Embolization and Protection
Prospective, multi-center, non-randomized registry / study, up to 164 patients enrolled and followed at 180 days +/- 45 days and again at 365 days +/- 90 days post procedure
- Trial name
- KEEP (NCT05563051)
- Testing
- i-ED COIL
- Where
- 4 sites in United States
- Volunteers
- 164 people
- Sponsor
- Kaneka Medical America LLC
Intracranial Aneurysms
A Volumetric Coiling in Aneurysm Registry of the Penumbra Coil 400TM System
This study is a prospective, multi-center registry of patients with intracranial aneurysms who are treated by the PC 400 System. Data for each patient are collected up to 12 ± 3 months post-procedure for the study.
- Trial name
- VOLCAN (NCT01754051)
- Testing
- PC 400 coils
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Penumbra Inc.
Intracranial Aneurysm
Beta-blockade in Unruptured Intracranial Aneurysm
Subarachnoid haemorrhage is a devastating type of stroke, with high mortality and morbidity rate. In approximately 85% of cases, it is caused by an intracranial aneurysm rupture.
- Trial name
- BBLURAN (NCT06249802)
- Testing
- Nebivolol
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
Intracranial Aneurysms
Post-Market Product Surveillance of Intracranial ANeurysms Treated With Commercial ReGistered ACANDIS Devices in FrancE
The aims of this clinical data collection are to investigate mortality, morbidity and neurological outcome 12 months after treatment of subject's intracranial aneurysm(s) and additionally to evaluate potential residual risks…
- Trial name
- ANCRAGE PMS (NCT06940934)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Acandis GmbH
Embolic Stroke
Study of Antiplatelet Therapy for Intracranial Aneurysm Stent-assisted Coiling
Patients' responses to oral antiplatelet therapy are subject to variation. Bedside monitoring offers the opportunity to improve outcomes of intracranial aneurysm patients undergoing stent deployment by individualizing…
- Trial name
- ATIASC (NCT02224131)
- Testing
- Aspirin and clopidogrel
- Where
- China
- Volunteers
- 1,856 people
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Aneurysm Hemorrhage, Cerebral Vasospasm After Subarachnoid Hemorrhage
Delayed Cerebral Infarction Beyond Endoluminal Spasmolysis and Induced Hypertension
An observational study of patients with emerging or established severe cerebral vasospasm after subarachnoid haemorrhage, employing multimodal neuromonitoring.
- Trial name
- Decibel (NCT07305922)
- Testing
- Induced hypertension with norepinephrine, Endoluminal Spasmolysis
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Stockholm
Cervical Artery Dissection, Stroke
Looking For Genetic and Environmental Risk Factors and Therapeutic Aspects in Cervical Artery Dissections
The main purpose of this study is to look for genetic and environmental risk factors of cervical artery dissections, a major cause of ischemic stroke in young adults, in a large multicenter case-control trial
- Conditions
- Cervical Artery Dissection, Stroke, Brain Infarction
- Trial name
- CADISP (NCT00657969)
- Where
- 24 sites in Argentina, Belgium and 7 more
- Volunteers
- 4,169 people
- Sponsor
- Cervical Artery Dissections and Ischemic Stroke Patients - Consortium
Cerebral Aneurysm, Aneurysm, Middle Cerebral Artery
Safety Study of Minimally Invasive Approaches to Unruptured Anterior Circulation Aneurysms
The study is designed to evaluate the efficacy and safety of minimally invasive neurosurgical techniques for patients with incidental cerebral aneurysms of the anterior circulation in the Hospital das Clínicas of the University…
- Conditions
- Cerebral Aneurysm, Aneurysm, Middle Cerebral Artery, Aneurysm, Anterior Communicating Artery, Aneurysm, Posterior Communicating Artery
- Trial name
- MININCRUSP (NCT02345395)
- Testing
- Aneurysm Clipping
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo General Hospital
Aneurysm, Brain
Prediction of Outcomes After Surgery for Unruptured Intracranial Aneurysms
Accurate preoperative identification of patients at high risk for adverse outcomes would be clinically advantageous, as it would allow enhanced resource preparation, better surgical decision-making, enhanced patient education and…
- Trial name
- PRAEMIUM (NCT04819074)
- Testing
- Microsurgery
- Where
- 37 sites in United States, Australia and 8 more
- Volunteers
- 4,000 people
- Sponsor
- University of Zurich
Intracranial Aneurysm, AVM - Cerebral Arteriovenous Malformation
Postmarket Study of Tarvos Microguidewire in Neurovascular Interventional Surgery
This investigation is to evaluate the clinical effectiveness and safety of the Tarvos Microguidewire in the neurovascular interventional surgery.
- Conditions
- Intracranial Aneurysm, AVM - Cerebral Arteriovenous Malformation, AV Fistula, Acute Ischemic Stroke
- Trial name
- NCT07500155
- Testing
- Tarvos Microguidewire
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Keuro MedTech