Clinical trials: Brain Cancer, open to volunteers
Dementia, Movement Disorders
Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.
The goal of this clinical study is to compare the current standard-of-care PET/CT scanner with the new NeuroEXPLORER PET/CT, with the aim of demonstrating the added diagnostic value of the new scanner.
- Conditions
- Dementia, Movement Disorders, ALS - Amyotrophic Lateral Sclerosis, Epilepsy
- Trial name
- NCT07595666
- Testing
- Standard-of-care PET/CT, NeuroEXPLORER
- Where
- Belgium
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- prof. dr. Koen Van Laere
Metastatic Breast Cancer, Brain Metastases
Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients
Patients with metastatic breast cancer with at least 2 brain metastases will receive pembrolizumab every 3 weeks. Patients will undergo stereotactic radiosurgery (SRS) to one of the brain lesions.
- Trial name
- NCT03449238
- Testing
- Pembrolizumab
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Weill Medical College of Cornell University
Brain Metastases
Trial of Differential Margins in Single Isocenter Radiosurgery of Brain Metastases
Radiosurgery is the use of a focal high dose of radiation therapy to ablate or kill a tumor. This trial will enroll patients with brain metastases 4 cm or less in greatest diameter and will compare 0mm margin to a 2mm margin for…
- Trial name
- NCT06857006
- Testing
- brain metastases radiosurgery
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Alabama at Birmingham
Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm
Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery
This phase II trial studies the neurological function in patients with multiple brain metastases undergoing stereotactic radiosurgery (SRS) or stereotactic body radiation therapy (SBRT).
- Trial name
- NCT03184038
- Testing
- Cognitive Assessment, Stereotactic Radiosurgery, Stereotactic Body Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Intracranial Neoplasm
Fluoroethyltyrosine for the Evaluation of Intracranial Neoplasm
This is a single center study investigating the use of Fluoroethyltyrosine (FET) in the detection of brain tumors. FET accumulates in malignant cells within intracranial neoplasms and can be used to detect recurrent disease and…
- Trial name
- NCT06474533
- Testing
- Fluorethyltyrosine (18-F), Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Thomas Hope
Cognitive Impairment, Cognitive Decline
Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy
Randomized, placebo-controlled, double-blinded, parallel group clinical trial to investigate if 6 months of oral lithium tablets (S-lithium 0,5-1,0 mmol/l) will prevent cognitive decline after brain radiotherapy in pediatric…
- Conditions
- Cognitive Impairment, Cognitive Decline, Radiotherapy Side Effect, Radiotherapy; Complications
- Trial name
- LiBRA (NCT06051240)
- Testing
- Lithium
- Where
- 2 sites in Sweden
- Volunteers
- 84 people
- Sponsor
- Region Stockholm
Head and Neck Cancer, Ovarian Cancer
Deciphering Mechanisms Underlying Cancer Immunogenicity
This trial is a translational, open-label, multicentric, prospective cohort study of 1100 patients aiming to describe the PD-1 (programmed death) expression in T cells (T lymphocytes) in different solid tumors.
- Conditions
- Head and Neck Cancer, Ovarian Cancer, Cervical Cancer, Cervical Intraepithelial Neoplasia 3
- Trial name
- DECIDE (NCT03958240)
- Testing
- Blood samples, tumor biopsy specimens and ascites samples will be collected.
- Where
- 3 sites in France
- Volunteers
- 1,100 people
- Sponsor
- Institut Claudius Regaud
Brain Tumor
Brain Tumor Surgery and Postoperative Delirium
1. To explore whether the combined administration of dexmedetomidine during and after surgery in patients undergoing brain tumor resection is an effective and safe modality to prevent postoperative delirium and improve sleep…
- Trial name
- NCT06863064
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Lung Cancer, NSCLC
Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements
This study will consist of a Phase 1b and Phase 2 portion. The Phase 1b portion will enroll first followed by the Phase 2 portion. Each cycle of treatment = 28 days. Subjects will receive alectinib twice daily.
- Conditions
- Lung Cancer, NSCLC, Brain Metastases
- Trial name
- DURABLE (NCT05987644)
- Testing
- Alectinib, Stereotactic Radiosurgery
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Joshua Palmer
Breast Cancer Metastatic, Brain Metastasases
Study Investigating the Role of Routine Screening and Molecular Characterisation of Brain Metastasis in the Management of High-risk Metastatic Breast Cancer
The purpose of this study is to improve outcome of breast cancer patients who develop brain metastases. This will investigate the benefits of early detection of brain metastases using brain imaging.
- Trial name
- STORM (NCT06728150)
- Testing
- computerized tomography
- Where
- Australia
- Volunteers
- 45 people
- Sponsor
- Monash University
Melanoma (Skin Cancer), Breast Cancer
Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA)
To find a recommended dose of the combination of alpelisib and pembrolizumab that can be given to patients with metastatic breast cancer or melanoma.
- Conditions
- Melanoma (Skin Cancer), Breast Cancer, Brain Metastasases
- Trial name
- NCT06545682
- Testing
- Alpelisib + Pembrolizumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center