Clinical trials: Brain Cancer
Central Nervous System Neoplasm, Localized Brain Neoplasm
Blood Brain Barrier Differences in Patients with Brain Tumors Undergoing Surgery
This pilot research trial studies blood brain barrier differences in patients with brain tumors undergoing surgery. Studying samples of tissue and blood from patients with brain tumors in the laboratory may help doctors to…
- Conditions
- Central Nervous System Neoplasm, Localized Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain, Recurrent Brain Neoplasm
- Trial name
- NCT03071913
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Mayo Clinic
Head and Neck Squamous Cell Carcinoma, Brain Metastases
Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy
This study will apply novel MRI approaches with established sensitivity to tissue oxygen consumption and perfusion to predict hypoxia-associated radiation resistance, manifested as tumor recurrence and progression post-treatment.
- Trial name
- NCT05996432
- Testing
- Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), 18F-fluoromisonidazole
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Glioblastoma
Feasibility Study of Modified Atkins Ketogenic Diet in the Treatment of Newly Diagnosed Malignant Glioma
The purpose of this research study is to see if people can produce ketones in their blood with the modified Atkins diet. Modified Atkins diet is a diet that produces ketones in your blood by restricting carbohydrates to <20 grams…
- Trial name
- NCT03278249
- Testing
- Modified Atkins Ketogenic Diet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Cincinnati
Malignant Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain
Low Dose Versus Standard Dose Dexamethasone for Reduction of Swelling in Patients with Primary or Metastatic Brain Tumors
This phase II trial studies whether low dose dexamethasone works as well as standard dose dexamethasone to reduce brain swelling after brain surgery in patients with primary brain tumors or cancer that has spread from other…
- Conditions
- Malignant Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain, Recurrent Malignant Brain Neoplasm
- Trial name
- NCT05139043
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- City of Hope Medical Center
Triple Negative Breast Cancer (TNBC), Brain Metastasases
JK-1201I in Triple Negative Breast Cancer Patients with Brain Metastases
This study was designed to evaluate the safety, efficacy and pharmacokinetics of JK-1201I in triple negative breast cancer patients with brain metastases.
- Trial name
- NCT06586866
- Testing
- JK-1201I
- Volunteers
- 25 people
- Sponsor
- JenKem Technology Co., Ltd.
Posterior Fossa Tumor, Brain Tumor Adult
Fluid Responsiveness in Posterior Fossa Tumor Resection: PPV and CVP Guidance
To answer the question: What are the differences in intraoperative fluid administration volumes between PPV and CVP-guided strategies during posterior fossa tumor resection in the park bench position?
- Trial name
- NCT06595667
- Testing
- Pulse pressure variation, Central venous pressure
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Chiang Mai University
Brain Tumor, Brain Lesion (General)
Genetic and Molecular Characterization of Nervous System Lesions
Primary and secondary brain tumors, the leading cause of death from cancer before the age of 35, represent a complex and heterogeneous group of pathologies with a generally poor prognosis.
- Trial name
- ONCONEUROTEK 2 (NCT06314607)
- Testing
- Prospective Biological Collection, Retrospective Biological Collection
- Where
- 3 sites in France
- Volunteers
- 10,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Neoplasms
Multi-modality Localization of Eloquent Brain Function
Accurate identification of areas of eloquent brain function is vital to surgical decision making and to preservation of independence as patients with brain tumors who are higher functioning have better survival outcomes.
- Trial name
- NCT02795338
- Testing
- brain mapping
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Brain Tumor, Recurrent, Adult
18F-Fluciclovine PET and Multiparametric MR Imaging
The purpose of the study is to investigate the use of the investigational agent Axumin (fluciclovine-F18) with PET/CT imaging in combination with standard MR imaging to detect remaining or recurrent brain tumor.
- Trial name
- NCT03925675
- Testing
- PET/CT with F-Fluciclovine (Axumin)
- Where
- United States
- Sponsor
- Loma Linda University
Central Nervous System Tumor, Brain Tumor
Medical Marijuana in the Pediatric Central Nervous System Tumor Population
This study proposes to do a prospective observational cohort study evaluating the quality of life (QOL) of children with Central Nervous System (CNS) tumors and their families who choose to self-medicate with marijuana-derived…
- Conditions
- Central Nervous System Tumor, Brain Tumor, Spinal Tumor
- Trial name
- NCT03052738
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Colorado, Denver
NSCLC Stage IV, Brain Metastases
Cranial Radiotherapy Plus Chemoimmunotherapy in Untreated Driver-mutation Negative NSCLC With Stable Brain Metastasis
Non-small cell lung cancer (NSCLC), the most prevalent form of lung cancer, has a significant risk of brain metastasis (BM). Historically, the median overall survival for advanced NSCLC patients with BM was under six months with…
- Trial name
- NCT06501391
- Testing
- PD-L1/PD-1 inhibitor and chemotherapy, SRT or WBRT
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Fudan University
Primary Malignant Brain Tumors, Advanced Care Planning
Communication Training for Caregivers In Advanced Care Planning
The purpose of this research study is to develop and test a new communication training to help caregivers communicate more effectively with their loved ones and healthcare professionals about advanced care planning.
- Trial name
- NCT04171895
- Testing
- Questionnaires, Communication training Part 1 (no longer recruiting), Enhanced usual care
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Brain Metastases, Adult
Comparaison Between MRI Alone or Combined With Positron Emission Tomography for Brain Metastasis Diagnosis
During gamma scalpel treatment of brain tumors and metastases, a follow-up magnetic resonance imaging (MRI) scan is performed. The radiologist who reviews the MRI assesses whether there is an increase in signal at the tumor site.
- Trial name
- ITIRR (NCT05095766)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Brain Cancer, Neurological Disorder
Wearable Devices and Biomarkers Project (Healthiomics)
The purpose of this study is to collect clinical data, biological specimens (e.g., blood, tumor, cerebrospinal fluid, urine sample, etc.), and digital health data from patients with tumors, cancer and/or neurological disorders in…
- Conditions
- Brain Cancer, Neurological Disorder, Neurological Cancer
- Trial name
- NCT05106725
- Where
- United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- CureScience
Tumor, Brain, Tumor, Breast
Microscopy Imaging of Whole-mount Stained Human Tissues
The goal of this clinical trial is to develop an imaging platform for intraoperative tumor margin delineation in 250 cases of tumor-suffered patients.
- Conditions
- Tumor, Brain, Tumor, Breast, Tumor Skin
- Trial name
- NCT05689112
- Where
- Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Brain Diseases, Brain Tumor
Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling-Establish Reliably Electrophysiological Readouts From Human-induced Pluripotent Stem Cells (hiPSCs)-Derived Cerebral Organoids and Surgically Dissected Human Live Brains
The research aims to establish a big database of multiple kinds of brain tissues and prove the relevance of human brain tissue models and hiPSCs-derived organoid models.
- Trial name
- NCT05921786
- Testing
- Electrophysiological system, Multiphoton microscope
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Brain Tumor, Brain Cancer
Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling
The research aims to develop a novel pathological technology, including rapid whole-mount tissue H\&E \& IHC staining protocol and high-resolution nonlinear optical microscopy imaging system, to intraoperatively assess brain…
- Trial name
- NCT05943262
- Testing
- mesoscale nonlinear optical microscope
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
INTRACRANIAL TUMOR, INTRACRANIAL PRESSURE
Evaluation of Postoperative Intracranial Pressure in Patients Undergoing Intracranial Tumor Surgery
Ultrasonography(USG)-guided optic nerve sheath diameter measurement and its correlation with brain computed tomography in the evaluation of intracranial pressure in patients who underwent intracranial brain tumor surgery.
- Conditions
- INTRACRANIAL TUMOR, INTRACRANIAL PRESSURE, OPTIC NERVE
- Trial name
- NCT06559566
- Testing
- USG, BCT
- Volunteers
- 50 people
- Sponsor
- Sezen Kumaş Solak
HIV, Brain Tumors
Analysis of Data Collected From Individuals Administered Neurobehavioral Assessments
Background: People with chronic illness often are at risk for developing neurobehavioral problems due to effects of the disease or associated treatments.
- Conditions
- HIV, Brain Tumors, Neurofibromatosis Type 1
- Trial name
- NCT01445314
- Where
- United States
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8
Pharmacogenomics Testing in the Optimal Use of Supportive Care Medications in Stage III-IV Cancer
This early phase I trial studies how well a genetic test called pharmacogenomics works in directing the optimal use of supportive care medications in patients with stage III-IV cancer.
- Conditions
- Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8
- Trial name
- NCT04067960
- Testing
- Biospecimen Collection, Genetic Testing, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic