Clinical trials: Brain Connectivity, open to volunteers
Glaucoma
Magnetic Resonance Imaging of Cerebral Connectivity and Volume in Neurodegeneration and Glaucoma
The EVOLUTION is a 10-year extension of the ENVOL study. It seeks to compare the evolution of structural and functional connectivity (Hub Disruption Index) and cerebral volume on 3T MRI of the brain in glaucoma patients and…
- Trial name
- EVOLUTION (NCT07802769)
- Testing
- MRI
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Neonates and Preterm Infants, Neonates or Premature Babies
Prospective Study of the Feasibility of Brain Connectivity Imaging by Functional Ultrasound Imaging (fUS) in Newborn Infant
Neurodevelopmental disorders (NDD) affect how the brain develops and can lead to lifelong difficulties with movement, learning, behavior, and thinking.
- Trial name
- CONEXUS (NCT06940713)
- Testing
- Imaging Time
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Low Back Pain, Healthy
Brain Connectivity and Perceptive Surfaces in Chronic Low Back Pain (SUPER-RMNf)
Rationale: Chronic Low Back Pain (CLBP) is often associated with "cortical reorganization," where the brain's map of the back becomes less precise.
- Trial name
- NCT07568353
- Testing
- Perceptive Surface (SU-PER mat)
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Cerebral Small Vessel Disease, Cognitive Impairment
Remote Ischemic Conditioning for Cognitive Impairment in Cerebral Small Vessel Disease
This randomized, double-blind, sham-controlled trial aims to evaluate the effect of remote ischemic conditioning (RIC) on cognitive function in patients with cerebral small vessel disease-related mild cognitive impairment.
- Trial name
- RIC-CSVD (NCT07317557)
- Testing
- Remote ischemic conditioning using IPC-906 device
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Schizophrenia
Enhancing Brain Connectivity in Schizophrenia Through Neuromodulation (Study 2)
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from H coil combined with cognitive training for improving white matter integrity.
- Trial name
- NCT06961916
- Testing
- Active rTMS, Cognitive Training
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center, Houston
Depressive Disorder, Major, Cognitive Impairment
Brain Functional Connectivity Mechanism of Cognitive Flexibility Impairment and rTMS Intervention in Major Depressive Disorder
Major depressive disorder (MDD) often involves cognitive deficits, particularly in cognitive flexibility, which is inadequately addressed by standard antidepressants.
- Trial name
- NCT07161492
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Second Xiangya Hospital of Central South University
Brain Diseases, Ischemic Stroke
Stroke Cerebral Reorganization Pathways (SPECTRE)
SPECTRE is a prospective longitudinal study in order to identify whether patients with different degrees of motor recovery are distinguished by distinct brain post-stroke plasticity patterns in the acute and sub-acute phases.
- Conditions
- Brain Diseases, Ischemic Stroke, Stroke, Brain Infarction
- Trial name
- SPECTRE (NCT06784518)
- Testing
- Clinical scores and functional MRI
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Rennes University Hospital
Binge-Eating Disorder
Use of Circadian Reset Technology to Alter REM Sleep and Appetitive Control in Patients With Binge Eating Disorder
This project includes testing circadian reset technology (CRT) on frequency of binge eating in a sample of 40 individuals with binge eating disorder. Participants will be randomized to one of two groups.
- Trial name
- NCT06858774
- Testing
- Circadian Reset Technology, VR Headset
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Parkinson's Disease, Mild Cognitive Impairment
rTMS to Improve Cognition in Parkinson's
The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease or atypical…
- Trial name
- TMSCogReP (NCT03836950)
- Testing
- MagVenture MagProX100 stimulator (MagVenture, Falun, Denmark)
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- VA Office of Research and Development
Childhood Brain Tumor
Cognitive Biomarkers in Pediatric Brain Tumor Patients
The investigators will focus on three cohorts of brain tumor patients aged, 4-18 years, to answer two critical questions: 1) Can the investigators acquire high quality data relevant to cognitive function during the…
- Trial name
- NCT02914067
- Testing
- Neurocognitive testing, rsfcMRI
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Washington University School of Medicine
Migraine
Mechanistic Studies of Psilocybin in Headache Disorders
In previous clinical trial work, the investigators observed lasting reductions in headache burden after limited dosing of psilocybin. This purpose of this study is to examine potential sources for this observed effect.
- Trial name
- NCT06464367
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Anorexia Nervosa
Circuit-Guided Neuromodulation for Anorexia Nervosa
The goal of this clinical trial is to find out whether personalized, non-invasive brain stimulation can temporarily change communication within brain networks related to restrictive eating in adults with anorexia nervosa.
- Trial name
- RestrEAT (NCT07860320)
- Testing
- Intermittent theta-burst stimulation (iTBS), Continuous theta-burst stimulation (cTBS)
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Fundacao Champalimaud
Brain Connectivity
Resting State Changes Following Theta Burst Stimulation
Transcranial magnetic stimulation (TMS) is increasingly being applied to effectively treat mental illness, however efforts to quantify the effects of TMS on the network architecture of the brain have largely been limited in scope…
- Trial name
- NCT05322239
- Testing
- Intermittent Theta Burst Stimulation, Continuous Theta Burst Stimulation
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nicholas Balderston, PhD
Friedreich's Ataxia, Motor Disorders
Electroencephalogram in Patients With Friedreich's Ataxia for the Study of the Structural and Functional Connectome.
Prospective, exploratory, multicenter pilot study investigating the structural and functional connectome in patients with Friedreich's Ataxia (FRDA) using high-density electroencephalogram (HD-EEG).
- Trial name
- CONNETTOMA (NCT07095062)
- Testing
- HD-EEG recordings, combined with cognitive and motor assessment
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Stroke, Brain Disease
Brain Connections for Arm Movement After Stroke
The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after…
- Conditions
- Stroke, Brain Disease, Central Nervous System Diseases, Nervous System Diseases
- Trial name
- CAM (NCT04286516)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Brain Network Functional Connectivity
Brain Network fMRI Analysis in Proprioceptive Training for Chronic Low Back Pain
Through longitudinal analysis of dynamic changes in DMN functional connectivity before and after sensory training intervention, combined with pain behavioral and functional improvement indicators, this study systematically…
- Trial name
- NCT07308249
- Testing
- Multimodal Imaging Evaluation
- Volunteers
- 40 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Depression
Brain Connectivity in Depression
This study originally included 140 subjects with medication-refractory depression undergoing 10 Hz transcranial magnetic stimulation (10Hz-TMS) to the left dorsal lateral prefrontal cortex (DLPFC), with the goal of having 60…
- Trial name
- NCT03276793
- Testing
- MRI scan, Behavioral testing
- Where
- 4 sites in United States
- Volunteers
- 260 people
- Sponsor
- Brigham and Women's Hospital
Epilepsy, Drug Resistant Epilepsy
Evaluation of the Efficacy of Neurofeedback Technique Based on EEG Desynchronization in Epileptic Patients
A large proportion of patients (approximately 30%) with drug-resistant epilepsy are not eligible for surgical treatment. The alternatives that can be offered to reduce the frequency of seizures are neuromodulation (vagus nerve…
- Trial name
- EPIFEED (NCT07356661)
- Testing
- Neurofeedback
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Typical Development, Obsessive Compulsive Disorder
Developing Brain, Impulsivity and Compulsivity
Background: Impulsivity is acting 'without thinking.' Compulsivity is being overly inflexible. People vary in how impulsive or compulsive they are. Extreme versions of these behaviors play a role in mental disorders.
- Conditions
- Typical Development, Obsessive Compulsive Disorder, Conduct Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT04631042
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- National Institute of Mental Health (NIMH)
Knee Osteoarthritis (Knee OA), Knee Pain Chronic
Advanced Brain Imaging-TKA (fMRI-TKA)
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities.
- Conditions
- Knee Osteoarthritis (Knee OA), Knee Pain Chronic, Brain Network Connectivity, Patient Satisfaction
- Trial name
- fMRI-TKA (NCT07464080)
- Testing
- fMRI Brain Scan
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute