Clinical trials: Brain Developmental Diseases
Growth Hormone Deficiency
Efficacy and Safety of a High Dosage Compared to the Label Dosage of Somatropin in Early Pubertal Stage Children With Growth Hormone Deficiency
Multi-center, randomized, controlled, open-label, phase III study comparing the effects of two different dosages of somatropin treatment (in-label or doubled) after 12 and 24 months of treatment, on height velocity in early…
- Trial name
- NCT00191165
- Testing
- Somatropin
- Where
- 10 sites in Italy
- Volunteers
- 27 people
- Sponsor
- Eli Lilly and Company
Autism Spectrum Disorder, Healthy
Effects of Drugs on Responses to Brain and Emotional Processes
To study the effects of a psychostimulant on responses to affective touch in individuals with a range of autistic traits
- Trial name
- MAT (NCT04053036)
- Testing
- MDMA
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Brain Tumor
Development and Validation of Advanced MRI Methods for Clinical Applications
A critical aspect of brain tumor patient management is the radiographic assessment of tumor status, which is used for diagnosis, localization, surgical planning and surveillance.
- Trial name
- NCT03264300
- Testing
- MRI
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Concussion
Concussion Texting Study
This will be a prospective study of the implementation of a real-time assessment and intervention of a text messaging tool in mild traumatic brain injury (mTBI) patients post-discharge from the emergency department.
- Trial name
- texting (NCT03099733)
- Testing
- text message
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Traumatic Brain Injury
Crainio Non-invasive ICP Monitor for TBI
The clinical investigation aims to advance the Crainio device, designed for non-invasive intracranial pressure (ICP) monitoring.
- Trial name
- NCT06453733
- Testing
- Crainio
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Crainio Ltda
Alzheimer's Disease, 40 Hz Stimulation
Effects of Combined 40 Hz Audio-visual Stimulation and Cognitive Games on Alzheimer's Disease
In addition to ongoing drug treatments for Alzheimer Disease (AD), protective approaches that can halt the progression of the disease are of particular importance.
- Conditions
- Alzheimer's Disease, 40 Hz Stimulation, EEG Brain Oscillations
- Trial name
- NCT06595511
- Testing
- Sensory Entrainment-Integrated Cognitive Game Kit
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Dysphagia, Stroke
Development and Validation of an Online Independent Training Program for TOR-BSST© Dysphagia Screeners
Stroke is a leading cause of death and disability globally. Dysphagia, swallowing difficulty, is common following stroke, affecting about 55% of all stroke patients.
- Trial name
- NCT05379699
- Testing
- TOR-BSST© eLearning Training, Standard TOR-BSST© Training
- Where
- Canada
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Growth Hormone Deficiency
Safety and Efficacy of Y-shape Pegylated Somatropin in Growth Hormone Deficiency Children
This is a multicenter, randomized, open-labeled, positive controlled phase 2\&3 combined study to evaluate the safety and efficacy of weekly Y-shape pegylated somatropin, compared to daily somatropin (Norditropin®), in…
- Trial name
- NCT04513171
- Testing
- Y-shape pegylated somatropin, Norditropin®, Norditropin
- Where
- China
- Volunteers
- 434 people
- Sponsor
- Xiamen Amoytop Biotech Co., Ltd.
Intracranial Aneurysm
Prediction of Development and Rupture Risk for Intracranial Unruptured Aneurysms
In recent years, researches on the natural history and risk factors of intracranial unruptured aneurysms have become a hot topic at home and abroad. However, risk factors for aneurysm rupture is still unclear yet.
- Trial name
- NCT05576727
- Testing
- Unruptured intracranial aneurysms
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Typical Development, Obsessive Compulsive Disorder
Developing Brain, Impulsivity and Compulsivity
Background: Impulsivity is acting 'without thinking.' Compulsivity is being overly inflexible. People vary in how impulsive or compulsive they are. Extreme versions of these behaviors play a role in mental disorders.
- Conditions
- Typical Development, Obsessive Compulsive Disorder, Conduct Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT04631042
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- National Institute of Mental Health (NIMH)
Stroke, Caregiver Burden
Mindfulness After Stroke
The purpose of this study is to test the relevance, satisfaction and ease-of-use of an online mindfulness intervention among stroke survivors and their caregivers.
- Trial name
- NCT04553679
- Testing
- Mindfulness online intervention
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Southern California
Dementia, Mild, Accidental Falls
Development of Pressure Sensor Based Dementia and Fall Prevention Program for Older Adults
The goal of this intervention program is to test the effectiveness of pressure sensor based dementia and fall prevention program for improving cognitive and physical functions of community dwelling older adults.
- Conditions
- Dementia, Mild, Accidental Falls, Mild Cognitive Impairment
- Trial name
- NCT06664229
- Testing
- Fall and dementia prevention exercise
- Where
- South Korea
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Sunmi Song
Parkinson Disease
Primary Parkinsonian Pain Diagnostic Questionnaire: Development and Validation of This Questionnaire
Development and validation of a diagnosis questionnaire of parkinsonian primary pain: the "Primary Parkinsonian Pain Diagnostic Questionnaire" (3PDQ)
- Trial name
- 3PDQ (NCT03940872)
- Testing
- Self-questionnaire 3PDQ
- Where
- 10 sites in France
- Volunteers
- 227 people
- Sponsor
- University Hospital, Toulouse
Cerebral Palsy
Extending taVNS Paired With Infant CIMT Into a Home-Based Setting
Newborns who are born premature or suffer brain injury at birth are at risk for motor problems that may cause weakness in reaching and grasping on one side of the body.
- Trial name
- NCT05857527
- Testing
- Custom EMG triggered Soterix taVNS stimulation with CIMT therapy in lab, Custom EMG triggered Soterix taVNS stimulation with CIMT therapy in home
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medical University of South Carolina
Nystagmus, Strabismus
Screening for Studies on Nystagmus and Strabismus
This screening protocol is designed to help recruitment patients for National Eye Institute (NEI) studies on nystagmus and strabismus.
- Trial name
- NCT00001861
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- National Eye Institute (NEI)
Brain Developmental Diseases, Autism Spectrum Disorder
The Early Integrated Intervention for Child Brain-developmental Disorders in China
This study is focused on developing the early integrated intervention for child brain-developmental disorders, including globe developmental delay (GDD), autism spectrum disorder (ASD), and attention deficit-hyperactivity…
- Conditions
- Brain Developmental Diseases, Autism Spectrum Disorder, Global Developmental Delay, Attention Deficit-Hyperactivity Disorder
- Trial name
- NCT03847402
- Testing
- The early integrated intervention for GDD, The early integrated intervention for ASD, The early integrated intervention for ADHD
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Children's Hospital of Fudan University
Brain Injuries, Growth Hormone Deficiency Dwarfism
A Study to Evaluate the Efficacy of Somatropin in Adults With Growth Hormone Deficiency Caused by Trauma and/or Head Injury
The purpose of this study is to assess the prevalence of GHD in patients who sustain a head injury or suffer a major traumatic event and to evaluate the efficacy of growth hormone (GH) therapy in the treatment of GHD caused by…
- Trial name
- GHD (NCT00638053)
- Testing
- somatropin
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Pfizer
Foetal Differences Between Healthy and Schizophernic Parents
Schizophrenia Imaging
Schizophrenia is a common disorder with a lifetime prevalence of about 1%.Genetic studies strongly suggest a genetic component to the inheritance of schizophrenia.
- Trial name
- NCT01655472
- Testing
- imaging follow up: MRI scan, imaging follow up: Ultrasonographic examination
- Where
- 8 sites in Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Baker Gordon Syndrome, Rare Neurodevelopmental Conditions
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)
Rare genetic neurodevelopmental disorders, such as Syt-1 or Baker Gordon Syndrome (BAGOS) arise from mutations in genes essential for brain development and function, often disrupting neurotransmission and neuronal connectivity.
- Conditions
- Baker Gordon Syndrome, Rare Neurodevelopmental Conditions, Rare Neurogenetic Conditions, Syt-1 Disorder
- Trial name
- NCT07329257
- Testing
- No Intervention: Observational Cohort
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Growth Hormone Deficiency, Idiopathic Short Stature
Constructing an Insulin-Like Growth Factor-based Prediction Model
Serum insulin-like growth factor-I (IGF-I) measurements have been shown to correlate well with growth hormone action and effect, and recent data show that serum IGF-I may be related to safety and efficacy of growth hormone (GH)…
- Conditions
- Growth Hormone Deficiency, Idiopathic Short Stature, Small for Gestational Age
- Trial name
- NCT00263445
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
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