Clinical trials: Brain Diseases, Metabolic
Hepatic Encephalopathy, Chronic Liver Disease
Effectiveness of Oral Lactulose Versus Lactulose Enema in Hepatic Encephalopathy
Patients with chronic liver disease due to hepatitis B or C viruses, Non-alcoholic fatty liver disease, autoimmune hepatitis, wilson disease, cryptogenic hepatitis etc are prone to develop complications.
- Trial name
- NCT05788627
- Testing
- Tap water, Lactulose
- Volunteers
- 100 people
- Sponsor
- Khyber Medical College, Peshawar
Urea Cycle Disorders, Crigler Najjar Syndrome
Safety Study of HepaStem for the Treatment of Urea Cycle Disorders (UCD) and Crigler-Najjar Syndrome (CN)
The purpose of this study is to assess the safety and to appraise the efficacy of one cycle of Hepastem (Heterologous Human Adult Liver-derived Progenitor Cells, HHALPC) infusions in paediatric patients suffering from CN or UCD.
- Trial name
- HEP001 (NCT01765283)
- Testing
- HepaStem
- Where
- 11 sites in Belgium, France and 3 more
- Volunteers
- 20 people
- Sponsor
- Cellaion SA
Neurodegeneration With Brain Iron Accumulation (NBIA), Iron Metabolism Disorders
Brain Iron in Beta-Propeller Protein Associated Neurodegeneration (BPAN)
This study aims to quantify intracerebral iron load in patients with Beta-Propeller Protein-Associated Neurodegeneration (BPAN) using Quantitative Susceptibility Mapping (QSM) technique.
- Conditions
- Neurodegeneration With Brain Iron Accumulation (NBIA), Iron Metabolism Disorders, Brain Disease
- Trial name
- QUBIPAN (NCT07868120)
- Testing
- Standardized brain MRI including specific sequences usable for Quantitative Susceptibility Mapping (QSM)
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Bordeaux
Hemochromatosis, Cerebrovascular Accident
Stroke With Transfusions Changing to Hydroxyurea
The purpose of this study is to compare standard therapy (transfusions and chelation) with alternative therapy (hydroxyurea and phlebotomy) for the prevention of secondary stroke and management of iron overload in children with…
- Conditions
- Hemochromatosis, Cerebrovascular Accident, Anemia, Sickle Cell, Hematologic Diseases
- Trial name
- NCT00122980
- Testing
- Red Cell Transfusions, Iron Chelation, Hydroxyurea
- Where
- 28 sites in United States
- Volunteers
- 134 people
- Sponsor
- St. Jude Children's Research Hospital
Glycogen Storage Disease Type II
A Prospective, Observational Study in Patients With Late-Onset Pompe Disease
Pompe disease (also known as glycogen storage disease type II, "GSD-II") is caused by a deficiency of a critical enzyme in the body called acid alpha-glucosidase (GAA).
- Trial name
- NCT00077662
- Where
- 5 sites in United States, France and 1 more
- Volunteers
- 61 people
- Sponsor
- Genzyme, a Sanofi Company
Fabry Disease, Proteinuria
The Fabrazyme® and Arbs and ACE Inhibitor Treatment (FAACET) Study
The primary hypothesis is that titration of ACE inhibitor and Angiotensin Receptor Blockers (ARBs)to reduce urine protein excretion to < 500 mg per day in Fabry Patients receiving agalsidase beta therapy at 1 mg/kg every two…
- Trial name
- FAACET (NCT00446862)
- Testing
- enalapril and other angiotensin converting enzyme inhibitors; losartan and other angiotensin receptor blockers
- Where
- 6 sites in United States, Slovenia
- Volunteers
- 36 people
- Sponsor
- University of Alabama at Birmingham
Obesity
Executive Function Training in Childhood Obesity: Food Choice, Quality of Life and Brain Connectivity
This study evaluates if executive function training in obese children can improve food-related choices and produce cognitive and neuroimaging changes, but also improve psychological and physical status and quality of life…
- Trial name
- TOuCH (NCT03615274)
- Testing
- Executive function training, Psychoeducation
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- University of Barcelona
Atrial Fibrillation, Obesity
Effectiveness And Safety Of Oral Anticoagulants Among Obese Patients With Non-Valvular A-Fib In VA Patients With Medicare
The overall objective of this analysis is to understand patient characteristics, the use of treatment, and clinical outcomes among obese (overweight) and severely obese patients with non-valvular atrial fibrillation (NVAF) who…
- Conditions
- Atrial Fibrillation, Obesity, Anticoagulants
- Trial name
- NCT04681482
- Testing
- Apixaban
- Where
- United States
- Volunteers
- 107,383 people
- Sponsor
- Pfizer
Acute Liver Failure, Hepatic Encephalopathy
The Effect of Prometheus (R) Liver Support Dialysis on Cerebral Metabolism in Acute Liver Failure
The main objective of this study is to investigate the effect of Prometheus liver support dialysis on intracranial pressure, cerebral metabolism and circulation in patients with acute liver failure.
- Conditions
- Acute Liver Failure, Hepatic Encephalopathy, Intracranial Hypertension
- Trial name
- NCT00655304
- Testing
- Prometheus (R) liver support dialysis, CVVHDF (Continuously Veno-Venous Hemodiafiltration)
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Brain Swelling, Brain Edema
Furosemide vs Placebo for Brain Relaxation
Increased brain bulk may be problematic during brain surgery for tumors because it may limit surgical exposure and access to the surgical site.
- Conditions
- Brain Swelling, Brain Edema, Dehydration
- Trial name
- NCT01054404
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Northwestern University
Cerebral Palsy
Diet and Activity in Cerebral Palsy
This study aims to fill a gap in the literature, identify relevant clinical measures, and provide insight into the independent modifiable risk factors of obesity in the CP population with the long-term goal of improving…
- Trial name
- NCT02175108
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Shirley Ryan AbilityLab
Alzheimer Disease, Frontotemporal Dementia
Non-invasive Neurostimulation as a Tool for Diagnostics and Management for Neurodegenerative Diseases
Double blinded, sham-controlled, randomized trial on repeated transcranial alternating current brain stimulation (tACS) in neurodegenerative diseases.
- Conditions
- Alzheimer Disease, Frontotemporal Dementia, Dementia With Lewy Bodies
- Trial name
- NCT05326750
- Testing
- Gamma tACS (40 Hz) over the superior parietal cortex
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Kuopio University Hospital
Apgar; 0-3 at 1 Minute, Metabolic Acidosis
Autologous Stem Cells in Newborns With Oxygen Deprivation
The purpose of this study is to determine whether the plasticity of autologous intravenous application of cord blood stem cells would improve the clinical course of asphyxiated newborns.
- Conditions
- Apgar; 0-3 at 1 Minute, Metabolic Acidosis, Hypoxia, Brain, Multiple Organ Failure
- Trial name
- NCT01506258
- Testing
- Application of Stem Cells, Observation
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Major Depressive Disorder
Creatine Augmentation Treatment in Major Depressive Disorder Subjects
Given 1) the established safety with short-term or long-term supplementation of Cr, 2) its potential usefulness in improving brain energy metabolism, 3) the reported abnormality in brain energy metabolism in MDD subjects, and 4)…
- Trial name
- NCT00729755
- Testing
- Creatine monohydrate
- Where
- 4 sites in South Korea
- Volunteers
- 59 people
- Sponsor
- Ewha Womans University
Diabete Type 2
Reversibility of Brain Glucose Transport and Metabolism in T2DM: an Intervention Study
This study is designed to test if there is a difference in brain glucose transport kinetics in poorly controlled T2DM individuals with short duration and long duration of diabetes, using non-invasive magnetic resonance…
- Trial name
- NCT04283617
- Testing
- Intensification of insulin regimen/Nutrition
- Where
- United States
- Sponsor
- Yale University
Albuminuria
Towards HOMe-based Albuminuria Screening: an Implementation Study Testing Two Approaches
Chronic Kidney Disease (CKD) is a worldwide major public health problem that is associated with an increased incidence of kidney failure and cardiovascular events, that lead a high burden for affected patients and high costs for…
- Trial name
- THOMAS (NCT04295889)
- Testing
- Approach A (PeeSpot urine collection device)., Approach B (ACR | EU Test kit).
- Where
- Netherlands
- Volunteers
- 15,032 people
- Sponsor
- University Medical Center Groningen
Arthritis, Asthma
Mobility Assessment in Multi-morbidity
Multimorbidity (the presence of two or more coexisting long-term conditions) is a significant challenge facing the NHS, especially given UK's ageing population and the association with high levels of illness burden and healthcare…
- Conditions
- Arthritis, Asthma, Atrial Fibrillation, Bronchiectasis
- Trial name
- Multi-mobility (NCT06473168)
- Volunteers
- 55 people
- Sponsor
- Northumbria University
Mild Cognitive Impairment, Alzheimer Disease
Light, Metabolic Syndrome and Alzheimer's Disease - Aim 2
To test the long term effect of a light treatment on cognition, sleep and metabolism in patients with Mild cognitive impairment (MCI) or mild Alzheimer's disease or related dementia (ADRD).
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Type2 Diabetes
- Trial name
- NCT03933696
- Testing
- Tailored Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Insulin-like Growth Factor I, Insulin-like Growth Factor II
Neurotrophic Factors in Cerebrospinal Fluid in Diabetic Patients With Polyneuropathy
Background: The pathogenetic factors underlying development of diabetic polyneuropathy (DP) remain unclear. Reduced neurotrophic stimulation has been proposed as a possible mechanism.
- Conditions
- Insulin-like Growth Factor I, Insulin-like Growth Factor II, Diabetes Complications, Polyneuropathies
- Trial name
- NCT01718015
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Fabry Disease
Impact of Agalsidase Alfa Therapy on Cardiac funcTION in Patients With Fabry's Cardiomyopathy
Study Design: This is an observational study. No treatment or intervention will be assigned to the subjects. All patients will receive full standard of care concomitant medication for the treatment of their cardiac condition.
- Trial name
- NCT03230591
- Testing
- Echocardiography
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Yonsei University
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