Clinical trials: Brain Diseases, Metabolic
Idiopathic Intracranial Hypertension, Intracranial Pressure
The Effect of an Anti-obesity Drug, Semaglutide, as Treatment in New-onset Idiopathic Intracranial Hypertension (IIH) Compared to Standard Weight Management (Dietician) With Regards to Change in Weight and Intracranial Pressure
50 patients with verified new-onset Idiopathic Intracranial Hypertension are randomly allocated to standard weight management (dietician counselling) or trial intervention consisting of subcutaneous injections with Semaglutide…
- Conditions
- Idiopathic Intracranial Hypertension, Intracranial Pressure, Obesity, Pseudotumor Cerebri Syndrome
- Trial name
- IIH:DUAL (NCT06027567)
- Testing
- Semaglutide, Very Low Calorie Diet, Dietician counselling
- Where
- 2 sites in Denmark
- Volunteers
- 38 people
- Sponsor
- Rigmor Højland Jensen
Phenylketonurias
Remote Neurocognitive and Psychological Assessment in PKU
PKU is a rare autosomal recessive condition associated with disruption in dopamine synthesis. Although early diagnosis and treatment prevent the severe impairments associated with untreated PKU, individuals with early-treated PKU…
- Trial name
- NCT04943393
- Testing
- nointervention
- Where
- 2 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Stroke, Hyperglycemia
Glucose Regulation in Acute Stroke Patients (GRASP) Study
The purpose of this study is to assess the feasibility, safety and preliminary efficacy of the use of insulin infusions as treatment for hyperglycemic acute ischemic stroke patients.
- Trial name
- NCT00282867
- Testing
- IV glucose insulin and potassium, GIK, standard care
- Where
- 2 sites in United States
- Volunteers
- 74 people
- Sponsor
- University of Virginia
Acute Noninfectious Posterior, Intermediate, or Pan Uveitis
Study of FTY720 in Patients With Uveitis
This study will assess the safety, tolerability, and efficacy of FTY720 in patients with acute, noninfectious intermediate, posterior and pan uveitis
- Trial name
- NCT01791192
- Testing
- FTY720, Oral Corticosteroid
- Sponsor
- Novartis Pharmaceuticals
Diabetes Mellitus, Type 2
Effects of Rosiglitazone on Plasma BNP Levels and Left Ventricular Dysfunction
The present study aimed to evaluate the effect of rosiglitazone treatment on cardiac function compared with metformin
- Trial name
- NCT00300911
- Testing
- Rosiglitazone(drug), cardiac adverse effects
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Baskent University
Healthy Volunteers
A Study to Assess the Safety, Tolerability and PK of NPT520-34 in Healthy Subjects
To evaluate the PK, safety and tolerability of orally administered NPT520-34 in healthy subjects at single and multiple doses that may be therapeutically relevant.
- Trial name
- NCT03954600
- Testing
- NPT520-34 (125 mg)
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Neuropore Therapies Inc.
Type 2 Diabetes, PreDiabetes
The Sunnybrook Type 2 Diabetes Study
The Sunnybrook Type 2 Diabetes Study (S2DS) is a prospective observational study of people with prediabetes or Type 2 Diabetes Mellitus (T2DM), that aims to understand the aetiologies, manifestations, and clinical consequences of…
- Trial name
- S2DS (NCT04455867)
- Testing
- Diabetes Exercise and Healthy Lifestyle Program, Outpatient care
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Sunnybrook Health Sciences Centre
Phenylketonuria
The Effects of Kuvan on Functional Brain Connectivity in Individuals With Phenylketonuria (PKU)
The objective of the study is to determine whether Kuvan™ (sapropterin) improves the strength of the functional connectivity between brain regions in individuals with PKU.
- Trial name
- NCT00964236
- Testing
- Sapropterin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Pompe Disease
A Global Prospective Observational Registry of Patients With Pompe Disease
This is a global, multicenter, prospective, observational registry of patients with Pompe disease, including those with late-onset pompe disease (LOPD) and infantile-onset pompe disease (IOPD).
- Trial name
- NCT06121011
- Testing
- Cipaglucosidase alfa, Miglustat, Alglucosidase alfa or Avalglucosidase alfa
- Where
- 41 sites in United States, Austria and 10 more
- Volunteers
- 500 people
- Sponsor
- Amicus Therapeutics
Obesity (Disorder), Systemic Inflammation Markers
Understanding How Gut and Brain Barriers Are Linked to Inflammation in Obesity
The goal of this observational study is to understand how obesity affects the function of the gut and blood-brain barriers in adults.
- Conditions
- Obesity (Disorder), Systemic Inflammation Markers, Intestinal Barrier Dysfunction, Blood Brain Barrier
- Trial name
- GUTBBB (NCT06787001)
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Obesity, Insulin Resistance
Effects of Intermittent Fasting on Insulin Resistance, Cardiac Metabolism, and Cerebral Perfusion
The overall purpose of the study is to investigate whether three weeks of intermittent fasting (alternate-day fasting, (ADF)) result in a more pronounced "metabolic shift" towards the use of ketone bodies than three weeks of…
- Trial name
- NCT05181267
- Testing
- Intermittent fasting
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Frontotemporal Degeneration(FTD), Primary Progressive Aphasia(PPA)
UPenn Observational Research Repository on Neurodegenerative Disease
The aim of this study is to create a repository of both cross-sectional and longitudinal data, including cognitive, linguistic, imaging and biofluid biological specimens, for neurodegenerative disease research and treatment.
- Conditions
- Frontotemporal Degeneration(FTD), Primary Progressive Aphasia(PPA), Familial Frontotemporal Lobar Degeneration (fFTLD), Amyotrophic Lateral Sclerosis(ALS)
- Trial name
- UNICORN (NCT04715399)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Prediabetes, Healthy (Controls)
Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?
Brief Summary The goal of this clinical trial is to learn whether older adults with prediabetes, but no diagnosed cognitive impairment, show early changes in brain energy use and thinking speed compared to older adults with…
- Trial name
- NCT07546409
- Testing
- Ketone Monoester (KE)
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Empaglifozin, Physiological Effects of Drugs
Sodium-glucose Co Transporter 2 (sGLT2) Inhibitor and Endogenous Ketone Production
Background: The drug empagliflozin treats diabetes. It lowers blood sugar by increasing glucose the kidneys excrete. This increases levels of ketones formed in the blood.
- Conditions
- Empaglifozin, Physiological Effects of Drugs, Hypoglycemic Agents, Sodium-Glucose Transporter 2 Inhibitors
- Trial name
- NCT03852901
- Testing
- empagliflozin (Jardiance) 25 mg
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute on Aging (NIA)
Friedreich Ataxia, Cardiomyopathies
Phase IA and IB Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxia
The purpose of this study is to test the safety and preliminary efficacy of AAVrh.10hFXN to treat the cardiomyopathy associated with Friedreich's ataxia (FA).
- Conditions
- Friedreich Ataxia, Cardiomyopathies, Cardiac Hypertrophy, Myocardial Fibrosis
- Trial name
- NCT05302271
- Testing
- AAVrh.10hFXN, serotype rh.10 adeno-associated virus (AAV) gene transfer vector expressing the cDNA coding for human FXN, Prednisone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Weill Medical College of Cornell University
Niemann-Pick Disease, Type C
Establishment of Genomic and Phenotypic Database for Niemann-Pick Disease, Type C
Background: Niemann-Pick type C (NPC) disease is a rare, progressive neurodegenerative disease that affects mainly the brain, liver, and spleen but also other parts of the body.
- Trial name
- NCT05588167
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Obesity, Overweight
A Study of Tirzepatide in Overweight and Very Overweight Participants
The main purpose of this study is to measure the effect of tirzepatide on food intake in participants who are overweight or very overweight.
- Trial name
- NCT04311411
- Testing
- Tirzepatide, Liraglutide
- Where
- 3 sites in United States
- Volunteers
- 114 people
- Sponsor
- Eli Lilly and Company
Pituitary ACTH Hypersecretion, Acromegaly
Vitamin D Metabolism in Patients With Endocrine Disorders
This prospective controlled interventional study aims to reveal the diversity of vitamin D metabolism in patients with certain endocrine disorders (Cushing's disease, acromegaly, primary hyperparathyroidism, diabetes mellitus…
- Conditions
- Pituitary ACTH Hypersecretion, Acromegaly, Diabetes Mellitus, Type 1, Primary Hyperparathyroidism
- Trial name
- NCT04844164
- Testing
- Cholecalciferol 15000 UNT/ML Oral Solution
- Where
- Russia
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Endocrinology Research Centre, Moscow
Gaucher Disease Type 1
A Second-generation AI Based Therapeutic Regimen in Patients With Gaucher Disease Treated With Enzyme Replacement Therapy.
An open-labeled, prospective, single-center proof-of-concept study. Patients with Gaucher Disease aged 18-75 who received intravenous Enzyme Replacement Therapy once every two weeks were enrolled.
- Trial name
- NCT06050967
- Testing
- Enzyme replacement therapy for Gaucher disease in combination with altus care application
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Hadassah Medical Organization
Insomnia, Insomnia Chronic
SHADES Mechanistic Trial
Cardiovascular disease (CVD) is common, deadly, and costly, and adults with insomnia represent a large group of people at elevated risk of developing CVD in the future.
- Conditions
- Insomnia, Insomnia Chronic, Insomnia, Primary, Sleep Disturbance
- Trial name
- SHADES (NCT06041581)
- Testing
- Sleep Healthy Using The Internet (SHUTi), Telephonic CBT-I, Face-to-Face CBT-I
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
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