Clinical trials: Brain Diseases
TBI (Traumatic Brain Injury), Stroke
Guided Training for People With Cognitive Impairment
Abstract Objective: Investigators examined the feasibility of applying a participation-focused strategy training intervention to community-dwelling adults with cognitive impairments following stroke and brain injury and evaluated…
- Conditions
- TBI (Traumatic Brain Injury), Stroke, Cognitive Impairment
- Trial name
- GTPCI (NCT03225768)
- Testing
- Guided Training
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University WanFang Hospital
Dementia, Caregiver Stress
Penn State Emergency Medicine CarES: Care-partner Evaluation and Sourcing in the Emergency Department
Care partners of people living with dementia often experience ongoing stress and unmet support needs. This study evaluates the feasibility of a low-intensity, supportive education and resource intervention for care partners who…
- Conditions
- Dementia, Caregiver Stress, Caregiver Burden, Caregiver Burden of People With Dementia
- Trial name
- CarES (NCT07461168)
- Testing
- Care Partner Support and Education Messaging
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Acute Ischemic Stroke
Ali Pay Intelligent Navigation Applet-aided Pre-hospital Triage for Non-emergency Medical Service Patients With Acute Ischemic Stroke
According to the Bigdata Observatory platform for Stroke of China (BOSC), the proportion of patients with acute ischemic stroke (AIS) receiving intravenous thrombolysis or endovascular treatment in China is 5.64% and 1.45%…
- Trial name
- i-Path (NCT06613074)
- Testing
- Ali Pay intelligent navigation applet
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epilepsy
Study of Hormonal Sideeffects in Patients Taking Levetiracetam, Carbamazepine or Lamotrigine for Epilepsy
Some antiepileptic drugs are found to have hormonal side effects. We want to study possible hormonal side effects of the relatively new antiepileptic drug; levetiracetam and compare it to the older drugs; lamotrigine and…
- Trial name
- NCT00460070
- Where
- Norway
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Rikshospitalet University Hospital
Adults With Acquired Brain Injury
Translation and Cultural Adaptation of the Erasmus Modified Nottingham Sensory Assessment Scale for the Lower Limb in Acquired Brain Injury Into French
There is a lack of validated and standardized tools in French for assessing somatosensory perception in adults with brain injuries.
- Trial name
- F-EmNSA-MI (NCT07613541)
- Testing
- French Erasmus modified Nottingham Sensory Assessment scale, Self-Reported Somatosensory Sensations questionnaire, Sensitive digital scale
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Migraine Disorders, Muscle Tenderness
Muscle Tenderness and Hardness in Migraine Patients
The aim of the study is to examine symptomatology, quantitative sensory test (QST) parameters, muscle tenderness and muscle hardness in migraine patients interictally and compare with healthy controls
- Conditions
- Migraine Disorders, Muscle Tenderness, Headache Disorders, Primary, Nervous System Diseases
- Trial name
- NCT03626805
- Where
- Denmark
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
A Study Evaluating the Effectiveness of PEA Compared to Placebo for Reducing Pain Severity and Duration of Migraines.
This is a double-blind randomised controlled study to evaluate the effectiveness of orally-dosed Palmitoylethanolamide (PEA) compared to placebo for reducing pain severity and duration of migraines in otherwise healthy…
- Trial name
- NCT05046522
- Testing
- Palmitoylethanolamide sold as Levagen +
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- RDC Clinical Pty Ltd
Epilepsy
Double-Blind, Placebo-Controlled Trial of Vitamin E as Add-on Therapy for Children With Epilepsy
This is a study to see if vitamin E helps children with epilepsy have fewer seizures. About 20-30% of children with epilepsy do not have adequate seizure control with established antiepileptic drugs (AEDs).
- Trial name
- NCT00004637
- Testing
- Vitamin E
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
High Grade Gliomas, Glioblastoma
Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.
Better treatments are needed for high-grade gliomas (HGG), and new ways of treating this disease should be tested. The investigators want to see if giving medicine before radiation works well.
- Conditions
- High Grade Gliomas, Glioblastoma, Astrocytoma, Oligodendroglioma
- Trial name
- PRC (NCT07439172)
- Testing
- Pre-radiation temozolomide.
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Cooper Health System
Alcoholism
Imaging Cannabinoid CB1 Receptors in Alcohol Dependence
The cannabinoid type 1 (CB1) receptor is a protein found in the brain that is involved with the effects of marijuana; it may also play a role in the effects of alcohol dependence and withdrawal.
- Trial name
- NCT00816439
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Alzheimer Disease, Mild Cognitive Impairment
Novel Augmentation of DAOIB and Antioxidant for Early Dementia
Previous studies found that some NMDA-enhancing agents were able to improve cognitive function of patients with early-phase dementia.
- Trial name
- NCT06467539
- Testing
- DAOIB plus AO
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Chang Gung Memorial Hospital
Congenital Heart Disease
Brain Function in Children With Congenital Heart Disease (CHD)
The purpose of the study is to determine whether the neurodevelopmental outcome and in particular executive functions in 9 to 14 year old school children with congenital heart disease who underwent cardiopulmonary bypass surgery…
- Trial name
- NCT02814539
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bea Latal
Migraine
A Study of LY2951742 (Galcanezumab) in Japanese Participants With Episodic Migraine
The main purpose of this study is to determine the efficacy of the study drug Galcanezumab in Japanese participants with episodic migraine.
- Trial name
- NCT02959177
- Testing
- Galcanezumab
- Where
- 47 sites in Japan
- Volunteers
- 459 people
- Sponsor
- Eli Lilly and Company
Acquired Brain Injury
Family-Centred ACT After Paediatric ABI
Children and young people with acquired brain injury (ABI) commonly experience long-term emotional, behavioural, and participation difficulties that can affect quality of life for both them and their families.
- Trial name
- FamilyCARE-ABI (NCT07303075)
- Testing
- Acceptance and Commitment Therapy (DNA-V)
- Volunteers
- 6 people
- Sponsor
- University of Nottingham
Stroke
The Effect of Optic Flow During Treadmill Walking on the Gait Pattern in People Post-stroke
The aim of this study is to investigate the onset, magnitude and duration of the effect of manipulating the optic flow on the gait pattern during Virtual Reality (VR)-enhanced treadmill walking compared to treadmill walking…
- Trial name
- NCT03898375
- Testing
- Walking with different optic flow speeds
- Where
- Belgium
- Volunteers
- 2 people
- Sponsor
- Vrije Universiteit Brussel
Dementia, Cognitive Impairment
Implementation and Evaluation of Improved Access to Medical Imaging for Geriatric Patients of The Royal Ottawa Hospital
In this study, the investigators implement FDG-PET imaging for clients in the Geriatric Psychiatry department at The Royal Ottawa Hospital (ROH) and evaluate the impact of this advanced imaging technique on client care.
- Conditions
- Dementia, Cognitive Impairment, Dementia With Lewy Bodies
- Trial name
- NCT05428475
- Testing
- [18F]FDG-PET Scan
- Volunteers
- 15 people
- Sponsor
- Tim Lau
Epilepsy
Study The Knowledge and Attitude Towards Epilepsy Among Relatives of People With Epilepsy and Their Impact on The Patient's Quality of Life
Epilepsy is a common neurological condition that affects personal and familial behavior and social support . About 50 million people worldwide suffer from epilepsy and the prevalence of active epilepsy in developing countries is…
- Trial name
- NCT05671575
- Testing
- Questionnaire about Epilepsy
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mohamed Adel Abdellah
Brain Metastases
Study of Temozolomide to Treat Newly Diagnosed Brain Metastases
The purpose of this study is to determine if administering temozolomide after completion of stereotactic radiosurgery helps control existing brain metastases and prevents the developement of new brain metastases.
- Trial name
- NCT00717275
- Testing
- Temozolomide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Stroke, Balance; Distorted
Turkish Version of the Mini-BESTest: Transcultural Adaptation and Validation Study in Stroke Patients
"mini-BESTest (Turkish version)", "Berg Balance Test", "Timed Up and Go Test" and "Functional Reach Test" will be used for balance measurement in patients and the correlation of the mini-BEST with these tests will be checked.
- Trial name
- NCT04568070
- Testing
- mini-BESTest (Mini-Balance Evaluation Systems Test), Berg Balance Scale, Timed Up and Go Test
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Medeniyet University
Brain Injuries
Low Serum Ficolin-3 Levels on Admission Are Associated With Poor Outcomes After Severe Traumatic Brain Injury
The current study was designed to investigate the change of serum ficolin-3 levels and assess the prognostic predictive effect of serum ficolin-3 levels in the patients with severe traumatic brain injury.
- Trial name
- NCT02510573
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Sanmen People's Hospital