Clinical trials: Brain Disorders, open to volunteers
Disorder of Consciousness, Acquired Brain Injury
Describing the Effect of Familiar Song on Arousal and Awareness for Children With Disorders of Consciousness (DoC)
The goal of this clinical trial is to compare the effect of live music therapy and recorded music on recovery of consciousness in children aged 1 to 18 years who have a disorder of consciousness (DoC) after a severe brain injury.
- Trial name
- SongDoC (NCT07209657)
- Testing
- Live Music Therapy, Recorded Music
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Murdoch Childrens Research Institute
Stroke, Small Vessel Cerebrovascular Disease
Small Vessel Disease and Cerebral Infarct Healing InErvation Via Limb Distant Adaptation
Cerebral infarction (ischemic stroke) and cerebral small vessel disease (CSVD) represent major global causes of disability, cognitive decline, and mortality.
- Trial name
- SHIELD (NCT07503301)
- Testing
- Medical-grade ischemic preconditioning training instrument, Standard Treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Metachromatic Leukodystrophy (MLD)
Direct Lentiviral Injection Gene Therapy for MLD
This is a Phase I/II clinical trial of gene therapy for treating Metachromatic leukodystrophy (MLD) using a safety and efficacy improved self-inactivating lentiviral vector TYF-ARSA to functionally correct the genetic defect.
- Trial name
- NCT03725670
- Testing
- Intrathecal and intravenous LV gene therapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Cognitive Decline, Cognitive Dysfunction
Polyphenols and Cognitive Decline
Globally, populations are aging thereby increasing healthcare burden, overall cognitive impairment, and dementia including Alzheimers diseases (AD).
- Trial name
- MAEVE (NCT06507254)
- Testing
- Polyphenol Supplement
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Concussion, Brain
Objective Concussion Assessment Using MRI and Metabolomics
Mild traumatic brain injury (mTBI), also referred to as concussions, affect millions of people around the world and can cause harmful long term effects.
- Trial name
- NCT05993351
- Testing
- Magnetic resonance imaging (MRI), Urine and saliva samples, Questionnaires
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Mild Cognitive Impairment (MCI), Dementia (Diagnosis)
Loneliness as Risk Factor for Dementia
This study aims to determine whether loneliness is associated with a higher incidence of dementia in older adults with a prior diagnosis of mild cognitive impairment after 12 months of follow-up.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia (Diagnosis), Loneliness
- Trial name
- SOLETE (NCT07211945)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Focal Epilepsy, Intraoperative Monitoring
High-density Flexible μECoG for Epilepsy Surgery - A Single-Arm ECT
What's the clinical value of high-density flexible microelectrocorticography (μECoG) for guiding the resection of epileptogenic zone (EZ) in epilepsy surgery?
- Trial name
- Epi-PRECISE (NCT07656857)
- Testing
- Using High-density Flexible microElectrocorticography for intraoperative monitoring
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Beijing Tiantan Hospital
Major Depressive Disorder (MDD)
Efficacy and Safety of Transcranial Temporal Interference Stimulation for Depression
The goal of this clinical trial is to learn whether transcranial temporal interference stimulation (tTIS) can help treat major depressive disorder (MDD) in adults.
- Trial name
- NCT07612501
- Testing
- Active Transcranial Temporal Interference Stimulation Targeting Left ALIC, Active Transcranial Temporal Interference Stimulation Targeting Left sgACC
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yonggui Yuan
Disorders of Consciousness
REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study
The RE-CONNECT study is an early feasibility study to establish the safety, feasibility, and efficacy of two central thalamic deep brain stimulation targets in patients with chronic disorders of consciousness.
- Trial name
- NCT07228286
- Testing
- Deep brain stimulation (DBS) electrode implantation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Samuel Snider, MD
Primary Brain Neoplasm
Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors
This trial studies how an imaging agent, hyperpolarized carbon C 13 pyruvate, works in diagnosing glioma in patients with brain tumors.
- Trial name
- NCT03830151
- Testing
- Hyperpolarized Carbon C 13 Pyruvate, Magnetic Resonance Spectroscopic Imaging
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- M.D. Anderson Cancer Center
Parkinson Disease, Parkinson Disease Dementia
Monoamine Oxidase B PET/CT in Various MAO-B-Related Disease
To evaluate the potential usefulness of 18F-FPyCO/SMBT-1 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various MAO-B-related disease patients.
- Conditions
- Parkinson Disease, Parkinson Disease Dementia, Parkinson's Disease and Parkinsonism
- Trial name
- NCT07685873
- Testing
- Diagnostic Test: 18F-FPyCO/SMBT-1
- Where
- 3 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Stroke Acute
Virtual Reality Rehabilitation for Stroke Patients in the Hospital and at Home.
The goal of this clinical trial is to test whether a low-cost virtual reality (VR) motor rehabilitation platform can improve motor recovery in people recovering from a first-time ischemic stroke both in the hospital and at home.
- Trial name
- NCT06864741
- Testing
- Virtual reality guided motor rehabilitation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Nova Scotia Health Authority
Fibromyalgia
MDMA-assisted Therapy for Fibromyalgia
Fibromyalgia is a debilitating chronic pain disorder. Based on prior research with MDMA, it can be hypothesized MDMA-assisted therapy in fibromyalgia patients may increase the range of positive emotions, interpersonal trust, and…
- Trial name
- NCT06066853
- Testing
- MDMA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital
Parkinson Disease
Earlier Diagnosis and Better Treatment Mission Related to the Cohort Programme
The Luxembourg Parkinson's Study is an ongoing longitudinal nationwide monocentric observational study. It collects extensive clinical, molecular, genetic, and digital device-based longitudinal data, as well as foreseen…
- Trial name
- LuxPARK (NCT05266872)
- Testing
- Observational study with sample and data collection
- Where
- 2 sites in Luxembourg
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Essential Tremor
The STEREO-DBS ET Study: 7-Tesla MRI Brain Network Analysis for Deep Brain Stimulation in Essential Tremor
Rationale: Deep brain stimulation (DBS) of the thalamus is an effective surgical treatment for the patients with advanced essential tremor, despite optimal pharmacological treatment.
- Trial name
- STEREO-ET (NCT05909839)
- Testing
- 7T MRI network analysis for deep brain stimulation in essential tremor
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Glioma, Malignant, Metastases to Brain
Concurrent Fluorescence and Sonographically Guided Eradication of High-grade Gliomas and Metastases
The objective of the study is to determine whether the combined use of intraoperative fluorescence with 5-aminolevulinic acid (5-ALA) and sonography can achieve a higher rate of gross total resection in hemispheric high-grade…
- Trial name
- CONFLUENCE (NCT05474573)
- Testing
- Combined ultrasound and fluorescence-guided brain tumor resection, Fluorescence-guided brain tumor resection
- Where
- Russia
- Volunteers
- 52 people
- Sponsor
- Sklifosovsky Institute of Emergency Care
Stroke
NeuroReAlign Therapy for Balance and Gait Rehabilitation in Stroke Survivors
The goal of this randomized controlled trial is to investigate the effects of NeuroReAlign Therapy on balance and gait in stroke survivors in the chronic stage (>6 months).
- Trial name
- NCT06849102
- Testing
- NeuroReAlign Therapy, conventional physiotherapy interventions
- Volunteers
- 30 people
- Sponsor
- Middle East University
Acute Myocardial Infarction, Severe Periodontitis
Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)
Multicenter randomized clinical trial with two arms in patients hospitalized for an AMI nested in the Frenchie registry. Periodontal therapy is performed by periodontists in the intervention group versus treatment by dental…
- Conditions
- Acute Myocardial Infarction, Severe Periodontitis, Carotid Atherosclerosis
- Trial name
- PAROCARD (NCT04046237)
- Testing
- Periodontal treatment
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Ischemic Stroke From Large Vessel Occlusion
Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke
Stroke remains a predominant global public health challenge, ranking as the third leading cause of death and the fourth leading contributor to disability-adjusted life years (DALYs).
- Trial name
- AMASS2 (NCT07365475)
- Testing
- 20% human serum albumin
- Volunteers
- 306 people
- Sponsor
- Tianjin Huanhu Hospital
Diabetes Type 2, Diabetes Type 1
Disentangling the Effect of Brain Insulin Resistance on Brain Health
People with diabetes are at increased risk of developing dementia, including Alzheimer's disease and vascular dementia. In addition, persons with diabetes have more pronounced age-related brain atrophy and cognitive difficulties…
- Trial name
- BIR 1 (NCT07374705)
- Where
- 3 sites in Denmark, Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henrik Bo Wiberg Larsson
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