Clinical trials: Brain Function, open to volunteers
Ischaemic Stroke
Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis
The aim of this study is to assess the efficacy and safety of minocycline in improving functional outcome among patients with acute ischaemic stroke receiving intravenous thrombolysis.
- Trial name
- EMPHASIS-2 (NCT07526987)
- Testing
- Minocycline Hydrochloride Capsule (50 mg per capsule)
- Where
- 3 sites in China
- Volunteers
- 934 people
- Sponsor
- Beijing Tiantan Hospital
Hemiplegia, Subacute Stroke
Neurodevelopmental Technique Versus Mirror Therapy in Sub-acute Stroke Patients
As neurodevelopmental technique and mirror therapy had different effects on lower limb coordination, functions and ambulation. Both had proven to be helpful in the stroke patients to gain functional independency.
- Conditions
- Hemiplegia, Subacute Stroke, Stroke Rehabilitation
- Trial name
- NDTVSMT (NCT07742020)
- Testing
- Neurodevelopmental Technique (NDT), Mirror Therapy (MT)
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- University of Lahore
Stroke
fNIRS-Driven Visual Feedback Training to Restore Walking After Stroke
The objective of this clinical trial is to investigate whether intelligent visual feedback-based lower limb motor control training is more effective than conventional rehabilitation training in promoting walking ability recovery…
- Trial name
- NCT07014891
- Testing
- Intelligent Visual Feedback Motor Control Training, Bobath Ball Training
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Shengjing Hospital
Post-stroke Upper Limb Hemiparesis, Repetitive Transcranial Magnetic Stimulation (rTMS)
Repetitive Transcranial Magnetic Stimulation Combined With Bimanual Therapy for Upper Limb Stroke Rehabilitation
The goal of this clinical trial is to evaluate whether combining repetitive transcranial magnetic stimulation (rTMS) with machine-assisted bimanual therapy (BT) can improve upper limb function in stroke patients.
- Conditions
- Post-stroke Upper Limb Hemiparesis, Repetitive Transcranial Magnetic Stimulation (rTMS), Bimanual Therapy, Neuromodulation
- Trial name
- NCT07054424
- Testing
- Conventional occupation therapy, stretching exercise, rTMS
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- Chang Gung Memorial Hospital
Hemiplegia, Stroke
Effects of Wearable Vibratory Devices on Arm Function in Subacute Stroke Patients
Hemiplegia, or paralysis of one side of the body, often results from stroke and severely limits arm function. Standard physiotherapy helps, but recovery is often slow.
- Trial name
- WEVIB-HEMI (NCT07641790)
- Testing
- Wearable Focal Muscle Vibrator
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Faisalabad
Stroke Patients, Stroke
Young Stroke Service Deep Phenotyping: Exploring Recovery in Young Adult Survivors of Stroke
The Investigators are running a small, early-phase research study across several hospitals in Melbourne, Australia. The study will involve up to 100 young adults between the ages of 18 and 55 who have had a stroke.
- Conditions
- Stroke Patients, Stroke, Stroke; Sequelae, Young Adults
- Trial name
- NCT07019493
- Testing
- Observational Cohort
- Where
- 2 sites in Australia
- Volunteers
- 100 people
- Sponsor
- The Florey Institute of Neuroscience and Mental Health
Diplegic Cerebral Palsy With Spasticity, Motor İmagery Ability
Motor Imagery and Functional Performance in Diplegic Cerebral Palsy
The main purpose of this study was to examine the relationship between motor imagery capacity and functional mobility, walking and balance in children with diplegic type cerebral palsy.
- Trial name
- NCT07287215
- Testing
- Motor Imagery Ability Assessment, Mental Stopwatch Paradigm, Functional Mobility
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Inonu University
Stroke Patients With Hemiplegia or Hemiparesis in the Subacute Stage
The Effect of Combined Transcranial Pulse Current Stimulation (tPCS) and Transcutaneous Electrical Nerve Stimulation (TENS) on Lower Limb Motor Function in Subacute to Chronic Stroke Patients With Hemiplegia (COMPENSATOR-Stroke)
The goal of this study is to evaluate the effects of high frequency tPCS + TENS compared to Sham device stimulation + TENS (Control) in lower limb motor function recovery in stroke patients with hemiplegia or hemiparesis in the…
- Trial name
- COMPENSATOR (NCT06999876)
- Testing
- The AscenZ-VIII Stimulator (Investigational Medical Device)
- Where
- 2 sites in Singapore
- Volunteers
- 90 people
- Sponsor
- National University Health System, Singapore
Parkinson Disease
CsDCS on Functional Mobility in Parkinsons Disease
Parkinsons disease is a progressive neurological disorder marked by a decline in the efficacy of dopaminergic synapses in the nigrostriatal pathway, causing motor disturbances.
- Trial name
- NCT06856941
- Testing
- cerebello-spinal direct current stimulation
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Universidade Federal de Pernambuco
Primary Brain Tumors, Diffuse Glioma
Proton Versus Photon Radiotherapy in Adults With Primary Brain Tumors
This study will be done in adults with brain tumors having good prognosis requiring treatment with radiotherapy. The current practice for brain radiotherapy involves treatment using X rays (photon radiotherapy).
- Conditions
- Primary Brain Tumors, Diffuse Glioma, Meningioma, Pituitary Adenoma
- Trial name
- PRIDE (NCT06831461)
- Testing
- Proton Beam Therapy, Photon Radiotherapy
- Where
- India
- Volunteers
- 156 people
- Sponsor
- Tata Memorial Centre
Ischemic Stroke
A Phase 3 Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke.
- Trial name
- MASTRE-3 (NCT07645586)
- Testing
- LNM-navigated cTBS
- Where
- China
- Volunteers
- 584 people
- Sponsor
- Beijing Tiantan Hospital
Healthy
Physiology of Human Brain Connectivity
The purpose of this study is to investigate the effective connectivity between different regions of the human brain in healthy participants, and the mechanisms which influence and modulate its development.
- Trial name
- NCT06246942
- Testing
- Single-pulse transcranial magnetic stimulation (spTMS), Paired associative stimulation (PAS), Magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Primary CNS Lymphoma, Brain Lymphoma
Prospective Neurobehavioral Functions in Newly-diagnosed Patients With Primary CNS Lymphoma Treated With Hyperfractionated Conformal Whole-brain Radiation Therapy Plus Simultaneous Integrated Boost
Primary central nervous system lymphoma (PCNSL) is an uncommon disease. Conventional treatment has consisted of either whole-brain radiation therapy (WBRT) or methotrexate (MTX)-based combined modality therapy integrating…
- Trial name
- NCT04006561
- Testing
- A treatment protocol of combined chemoradiation delivered in the manner of hyperfractionated conformal whole-brain radiation therapy
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Osteopathic Medicine
Examining Relationships Between Musculoskeletal Function Measurements of Movement Efficiency and Nervous System Function After Chronic Stroke
Stroke remains the leading cause of severe disability, and survivors frequently have incomplete recovery. More than half of older survivors have impaired mobility which contributes to poorer quality-of-life (QoL) and suffering.
- Conditions
- Stroke, Osteopathic Medicine, Physical Examination, Heart Rate Variability (HRV)
- Trial name
- SOMADC-CC (NCT07737873)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Davis
Stroke, Stroke, Acute
Comperative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation in Subacute Stroke Patients
This study aims to determine whether transcutaneous vagus nerve stimulation (tVNS) via auricular or cervical branches enhances recovery when combined with task-specific training in subacute stroke patients.
- Trial name
- NCT07253870
- Testing
- Transcutaneous vagus nerve stimulation through auricular branch along with task specific exercises, Transcutaneous vagus nerve stimulation through cervical branch along with task specific exercises
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Cerebral Palsy
Cognitive Functioning in Children and Adolescents With Cerebral Palsy
Background: Cerebral palsy (CP) is characterized by motor impairment but commonly involves more widespread difficulties, including cognitive impairment.
- Trial name
- CPCog-Youth-DK (NCT05921422)
- Testing
- Cognitive assessment
- Where
- 2 sites in Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Unilateral Spastic Cerebral Palsy
Robotic Glove Training on Hand Function in Unilateral Cerebral Palsy
The purpose of the study is to investigate the effect of task-oriented robotic glove training on hand function in children with unilateral spastic cerebral palsy.
- Trial name
- NCT07482631
- Testing
- Conventional Physical Therapy Program, Robotic Glove Training
- Volunteers
- 40 people
- Sponsor
- Beni-Suef University
Amblyopia, Strabismus
VISION-3D: Visual Skills Improvement With On-screen 3D Movies.
This clinical study investigates whether watching 3D films can help improve the vision of children with residual amblyopia (lazy eye), that is, those children who, despite having undergone usual treatments such as glasses or…
- Trial name
- VISION3D (NCT07301645)
- Testing
- Stereoscopic (3D) Movie Viewing, 2D Movie Viewing
- Volunteers
- 40 people
- Sponsor
- Universitat Politècnica de Catalunya
Cerebral Palsy, Spastic
Effect of Robotic Assisted Therapy on Hand Functions, Grip Strength and Proprioception in Children With Hemiplegia
Statement of the problem: Does robotic assisted therapy have an effect on hand functions, grip strength and proprioception in children with hemiplegic cerebral palsy? Significance of the study: New technologies allow and promote…
- Trial name
- NCT07249866
- Testing
- Hand rehabilitation robotic gloves, occupational therapy
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Cairo University
Parkinson Disease
Exercise to Improve Sleep in Parkinson's Disease
This study will investigate the impact of three common exercise modalities, cardiovascular, resistance, and multimodal (i.e., a combination of the previous two) training, on sleep quality and architecture in persons with…
- Trial name
- NCT05644327
- Testing
- Cardiovascular training (CT), Resistance training (RT), Multimodal training (MT)
- Where
- 3 sites in Canada
- Volunteers
- 150 people
- Sponsor
- McGill University
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