Clinical trials: Brain Injuries,Traumatic
Dizziness, Brain Injury
Vestibular Consequences of Blast-related Mild Traumatic Brain Injury (TBI)
The purpose of this project is to determine the effects of mild traumatic brain injury and blast exposure on the inner ear balance and central nervous systems.
- Trial name
- NCT01021137
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Brain Injuries, Traumatic
Hypertonic Resuscitation Following Severe Traumatic Brain Injury (TBI)
The purpose of this study is to determine if hypertonic saline with and without dextran can improve neurologic outcomes in victims of severe traumatic brain injury (TBI).
- Trial name
- NCT00316004
- Testing
- 7.5% Hypertonic Saline in 6% Dextran-70 (HSD), 7.5% Hypertonic Saline (HS), 0.9% Normal Saline (NS)
- Where
- 12 sites in United States, Canada
- Volunteers
- 1,331 people
- Sponsor
- University of Washington
Mild Traumatic Brain Injury, Chronic Pain
Neuromodulation and Yoga for Mild Traumatic Brain Injury and Chronic Pain
The objectives of this VA SPiRE application are to develop a combined neuromodulation and yoga (iTBS+yoga) intervention for Veterans with mild traumatic brain injury (mTBI) and chronic pain, assess the intervention's feasibility…
- Trial name
- NCT04517604
- Testing
- Magventure MagProx100 with MagOption
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Pilot and Feasibility of MEMI for Chronic Traumatic Brain Injury
This is a pilot and feasibility study for a mobile phone-delivered intervention for memory, called MEMI (memory ecological momentary intervention), that was designed to support adults with chronic traumatic brain injury with…
- Trial name
- NCT06375421
- Testing
- MEMI (Memory Ecological Momentary Intervention) Spaced Retrieval, Blocked Retrieval
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Traumatic Brain Injury (TBI), Alcoholism
Valproate for Mood Swings and Alcohol Use Following Head Injury
Successful treatment of traumatic brain injury (TBI)-induced mood lability may reduce or eliminate drinking behaviors in persons with alcohol abuse/dependence (AA/D) and affective lability following TBI.
- Trial name
- NCT01760785
- Testing
- divalproex sodium
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Traumatic Brain Injury
rTMS to Improve Cognitive Function in TBI
This project will study 40 Veterans identified with symptoms understood to characterize mild to moderate Traumatic Brain Injury (TBI) including Post Traumatic Stress Disorder (PTSD).
- Trial name
- rTMSTBI (NCT02152540)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Headache, PTSD
Cognitive-Behavior Therapy for Posttraumatic Headache
The overall purpose of the study is to compare two talk therapies (Clinic-Based Cognitive Behavioral Therapy and Cognitive Processing Therapy-Cognitive Only) for the treatment of posttraumatic headache (PTHA) and co-morbid…
- Trial name
- NCT02419131
- Testing
- Behavioral Headache Therapy, Cognitive Processing Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Traumatic Brain Injury
Prehospital Tranexamic Acid Use for Traumatic Brain Injury
Primary aim: To determine the efficacy of two dosing regimens of TXA initiated in the prehospital setting in patients with moderate to severe TBI (GCS score ≤12).
- Trial name
- TXA (NCT01990768)
- Testing
- 1 gram Tranexamic Acid (TXA), 2 grams TXA, 0.9% Sodium Chloride injectable
- Where
- 12 sites in United States, Canada
- Volunteers
- 967 people
- Sponsor
- University of Washington
Traumatic Brain Injury, Fatigue
Treatment of Post-Traumatic Brain Injury (Post-TBI) Fatigue With Light Therapy
This study aims to evaluate the efficacy of 4 weeks of daily light exposure in reducing Post-Traumatic Brain Injury (TBI) Fatigue immediately post-treatment and at a one-month follow up.
- Trial name
- NCT01725750
- Testing
- Bright White Light (BWL), Dim Red Light (DRL)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Injury, Brain, Traumatic, Traumatic Brain Injury
Study of Airway Pressure Release Ventilation and Intracranial Pressure in Patients With Severe Traumatic Brain Injury
The investigators will conduct an observational crossover study. The investigators aim to recruit 50 participants with severe Traumatic Brain Injury (TBI) requiring intracranial pressure (ICP) monitoring during their stay at the…
- Trial name
- NCT02507973
- Testing
- Airway Pressure Release Ventilation, Low Tidal Volume Ventilation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Maryland, Baltimore
Traumatic Brain Injury
Study of Oxycyte in Severe Closed Head Injury
Brain damage as a result of decreased oxygen to the brain is found in 80% of patients that die with severe head injuries. Laboratory studies in animals and clinical trials have shown that increasing oxygen in the brain results in…
- Trial name
- NCT00174980
- Testing
- Oxycyte
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Tenax Therapeutics, Inc.
Venous Thromboembolism, Traumatic Brain Injury
Delayed Versus Early Enoxaparin Prophylaxis After Traumatic Brain Injury (TBI)
Brain injured patients are at high risk for forming blood clots in the legs and lungs. For non-brain injured trauma patients, we decrease the chances of these blood clots forming by placing the patients on a low dose of the blood…
- Trial name
- DEEP (NCT01014403)
- Testing
- enoxaparin
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Texas Southwestern Medical Center