Clinical trials: Brain Injuries,Traumatic
Traumatic Brain Injury, Subarachnoid Hemorrhage
Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention
To show that the use of intravenous levetiracetam(LEV;Keppra)for seizure prevention in patients in the Neuroscience Intensive Care Unit will result in fewer side effects compared to the current standard of care anticonvulsant and…
- Trial name
- Keppra (NCT00618436)
- Testing
- Levetiracetam, Phenytoin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Cincinnati
PTSD
Open Label Study of MDMA-assisted Psychotherapy for Treatment of PTSD With Optional fMRI Sub-Study
The goal of this clinical trial is to learn if MDMA-assisted therapy is safe and effective in people diagnosed with at least severe PTSD.
- Trial name
- NCT04030169
- Testing
- Midomafetamine HCl
- Where
- 6 sites in Czechia, Germany and 3 more
- Volunteers
- 21 people
- Sponsor
- MAPS Europe B.V.
Post-stroke Spasticity, Spasticity Post-Traumatic Brain Injury
Dysport® Adult Lower Limb Spasticity Follow-on Study
The purpose of this research study is to assess the long term safety of Dysport® in hemiparetic subjects with lower limb spasticity due to stroke or traumatic brain injury over repeated treatment cycles.
- Trial name
- NCT01251367
- Testing
- Botulinum toxin type A
- Where
- 50 sites in United States, Australia and 9 more
- Volunteers
- 352 people
- Sponsor
- Ipsen
Brain Injuries, Post-Traumatic Headache
Amitriptyline to Prevent Headache After Traumatic Brain Injury
The investigators propose to conduct a 2-arm, open-label pilot study to determine if early treatment with amitriptyline will decrease the frequency and severity of headaches after mild traumatic brain injury (TBI).
- Trial name
- NCT01856270
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Traumatic Brain Injury
Study to Evaluate the Safety, Tolerability, and Efficacy of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury
The primary objective of this study is to evaluate the safety and tolerability of long-term (12 months) armodafinil treatment in patients with excessive sleepiness associated with mild or moderate closed traumatic brain injury…
- Trial name
- NCT00983437
- Testing
- Armodafinil
- Where
- 61 sites in United States
- Volunteers
- 49 people
- Sponsor
- Cephalon, Inc.
Alzheimer's Disease, Traumatic Brain Injury
Clinical Evaluation of Flortaucipir F 18
This study is designed to expand the database of flortaucipir F 18 safety and tau binding as measured by PET imaging and to provide standardized conditions for flortaucipir PET use, data collection and analysis to facilitate…
- Conditions
- Alzheimer's Disease, Traumatic Brain Injury, Depression
- Trial name
- NCT02278367
- Testing
- Flortaucipir F18, Brain PET scan
- Where
- 5 sites in United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
TBI (Traumatic Brain Injury)
VR Cognitive Rehabiliation for Pediatric TBI
Childhood traumatic brain injury (TBI) poses significant impairment in children's executive functions (EFs) for moderate to severe injuries, yet interventions specifically designed for children's EF rehabilitation post-TBI and…
- Trial name
- NCT04526639
- Testing
- Virtual Reality-based Interactive Cognitive Training Program
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Massachusetts, Lowell
Vascular System Injuries, Concussion, Brain
Sildenafil Treatment for Mild TBI
About 300,000 people are hospitalized for traumatic brain injury (TBI) each year. After TBI, secondary brain injury escalates due in part to heightened levels of oxidant injury, inflammation, and vascular injury.
- Conditions
- Vascular System Injuries, Concussion, Brain, Post-Concussion Syndrome
- Trial name
- NCT03598140
- Testing
- Sildenafil Citrate
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Traumatic Brain Injury, Depression
Feasibility Study of Duloxetine in the Treatment of Depression in Patients With Traumatic Brain Injury
The primary objective of the study is to compare the efficacy of duloxetine 60 mg by mouth daily with placebo in the prevention of depression associated with mild/moderate traumatic brain injury and to enhance cognitive function.
- Trial name
- Duloxetine (NCT01223001)
- Testing
- Duloxetine, Sugar pill
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rehabilitation Hospital of Indiana
Brain Concussion
Enhanced Problem-Solving Training
Mild traumatic brain injury (mTBI) is among the most common injuries sustained by Veterans of Operations Enduring and Iraqi Freedom.
- Trial name
- E-PST (NCT03759223)
- Testing
- Enhanced Problem-Solving Training (E-PST), Healthy Living Messages (HLM), Enhanced Problem-Solving Training (E-PST) (non-randomized)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Head Trauma
Pain in Traumatic Brain Injury - Basile, MD
The observation through a chart review of persistent pain on neuro psychological functioning and how it applies to the community integration with patients that had suffered traumatic brain injury.
- Trial name
- NCT01136486
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Northwell Health
Chronic Troublesome Sialorrhea, Parkinson's Disease
Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions
The objective of this study is to investigate the efficacy and safety of two different dose levels of NT 201 (75 U or 100 U per cycle), compared with placebo, in reducing the salivary flow rate, and the severity and frequency of…
- Conditions
- Chronic Troublesome Sialorrhea, Parkinson's Disease, Post-stroke, Traumatic Brain Injury
- Trial name
- SIAXI (NCT02091739)
- Testing
- IncobotulinumtoxinA (100 Units), IncobotulinumtoxinA (75 Units)
- Where
- 31 sites in Germany, Poland
- Volunteers
- 184 people
- Sponsor
- Merz Pharmaceuticals GmbH
Sport-related Concussion, Brain Concussion
How do the Neck Muscles Influence Head Acceleration During Sport-associated Impact Events in High School Athletes?
Sport-related concussion is a common and serious injury that can affect athletes of all ages in any sport. The purpose of this project is to study the effect of a 12-week manual resistance neck strengthening exercise program on…
- Conditions
- Sport-related Concussion, Brain Concussion, Healthy
- Trial name
- NCT03883165
- Testing
- high-intensity neck strengthening, Control group
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Brain Injuries, Craniocerebral Trauma
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury
The investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI).
- Conditions
- Brain Injuries, Craniocerebral Trauma, Trauma, Nervous System, Traumatic Brain Injury
- Trial name
- NCT01322048
- Testing
- IV Propranolol and Per Tube Clonidine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University
Traumatic Brain Injury
Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury.
Growth Hormone (GH) deficiency, defined by insufficient GH response to a variety of stimulating compounds, is found in 20-35% of adults who suffer traumatic brain injuries (TBI) requiring inpatient rehabilitation1.
- Trial name
- Growth-TBI (NCT00766038)
- Testing
- Recombinant human Growth Hormone
- Where
- 3 sites in United States
- Volunteers
- 63 people
- Sponsor
- University of Pennsylvania
Concussion, Mild Traumatic Brain Injury
DHA For The Treatment of Pediatric Concussion Related to Sports Injury
In recent years, media attention has focused on the long-term sequelae of repeated concussive episodes in professional athletes.
- Trial name
- NCT01903525
- Testing
- Docosahexaenoic acid (DHA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Concussion, Traumatic Brain Injury
Concussion Device Audiological Measures
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). A simple, effective, and lightweight device worn by athletes or war fighters in the field, designed to mitigate TBI resulting from…
- Trial name
- NCT02262507
- Testing
- Device Wearing
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Traumatic Brain Injury
CENTER-TBI: Collaborative European NeuroTrauma Effectiveness Research in TBI
The research aims of the CENTER-TBI study are to: 1. better characterize Traumatic Brain Injury (TBI) as a disease and describe it in a European context, and 2. identify the most effective clinical interventions for managing TBI.
- Trial name
- CENTER-TBI (NCT02210221)
- Where
- 65 sites in Austria, Belgium and 17 more
- Volunteers
- 4,559 people
- Sponsor
- University Hospital, Antwerp
Brain Injuries
Efficacy and Safety Study of Intravenous Progesterone in Patients With Severe Traumatic Brain Injury
The SyNAPSe trial will study if giving intravenous (i.v.) progesterone within 8 hours of the injury for a total of 120 hours to severe traumatic brain injury patients improves their recovery.
- Trial name
- SyNAPSe (NCT01143064)
- Testing
- Progesterone, Lipid emulsion without progesterone
- Where
- 156 sites in United States, Argentina and 19 more
- Volunteers
- 1,195 people
- Sponsor
- BHR Pharma, LLC