Clinical trials: Brain Injuries,Traumatic, open to volunteers
Traumatic Brain Injury, Stroke
Remote Neuropsychological Assessment of Patients With Neurological Disorders and Injuries
For the last decades, many aspects of human life have been altered by digital technology. For health care, this have opened a possibility for patients who have difficulties travelling a long distance to a hospital to meet with…
- Conditions
- Traumatic Brain Injury, Stroke, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT05819008
- Testing
- Neuropsychological Assessment
- Where
- Sweden
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Umeå University
Post Traumatic Stress Disorder, Traumatic Brain Injury
Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation
This study will test the clinical efficacy of an accelerated TMS (accel-TMS) protocol that rapidly addresses PTSD symptoms with 1 week (25 sessions over 5 days) of condensed treatment.
- Trial name
- NCT06544408
- Testing
- Cool B70 AP Coil - Active (dl-PFC), Cool D-B80 AP Coil - Active (dm-PFC), Cool B70 Treatment Coil - Active Only
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Florida State University
Traumatic Brain Injury
Evaluation of the Safety of Inhaled Sedation With Isoflurane in Head Trauma Patients
Intensive care management of patient with severe traumatic brain injury (TBI) includes deep and prolonged sedation with intravenous hypnotics (propofol, midazolam, ketamine) in combination with opioids to prevent and/or treat…
- Trial name
- IsoSAFE (NCT06311604)
- Testing
- Isoflurane
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Intracranial Hypertension, Traumatic Brain Injury
Intracranial PrEssure Time dOse (ImPETO)
The new Integra CereLink ICP monitor integrate the possibility of recording and displaying continuously the AUC (Pressure Time Dose, PTD) and other ICP derived variables and provide the possibility of evaluating the utility of…
- Conditions
- Intracranial Hypertension, Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracranial Hemorrhages
- Trial name
- ImPETO (NCT04459806)
- Testing
- intracranial pressure monitoring
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- University of Milano Bicocca
Traumatic Brain Injury
Cortical Spreading Depolarization After Severe Traumatic Brain Injury
Preliminary evaluation of electrodes placed on the brain for recording brain activity and novel algorithms to determine cortical spreading depolarization foci of origination following severe traumatic brain injury requiring…
- Trial name
- NCT03321370
- Testing
- Continuous electrocorticography post severe traumatic brain injury requiring neurosurgical intervention
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Samuel Cramer
Muscle Spasticity, Spinal Cord Injury
Comparing Upper Limb Surgery and Botulinum Toxin for Spasticity: A Paired Design Study
Spasticity is a common complication following central nervous system injuries. Left untreated, spasticity can lead to various complications, hindering activities of daily living and diminishing independence.
- Conditions
- Muscle Spasticity, Spinal Cord Injury, Stroke, Traumatic Brain Injuries
- Trial name
- NCT06733025
- Testing
- Tendon lengthening surgery, BoNT Injections
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Vastra Gotaland Region
Traumatic Brain Injuries
Anti-inflammatory Effect of MgSO₄ in Patients With Moderate Traumatic Brain Injury by Measurming Nucleotide-binding Oligomerization Domain-Like Receptor Pyrin Domain-containing 3 (NLRP3) Inflammasome-a Multiprotein Complex
The primary objective of this study is to evaluate the biochemical efficacy of Magnesium Sulfate (MgSO₄) as an anti-inflammatory therapeutic agent in patients suffering from moderate traumatic brain injury (TBI) at Assiut…
- Trial name
- NCT07763665
- Testing
- Magnesium sulfate (MgSO4), Normal Saline
- Volunteers
- 64 people
- Sponsor
- Assiut University
Chronic Subdural Hematoma, Surgical Procedures, Operative
A National Study Examining the Most Effective Drainage Method After Burr Hole Evacuation of Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease. The main treatment is neurosurgical evacuation and subsequent hematoma drainage.
- Conditions
- Chronic Subdural Hematoma, Surgical Procedures, Operative, Recurrence, Mortality
- Trial name
- SUPERDURA (NCT06621407)
- Testing
- 24 hours active subperiostal drainage, 24 hours passive subdural drainage
- Where
- 4 sites in Denmark
- Volunteers
- 354 people
- Sponsor
- Aalborg University Hospital
Traumatic Brain Injury, Stroke
Internet Delivered Cognitive Rehabilitation for Mild Cognitive Impairments
Acquired brain injury and neurological disorders cause cognitive deficits, which in turn cause reduced participation in everyday life.
- Conditions
- Traumatic Brain Injury, Stroke, Multiple Sclerosis, Parkinsons Disease (PD)
- Trial name
- eRehabCog (NCT06973018)
- Testing
- eRehabCog, CogMed QM
- Where
- Sweden
- Volunteers
- 64 people
- Sponsor
- Aniko Bartfai
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Brain Concussion, Mild Traumatic Brain Injury
Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) often causes persistent motor and cognitive deficits in children resulting in functional limitations.
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Motor Disorders, Cognitive Impairment
- Trial name
- CI-tDCS (NCT05762796)
- Testing
- tDCS in Youth with mild traumatic brain injury
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Elbow Dislocation, Elbow Fractures
Neuro-Inflammation in Extremity Trauma: Risk Verification in Elbow Trauma: The NERVE Study
The primary goal of this proposal is to improve the understanding of the mechanisms causing persistent pain and disability in elbow fracture patients and their associated functional limitations.
- Conditions
- Elbow Dislocation, Elbow Fractures, Inflammation Biomarkers, TBI Traumatic Brain Injury
- Trial name
- NERVE (NCT07259382)
- Testing
- Biomarkers evaluation
- Volunteers
- 60 people
- Sponsor
- Université de Montréal
TBI (Traumatic Brain Injury), ICP (Intracranial Pressure) Increase
Comparison of Hyperosmolar Agent in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Ultrasonography
The aim of this study to compare the efficacy of hypertonic saline and mannitol in reducing intracranial pressure, as assessed by serial optic nerve sheath diameter (ONSD) ultrasound measurements, in patients with traumatic brain…
- Conditions
- TBI (Traumatic Brain Injury), ICP (Intracranial Pressure) Increase, Optic Nerve Sheath Diameter Measurement
- Trial name
- MHTS-ONSD (NCT07786324)
- Testing
- Mannitol (20%), Hypertonic Saline ( 3% Sodium Chloride Saline)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Traumatic Brain Injury
Treating Traumatic Brain Injury With Transcranial Direct Current Stimulation
Traumatic Brain Injury (TBI) often results in a wide array of cognitive impairments, which can significantly diminish quality of life for affected individuals.
- Trial name
- NCT06989970
- Testing
- Active tDCS on the DLPFC + Cognitive Intervention(s)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Concussion, Mild, Mild Traumatic Brain Injury (mTBI)
Acceptance and Commitment Therapy Integrated Vestibular Rehabilitation (ACTIVE) RCT
The primary objective of this multi-site randomized clinical trial (RCT) is to compare Acceptance and Commitment Therapy Integrated Rehabilitation (ACT) with usual care rehabilitation (CONTROL) in 250 individuals with…
- Conditions
- Concussion, Mild, Mild Traumatic Brain Injury (mTBI), Psychological Health
- Trial name
- NCT06819904
- Testing
- Acceptance and Commitment Therapy Integrated Rehabilitation (ACT), Usual Care Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury, Upper Extremity
Transcutaneous Auricular Vagus Nerve Stimulation to Improve Upper Extremity Recovery After Traumatic Brain Injury
Upper extremity weakness, impaired coordination, reduced dexterity, and limited arm and hand use may continue after TBI. Repetitive, task-specific rehabilitation may improve function, but recovery can remain incomplete.
- Trial name
- taVNS (NCT07867015)
- Testing
- taVNS, FTP
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Craig Hospital
Severe Traumatic Brain Injury
The Systemic Nature of Severe Traumatic Brain Injury
Severe traumatic brain injury (sTBI) is a devastating condition with no targeted therapies available to prevent secondary injury.
- Trial name
- MANTRA (NCT07679126)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Corewell Health West
Traumatic Brain Injury
High Intensity Step Training After Traumatic Brain Injury
This study will explore whether the types and intensity of the interventions being delivered will yield measurable cognitive benefits in addition to improved mobility and balance.
- Trial name
- B-HIST (NCT05702138)
- Testing
- Physical therapy
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Craig Hospital
Military Sexual Trauma, Intimate Partner Violence
Multifaceted Intervention to Restore Resilience and Overcome Risk
The MIRROR study will compare the effectiveness of two interventions in improving emotion regulation and reducing PTSD symptoms in female Veterans with military sexual trauma (MST) and/or intimate partner violence (IPV) and…
- Conditions
- Military Sexual Trauma, Intimate Partner Violence, Brain Injury, Post Traumatic Stress Disorder
- Trial name
- MIRROR (NCT06988787)
- Testing
- webSTAIR, ExpoTx, PsychoEd
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Subdural Hematoma
Aspirin Continuation or Discontinuation in Conservative Treatment for Chronic Subdural Hematoma
This clinical study aims to learn about the efficacy and safety of aspirin continuation or discontinuation in conservative treatment for chronic subdural hematoma.
- Trial name
- NCT07240454
- Testing
- Aspirin Continuation, Aspirin Discontinuation
- Where
- 2 sites in China
- Volunteers
- 143 people
- Sponsor
- Tao Liu