Clinical trials: Brain Injury, Acute
Rhabdomyolysis, Myopathy
Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients
1. Analyze the various causes of breakdown of muscle fibers in hospitalized patients. 2. Analyze the characteristics of these patients in Taiwan (including the drugs history, risk factors and the incidence of complications).
- Conditions
- Rhabdomyolysis, Myopathy, Acute Renal Failure, Neuroleptic Malignant Syndrome
- Trial name
- NCT01022450
- Where
- Taiwan
- Volunteers
- 2,500 people
- Sponsor
- National Taiwan University Hospital
Stress Response, Mood State
Post-biotic Intervention for Acute Stress Management
The study aims to evaluate the sub-chronic effects of colonic delivery of a post-biotic on stress response, mood state, sleep, and cognition in healthy young subjects with elevated self-reported stress levels.
- Conditions
- Stress Response, Mood State, Sleep, Cognition
- Trial name
- PIAS (NCT06097182)
- Testing
- Post-biotic (Colonic-Delivery capsule), Post-biotic (Regular Administration capsule)
- Where
- Singapore
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Acute Brain Injury, Traumatic Brain Injury
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury
Acute brain injury (ABI) is a leading cause of death and long-term disability in children. Diagnosis depends on fast neuroimaging, and head computed tomography (CT) is the bedside reference standard despite exposing the…
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Hydrocephalus
- Trial name
- CUPID-Peds (NCT07772323)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Injury;Sports
Acute Effect of Motor-Cognitive Training
Participants will complete a functional MRI to evaluate brain activation, functional connectivity, and behavioral performance immediately before and after a training program (approximately 30 minutes).
- Trial name
- NCT06017154
- Testing
- Motor-Cognitive Training Program
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Ke'La H Porter
Brain Concussion
The s100β Levels in Patients With Mild Brain Injury.
Mild traumatic brain injury (TBI) accounts for the majority of TBI. At present, whether TBI has traumatic intracranial lession is mainly diagnosed by computed tomography (CT), while only 5% of mild TBI has positive CT results.
- Trial name
- NCT06131242
- Testing
- It is an observational study
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Sumei Lu
Stroke, Ischemic, Cerebrovascular; Disorder, Occlusive
Rescue Endovascular Therapy for Progressive Acute Mild Ischemic Stroke With Large Vascular Occlusion
Endovascular therapy (EVT) added on best medical management is currently recommended in acute large vascular occlusion (LVO) stroke patients with National Institutes of Health Stroke Scale (NIHSS) score >5.
- Trial name
- NCT06155032
- Testing
- Endovascular therapy, Best medical management
- Where
- 7 sites in China
- Volunteers
- 272 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Traumatic Brain Injury
The Effects of Hyperbaric Oxygen on Non-acute Traumatic Brain Injury
Traumatic brain injury (TBI) continues to be a major cause of death and disability throughout the world. The reduced cerebral blood flow secondary to the direct trauma-induced damage deregulates cerebral metabolism and depletes…
- Trial name
- NCT05387018
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Traumatic Brain Injury
Participation and Executive Functions in Adults Following Traumatic Brain Injury In Sub-Acute Inpatient Rehabilitation
Aim: To examine the feasibility of a new treatment protocol in improving executive function deficits and participation in daily activities of adults with TBI at discharge and one month post-discharge.
- Trial name
- NCT04292925
- Testing
- New treatment protocol, Conventional therapy
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Loewenstein Hospital
Stroke, Acute, TBI
Tracheostomy With Bedside Simultaneous Gastrostomy Vs Usual Care Tracheostomy And Delayed Gastrostomy Placement
There is currently no prospective study analyzing the effect of tracheostomy with bedside simultaneous gastrostomy versus tracheostomy with delayed gastrostomy placement (TSG versus TDG) on the outcomes of neurocritically-ill…
- Conditions
- Stroke, Acute, TBI, Neuromuscular Diseases, Status Epilepticus
- Trial name
- BEGASTON (NCT04758052)
- Testing
- Timing of placement
- Where
- United States
- Sponsor
- University of Mississippi Medical Center
Traumatic Brain Injury
Brain Injury Rehabilitation Improving the Transition Experience
Each year, about 2.8 million people sustain a traumatic brain injury (TBI) in the United States, and at least 25 percent of these injuries are classified as moderate to severe.
- Trial name
- BRITE (NCT03422276)
- Testing
- Rehabilitation Discharge Plan, Rehabilitation Transition Plan
- Where
- 6 sites in United States
- Volunteers
- 1,555 people
- Sponsor
- University of Washington
Brain Injuries, Traumatic, Brain Injuries, Acute
Critical Hyperacute Assessment Research On Neurobiomarker Kinetics in Acute Brain Injury
Traumatic brain injury (TBI) and other conditions that reduce blood flow to the brain - such as cardiac arrest (CA) - are life-threatening medical emergencies.
- Conditions
- Brain Injuries, Traumatic, Brain Injuries, Acute, Hypoxia, Brain, Cardiac Arrest (CA)
- Trial name
- CHARON (NCT07782216)
- Where
- 4 sites in Hungary
- Volunteers
- 477 people
- Sponsor
- University of Pecs
Ambulances, Traumatic Brain Injury
Differences in Mortality and Morbidity in Patients Suffering a Time-critical Condition Between GEMS and HEMS
Introduction: Patients suffering a time-critical medical condition require rapid prehospital assessment and treatment and most often quick transportation to definitive care. This can be decisive for patient outcome.
- Conditions
- Ambulances, Traumatic Brain Injury, Acute Myocardial Infarction
- Trial name
- NCT03940443
- Where
- Sweden
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Dalarna County Council, Sweden
Cerebral Palsy, Spastic
Nervus Vagus Stimulation and Cerebral Palsy
When the literature is reviewed, it is difficult to find direct research on the effects of auricular vagus nerve stimulation (aVNS) on the autonomic nervous system and spasticity in children with spastic cerebral palsy.
- Trial name
- NCT06880887
- Testing
- nervus vagus stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Istanbul Medipol University Hospital
Brain Ischemia, Stroke
Effects Of DP-b99 On Neurological Function In Subjects With Acute Ischemic Hemispheric Stroke
This study will examine if DP-b99 can improve neurological function (for example strength and coordination) in the 3 months after an acute stroke
- Conditions
- Brain Ischemia, Stroke, Cerebrovascular Disorders
- Trial name
- NCT00190047
- Testing
- DP-b99
- Where
- 22 sites in Germany, Israel
- Volunteers
- 150 people
- Sponsor
- D-Pharm Ltd.
Acute Brain Injury, Mechanical Ventilation
Brain Monitoring During PEEP-Based Respiratory Therapy in Critically Ill Patients
Mechanical ventilation is commonly used in critically ill patients with acute brain injury. Positive end-expiratory pressure (PEEP) and lung recruitment maneuvers are important ventilator strategies for improving oxygenation, but…
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Neurocritical Care
- Trial name
- NCT07716787
- Testing
- Recruitment Maneuver, Positive End-Expiratory Pressure Adjustment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shengli Oilfield Hospital
Physical Fatigue, Return to Sport
The Effect of Physical Fatigue on Different Balance Tests and Brain Activity in a Healthy Population
The main objective of this project is: 1. To assess the influence of physical fatigue on brain functioning during a balance and reaction time task in a healthy population.
- Conditions
- Physical Fatigue, Return to Sport, Injury Prevention, EEG
- Trial name
- NCT04030390
- Testing
- Physical Fatigue, Control
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Concussion, Brain
Post-acute Structured Exercise Following Sport Concussion
This study will investigate the effect of structured, standardized aerobic exercise (AE) compared to usual care on clinical recovery from sport-related concussion (SRC) within the post-acute phase of injury.
- Trial name
- NCT02969824
- Testing
- Supervised Aerobic Exercise
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Toronto
Acute Neurological Injury, Emotional Distress
Building Resiliency in Dyads of Patients With an ANI Admitted to the Neuro-ICU and Their Informal Caregivers
The purpose of the present investigation is to test the efficacy of a brief (6 sessions) dyadic (patient and caregiver together) intervention to prevent chronic emotional distress in at risk dyads admitted to a Neuroscience…
- Trial name
- NCT05157880
- Testing
- Recovering Together
- Where
- United States
- Volunteers
- 388 people
- Sponsor
- Massachusetts General Hospital
Neck Pain, Ankle Injuries
Acupuncture for Pain Control in the Emergency Department
Acupuncture is widely used for managing acute and chronic pain conditions. In the context of an emergency department (ED), patients often present with non-emergent acute pain symptoms.
- Conditions
- Neck Pain, Ankle Injuries, Headache Disorders, Primary
- Trial name
- NCT02013908
- Testing
- Acupuncture plus standard ED management, Standard ED management alone
- Where
- South Korea
- Volunteers
- 17 people
- Sponsor
- Korean Medicine Hospital of Pusan National University
Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke
Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI
The goal is to pilot test a highly accessible, web-based, pragmatic, scalable intervention to overcome ongoing problems with high stakes decision-making by surrogate decision-makers of patients in ICUs with severe acute brain…
- Conditions
- Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke, Traumatic Brain Injury
- Trial name
- NCT05671874
- Testing
- Web/mobile/tablet-based digital decision aid + communication (DA+C) tool
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester