Clinical trials: Brain Injury, Traumatic
Concussion, Brain
Developing a Tool to Support Shared Decision Making Post-Concussion Between Adolescents, Parents and Clinicians
Investigators will conduct a pilot efficacy test of a decision aid about contact sport participation post-concussion.
- Trial name
- NCT04777864
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Chronic Troublesome Sialorrhea, Parkinson's Disease
Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions
The objective of this study is to investigate the efficacy and safety of two different dose levels of NT 201 (75 U or 100 U per cycle), compared with placebo, in reducing the salivary flow rate, and the severity and frequency of…
- Conditions
- Chronic Troublesome Sialorrhea, Parkinson's Disease, Post-stroke, Traumatic Brain Injury
- Trial name
- SIAXI (NCT02091739)
- Testing
- IncobotulinumtoxinA (100 Units), IncobotulinumtoxinA (75 Units)
- Where
- 31 sites in Germany, Poland
- Volunteers
- 184 people
- Sponsor
- Merz Pharmaceuticals GmbH
Brain Injuries, Post-Traumatic Headache
Amitriptyline to Prevent Headache After Traumatic Brain Injury
The investigators propose to conduct a 2-arm, open-label pilot study to determine if early treatment with amitriptyline will decrease the frequency and severity of headaches after mild traumatic brain injury (TBI).
- Trial name
- NCT01856270
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Traumatic Brain Injury, Cognitive Impairment
Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI
Difficulties with intellectual functioning, particularly memory functions, are common and source of long-term disability after Traumatic Brain Injury (TBI).
- Trial name
- RIVET (NCT01670526)
- Testing
- Rivastigmine Transdermal Patch
- Where
- 8 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, Major Depressive Disorder
Accelerated TMS to a Novel Brain Target in MDD and PTSD
This is a Clinical Trial designed to evaluate novel transcranial magnetic stimulation (TMS) methods for treating depression/PTSD. TMS is an FDA-approved procedure for treatment-resistant depression.
- Trial name
- NCT03114891
- Testing
- Transcranial Magnetic Stimulation (TMS), Task, fMRI-guided TMS target
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Traumatic Brain Injury (TBI)
Managing Mild Traumatic Brain Injury Related Headaches With Repetitive Transcranial Magnetic Stimulation
Persistent headache is one of the most common debilitating symptoms in military personnel suffering from mild traumatic brain injury (MTBI).
- Trial name
- NCT03314584
- Testing
- Transcranial Magnetic Stimulation, Magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- VA Office of Research and Development
TBI
A Brief Educational Intervention to Improve Traumatic Brain Injury (TBI) Screening Outcomes
This research study is designed to learn about Veterans' understanding of mild TBI (traumatic brain injury) and the VA TBI screening process.
- Trial name
- TBI (NCT01558791)
- Testing
- TBI handout
- Where
- 5 sites in United States
- Volunteers
- 1,236 people
- Sponsor
- VA Office of Research and Development
TBI (Traumatic Brain Injury)
Impact Of Early Cognitive Rehabilitation On Functional Outcomes Following Moderate Traumatic Brain Injury
Purpose of the study: This study aims to detect the impact of early cognitive rehabilitation on functional outcomes with patients following moderate traumatic brain injury.
- Trial name
- NCT06981897
- Testing
- early cognitive therapy program in addition to selected physical therapy program (positioning, chest care exercise)., selected physical therapy program (Chest care exercise, passive movement of the four limbs) in addition to early cognitive therapy program, Control group
- Where
- 3 sites in Egypt
- Volunteers
- 34 people
- Sponsor
- Amany Saadallah Hassan Mobarez
PTSD, Depression
Online and Shared Decision-Making Interventions to Engage Service Men and Women in Post-Deployment Mental Health Care
OEF/OIF/OND war Veterans have unique post-deployment care needs that the VA is striving to understand and address. Unfortunately, there is a significant disparity in utilization of mental health (MH) care and VA access as most…
- Conditions
- PTSD, Depression, Substance Use Disorder, Traumatic Brain Injury
- Trial name
- eSDM (NCT03539068)
- Testing
- WEB-ED+ Treatment Arm
- Where
- United States
- Volunteers
- 1,312 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Memantine for Neuroprotection and Cognitive Enhancement Following Traumatic Brain Injury
The purpose of this study is to determine if memantine can improve cognitive and neuropsychiatric outcomes after severe traumatic brain injury.
- Trial name
- NCT02240589
- Testing
- Memantine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Indiana University
Traumatic Brain Injury
Effects of Hypothermia Upon Outcomes After Acute Traumatic Brain Injury
Induction of hypothermia to < 35˚C by < 2.5 hours after severe traumatic brain injury, reaching 33˚C by 4 hours after injury and maintained for 48 hours in patients aged 16-45 will result in an increased number of patients with…
- Trial name
- NABIS:HIIR (NCT00178711)
- Testing
- Hypothermia
- Where
- 5 sites in United States, Canada
- Volunteers
- 232 people
- Sponsor
- The University of Texas Health Science Center, Houston
Traumatic Brain Injury
Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury
The purpose of this study is to examine the efficacy of sertraline to prevent the onset of mood and anxiety disorders during the first six months after traumatic brain injury.
- Trial name
- NCT00704379
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Baylor College of Medicine
Concussion Mild
Yoga and Female Concussion
Most research on the impact of mild Traumatic Brain Injury/Concussions have been deficit-based and focused on the impairments induced by the injury. Research shows that trauma doesn't always have negative effects.
- Trial name
- NCT07170488
- Testing
- Yoga, Yoga for wait list control
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Pittsburgh
Post-traumatic Stress Disorder
Brain Markers of Treatment Response in Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to examine if treatment of post-traumatic stress disorder in combat veterans with paroxetine changes brain responses as measured by functional magnetic resonance imaging and if brain responses can…
- Trial name
- NCT00700999
- Testing
- Paroxetine
- Where
- 3 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Stress Disorders, Post-Traumatic
Real-time fMRI and Neurofeedback of Brain Networks Mediating Trauma Memory Recall in PTSD
The purpose of the current study is to develop a better understanding of the brain mechanisms involved in psychological treatments for posttraumatic stress disorder (PTSD).
- Trial name
- NCT02500719
- Testing
- Computational Model - Real-time Support Vector Machine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Brain Injuries, Traumatic
Neuroactive Steroids and Traumatic Brain Injury (TBI) in OEF/OIF Veterans
Purpose: Mild traumatic brain injury (TBI) is extremely common among Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era Veterans.
- Trial name
- NCT01336413
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Transforming Research and Clinical Knowledge in TBI Pilot
The global aim of this proposal is to test and refine Common Data Elements (CDEs), neuroimaging standards, and best practices for genetics and proteomics in Traumatic Brain Injury (TBI) studies.
- Trial name
- NCT01565551
- Testing
- N/A (Observational Study)
- Where
- 4 sites in United States
- Volunteers
- 650 people
- Sponsor
- University of California, San Francisco
Chronic Traumatic Encephalopathy
18F-AV-1451 and Florbetapir F 18 PET (Positron Emission Tomography) Imaging in Subjects at Risk for Chronic Traumatic Encephalopathy
This study will explore the use of flortaucipir as a biomarker for chronic traumatic encephalopathy (CTE) and examine the relationship between clinical presentation and tau deposition.
- Trial name
- NCT02079766
- Testing
- florbetapir F 18, Flortaucipir F18
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Concussion
Concussion Testing: A Novel Non-invasive Concussion Detection Device
The purpose of this study is to establish and evaluate a distinctive signal for concussion.
- Trial name
- NCT02370914
- Testing
- Nautilus NeuroWaveTM System, SCAT
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Traumatic Brain Injury, Post-traumatic Stress Disorder
Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol
The purpose of this study is to improve the ability to diagnose problems after mild traumatic brain injury (MTBI) and to test a drug that may improve the outcome from these injuries.
- Trial name
- NCT01013870
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine