Clinical trials: Brain Injury, Vascular
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization With Liquid Embolic Agent for Treatment of Chronic Subdural Hematoma
The study evaluates the clinical and imaging outcome of middle meningeal artery (MMA) embolization with liquid embolic agent for treatment of chronic subdural hematoma (CSDH)
- Trial name
- NCT04574843
- Testing
- Embolization of MMA
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Mashhad University of Medical Sciences
Spinal Cord Injuries, Stroke
Transcutaneous Spinal Cord Stimulation for Upper Extremity Function
Transcutaneous electrical stimulation (tcES) of the spinal cord has shown great promise in restoring upper extremity function after spinal cord injury (SCI).
- Trial name
- NCT06596369
- Testing
- Transcutaneous spinal cord stimulation, Upper extremity rehabilitation
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Neurocritical Conditions, Traumatic Brain Injury
Protein Intake Dosage on the Prognosis of Neurocritical Patients
This study investigates the effect of different early protein supplementation levels (1.0-2.0g/kg/d, divided into three groups) on the prognosis of neurocritical patients, focusing on the 28-day Glasgow Coma Scale (GCS) score…
- Conditions
- Neurocritical Conditions, Traumatic Brain Injury, Ischemic Stroke
- Trial name
- NCT07295301
- Testing
- Low-Dose Enteral Protein Supplementation (Enteral Nutrition Formulas + Whey Protein Powder), Moderate-Dose Enteral Protein Supplementation (Enteral Nutrition Formulas + Whey Protein Powder), High-Dose Enteral Protein Supplementation (Enteral Nutrition Formulas + Whey Protein Powder)
- Volunteers
- 216 people
- Sponsor
- Wenshan City People's Hospital
Traumatic Brain Injury, Cerebral Stroke
Exoskeleton Rehabilitation on TBI
Background: Traumatic brain injury (TBI) is one of the leading causes of disability in the United States. The EKSO GT Bionics® (EKSO®) is a robotic exoskeleton approved by the Federal Drug Administration (FDA) for rehabilitation…
- Trial name
- Ekso-TBI (NCT04465019)
- Testing
- Exoskeleton Rehabilitation
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- DHR Health Institute for Research and Development
Cerebral Hemorrhage, Head Injury
Biomarkers Correlation With Volemia
The purpose of this study is to determine whether the Biomarkers (pro adrenomedullin (MR proADM), pro arginin vasopressin (CT proAVP), pro atrial natriuretic peptid (MR proANP), Pro Endothelin) changes at Day 2, Day 5 and Day 7…
- Conditions
- Cerebral Hemorrhage, Head Injury, Non Traumatic Post Surgery, Poly Trauma Patients Without Heart Failure
- Trial name
- ENVOL (NCT01858675)
- Testing
- Biomarkers, red blood cells and plasma assessment
- Where
- France
- Volunteers
- 66 people
- Sponsor
- ThermoFisher Scientific Brahms Biomarkers France
Alzheimer Disease, Parkinson Disease
Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies
The role of disorders of socio-emotional processes in cerebral diseases such as Alzheimer's disease, frontal temporal dementia, Parkinson's disease, Huntington's disease, traumatic brain injury, stroke, focal lesions, has been…
- Conditions
- Alzheimer Disease, Parkinson Disease, Frontal Dementia, Huntington Disease
- Trial name
- GREFEXII (NCT03052712)
- Testing
- social cognition
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Stroke, Parkinson Disease
Wearable Airbag Technology to Mitigate Falls in Individuals With High Fall Risk
The purpose of this study is to evaluate the feasibility and efficacy of a smart airbag system that detects and mitigates fall-related impact in individuals with high fall risk.
- Conditions
- Stroke, Parkinson Disease, Lower Limb Amputation Knee, Fall Injury
- Trial name
- NCT05076565
- Testing
- Airbag Belt Fall Protection System
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Chronic Subdural Hematoma
Outcome of Chronic Subdural Hematoma Management With Double Burr Hole Craniotomy Versus Single Burr Hole Craniotomy and Subdural Drain Evacuation
The goal of this clinical trial is to compare the outcome of double burr hole versus single burr hole in patients of chronic subdural hematoma undergoing subdural drain evacuation. The main questions it aims to answers are 1.
- Trial name
- NCT07368101
- Testing
- Single Burr hole Craniotomy, Double Burr hole Craniotomy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage (ICH)
Non-invasive Measuring of Cerebral Perfusion After Severe Brain Injury With Near-infrared-spectroscopy and ICG
The purpose of this study is to show if it is possible to detect secondary ischemic events in patients with severe brain injury or cerebral haemorrhage with the help of non-invasive near-infrared spectroscopy (NIRS) by using the…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage (ICH), Traumatic Brain Injury
- Trial name
- NCT01836848
- Testing
- measuring cerebral perfusion by NIRS with ICG
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Cologne
Stroke, Stroke, Acute
PRecisiOn Medicine In StrokE: Evolution of Plasma Brain-Derived Tau in Acute Stroke
The investigators recently identified Brain-derived tau (BD-tau) as a sensitive blood-based biomarker for brain injury in acute ischemic stroke: in patients with acute ischemic stroke, plasma BD-tau was associated with…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Cerebrovascular Disorders
- Trial name
- PROMISE-BD-100 (NCT06121336)
- Testing
- Plasma levels of BD-tau
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Chronic Subdural Hematoma
Middle Meningeal Artery Embolisation in Chronic Subdural Hematoma
This international multicenter study evaluates the efficacy and safety of middle meningeal artery embolization (MMAE) using PVA particles or liquid embolic agents as a perioperative treatment to prevent the recurrence of chronic…
- Trial name
- EMMA-CS (NCT07751887)
- Testing
- Middle Meningeal Artery Embolisation
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Hradec Kralove
Amyotrophic Lateral Sclerosis, Neuromuscular Disease
Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)
The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI).
- Conditions
- Amyotrophic Lateral Sclerosis, Neuromuscular Disease, Stroke, Tetraplegia/Tetraparesis
- Trial name
- CONNECT-ONE (NCT07357428)
- Testing
- Connexus Brain-Computer Interface
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Paradromics
Stroke, Spinal Cord Injury
Robotic Assisted Balance and Exoskeleton Training (REACTION) in Neurorehabilitation: a Feasibility Study
The goal of this clinical trial is to explore the effect on walking speed of a new robotic assisted balance and gait trainer (REACTION) and their subsystems in individuals with neurological disorders.
- Trial name
- REACTION (NCT06805500)
- Testing
- REACTION, ABLE Regain, GABLE Core
- Where
- 2 sites in Netherlands
- Volunteers
- 7 people
- Sponsor
- Roessingh Research and Development
Stroke, Spinal Cord Injuries
The Study of a Neural Interface and a Neurostimulation in the Rehabilitation of Upper Limb Movement Impairments.
The aim of the study is to investigate the effectiveness of a new rehabilitation technology for paralysis that occurs after stroke or spinal cord injury.
- Trial name
- NCT05115149
- Testing
- VIBRAINT RehUp robotic orthosis, tSCS during the exercise, tSCS prior to the exercise
- Where
- 6 sites in Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Stroke (CVA) or TIA, Headache, Migraine
Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache
Post stroke headache occurs in approximately 10-23% of all stroke patients. Its onset is shortly after experiencing a stroke, or stroke like event, and persists for at least three months.
- Conditions
- Stroke (CVA) or TIA, Headache, Migraine, Botulinum Toxins, Type A, Cerebral Venous Sinus Thrombosis
- Trial name
- NCT04580238
- Testing
- Botox 200 UNT Injection, Non Botox based Standard of Care Treatments for Headache/Migraine
- Where
- Canada
- Sponsor
- University of Alberta
Intracranial Aneurysm, Aneurysm
Coated Mongolian Aneurysm Treatment Study 2
The purpose of this study is to assess safety and effectiveness of the p64 MW HPC or p48 MW HPC Flow Modulation Device under prasugrel.
- Conditions
- Intracranial Aneurysm, Aneurysm, Vascular Diseases
- Trial name
- COMATS 2 (NCT04305704)
- Where
- Mongolia
- Volunteers
- 90 people
- Sponsor
- Phenox GmbH
Anemia, Neonatal, Intracranial Hemorrhages
Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates
The purpose of this study is to test the safety and effectiveness of a whole own (autologous) umbilical cord blood transfusion in the first 5 days after birth if the baby is born premature <34 weeks and developed anemia of…
- Conditions
- Anemia, Neonatal, Intracranial Hemorrhages, Necrotizing Enterocolitis, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT02050971
- Testing
- Umbilical Cord Blood Infusion, Intravenous Infusion of Peripheral Blood or its Components
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Pomeranian Medical University Szczecin
Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome
Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage
Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome, Mass Spectrometry, Heart Failure
- Trial name
- NCT06906432
- Testing
- Multi-disciplinary assessment
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Stroke Acute, Encephalitis
Inflammatory and Metabolic Prognostic Assessment in Critically Ill Neurological Patients
The study aims to develop and validate a prognostic prediction model for adverse outcomes in neurocritical patients receiving enteral nutrition based on key inflammatory and metabolic markers.
- Conditions
- Stroke Acute, Encephalitis, Non-traumatic Brain Injury
- Trial name
- IMPACT-NEURO (NCT06849011)
- Where
- 19 sites in China
- Volunteers
- 1,185 people
- Sponsor
- Yan Zhang
Anoxic Brain Injury, Cardiac Arrest
Temperature Control With an Esophageal Cooling Device in Post Cardiac Arrest Patients
This is a prospective, interventional study aiming to assess the effectiveness of the Esophageal Cooling Device (ECD) as a temperature control modality in post cardiac arrest patients.
- Trial name
- E-Chill (NCT02387775)
- Testing
- Esophageal temperature control
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's