Clinical trials: Brain Injury
Traumatic Brain Injury
Using the Xbox Kinect for Chronic TBI
This study will evaluate the potential for improving balance for a single individual with a history of traumatic brain injury (TBI). The participant will engage in supervised therapy using commercial games on the Xbox Kinect.
- Trial name
- NCT02889289
- Testing
- Xbox One Kinect Gaming
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Mild Traumatic Brain Injury, Chronic Pain
Neuromodulation and Yoga for Mild Traumatic Brain Injury and Chronic Pain
The objectives of this VA SPiRE application are to develop a combined neuromodulation and yoga (iTBS+yoga) intervention for Veterans with mild traumatic brain injury (mTBI) and chronic pain, assess the intervention's feasibility…
- Trial name
- NCT04517604
- Testing
- Magventure MagProx100 with MagOption
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Arm Spasticity
Comparing Lower-concentration Dysport Treatment Targeted to the Neuromuscular Junction With Current Clinical Practice
The aim of the study was to compare Dysport treatment results (as assessed by Modified Ashworth Scale (MAS) in the elbow joint 4 weeks post treatment) following two treatment techniques: the current clinical practice injection…
- Trial name
- NMJ (NCT01682148)
- Testing
- Botulinum toxin type A
- Where
- 23 sites in Denmark, Finland and 2 more
- Volunteers
- 100 people
- Sponsor
- Ipsen
Persian Gulf Syndrome
Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)
The purpose of this study is to perform a randomized double-blind, placebo-controlled, 12 week study of the effects of carnosine on cognitive, psychometric, autonomic, and muscle strength outcomes in 100 GWI subjects.
- Trial name
- NCT00810368
- Testing
- Carnosine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Georgetown University
Nasopharyngeal Carcinoma, Adverse Effect of Radiation Therapy
Effect of Bevacizumab on Radiation-induced Brain Necrosis in Patients With Nasopharyngeal Carcinoma
Bevacizumab may have a better effect on brain necrosis caused by radiotherapy.This randomized trial aims to investigate whether bevacizumab may alleviate radiation-induced brain necrosis in patients with nasopharyngeal carcinoma.
- Conditions
- Nasopharyngeal Carcinoma, Adverse Effect of Radiation Therapy, Brain Necrosis
- Trial name
- BRAIN (NCT01621880)
- Testing
- bevacizumab, Corticosteroid
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sialorrhea
Open-Label and Single-Arm Study of MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adults
Multicenter, open-label, outpatient study of the safety and effectiveness of repeated doses of MYOBLOC over a 1-year duration in adult subjects with troublesome sialorrhea.
- Trial name
- OPTIMYST (NCT02610868)
- Testing
- MYOBLOC
- Where
- 35 sites in United States, Belarus and 1 more
- Volunteers
- 187 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of US WorldMeds, LLC
Concussion, Brain, Traumatic Brain Injury
Ghrelin (OXE--103) for Acute Concussion Management
Concussions are the leading form of mild traumatic brain injury. Management of concussions and mild traumatic brain injury is a high priority medical focus, social concern, and research topic.
- Trial name
- NCT04558346
- Testing
- Ghrelin (OXE-103)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Michael Rippee
Brain Injuries, Traumatic
Neuroactive Steroids and Traumatic Brain Injury (TBI) in OEF/OIF Veterans
Purpose: Mild traumatic brain injury (TBI) is extremely common among Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era Veterans.
- Trial name
- NCT01336413
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- VA Office of Research and Development
Alcohol Drinking, Alcohol Use Disorder
Effect of Theta Burst Stimulation on Alcohol Cue Reactivity
Alcohol Use Disorder (AUD) is prevalent, devastating, and difficult to treat. The intransigence of AUD is readily apparent in the Trauma Unit of Wake Forest University Baptist Hospital, wherein 23% of trauma related admissions…
- Conditions
- Alcohol Drinking, Alcohol Use Disorder, Trauma Injury, Alcohol Dependence
- Trial name
- NCT04223154
- Testing
- Real iTBS to the dlPFC
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
Spastic Cerebral Palsy
Extended-release Epidural Morphine for Acute Post-operative Analgesia Following Selective Dorsal Rhizotomy in Children
The purpose of this proposal is to improve the investigators' current Selective Dorsal Rhizotomy (SDR) analgesia protocol by eliminating or minimizing the use of fentanyl in the post-operative period.
- Trial name
- NCT00955877
- Testing
- Extended-release Epidural morphine (EREM) 80, Extended-release Epidural Morphine (EREM) 120, Control: Saline
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine
Traumatic Brain Injury, Posttraumatic Stress Disorder
Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD
The primary objective of this study is to evaluate the efficacy of Cognitively Augmented Behavioral Activation (CABA), a new hybrid treatment for Veterans diagnosed with comorbid mild Traumatic Brain Injury (mTBI) and…
- Trial name
- CABA (NCT02391402)
- Testing
- Cognitively Augmented Behavioral Activation, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Cerebral Palsy, Hemiplegic Cerebral Palsy
Dynamic Gait Index in Hemiplegic Cerebral Palsy
The purpose of this study is to assess validity and reliability of Dynamic Gait Index (DGI) in patients with unilateral spastic cerebral palsy
- Conditions
- Cerebral Palsy, Hemiplegic Cerebral Palsy, Gait Disorders, Neurologic
- Trial name
- NCT03662139
- Testing
- Dynamic Gait Index
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Marmara University
Acquired Brain Injury
Effects of Combined Spinal Direct Current Stimulation on Upper Limb Recovery in Acquired Brain Injury
This study will compare different polarities of transcutaneous spinal direct current stimulation combined with robotic-assisted arm training (RAT) in adults with acquired brain injury (ABI).
- Trial name
- NCT03100370
- Testing
- tsDCS-Anodal Stimulation, tsDCS-Cathodal Stimulation, Robotic-assisted training of arm and hand functions
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pain
A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)
The purpose of this study is to see if changing from one pain medication like morphine or oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients.
- Trial name
- NCT00580294
- Testing
- Oxymorphone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Concussion
Does Oral Micronized Progesterone Shorten Time of Symptoms From Concussion
Concussions are a common injury among athletes in the United States. The annual incidence of sports and recreational related traumatic brain injuries in the United States is 1.6 to 3.8 million, and the likelihood of an athlete in…
- Trial name
- NCT01809639
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Stiff Knee Gait, Brain Injuries
Efficacy of Botulinum Toxin Injections in the Rectus Femoris to Treat Stiff Knee Gait Following Acquired Brain Injury
Stiff knee gait is a common gait dysfunction following acquired brain injury. This gait deviation is characterized by reduced knee flexion during swing phase of the gait cycle and adversely impacts safe foot clearance.
- Trial name
- NCT00900666
- Testing
- botulinum toxin A (BTX-A)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mary Free Bed Rehabilitation Hospital