Clinical trials: Brain Insulin Sensitivity
Obesity
Effect of Bariatric Surgery on Brain Insulin Sensitivity
Adiposity is associated with prediabetes and type 2 diabetes. In very severe cases of adiposity in combination with type 2 diabetes, bariatric surgery has proven to be a successful therapy option.
- Trial name
- NCT03705923
- Testing
- Bariatric surgery
- Where
- Germany
- Volunteers
- 3 people
- Sponsor
- University Hospital Tuebingen
Insulin Resistance, Transcranial Direct Current Stimulation
Improving Insulin Sensitivity by Non-invasive Brain Stimulation
Efforts in curing and preventing obesity and type 2 diabetes (T2D) have been elusive thus far. One reason for that is the lack of understanding of the role of the brain in the development and treatment of the disease.
- Conditions
- Insulin Resistance, Transcranial Direct Current Stimulation, Obesity, Diabetes
- Trial name
- NCT04420650
- Testing
- transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Impairment of Oral Perception, Insulin Resistance
The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults
The purpose of this study is to investigate the effects of dietary exposure to artificial sweeteners on taste sensitivity, preference and brain response in adults.
- Trial name
- AFS-adult (NCT02335021)
- Testing
- Sucralose, Sucrose, Sucralose + maltodextrin
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Yale University
Acromegaly, Excessive Growth Hormone Secretion
Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment
The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.
- Conditions
- Acromegaly, Excessive Growth Hormone Secretion, Insulin Resistance
- Trial name
- NCT00647179
- Testing
- Transsphenoidal adenomectomy
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Brain Vascular Function, Cerebral Blood Flow
Mixed Nuts and Brain Vascular Function
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is also associated with cognitive decline.
- Trial name
- NCT04210869
- Testing
- Mixed Nuts
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Human Physiology of Energy Homeostasis
Insulin Sensitivity of the Brain in Pathogenesis of Diabetes Mellitus Type 2
The purpose of the study is to investigate whether insulin sensitivity of the human brain correlates with insulin sensitivity of the liver.
- Trial name
- NCT00638209
- Testing
- Human insulin, Saline
- Where
- 2 sites in Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
PreDiabetes, Body Weight
Effect of Empagliflozin Versus Placebo on Brain Insulin Sensitivity in Patients With Prediabetes
Recently, various sodium glucose cotransporter 2 (SGLT2) inhibitors have been approved for the treatment of type 2 diabetes mellitus. Empagliflozin is a preparation of this class of substances.
- Trial name
- NCT03227484
- Testing
- Empagliflozin 25mg
- Where
- Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Cerebral Infarction
Physical Activity After Stroke: How Does it Effect Chronical Inflammation and Insulin Sensitivity
Decreased insulin sensitivity is and independent risk factor for stroke despite glycemic control. It is known that physical exercise increases insulin sensitivity in healthy subjects.
- Trial name
- NCT00376207
- Testing
- Physical exercise
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Bispebjerg Hospital
Growth Hormone Deficiency
The Effects of TZD on Fat Metabolism and Insulin Sensitivity in GH-Replaced GHD Patients
In the present double blind, placebo-controlled, parallel study we evaluated the impact of 12 weeks thiazolidinedione (TZD) administration on basal and insulin-stimulated substrate metabolism in growth hormone-replaced adults…
- Trial name
- NCT00459940
- Testing
- Pioglitazone
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Obesity, Diabetes Mellitus, Type 2
Effect of High Caloric Diet on Brain Insulin Sensitivity and Inflammation
Obesity if known to be associated with brain insulin resistance in humans and evidence is rapidly accumulating that brain insulin resistance influences peripheral metabolism, eating behavior and cognition.
- Trial name
- NCT03590561
- Testing
- High caloric diet
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Mild Cognitive Impairment
Intervention to Reduce Sedentary Time
The purpose of this study is to determine whether the researchers can help people change the amount of time they spend in sitting activities and whether this change might improve health outcomes.
- Trial name
- ReST-MCI (NCT02878486)
- Testing
- Jawbone Up, Physical Activity Education, ActivPAL
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Kansas Medical Center
Insulin Resistance, Obesity
Effects of Age and Obesity on Brain Insulin Sensitivity
Obesity and especially type 2 diabetes (T2D) increases the risk of neurocognitive dysfunctions including adverse effects on brain structure and function.
- Trial name
- Aging (NCT04372849)
- Testing
- Human nasal insulin
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Brain Insulin Sensitivity, Brain Vascular Function
Effects of Ketone Monoesters on Brain Function
Disturbances in brain insulin-sensitivity are not only observed in obesity and type 2 diabetes (T2D), but also during brain aging and in dementia.
- Conditions
- Brain Insulin Sensitivity, Brain Vascular Function, Cerebral Blood Flow, Cognitive Performance
- Trial name
- NCT06395051
- Testing
- Ketone Monoester
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hyperprolactinemia, Insulin Resistance
Substrate Metabolism and Insulin Sensitivity in Patients With Hyperprolactinemia Before and After Treatment
The purpose of this study is to investigate the effects of chronic elevated levels of Prolactin on metabolism and insulin sensitivity by studying patients with hyperprolactinemia before and after treatment.
- Trial name
- NCT00699530
- Testing
- Cabergoline
- Where
- Denmark
- Sponsor
- University of Aarhus
Brain Vascular Function, Cognition
Aronia and Cognitive Fitness
Previously, beneficial effects of Aronia Melanocarpa extract (AME) supplementation on cognitive performance has been observed in healthy middle-aged adults. However, underlying mechanisms have not yet been addressed.
- Trial name
- NCT05268133
- Testing
- Aronia, Control
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Nitrate, Brain Insulin-sensitivity
Nitrate and Brain Insulin-Sensitivity
Disturbances in brain insulin-sensitivity are not only observed in abdominal obesity and type 2 diabetes mellitus (T2D), but also during brain aging and in dementia.
- Conditions
- Nitrate, Brain Insulin-sensitivity, Vascular Function
- Trial name
- NO-BRAINS (NCT04700241)
- Testing
- Potassium nitrate
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Ectopic Lipids, Insulin Sensitivity
The Effect of Dietary Fat Load and Physical Exercise on the Flexibility and Partitioning of Ectopic Lipids.
This study aims at assessing the effect of standardized dietary fat load and short-term aerobic exercise on systemic lipolysis, flexibility and partitioning of ectopic fat stores (intramyocellular = IMCL, intrahepatocellular =…
- Conditions
- Ectopic Lipids, Insulin Sensitivity, Aerobic Exercise, Fat Load
- Trial name
- NCT01467193
- Testing
- Fat diet, 2h standardized aerobic exercise
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Glucose Metabolism Disorders
Relative Contribution of Brain Insulin Action for Postprandial Metabolism
The goal of this clinical trial is to clarify (i) the contribution of brain insulin action on regulation of systemic metabolism, (ii) sex-specific differences in the central regulation and (iii) the influence of the menstrual…
- Trial name
- BrainInsPPM (NCT06295640)
- Testing
- Oral glucose tolerance test with double-tracer dilution and intranasal insulin spray
- Where
- Germany
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Diabetes
Metabolic Effects of GH and IGF-I in Growth Hormone Deficient(GHD) and Diabetes and Impaired Glucose Tolerance(IGT)
The aim of this study is to measure effects of the combined treatment with GH and IGF-I on glucose sensitivity and body composition in patients with GHD and IGT or diabetes.
- Trial name
- NCT01020955
- Testing
- NutropinAq (GH) and Increlex (IGF-I)
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Karolinska University Hospital
Growth Hormone Deficiency
Evalutation of Insulin Sensitivity Through Hyperinsulinemic Clamp in Children With GH Deficiency
Data about the impact of growth hormone treatment on insulin sensitivity in children are quite controversial, due to the different surrogate indexes that have been used, like Homa-IR, QUICKI, ISI-Matsuda or adipokine levels.
- Trial name
- clamp-GHD (NCT03525171)
- Testing
- euglycemic hyperinsulinemic clamp
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- University of Palermo