Clinical trials: Brain Lesions
Drug Resistant Epilepsy, Epilepsy
MRgFUS for Childhood Epilepsy
The goal of this observational study is to learn if magnetic resonance imaging guided focused ultrasound (MRgFUS) can treat brain lesions causing epilepsy in children with drug resistant epilepsy.
- Trial name
- NCT07497178
- Testing
- Ablation
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Adult Intracranial Neoplasm, Vascular: Intracranial
Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions
The purpose of this study is to evaluate the effectiveness of using Fluorescein Sodium and the Yellow 560 microscope to aid in treatment of intracranial tumors and vascular lesions.
- Trial name
- Fluorescein (NCT02028325)
- Testing
- Fluorescein Sodium
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Indiana University
Brain Neoplasms
Magnevist (SH L 451A) Intra-individual Dose Comparison Study in Patients With Brain Metastasis
To verify the number of metastatic brain tumors detected in contrast-enhanced MRI, which is the primary variable, increases after an additional dose of Magnevist (SH L 451A) comparing images after an initial dose (0.1 mmol/kg)…
- Trial name
- NCT00681551
- Testing
- Magnevist (SH L 451A)
- Where
- 9 sites in Japan
- Volunteers
- 45 people
- Sponsor
- Bayer
Carotid Artery Stenosis
Prospective Trial of IVL for Calcified Carotid Lesions(CREATE Trial)(Extended Follow-Up)
Purpose: To assess the long-term safety and efficacy of the intravascular lithotripsy system for pre-treatment of calcified carotid artery stenosis.
- Trial name
- NCT06936189
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
Patient With Atrial Fibrillation or High Stroke Risk
Continuous EKG Monitoring Using S-Patch Ex : Prospective Observational Study (S-patch Registry)
Atrial fibrillation (AF) is associated with increased mortality and morbidity, and is a dominant, yet preventable, cause of cardioembolic stroke, which has more severe outcomes than other ischaemic stroke causes if left…
- Trial name
- NCT05119725
- Testing
- continous 3 day EKG monitoring with S-Patch Cardio
- Where
- South Korea
- Volunteers
- 2,450 people
- Sponsor
- Yonsei University
Neuroepithelial Cyst
Assessment of the Efficacy of Stereotactic Intracavitary Instillation of 90Yttrium Colloid
Neuroepithelial cysts are rare, representing less than 1% of the intracranial cysts. Neuroepithelial cysts, are benign and mostly asymptomatic. These cysts are lined by thin columnar or low cuboidal epithelium.
- Trial name
- NCT04758104
- Testing
- Yttrium90
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- David Clarke
Tuberous Sclerosis Complex, Aspirin
Aspirin as an add-on Treatment of Refractory Epilepsy in Tuberous Sclerosis Complex
There had been much evidence in aspirin controlling tumorous conditions conducted by basic researches, especially through mammilian target of rapamycin (mTOR) pathway.
- Conditions
- Tuberous Sclerosis Complex, Aspirin, Epilepsy, Cognitive Decline
- Trial name
- NCT03356769
- Testing
- Aspirin, AED
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Peking Union Medical College Hospital
Traumatic Brain Injury, Intracranial Injury
Usefulness of Biomarkers in the Management of Mild Traumatic Brain Injury in Adults (Biotraumap)
The indication of cranial computed tomography (CCT) is difficult to define for patients with mild traumatic brain injury (mTBI).
- Trial name
- Biotraumap (NCT04543162)
- Where
- France
- Volunteers
- 1,025 people
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy Cognition
T-mult: Exploring the Impact of TMS Induced Virtual Lesions on the Multimodal Brain Network and Cognition
T-mult is an experimental study using low-frequency (1Hz) single-sesson rTMS to the DLPFC (versus sham rTMS) to explore the effect of virtual lesions on the brain network and cognition in 100 healthy adults (20-65 years old).
- Trial name
- NCT05542641
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- Netherlands
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Migraine Disorders
An Open-Label Study to Evaluate the Safety of NP101 in the Treatment of Acute Migraine Over 12 Months
The primary objective is to evaluate the safety of long-term treatment with NP101 as assessed by: Subject self-examination skin irritation scores Adverse events Changes in vital signs and ECG parameters The secondary objective is…
- Trial name
- NP101-008 (NCT00792103)
- Testing
- NP101
- Where
- 34 sites in United States
- Volunteers
- 198 people
- Sponsor
- NuPathe Inc.
Demyelinating Disorders, Multiple Sclerosis
Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event.
The participant will receive weekly intramuscular treatment with AVONEX® (interferon beta 1-a) and a one-time high dose intravenous methotrexate with Leucovorin rescue, along with the standard solumedrol treatment before…
- Conditions
- Demyelinating Disorders, Multiple Sclerosis, Optic Neuritis, Myelitis
- Trial name
- NCT00037115
- Testing
- interferon beta 1a, methotrexate, methylprednisolone
- Where
- United States
- Sponsor
- MidAmerica Neuroscience Research Foundation at Rowe Neurology Institute
Traumatic Brain Injury, Cognitive Impairment
Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI
Difficulties with intellectual functioning, particularly memory functions, are common and source of long-term disability after Traumatic Brain Injury (TBI).
- Trial name
- RIVET (NCT01670526)
- Testing
- Rivastigmine Transdermal Patch
- Where
- 8 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Patients Who Are Diagnosed to Have Intracranial Lesions
Ultrasonography Guided Brain Lesions Resection:
1. Evaluate the clinical value of intraoperative ultrasonography as a real-time guidance 2. Combination of data of MRI Tractography and intra operative ultrasonography will be useful in good localization of lesions or not . 3.
- Trial name
- NCT04569526
- Testing
- use of intraoperative ultrasound
- Volunteers
- 1 people
- Sponsor
- Assiut University
Amblyopia, Amblyopia Unilateral
Valproate for the Treatment of Residual Amblyopia
The goal of this clinical trial is to determine the efficacy of valproate as an adjunct therapy to treat amblyopia beyond the critical period in children aged 8-17 years who have amblyopia of ≥3 lines of interocular…
- Conditions
- Amblyopia, Amblyopia Unilateral, Amblyopia, Anisometropic, Amblyopia Strabismic
- Trial name
- VARA (NCT07226141)
- Testing
- Valproate, Patch
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Boston Children's Hospital
Visuomotor Skills, Brain Lesion (General)
Closed-loop rTMS-EEG During Visuomotor Integration.
This pilot study aims at establishing personalized state-based rTMS for precision neurorehabilitation, we designed a within-subject cross-over study to test closed-loop repetitive transcranial magnetic stimulation and…
- Trial name
- SYNC (NCT07249801)
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Brain Tumor
Pharmacokinetic and -Dynamic of Propofol During Awake Craniotomy
Certain kind of neurosurgical procedures require intraoperative alertness of the patient, for example to perform speech tests during brain tumor resection.
- Trial name
- NCT01128465
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bonn
Severe Traumatic Brain Injury
Identification of Predictive Neuroinflammatory Biomarkers of Neuro-radiological Evolution in Severe Traumatic Brain Injury
Tertiary lesions responsible of the neurological decline after severe traumatic brain injury (TBI) are partially due to a persistent neuro-inflammation directly modulated by inflammatory mediators during the acute phase and…
- Trial name
- ICON-TBI (NCT03659006)
- Testing
- Biological Collection
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intracranial Hypotension
The Blood Patch in the Management of Intracranial Hypotension
Intracranial hypotension results from leakage and/or hypotension of cerebrospinal fluid. It can be spontaneous or secondary to a dural puncture complicating perimedullary anesthesia or a lumbar puncture.
- Trial name
- BPIH (NCT06498804)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Cerebral Small Vessel Diseases, Retinopathy
Cognitive Impairment, Retinopathy, and Cerebrovascular Lesions in the Elderly
The CIRCLE study is a single-center prospective observational study that enrolled individuals with cerebral small vessel disease (SVD), while free of known dementia or stroke (both cerebral infarction and hemorrhage).
- Conditions
- Cerebral Small Vessel Diseases, Retinopathy, Cognitive Dysfunction
- Trial name
- CIRCLE (NCT03542734)
- Testing
- multimodal magnetic resonance imaging
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracranial Pressure
Wideband Tympanometry for Monitoring Intracranial Pressure in Adult Patients in Intensive Care, Operated on for an Intracranial Lesion After Traumatic Brain Injury, or With Intracranial Hemorrhage
Intracranial pressure is usually measured by invasive methods requiring an intracranial sensor. There is no non-invasive monitoring method recognized as a gold standard.
- Trial name
- TYMPIC (NCT04849221)
- Testing
- Tympanometry measurement in both ears, Collection of clinical and paraclinical data, Intracranial pressure reading (ICP)
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon