Clinical trials: Brain Lesions
Stroke
Feasibility of Using Prism Adaptation to Treat Spatial Neglect and Motor Function in Stroke
This research project is a study designed to address both motor and cognitive changes after stroke. Treatment for SN is elusive however there is support for prism adaptation treatment (PAT).
- Trial name
- NCT02419222
- Testing
- Prism Adaptation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Alzheimer's Disease
A Phase IV Study to Evaluate Safety, Tolerability and Effectiveness of Rivastigmine Patch 15cm2 in Patients With Severe Dementia of the Alzheimer's Type.
This was a multicenter, prospective, phase IV study evaluating safety, tolerability and effectiveness of rivastigmine 27 mg -15 cm^2 transdermal patch prescribed in patients with severe dementia of the Alzheimer's type as per…
- Trial name
- NCT02989402
- Testing
- Rivastigmine
- Where
- 9 sites in India
- Volunteers
- 100 people
- Sponsor
- Novartis Pharmaceuticals
Vascular Cognitive Impairment, White Matter Lesions
Mechanism of Gamma Oscillation Synchronization in the Prefrontal-hippocampal Circuit for Memory Dysfunction in Patients With White Matter Lesions of Cerebral Small Vessel Disease
The mechanism underlying memory impairment caused by white matter lesions of cerebral small vessel disease is still unclear. The disrupted synchronization of gamma oscillations in the prefrontal-hippocampal circuit is a potential…
- Conditions
- Vascular Cognitive Impairment, White Matter Lesions, Gamma Oscillation
- Trial name
- NCT07042633
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Cerebellar Disorders, Cerebellar Degeneration
Variable Intense Training for Ataxia and Locomotion
The goal of this study is to evaluate the feasibility and potential preliminary efficiency of high-intensity training focused on stepping in variable contexts as compared to conventional training in individuals with cerebellar…
- Conditions
- Cerebellar Disorders, Cerebellar Degeneration, Cerebellar Atrophy, Cerebellar Lesions
- Trial name
- VITAL (NCT07621978)
- Testing
- High-intensity training in variable contexts, Conventional balance training
- Volunteers
- 20 people
- Sponsor
- Indiana University
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Brain Lesion, Stereotactic Biopsy
General Anesthesia vs. Local Anesthesia in Stereotaxy
Examination of stress level in general anesthesia in comparison to local anesthesia in stereotactic biopsy
- Trial name
- GALAXY (NCT01515852)
- Testing
- general anesthesia in stereotactic biopsy, local anesthesia in stereotactic biopsy
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Spontaneous Intracranial Hypotension
Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension
Spontaneous intracranial hypotension (SIH) is a condition characterized by refractory orthostatic headache, mostly due to leaks of cerebrospinal fluid (CSF).
- Trial name
- NCT07602556
- Testing
- PRP Patch group, Whole Blood Patch Group
- Volunteers
- 218 people
- Sponsor
- Beijing Tiantan Hospital
Meningioma, Tumor, Brain
MiDura-Study (Neuro-Patch in Duraplasty)
The aim of this study is to collect systematically and proactively data regarding the performance of Neuro-Patch, like complications and handling, under daily clinical practice when used as intended by the manufacturer
- Conditions
- Meningioma, Tumor, Brain, Chiari Malformation, Vascular Malformation
- Trial name
- MiDura (NCT04189172)
- Where
- 4 sites in France, Germany
- Volunteers
- 328 people
- Sponsor
- Aesculap AG
Anosognosia, Neglect, Hemispatial
Lesion Site and Neglect Anosognosia in Patients With Left Hemispatial Neglect
The goal of this retrospective is to investigate the relationship between lesion site and neglect anosognosia in subacute or chronic right hemispheric stroke patients with left hemispatial neglect.
- Conditions
- Anosognosia, Neglect, Hemispatial, Stroke, Neurobehavioral Problems
- Trial name
- NCT05654350
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Gazi University
Brain-injured Patients on Extracorporeal Life Support
Multimodal Assessment of the Neurological Prognosis of Patients With Brain Lesions on ExtraCorporeal Life Support
It seems of the greatest importance to evaluate the neurological prognosis of patients with brain lesions after cardiorespiratory arrest or circulatory failure requiring circulatory assistance.
- Trial name
- NeuroECMO (NCT03633981)
- Testing
- clinical examinations, neurological assessment when a neurological event occurs, mortality assessment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cerebral Lesion
Questionnaire for the Evaluation of Anger, Hostility and Aggression After Acquired Brain Injury.
The incidence of aggression and violent behavior is usually reported to be high after acquired brain injury, around 54%. Behaviors with verbal agression and, less frequently, physical agressions, are described.
- Trial name
- NCT04034875
- Testing
- Questionnaire
- Where
- 3 sites in Belgium, France
- Volunteers
- 50 people
- Sponsor
- Brugmann University Hospital
Intracerebral Haemorrhage
Ischaemic Lesions in Acute Intracerebral Haemorrhage
The aim of this observational study is to determine how and why inadequate brain blood flow occurs after bleeding in patients with intracerebral haemorrhage (ICH).
- Trial name
- CHALLENGE-ICH (NCT06410274)
- Testing
- Transcranial Doppler ultrasonography (TCD)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Leicester
Silent Stroke, Silent Cerebral Infarct
Incidence of Silent Atrial Fibrillation in Patients With Clinically Silent Brain Ischemic Lesions
Arterial Fibrillation (AF) is well-recognized as a cause for cryptogenic Acute Ischemic Stroke (AIS) and is associated with Silent Brain Infarction (SBI).
- Conditions
- Silent Stroke, Silent Cerebral Infarct, Fibrillation
- Trial name
- SILENT2 (NCT04449523)
- Where
- 8 sites in Austria, Germany and 1 more
- Volunteers
- 150 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Demyelinating Diseases, Demyelination; Corpus Callosum
Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a Myelin Repair Therapy
The clinical trial is intended to assess for clinical evidence of Clemastine Fumarate as a myelin repair therapy in patients with acute inflammatory injury-causing demyelination as measured by multi-parametric MRI assessments.
- Conditions
- Demyelinating Diseases, Demyelination; Corpus Callosum, Multiple Sclerosis Brain Lesion, Multiple Sclerosis Acute and Progressive
- Trial name
- ReINFORCE (NCT06065670)
- Testing
- Clemastine Fumarate
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Punctate White Matter Lesions, Neurodevelopmental Outcomes
MRI-Based Neurodevelopmental Risk Stratification in Infants With White Matter Injury
The goal of this observational study is to develop and evaluate an MRI-based assessment system for predicting neurodevelopmental outcomes in infants with punctate white matter lesions (PWML).
- Conditions
- Punctate White Matter Lesions, Neurodevelopmental Outcomes, Preterm Infants
- Trial name
- NCT07860749
- Where
- 10 sites in China
- Volunteers
- 260 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Multiple Sclerosis (MS), Cerebral Small Vessel Diseases
MRI-Based Lesion Differentiation in Older Patients With Multiple Sclerosis
This study investigates whether an advanced MRI technique called Quantitative Susceptibility Mapping (QSM) can improve the differentiation of white matter lesions in people aged 50-70 years with multiple sclerosis (MS).
- Trial name
- NCT07444047
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Oslo University Hospital
Postdural Puncture Headache
Therapeutic Epidural Patch Versus Pain Block in the Midface for Headache
The purpose of this study is to compare a pain block in the midface, versus the traditional, more invasive, therapeutic epidural patch for the treatment of headaches
- Trial name
- NCT03112720
- Testing
- Epidural Blood Patch, Sphenopalatine Ganglion Block
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Stroke, Acute
ERILs Und SNILs Unter SOC
1. How many ERILs occur in caucasian patients with LAA stroke during 7 days on standard treatment? 2. How many SNILs occur between 7 and 30 days after acute ischemic event on standard treatment? 3.
- Trial name
- NCT05786170
- Testing
- diffusion-weighted magnetic resonance imaging
- Sponsor
- Medical University of Vienna
Cerebral Palsy
Whole Body Vibration in Rehabilitation of Spastic Cerebral Palsy
Spasticity is one of the most common features in children with cerebral palsy (CP) and is evident in the majority of CP types such as hemiplegia, diplegia, quadriplegia, etc.
- Trial name
- WBV (NCT06077136)
- Testing
- whole body vibration, standard physical therapy
- Where
- Saudi Arabia
- Volunteers
- 56 people
- Sponsor
- University of Hail
Multiple Sclerosis
Ultra-high-field Brain MRI in Multiple Sclerosis
The MRI scan is one of the most important tools for diagnosing multiple sclerosis (MS) and for monitoring disease progression and medication effects.
- Trial name
- ULTIMS (NCT05718947)
- Testing
- Brain MRI (3T, 7T, 9.4T)
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Zuyderland Medisch Centrum