Clinical trials: Brain MRI
Vertebrobasilar Dolichoectasia
Vertebrobasilar Dolichoectasia Treatment With Sirolimus
The aim of this pilot trial is to assess the efficacy of sirolimus in reducing wall enhancement in vertebrobasilar dolichoectasia(VBD) on 5 T high-resolution magnetic resonance vessel wall imaging(HR-VWI) via anti-inflammatory…
- Trial name
- NCT07634120
- Testing
- Sirolimus
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Huashan Hospital
Ulcerative Colitis, Irritable Bowel Syndrome
Cerebral Resonance Magnetic Imaging During Rectal Distention
Irritable bowel syndrome is responsible for chronic abdominal pain, diarrhea and/or constipation. It is a very frequent problem. However, the exact cause of irritable bowel syndrome remains unknown.
- Trial name
- NCT00213330
- Testing
- rectal distension
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Cerebral Palsy, Lower Urinary Tract Symptoms
Incontinence and MRI Results in Children with Cerebral Palsy
More than 50 % of children and adults with cerebral palsy experience lower urinary tract symptoms (LUTS). This can negatively influence quality of life of the child and the total social environment.
- Trial name
- NCT05060211
- Testing
- Vancouver symptom score for dysfunctional elimination syndroms, Magnetic resonance imaging
- Where
- Belgium
- Volunteers
- 125 people
- Sponsor
- University Hospital, Ghent
Gliomas, Malignant, Metastases to Brain
Intraoperative Sonographically Versus Fluorescence-guided Resection of Contrast-enhancing Gliomas and Brain Metastases
Objective of the study is to determine whether intraoperative ultrasound guided resection of gliomas with contrast enhancement in magnetic resonance imaging and brain metastases can achieve as high rate of gross total resection…
- Trial name
- SONOFLUO (NCT05475522)
- Testing
- Ultrasound guided brain tumor resection, 5-aminolevulinic acid fluorescence-guided brain tumor resection
- Where
- Russia
- Volunteers
- 134 people
- Sponsor
- Sklifosovsky Institute of Emergency Care
Parkinson Disease, Depressive Symptoms
Low Voltage Electrical Stimulation for Depression in Parkinson's Patients
The goal of this clinical trial is to determine the relative efficacy of fMRI model guided Transcranial Direct Current Stimulation (mgTDCS) in improving the depressive symptoms of patients with Parkinson's Disease (PD).
- Trial name
- LVESDIPP (NCT06467695)
- Testing
- BIOPAC Stimsola
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Alabama
Motor Neuropathy
Stroke Recovery Research Based on EEG-fMRI
This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.
- Trial name
- EEG-fMRI (NCT05427422)
- Testing
- MRI recording, EEG recording
- Where
- China
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Bipolar I Disorder, Schizoaffective Disorder
Open Label Extension Study of NCT06221852
This is a 12-week open-label extension study for participants completing study NCT06221852.
- Conditions
- Bipolar I Disorder, Schizoaffective Disorder, Psychosis
- Trial name
- NCT06558201
- Testing
- Ketogenic diet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mclean Hospital
Painful Diabetic Neuropathy
Functional Magnetic Resonance Imaging of Brain Activity in Patients With Painful Diabetic Neuropathy
Patients with painful diabetic neuropathy (PDN) often combine with anxiety and depression. However, the pathogenesis of PDN is unclear, especially the mechanism associated with central nervous system.
- Trial name
- NCT03700502
- Testing
- resting-state functional Magnetic Resonance Imaging
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
fMRI Research
Brain Activity During Bladder Filling: Pilot Study of an fMRI Protocol
Urinary incontinence is the most frequently observed lower urinary tract symptom (LUTS) in children with cerebral palsy (CP) (Samijn et al., 2016).
- Trial name
- NCT05255692
- Testing
- invasive urodynamic evaluation, functional magnetic resonance imaging during bladder filling
- Where
- Belgium
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Autism
Therapeutic Intervention Effects of rTMS on Children With Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a common and complex neurodevelopmental disorder, which is characterized by impairments of social communication, social reciprocity, as well as restricted and repetitive behaviors (RRB).
- Trial name
- NCT05140356
- Testing
- Applied high amplitude repeated transcranial magnetic stimulation, Applied low amplitude repeated transcranial magnetic stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- University of Electronic Science and Technology of China
Parkinson Disease, Dystonia
Spine MRI in Patients With Deep Brain Stimulation (DBS)
Magnetic resonance imaging (MRI) of patients implanted with deep brain stimulation (DBS) is under strict safety guidelines. Depending on the body part being imaged, the safety may vary.
- Conditions
- Parkinson Disease, Dystonia, Depression, Spinal Stenosis
- Trial name
- NCT03753945
- Testing
- MRI of the spine
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University Health Network, Toronto
Stroke
Extending the Time for Thrombolysis in Emergency Neurological Deficits
The primary hypothesis being tested in this trial is that ischaemic stroke patients selected with significant penumbral mismatch (measured by MRI criteria) at 3 - 9 hours post onset of stroke will have improved clinical outcomes…
- Trial name
- EXTEND (NCT00887328)
- Testing
- Tissue Plasminogen Activator (Alteplase)
- Where
- 22 sites in Australia, Finland and 1 more
- Volunteers
- 180 people
- Sponsor
- Neuroscience Trials Australia
Anorexia Nervosa
Impact of Fatty Stimuli on Cerebral Activity in Anorexia Nervosa: a Multi-sensory Approach
Lipid restriction is significant in anorexia nervosa and limits therapeutic management. The multisensory perception of fat is altered, creating an aversion to lipids.
- Trial name
- ANOVERSION (NCT07344831)
- Testing
- MRI examination, Smell and taste capacity testings
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Disruptive Mood Dysregulation Disorder, Attention Deficit Hyperactivity Disorder
Characterization and Brain Mechanisms of Frustration in Youth With Severe Irritability or Attention Deficit Hyperactivity Disorder (ADHD)
Background: Irritability is an elevated proneness to anger. Children with irritability have difficulty tolerating frustration. They get angry and have temper outbursts more easily than their others their age.
- Conditions
- Disruptive Mood Dysregulation Disorder, Attention Deficit Hyperactivity Disorder, Normal Physiology
- Trial name
- NCT05357495
- Testing
- Affective Posner fMRI frustration induction task
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Parkinsons Disease (PD)
Neuroimaging of Parkinson's
Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network…
- Trial name
- NCT07024875
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Disorder of Consciousness, Vegetative State
Cerebellar iTBS in Patients With Disorders of Consciousness
Previous studies showed the excitatory effect of cerebellar transcranial magnetic stimulation(TMS) on motor cortex.Investigator evaluate the effects of bilateral cerebellar TMS on Coma Recovery Scale-Revised (CRS-R) scores in…
- Conditions
- Disorder of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- CTPDOC (NCT05558930)
- Testing
- iTBS stimulation
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Xijing Hospital
High Grade Glioma
Tumor DNA and MRI/CT Scan Findings in Patients With Grade III or Grade IV Malignant Glioma
RATIONALE: Studying levels of tumor DNA in the samples of blood from patients with cancer may help doctors find out whether the cancer has grown and how much.
- Trial name
- NCT00897611
- Testing
- DNA methylation analysis, polymerase chain reaction, computed tomography
- Volunteers
- 42 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Eating Disorders, Anorexia Nervosa
Appetite-Related Brain Activity in Women With Anorexia Nervosa
This study will use functional magnetic resonance imaging to compare appetite-related brain activity in women with anorexia nervosa before and after receiving treatment for the disorder.
- Trial name
- NCT00344656
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Parkinson Disease
Brain Bioenergetics in Parkinson's Disease and Response to Repeated Oral UDCA Treatment
The objective of this study is to understand the bioenergetic impairments that underlie Parkinson's disease (PD) and evaluating treatments that may improve abnormal mitochondrial function that is present in PD.
- Trial name
- NCT02967250
- Testing
- ursodeoxycholic acid
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Minnesota
Acute Stroke, MRI Imaging
Low-Field MRI in Stroke Code Patients
This study evaluates the accuracy and feasibility of a portable low-field MRI (Hyperfine) device in patients presenting to the emergency department with suspected acute stroke.
- Trial name
- LFMIS (NCT07702968)
- Testing
- Low-field MRI
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Leiden University Medical Center