Clinical trials: Brain Mapping, open to volunteers
Memory Performance, Hippocampal Activity
Towards Causal Mapping of Episodic Memory iEEG Networks Via Multi-method Brain Stimulation
Human intracranial electroencephalography (EEG) can provide brain-activity correlates of memory with high spatial and temporal resolution.
- Trial name
- NCT07378332
- Testing
- TMS electrical stimulation parameters during cognitive and memory demands, DES electrical stimulation parameters during cognitive and memory demands
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of Chicago
Cavernous Malformation, Cerebral, Cavernous Angioma
Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy
Cerebral cavernous malformation (CCM)-related epilepsy (CRE) impairs the quality of life in patients with CCM. Patients could not always achieve seizure freedom after surgical resection of the lesion, suggesting an inadequate…
- Conditions
- Cavernous Malformation, Cerebral, Cavernous Angioma, Cavernous Hemangioma, Cavernous Hemangioma of Brain
- Trial name
- CRESS (NCT04076449)
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- yuanli Zhao
Superficial Siderosis
Haemdall: Developing a Quantitative MRI Biomarker of Infratentorial Superficial Siderosis of the Central Nervous System
Haemdall: Using Medical Imaging to measure Brain Iron in Superficial Siderosis. This study is looking at a new way of using MRI scans to potentially measure the amount of iron on the surface of the brain.
- Trial name
- Haemdall (NCT07098650)
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Perspectum
Epilepsy (Treatment Refractory), Epilepsy in Children
OPM MEG in Pre-surgical Mapping for Patients With Epilepsy
Magnetoencephalography, or "MEG", is a brain-scanning method which has been available for many years. It is used in the UK and worldwide to help patients with epilepsy, who need surgery to resolve their seizures.
- Conditions
- Epilepsy (Treatment Refractory), Epilepsy in Children, Epilepsy in Youth
- Trial name
- NCT07378397
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Aston University
Epilepsy
An Examination of Cognitive and Sensorimotor Processes in Patients With Epilepsy
The overall goal of this project is to better understand the micro-physiology of human epilepsy and cognition using the intracranial electroencephalogram (iEEG), electrical brain stimulation, functional magnetic resonance imaging…
- Trial name
- NCT00859794
- Testing
- fMRI, Neuropsychological Testing, Additional electrode implantation
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Northwell Health
GBM, Glioma Glioblastoma Multiforme
WBSI Guided Personalized Delivery of TTFields
This research study is for Glioblastoma (GBM) patients who will be beginning Optune as part of their clinical care, which is a novel treatment that utilizes - tumor treating fields (TTFields), (aka, electrical therapy), which has…
- Conditions
- GBM, Glioma Glioblastoma Multiforme, Tumor, Brain
- Trial name
- NCT05086497
- Testing
- Whole Brain Spectroscopy Imaging Array Mapping Layout
- Where
- 2 sites in United States
- Volunteers
- 155 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Primary Brain Tumor, Metastatic Brain Tumor
Assessment of Eloquent Function in Brain Tumor Patients
Purpose of the study: AIM 1: Prospectively collect pre-operative [functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), magnetoencephalography (MEG)] and intra-operative mapping data in patients with…
- Trial name
- NCT01535430
- Testing
- Brain mapping
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Nebraska
Epilepsy
Study of the Intracerebral Electrophysiological Signature in the Epileptic Patient
As part of the clinical management of certain severe, drug-resistant forms of epilepsy, it is necessary to implant electrodes in the brain to identify the epileptic network prior to potential neurosurgical resection of the source…
- Trial name
- ACTELIN 2 (NCT07796984)
- Testing
- Cognitive tasks in the form of questionnaires
- Where
- France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Toulouse
Traumatic Brain Injury, Cerebrocardiac Syndrome
Neural Mechanism of Cerebrocardiac Syndrome Following Traumatic Brain Injury
Cerebrocardiac syndrome (CCS), including myocardial injury, arrhythmia or heart failure is one of serious complications of traumatic brain injury (TBI), mostly occurs within seven days after TBI, which directly aggravates the…
- Trial name
- NCT06958406
- Where
- 2 sites in China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai 6th People's Hospital
Epilepsy, Temporal Lobe, Cognitive Decline
Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients
Anterior temporal epilepsy is the most frequent form of focal epilepsy (more than 50% of focal epilepsies). The epilepsy is drug-resistant when epileptic seizures persist despite antiepileptic treatment (25% of cases).
- Trial name
- CARTA (NCT05339438)
- Testing
- functional MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Epilepsy
Functional Brain Mapping for Patients with Epilepsy
We aim to determine the clinical utility of 'dynamic tractography': a novel method for visualizing electrical neural transfers that incorporates the underlying white matter tracts and supporting linguistic processing.
- Trial name
- NCT05755919
- Testing
- Epilepsy surgery
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Wayne State University
Anorexia Nervosa
Circuit-Guided Neuromodulation for Anorexia Nervosa
The goal of this clinical trial is to find out whether personalized, non-invasive brain stimulation can temporarily change communication within brain networks related to restrictive eating in adults with anorexia nervosa.
- Trial name
- RestrEAT (NCT07860320)
- Testing
- Intermittent theta-burst stimulation (iTBS), Continuous theta-burst stimulation (cTBS)
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Fundacao Champalimaud
Healthy
Mapping Auricular Vagus Nerve Circuitry
This study will determine how noninvasive nerve stimulation affects human brain, stomach, and autonomic activity.
- Trial name
- NCT00200889
- Testing
- active TEAS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
EEG, TMS
TMS for iEEG Monitoring Recordings
The current study presents a unique opportunity to measure the direct effects of transcranial magnetic stimulation (TMS) by using intracranial electrodes to record neural activity in deep brain regions when TMS single pulses are…
- Trial name
- NCT07518745
- Testing
- Single Pulse TMS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Healthy Control Subjects, Schizophrenia Diagnosis
Understanding Lifespan Trajectories of Social Cognition, Brain Microstructure and Iron Dysregulation in Schizophrenia
This study aims to better understand how schizophrenia may affect social thinking, emotion regulation, brain function, and biological processes over time. Two groups will take part in the study: 1.
- Trial name
- NCT07856381
- Where
- Austria
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Acute Ischemic Stroke, Transient Ischemic Attack
Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke
The goal of this observational study is to to investigate the prevalence and time course of autonomic dysfunction in acute ischemic stroke patients; to evaluate the influence of lesion location on autonomic dysfunction; to…
- Trial name
- ARIADNE (NCT06740942)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Traumatic Intracranial Hemorrhage
Platelet Transfusion and Repeat TEG-PM in Patients With Severe TBI on Antiplatelet Therapy (Repeat TEG-PM)
The aim of this study is to see if administering platelets (cells in our blood that stop or prevent bleeding) results in improved platelet function and slows/stops the progression of a head bleed for patients who have a traumatic…
- Trial name
- NCT06433622
- Testing
- Repeat Thromboelastography with Platelet Mapping
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Lancaster General Hospital
Cannabis
Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users
The growing legalization of cannabis across the U.S. is associated with increases in cannabis use, and accordingly, an increase in the number of individuals with cannabis use problems, including cannabis use disorder (CUD).
- Trial name
- iCURE (NCT05401929)
- Testing
- iTBS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Low Grade Glioma of Brain
Measure of the Potential Evoked by Electric Stimulation
This study is about an experimental biomedical monocentric search concerning twelves patients presenting a infiltrative glioma of low rank OMS type II and realizing a surgery awakened on the site of the CHU of Montpellier.
- Trial name
- PE&CE (NCT02509442)
- Testing
- Diffusion of direct electric stimulation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Montpellier
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis