Clinical trials: Brain Modulation
Brain Diseases
Effects of Sensory Flicker and Electrical Flicker Stimulation
The study will evaluate whether sensory flicker can modulate neural activity of deep brain regions in humans, and whether it can have relevant effects on behavior.
- Trial name
- NCT04188834
- Testing
- Customized version of DAVID device, Blackrock CereStim
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Emory University
Metastatic Malignant Neoplasm in the Brain, Recurrent Non-Small Cell Lung Carcinoma
PET-Adjusted Intensity Modulated Radiation Therapy and Combination Chemotherapy in Treating Patients With Stage II-IV Non-small Cell Lung Cancer
This phase II trial studies how well intensity modulated radiation therapy adjusted by positron emission tomography (PET) scanning together with combination chemotherapy works in treating patients with stage II-IV non-small cell…
- Conditions
- Metastatic Malignant Neoplasm in the Brain, Recurrent Non-Small Cell Lung Carcinoma, Stage IIA Non-Small Cell Lung Carcinoma, Stage IIB Non-Small Cell Lung Carcinoma
- Trial name
- PAINT (NCT02073968)
- Testing
- Carboplatin, Computed Tomography, Intensity-Modulated Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Albert Einstein College of Medicine
Aging
Modulating Brain Activity to Improve Goal-directed Physical Activity in Older Adults
Although the majority of older adults are aware of the compelling evidence that regular exercise is critical to the maintenance of health into old age, most do not meet recommendations for daily exercise.
- Trial name
- Stim-Fit (NCT04278560)
- Testing
- Transcranial direct current stimulation (tDCS), Behavioral intervention to increase physical activity
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Postoperative Delirium, Postoperative Cognitive Dysfunction
Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction
This research study will evaluate the effectiveness and estimate the feasibility of administering an investigational drug called 'CN-105' (the study drug), to prevent postoperative cognitive decline, delirium (serious confusion)…
- Trial name
- MARBLE (NCT03802396)
- Testing
- CN-105
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Miles Berger, MD PhD
Alzheimer Disease
The CIRCADIAN Study: Evaluation of Modulating Effect of Galantamine on Circadian Rhythm in Patients With Mild to Moderate Alzheimer's Disease
The purpose of this study is to assess the modulating effect of galantamine on circadian rhythm in patients with moderate Alzheimer's disease.
- Trial name
- NCT01181921
- Testing
- Galantamine
- Where
- Spain
- Volunteers
- 1 people
- Sponsor
- Janssen-Cilag, S.A.
Menopause
Estrogen and Serotonin on Changing Brain Chemistry
The aim of this study is to examine the effects of estrogen and serotonin on cognition, emotional processing, and brain activation.
- Trial name
- NCT01208324
- Testing
- estrogen patch, Amino acids
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
HIV Dementia
Modulation of Monocyte Activation by Atorvastatin in HIV Infection
Activated monocytes play a key role in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Individuals with HAND have expanded populations of activated monocytes.
- Trial name
- NCT01263938
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Alcohol Use Disorder (AUD)
Brain Network Modulation and Alcohol Use
The investigators will use real-time fMRI neurofeedback to enhance participants' ability to control their ability to modulate alcohol valuation.
- Trial name
- RP2B (NCT04828577)
- Testing
- Real Time Neurofeedback
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Refractory Epilepsy
Modulation of Emotion Perception in Humans Via Amygdala Stimulation
This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have intracranial EEG electrodes.
- Trial name
- NCT05292183
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Migraine
Investigation and Modulation of the Mu-Opioid Mechanisms in Migraine (in Vivo)
This study investigates whether non-invasive brain stimulation, given for 20 minutes/once per day for ten days (M-F) can reduce migraine pain.
- Trial name
- NCT02964741
- Testing
- Active Comparator
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Stroke
Optimizing Parameters of Low-Intensity Focused Ultrasound for Cortical Modulation in Stroke Patients
The purpose of this research study is to find out the optimal intensity and frequency of Low Intensity Focused Ultrasound (LIFU) that is safe and tolerable in people who have had a stroke.
- Trial name
- LIFU (NCT05016531)
- Testing
- Low Intensity Focused Ultrasonic Stimulation, Low Intensity Focused Ultrasonic Stimulation Frequency
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Parkinson's Disease
Transcranial Direct Current Stimulation (tDCS) and Parkinson's Disease
The use of low level electrical stimulation when applied over the head, also called transcranial direct current stimulation (tDCS), is being tested by several groups of researchers to see if tDCS can improve movements of persons…
- Trial name
- NCT01100762
- Testing
- Cranial Electric Stimulation (CES), Treadmill, CES and Treadmill
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine
Individuals with irritable bowel syndrome (IBS) may experience abdominal pain as a result of pain signals in the bowel and how these signals are processed in the brain.
- Trial name
- NCT00880594
- Testing
- Desipramine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
HIV Dementia
Downmodulating Monocyte Activation for HIV-1 Associated Neurocognitive Disorders (HAND)
HIV associated neurological disorders (HAND), are a major problem even in ART treated people. HAND results from chronic inflammation which is largely attributed to expansion and activation of monocytes.
- Trial name
- NCT01600170
- Testing
- Atorvastatin (generic Lipitor)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Pennsylvania
Parkinson Disease, Parkinson's Disease and Parkinsonism
STEM-Parkinson's Disease
This is a double-blinded, controlled, and randomized clinical trial (RCT) to establish the safety and efficacy of a non-invasive neuromodulation device for treating symptoms associated with Parkinson's disease.
- Trial name
- STEM-PD (NCT04797611)
- Testing
- TNM Device
- Where
- 23 sites in United States, United Kingdom
- Volunteers
- 188 people
- Sponsor
- Scion NeuroStim
Stroke, Acute
The Intravascular Cooling in the Treatment of Stroke 2/3 Trial
The purpose of this trial is to determine whether the combination of thrombolysis and hypothermia is superior to thrombolysis alone for the treatment of acute ischemic stroke.
- Trial name
- ICTuS2/3 (NCT01123161)
- Testing
- hypothermia and anti-shivering treatment, Group1: IV t-PA and normothermia
- Where
- 31 sites in United States, Austria and 1 more
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Acute Cerebrovascular Accident, Cerebral Edema
Histamine Glutamate Antagonism in Stroke
Stroke is the 4th leading cause of death in United States with an estimated 1 death every 4 minutes. On average, someone suffers from stroke in United States every 40th second. Stroke recurs in 1 out of 4 stroke patients.
- Trial name
- NCT02142712
- Testing
- Diphenhydramine, Pantoprazole, Famotidine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Magnetic Resonance Imaging, Cognition
Nicotinic Modulation of the Default Network
Many disorders where attentional problems are a hallmark, such as Alzheimer's disease and schizophrenia, display abnormal regulation of the so-called default network of resting brain function that maintains internally directed…
- Conditions
- Magnetic Resonance Imaging, Cognition, Nicotine, Mecamylamine
- Trial name
- NCT01223404
- Testing
- Nicotine, Mecamylamine
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Lysosomal Storage Disease, Peroxisomal Disorder
Reduced-Intensity Hematopoietic Stem Cell Transplant for High Risk Lysosomal and Peroxisomal Disorders
This study is designed to test the ability to achieve donor hematopoietic engraftment while maintaining low rates of transplant-related mortality (TRM) in patients with high-risk lysosomal and peroxisomal disorders using a novel…
- Trial name
- NCT01626092
- Testing
- Campath-1H, Clofarabine, Melphalan
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Multiple Sclerosis
Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis
Background: Some multiple sclerosis (MS) lesions stay inflamed for very long periods of time. This type of inflammation is not affected by any MS medications. These lesions can lead to slow worsening of MS symptoms.
- Trial name
- NCT04742400
- Testing
- tolebrutinib 60mg, tolebrutinib 120mg
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)