Clinical trials: Brain Network Connectivity
Subjective Cognitive Decline, Age-Related Cognitive Decline
Lifestyle, Exercise and Diet: The LEAD Study
This study will explore the impact of an exercise and nutrition (EX+NUTR) , relative to exercise alone (EX) intervention, on brain structure and function as well as blood biomarkers in older adults with subjective cognitive…
- Trial name
- LEAD (NCT03056508)
- Testing
- Exercise plus nutrition, Exercise
- Where
- 4 sites in Canada
- Volunteers
- 14 people
- Sponsor
- Rotman Research Institute at Baycrest
Consciousness Disorder
Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness
Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness based on Electroencephalography and Auditory Event-related Potentials
- Trial name
- NCT05823454
- Testing
- Different drug dosage
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Binge-Eating Disorder
Use of Circadian Reset Technology to Alter REM Sleep and Appetitive Control in Patients With Binge Eating Disorder
This project includes testing circadian reset technology (CRT) on frequency of binge eating in a sample of 40 individuals with binge eating disorder. Participants will be randomized to one of two groups.
- Trial name
- NCT06858774
- Testing
- Circadian Reset Technology, VR Headset
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mild Cognitive Impairment
Effects of Telerehabilitation on Brain Network Connectivity
The current project aims at assessing the impact of various cognitive telerehabilitation approaches on patients with Mild Cognitive Impairment (MCI) associated with neurodegenerative diseases, namely Alzheimer's disease (AD) and…
- Trial name
- NCT06278818
- Testing
- Cognitive Telerehabilitation, Control Condition
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- University of Pavia
Premature Ejaculation, Sexual Dysfunction
Brain Networks Implicated in Lifelong Premature Ejaculation Patients
Using Brain Mapping and Cognitive ERPs, the investigatos have searched for a Brain Networks involved during Inhibitory Control in Lifelong Premature Ejaculation (LPE) participants.
- Trial name
- LPE (NCT04850703)
- Testing
- Transcranial Radom Noise Stimulation, Take Dapoxetine, Compare LPE EEG endophenotype between participants and healthy controls
- Where
- Spain
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Moises Domingo
Migraine Disorders
A Functional MRI Study on Erenumab Treatment Effects in Episodic Migraine Patients
The purpose of this study is to investigate the effects of erenumab on central sensitization and brain networks connectivity of migraine patients
- Trial name
- RESET BRAIN (NCT03977649)
- Testing
- erenumab
- Where
- 5 sites in Italy
- Volunteers
- 62 people
- Sponsor
- Novartis Pharmaceuticals
Vision Functional Brain Networks in Patients With Hereditary Retinal Dystrophies
VIsual Cerebral ConnecTivity On Functional Magnetic Resonance Imaging in Patients With Hereditary REtinal Dystrophies
The Rothschild Foundation A Hospital follows a cohort of approximately 300 patients with hereditary retinal dystrophy. These patients are followed in ophthalmology consultation every year.
- Trial name
- VICTOIRE (NCT04648124)
- Testing
- IRMf-r (séquence resting state)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Major Depressive Disorder (MDD)
Open-label Brexpiprazole fMRI Trial in Adults With Major Depressive Disorder and Anxiety
The purpose of this study is to use fMRI to evaluate the effects of brexpiprazole as add-on therapy to antidepressants on brain connectivity in individuals with MDD and symptoms of anxiety, aged 18 to 65.
- Trial name
- NCT05504486
- Testing
- Brexpiprazole
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Cerebrovascular Circulation
Blood Brain Flow and Exercise
Cerebral vasodilator responses to CO2 will be measured in young healthy adults, healthy sedentary older adults, and healthy exercise trained older adults.
- Trial name
- NCT02653638
- Testing
- Control, Indomethacin
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alzheimer's Disease, Mild Cognitive Impairment
The Treatment of High Intensity Transcranial Current Stimulation for Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive dysfunction and behavioral impairment. It is currently the most common type of dementia in the old age.
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06380725
- Testing
- Transcranial alternating current stimulation(real stimulation)
- Volunteers
- 60 people
- Sponsor
- Anhui Provincial Hospital
Metabolic Disease
Brain Network Connectivity of Patients With Metabolic Diseases
The global prevalence of metabolic diseases, including hypertension, type 2 T2DM mellitus (T2DM), gout and obesity, has risen over the past two decades. Brain controls human behavior and metabolism in organisms.
- Trial name
- NCT06725589
- Testing
- metabolic disease
- Where
- China
- Volunteers
- 690 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
PTSD
Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSD
The goal of this clinical trial is to learn about the effects of Ketamine Assisted Psychotherapy [KAP] on individuals with Post Traumatic Stress Disorder [PTSD]. The main questions it aims to answer are: 1.
- Trial name
- CONCHKAP (NCT06036511)
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Sponsor
- University of New Mexico
Coma
Longitudinal Study of the Default-mode Network Connectivity in Brain Injured Patients Recovering From Coma
Several studies in healthy volunteers have suggested that the synchronized functional connectivity in the DMN (Deafult-Mode Network) would sustain the mental content at rest, and when required, a switch in the activity between…
- Trial name
- ACI-Coma (NCT01620957)
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Stroke, Hemiparesis
Biomarkers for Prediction of Hand Function After Stroke - The ProHand Study
The overall aim is to identify key determinants for recovery of hand function after stroke by applying newly developed hand function measures together with MRI measurements of the lesioned cerebral structures.
- Trial name
- ProHand (NCT02878304)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Danderyd Hospital
Brain Network Functional Connectivity
Brain Network fMRI Analysis in Proprioceptive Training for Chronic Low Back Pain
Through longitudinal analysis of dynamic changes in DMN functional connectivity before and after sensory training intervention, combined with pain behavioral and functional improvement indicators, this study systematically…
- Trial name
- NCT07308249
- Testing
- Multimodal Imaging Evaluation
- Volunteers
- 40 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Adhd
Psychostimulants Effects on Brain Functional Connectivity in Youth With Attention Deficit Hyperactivity Disorder
In the current study, we will administer three widely administered cognitive tasks while simultaneously measuring electroencephalography (EEG) in ADHD patients before and after methylphenidate immediate release (IR) treatment…
- Trial name
- NCT02318017
- Testing
- Methylphenidate
- Where
- Israel
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Anorexia Nervosa
Circuit-Guided Neuromodulation for Anorexia Nervosa
The goal of this clinical trial is to find out whether personalized, non-invasive brain stimulation can temporarily change communication within brain networks related to restrictive eating in adults with anorexia nervosa.
- Trial name
- RestrEAT (NCT07860320)
- Testing
- Intermittent theta-burst stimulation (iTBS), Continuous theta-burst stimulation (cTBS)
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Fundacao Champalimaud
Healthy Participants
Combined Regulatory Effects of 40 Hz eTNS and Multisensory Stimulation on Brain Networks
The purpose of this study is to investigate the independent and interactive effects of 40Hz auditory, visual, and external trigeminal nerve stimulation (eTNS) on brain state dynamics and functional connectivity.
- Trial name
- NCT07668167
- Testing
- 40 Hz External Trigeminal Nerve Stimulation, 40 Hz Auditory Stimulation, 40 Hz Visual Stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xidian University
Movement Disorder, Focal Dystonia
Movement-Related Brain Networks Involved in Hand Dystonia
This study will use various methods to measure the activity of the motor cortex (the part of the brain that controls movements) in order to learn more about focal hand dystonia.
- Trial name
- NCT00137384
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pediatric Obesity, Behavior and Behavior Mechanisms
Neuro-cognitive Impact of Juvenile Obesity
Recent studies indicate that obese teenagers exhibit memory disturbances. Adolescence represents a crucial period in the development of the hippocampus and the amygdala, necessary for the implementation of memory and emotional…
- Conditions
- Pediatric Obesity, Behavior and Behavior Mechanisms, Emotions
- Trial name
- OBETEEN (NCT03776513)
- Testing
- an MRI examination
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux