Clinical trials: Brain Plasticity
Stroke
Neurofeedback for Stroke Rehabilitation
Real-time neurofeedback aims to alter brain activation patterns through online feedback of ongoing brain activity using magnetic resonance imagining (MRI).
- Trial name
- NCT03775915
- Testing
- Neurofeedback
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Oxford
Stroke, Stroke Hemorrhagic
FIND Stroke Recovery - A Longitudinal Study
Stroke survivors frequently suffer disabilities including motor and cognitive problems, impairments in speech and vision, depression, and several other disabilities that worsen their quality of life.
- Conditions
- Stroke, Stroke Hemorrhagic, Stroke, Ischemic, Risk Factor, Cardiovascular
- Trial name
- FIND (NCT05708807)
- Testing
- Observational - all
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Göteborg University
Autism
Therapeutic Intervention Effects of rTMS on Children With Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a common and complex neurodevelopmental disorder, which is characterized by impairments of social communication, social reciprocity, as well as restricted and repetitive behaviors (RRB).
- Trial name
- NCT05140356
- Testing
- Applied high amplitude repeated transcranial magnetic stimulation, Applied low amplitude repeated transcranial magnetic stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- University of Electronic Science and Technology of China
Blindness
Sensory Substitution and Brain Plasticity Following Vision Loss
The goal of this clinical investigation is to learn how the brain responds when visual information is converted into patterns of sound or touch in blind and sighted participants.
- Trial name
- SenSubMRI (NCT07450677)
- Testing
- Electrotactile display (BrainPort), Vision-to-sound converter (AI Sight)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stanford University
Aphasia, Stroke
tDCS Effects on Brain Plasticity in Aphasia Treatment
The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.
- Trial name
- NCT05483556
- Testing
- Real tDCS
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke, Gait, Hemiplegic
Transcranial Direct Current Stimulation for Gait Recovery Following Stroke
Background: Stroke is a leading cause of adult disability. The ability to walk is considered as the most important physical activity in daily life and strongly associated with quality of life in patients with stroke sequela.
- Trial name
- TransGait (NCT05740228)
- Testing
- Anodal tDCS - Direct Current (DC)-stimulator (Soterix Medical, New York, NY, USA), Anodal High-Definition (HD) tDCS - Direct Current (DC)-stimulator (Soterix Medical, New York, NY, USA)
- Where
- 2 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- School of Health Sciences Geneva
Tactile Spatial Acuity, Healthy
Role of Brain Region Changes in Tactile (Touch) Ability Following Nerve Block
This study will examine the role of different brain regions in tactile (touch) ability after application of a tourniquet (inflated blood pressure cuff).
- Trial name
- NCT00357058
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Head Injury
Warfighter Head Injury Study
This study will examine the long-term outcome of brain injuries, the effects of treatment on outcome and the effects of brain injury on people s behavior and abilities.
- Trial name
- NCT00754169
- Where
- United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Mild Traumatic Brain Injury
Auditory Plasticity Training
The investigators are working on a project to help people who have had mild brain injuries hear better. Sometimes, these injuries can make it hard for people to hear clearly, especially in noisy places or when trying to tell…
- Trial name
- NCT06628505
- Testing
- Speech in Noise Training, Spatial Hearing Training Group, Spatial Hearing Control Group
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Stroke, Motor Disorders
BCI-assisted MI Intervention in Subacute Stroke
Stroke is a leading cause of long-term disability. Cost-effective post-stroke rehabilitation programs are critically needed. Brain-Computer Interface (BCI) systems which enable the modulation of EEG sensorimotor rhythms are…
- Trial name
- Promotoer (NCT04353297)
- Testing
- EEG-based BCI system for (hand) Motor Imagery training, Motor Imagery training
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Tinnitus, Hyperacusis
Closed-loop Rehabilitation for Hyperactive Hearing
There are no widely available treatments for the underserved populations with tinnitus, hyperacusis, and hearing-in-noise deficits.
- Trial name
- NCT07302373
- Testing
- Sound Therapy 1, Sound therapy 2
- Sponsor
- Massachusetts Eye and Ear Infirmary
Stroke, Neuronal Plasticity
Effects of a Computerised Exercise System on Functionality of the Arm,Cognition and Quality of Life in Stroke Patients
Stroke occurs as a result of blood vessels of the brain becoming blocked or bleeding which in turn can result in loss of function in the limbs.
- Conditions
- Stroke, Neuronal Plasticity, Hemiplegia
- Trial name
- NCT04036422
- Testing
- Rejoyce (Rehabilitation Joystick for Computerized Exercise), Conventional physical therapy, Occupational therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Baskent University
Amblyopia
Optical Correction and Visual Functions of Adults With Amblyopia
Amblyopia is a developmental anomaly resulting from abnormal visual experiences in early life. Amblyopia causes reduced visual acuity in the absence of a pathology.
- Trial name
- SPECTRA (NCT05394987)
- Testing
- Spectacles
- Where
- 2 sites in Canada, Hong Kong
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre for Eye and Vision Research
Hallucinations, Verbal Auditory
Symptom Based Treatment Affects Brain Plasticity - the Role of Verbal Auditory Hallucinations
The aim of the study is the examination of brain plasticity on verbal auditory hallucinations (AVH) after neuromodulation with fMRI (functional magnetic resonance imaging) neurofeedback.
- Trial name
- APIC-II (NCT02722915)
- Testing
- fMRI, Neurofeedback, PANAS
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Stroke, Cerebrovascular Disorders
Novel Brain Stimulation Therapies in Stroke Guided Expressions of Plasticity
The investigators ultimate goal is to personalize brain stimulation for stroke so outcomes of the upper limb can be maximized for each individual patient.
- Conditions
- Stroke, Cerebrovascular Disorders, Nervous System Diseases, Brain Diseases
- Trial name
- NCT03020433
- Testing
- rTMS Contralesional M1, rTMS Contralesional PMC, rTMS Ipsilesional PMC
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Cerebrovascular Accident, Neurorehabilitation
Neurorehabilitation Through Hippotherapy of a Brain Stroke
Cerebrovascular accident [CVA] (medical term for stroke) is a high burden worldwide disorder and the second leading cause of disability.
- Conditions
- Cerebrovascular Accident, Neurorehabilitation, Neuroplasticity, Hippotherapy
- Trial name
- HippoPostCVA (NCT04759326)
- Testing
- Hippotherapy, Conventional Neurorehabilitation
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Alliance Equiphoria
Temporomandibular Disorders, Temporomandibular Joint Pain
Neck Exercises in Patients With Temporomandibular Disorders
Musculoskeletal (MSK) pain is a common reason to seek medical treatment. Temporomandibular disorders (TMDs) are MSK disorders that affect the masticatory muscles, the temporomandibular joint, and related structures in the neck…
- Trial name
- NCT03403998
- Testing
- Exercises
- Where
- Canada
- Volunteers
- 113 people
- Sponsor
- University of Alberta
Ischemic Stroke, Motor Impairment
Fluoxetine on Motor Rehabilitation After Ischemic Stroke
Recovery from stroke is a major process and, except for acute intravenous thrombolysis, no treatment able to enhance recovery has yet been validated.
- Trial name
- FLAME (NCT00657163)
- Testing
- fluoxetine
- Where
- 9 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Chronic Stroke
Brain Stimulation for Improving Cognition in Chronic Stroke (NEPTUNE)
Few treatments are available for post-stroke rehabilitation. The current study aims to develop a novel, short-term, high-dose repetitive transcranial magnetic stimulation (rTMS) based intervention to improve post-stroke cognitive…
- Trial name
- NEPTUNE (NCT04655963)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Healthy, Blindness
Multisensory Body and Space Representations (BASES-EXTINCTION)
To accurately control body movements to interact with objects, our brain needs representations of the body and the nearby space.
- Trial name
- NCT03201341
- Testing
- Electrooculogram (EOG), Surface Electromyography (EMG), Electrodermal response
- Where
- France
- Volunteers
- 1,540 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon