Clinical trials: Brain Plasticity
Cerebral Palsy
Robot-assisted Training in Children With CP
Cerebral palsy (CP) is the most common physical disability in early childhood causing serious motor and sensory impairments. Effective interventions for the recovery of motor functions are of profound significance to children…
- Trial name
- NCT06450158
- Testing
- Robot (Amadeo)-assisted Training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cook Children's Health Care System
Spinal Cord Injuries
Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury
Early detection of response to therapeutic intervention is vital, as it will enable early termination of intervention in non-responding patients, prevent unnecessary financial burden, and allow for early changes to the…
- Trial name
- NCT03854214
- Testing
- Functional Electric Stimulation cycling, Passive cycling
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Sub-acute Back Pain
Effect of L-dopa In Subacute Back Pain Population
This study aims to determine if early treatment with Carbidopa/Levodopa and Naproxen in individuals with sub-acute back pain (SBP) is associated with changes in blocking transition to chronic back pain (CBP).
- Trial name
- NCT01951105
- Testing
- Naproxen, Carbidopa/Levodopa
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Northwestern University
Cerebrovascular Accident
Neural Mechanisms and Efficacy of Dual Neurotechnology-aided Mirror Therapy in Chronic Stroke: Neural and Motor Plasticity, Movement Performance, Daily Function, and Quality of Life
Mirror therapy (MT) has been demonstrated, in terms of neuroplasticity, to improve sensorimotor function of paretic upper extremity (UE) in chronic stroke patients.
- Trial name
- NCT04326205
- Testing
- transcranial direct current stimulation, tDCS, functional electrical stimulation, FES, no stimulation
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- Chang Gung Memorial Hospital
Cerebrovascular Accident
Enhancement of Use-Dependent Plasticity by Somatosensory Stimulation in Chronic Stroke
Recent studies have demonstrated that electrical stimulation delivered over the skin increases the muscle strength as measured by a dynamometer in chronic stroke patients.
- Trial name
- NCT00028379
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease
Motor Skill Learning in People With Parkinson's Disease
This study will compare brain changes in people with Parkinson's disease with those of normal control subjects while they learn motor skills.
- Trial name
- NCT00396942
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Major Depressive Disorder (MDD)
Theta-Burst Stimulation to Treat Depression
The goal of this clinical trial is to explore the effects of non-invasive brain stimulation protocols using intermittent theta-burst stimulation (iTBS) on brain plasticity and depression severity in depressed individuals aged 18…
- Trial name
- INSPiRE-D (NCT07033780)
- Testing
- Spaced iTBS, Compressed iTBS
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Centre for Addiction and Mental Health
Stroke, Stroke, Cardiovascular
EMG Control Assistance Virtual Reality Interface Coupled With Cerebellar-iTBS for Arm Recovery After Stroke (ERICA)
The investigators hypothesize that a myoelectric (EMG) controlled virtual reality (VR) interface allows for effective upper limb motor recovery of stroke patients.
- Trial name
- ERICA (NCT06911671)
- Testing
- Virtual Reality Interface + Cerebellar iTBS (c-iTBS), Physical Therapy
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Spastic Diplegia
Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy
The purpose of this study is to characterize the cortical connectivity changes in the brain of spastic diplegic children after Selective Dorsal Rhizotomy.
- Trial name
- NCT02535936
- Testing
- 3Tesla MRI with DTI-MRI and rsfcMRI under general anesthesia
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Muscle Atrophy
Brain and Muscle Plasticity During Immobilization
Patients in rehabilitation may undergo periods of prolonged limb immobilization in response to injury, surgery, or illness. Due to disuse, the size and strength of muscles controlling the affected limb can decrease significantly…
- Trial name
- NCT05115643
- Testing
- Immobilization
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- McGill University
Concussion
Cortical Plasticity Assessment in Athletes With a History of Concussion
The purpose of this research is to determine whether athletes with concussion have changes in cortical excitability. Single and paired transcranial magnetic stimulation (TMS) can be used as reliable neurophysiological marker of…
- Trial name
- NCT01112761
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Obesity/Therapy
Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity
Glucagon-like peptide 1 receptor agonists (GLP-1RA), such as Ozempic and Wegovy, have been rapidly adopted for the treatment of obesity in both youth and adults.
- Trial name
- PLASTIC (NCT07021937)
- Testing
- Semaglutide 1.7mg subcutaneous
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Stroke, Acute Hemiplegia, Apraxia
Action Observation Treatment (AOT) as a Rehabilitation Tool
Epidemiological studies report that 85% of stroke survivors show hemiparesis and a percentage ranging from 55% to 75% report upper limb functional impairment.
- Trial name
- AOT (NCT02235350)
- Testing
- Action Observation Treatment (AOT), Observation of videos with no motor content (MNO)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Neuromed IRCCS
Spinal Cord Injuries, Spine Disease
Temporary Inactivation of Strong Muscle Sensation to Improve Rehabilitation Interventions in SCI
The investigators are conducting a research study to try to improve rehabilitation interventions for individuals with spinal cord injury (SCI).
- Conditions
- Spinal Cord Injuries, Spine Disease, Stroke
- Trial name
- NCT05589402
- Testing
- Lidocaine Cream 5%, Rehabilitation Movement Training
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Texas Rio Grande Valley
Healthy
Innovative Brain Stimulation for Induction of Learning Plasticity
Recent studies have identified new neurobiological biomarker (i.e. functional connectivity of the parietal cortex) of motor learning among healthy people.
- Trial name
- NCT04140994
- Testing
- rTMS device
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Chronic Stroke
Magnetic Brain Stimulation and Computer-based Motor Training for Rehabilitation After Stroke
The goal of the present clinical trial is to explore whether an innovative technology-based approach can help individuals who have had a stroke and can no longer move their hands with ease.
- Trial name
- NCT06116942
- Testing
- Active rTMS
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Stroke, Gait, Hemiplegic
Cerebellar rTMS to Improve Gait Recovery
The cerebellum is known to be strongly implicated in the functional reorganization of motor networks in stroke patients, especially for gait an balance functions.
- Trial name
- NCT03456362
- Testing
- REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Stroke
Power Training Post-stroke
Hemiparesis, strictly defined as (muscular) weakness affecting one side of the body, is seen in three-quarters of individuals following stroke.
- Trial name
- NCT01970592
- Testing
- POWER training
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Healthy
Brain Power: Resistance Training and Cognitive Function
Primary Objectives: 1. To ascertain whether a 12-month, twice-weekly or once-weekly resistance training (RT) program will significantly improve executive function in community-dwelling women aged 65 to 75 years old compared with…
- Trial name
- NCT00426881
- Testing
- Exercise Training
- Where
- 2 sites in Canada
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cerebrovascular Accident
Motor Changes Associated With Recovery From Stroke After Therapy
Researchers have been interested in the changes associated with motor function in humans after suffering a stroke. Presently, the mechanism by which a person recovers motor function following a stroke is poorly understood.
- Trial name
- NCT00001553
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)