Clinical trials: Brain Plasticity
Movement Disorders, Parkinson Disease
Non-invasive Assessment of Synaptic Plasticity
The pathophysiological mechanisms underlying Movement Disorders, including Parkinson's disease, have been related to altered synaptic plasticity affecting several structures of the central nervous system.
- Trial name
- NEUROPLAST (NCT05353517)
- Testing
- Device: focal muscle vibration and theta burst stimulation
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Dravet Syndrome (DS)
Biomarkers of Neurodegeneration, Synaptic Plasticity and Neuroinflammation in Dravet Syndrome
Dravet syndrome (DS) is a developmental and epileptic encephalopathy, usually caused by de novo pathogenic SCN1A variants, characterized by early-onset prolonged febrile seizures, subsequent drug-resistant polymorphic epilepsy…
- Trial name
- TEMBO-DS (NCT07801404)
- Where
- 9 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Blood Pressure, Depression
Essential Hypotension and Allostasis Registry
The essential arterial hypotension and allostasis registry is a prospective, observational research that has the purpose of demonstrating that essential blood pressure (BP) disorders and the associated comorbidities are a result…
- Conditions
- Blood Pressure, Depression, Panic Attack, Fibromyalgia
- Trial name
- ESSENTIAL (NCT02018497)
- Where
- Colombia
- Volunteers
- 5,000 people
- Sponsor
- CES University
It is Possible That Amadeo Will Guarantee a Greater Clinical Improvement as Compared to an Occupational Therapy Thanks to the Strengthening of Brain Plasticity
Improving Hand Motor Function After Stroke: Role of Robotics
Two recent randomized clinical trials reported a significant contribute of Amadeo toward the recovery of hand motor function in acute stroke patients in association with physiotherapy and/or occupational therapy.
- Trial name
- NCT03292276
- Testing
- Amadeo Training
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Healthy, Cognition
Reliability of Standardized IQ Testing Under Modafinil, Racetam-Class Compounds, Sleep Restriction and Daily Activity
This study examined whether standardized IQ test scores in healthy adults aged 18-35 are stable measures of cognitive ability and evaluated whether standardized cognitive-test performance and response-initiation measures vary…
- Conditions
- Healthy, Cognition, Sleep Deprivation
- Trial name
- NCT07852130
- Testing
- Modafinil, Oxiracetam, Pramiracetam
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Abdulraheem Mohamed Gouda
Stroke, Blindness
Functional Neuroimaging of Cortical Plasticity in the Human Visual System
The study's objective is to measure changes in human visual cortex organization that may arise as a result of injury to the visual pathways.
- Conditions
- Stroke, Blindness, Vision
- Trial name
- NCT01062672
- Where
- 2 sites in United States, Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Corticospinal Plasticity, Neuromuscular Plasticity
Study of the Reaction of the Brain to Various Stimulations
Physical activity is considered a therapeutic strategy in its own right in a vast majority of disabling chronic disorders. It leads to an increase in physical and probably cognitive capacity, thanks to its effects on both…
- Trial name
- NCT03334526
- Testing
- physical training, mental training, electrical stimulation
- Where
- France
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Brain Function, Cerebral Palsy
7T Anatomo-functional Characterization of Structures in the Action Observation Network
The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the…
- Trial name
- 7T-ATHENA (NCT06826287)
- Testing
- 7T MR exam, clinical assessment
- Where
- 2 sites in Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Postoperative Cognitive Dysfunction
Feasibility Study of Preoperative Cognitive Training in Cardiac Surgical Patients
The purpose of this study is to evaluate the feasibility of administering a 20-day preoperative cognitive training intervention (Cog-Train) to a widely inclusive sample of cardiac surgical patients.
- Trial name
- Cog-Train (NCT02053207)
- Testing
- Cog-Train Intervention
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Stroke
ROOD's Sensory Motor Training in Sub-acute Stroke
The aim of this randomized controlled trial is to determine the effects of ROOD's sensory motor training along with Constraint Induced Movement Therapy (CIMT) in sub-acute stroke.
- Trial name
- NCT04173481
- Testing
- Rood's Group, Conventional Physical Therapy Group
- Where
- Pakistan
- Volunteers
- 29 people
- Sponsor
- Riphah International University
Stroke, Aphasia
Facilitation of Brain Plasticity for Language Recovery in Patients With Aphasia Due to Stroke
The purpose of this study is to investigate effects of tDCS stimulation in the left primary motor area followed by naming therapy to improve language functions in patients with aphasia in the sub-acute stage.
- Trial name
- NCT03164213
- Testing
- experimental: tDCS
- Volunteers
- 30 people
- Sponsor
- Nachum Soroker, MD
Stroke, Arm
Enhancing Recovery of Arm Movement in Stroke Patients
Many people who have had a stroke have problems recovering the use of their affected arm and these problems may persist for a long time.
- Conditions
- Stroke, Arm, Paresis
- Trial name
- ENHANCE (NCT02725853)
- Testing
- tDCS, personalized practice, non-personalized practice
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University
Cognitive Change
Brain Exercises for Synaptic Plasticity
The BEST study will investigate the feasibility of cognitive interventions in a randomized, placebo-controlled, clinical trial. The investigators will recruit 45 cognitively normal subjects and engage them in one of three cohorts…
- Trial name
- BEST (NCT03058055)
- Testing
- Origami, Reading
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Mild Cognitive Impairment
A Health Game Intervention for Cancer and Post-ICU Patients Suffering From Acute Cognitive Impairment
Millions of patients each year suffer from acute cognitive impairment caused by traumatic brain injury, stroke, Parkinson's disease, etc.
- Trial name
- NCT07596940
- Testing
- VR cognitive training platform
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Cincinnati
Anti-NMDA Receptor Encephalitis
Transcranial Direct Current Stimulation on Cortical Plasticity in Patients With Anti-NMDA Receptor Encephalitis
Patients suffering from anti-NMDA receptor encephalitis show impaired NMDA-receptor dependent neuronal transmission. Furthermore, they often have cognitive deficits of different magnitude.
- Trial name
- NCT01865578
- Testing
- tDCS
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Cerebral Palsy
Effects of Transcranial Direct Current Stimulation (tDCS) and Motor Learning in Children With Cerebral Palsy (CP)
In this study, the investigators aim to assess the clinical and neurophysiological effects of a non-invasive brain stimulation technique - transcranial direct current stimulation (tDCS)- on cortical plasticity and motor learning…
- Trial name
- NCT01852474
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Spaulding Rehabilitation Hospital
Parkinson Disease
Exercise and Transcranial Magnetic Stimulation: Increasing Brain Plasticity in Parkinson's Disease
This is a feasibility and exploratory study consisting of two parts: first, a cross-sectional (one-time) biomarker measurement comparing BDNF-TrkB (Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB,) signaling and…
- Trial name
- NCT02741765
- Testing
- Real rTMS, Supervised aerobic exercise
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Central Nervous System Disease, Cerebrovascular Accident
Influence of Area of Brain Damage on Brain Reorganization After Chronic Stroke
This study will examine how the brain rewires itself to make up for the lack of movement many people with stroke experience. It will try to determine if the rewiring differs depending on the location of the stroke and the amount…
- Conditions
- Central Nervous System Disease, Cerebrovascular Accident, Stroke
- Trial name
- NCT00474292
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cerebral Stroke, Cerebrovascular Accident
Brain and Coordination Changes Induced By Robotics and FES Treatment Following Stroke
The long-range goal of this work is to identify how to target treatment so that the brain is functionally re-organized to produce movement.
- Conditions
- Cerebral Stroke, Cerebrovascular Accident, Stroke
- Trial name
- NCT00237744
- Testing
- Robotics training for shoulder elbow., Surface Functional Neuromuscular Stimulation, whole arm motor learning
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Brain Plasticity
Effect of aiTBS on Intrinsic Spectral Dynamics and Task Performance
Aim 1: Measure local shifts in cortical spectral dynamics following aiTBS. Aim 2: Measure network-specific shifts in task performance following aiTBS.
- Trial name
- NCT07565207
- Testing
- TBS
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania