Clinical trials: Brain Stroke
Hemiplegia, Cerebral Palsy
Bimanual Training in Children With Hemiplegia
A randomized control trial of bimanual training in children with hemiplegia. The protocols have been developed at Columbia University to be child friendly and draws upon our experience since 1997 with constraint-induced movement…
- Conditions
- Hemiplegia, Cerebral Palsy, Children
- Trial name
- HABIT (NCT01413594)
- Testing
- HABIT
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Teachers College, Columbia University
Stroke, Ischemic, Balance; Distorted
Effects of Bilateral Versus Unilateral Lower Limb Training on Balance and Gait Parameters in Stroke Patients
To determine the effects of bilateral versus unilateral lower limb training on balance and gait parameters in stroke patients
- Conditions
- Stroke, Ischemic, Balance; Distorted, Gait, Hemiplegic
- Trial name
- NCT05945966
- Testing
- Unilateral training group (UTG), Bilateral training group (BTG).
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Stroke
Multicenter Rehabilitation Study in Acute Stroke
The purpose of the first part of this study is to understand plastic brain mechanisms associated with successful gait-oriented stroke rehabilitation.
- Trial name
- NCT00849303
- Testing
- gait-oriented rehabilitation
- Where
- 4 sites in Finland
- Volunteers
- 80 people
- Sponsor
- University of Jyvaskyla
Stroke, Acute
Biomarker Signature of Stroke Aetiology Study: The BIOSIGNAL-Study
The three-year cumulative risk of a recurrent stroke, dependent on aetiology, is up to 25 per cent. At present, preventing recurrence relies on a broad approach to reduce risk factors associated with atherosclerosis, heart…
- Trial name
- NCT02274727
- Where
- 9 sites in Germany, Greece and 2 more
- Volunteers
- 1,800 people
- Sponsor
- University of Zurich
Ischemic Stroke
Combination Anti-Platelet and Anti-Coagulation Treatment After Lysis of Ischemic Stroke Trial (CATALIST)
Ischemic stroke is caused by a blood clot that blocks the flow of blood to the brain and damages brain cells. The clot, or thrombus, is made up of platelets and fibrin.
- Trial name
- CATALIST (NCT00061373)
- Testing
- Aspirin, tinzaparin sodium, eptifibatide
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Patent Foramen Ovale
Internal Microstructure of Patent Foramen Ovale Related to Stroke
This study aims to (1) investigate the internal microstructure of patent foramen ovale related to cryptogenic stroke, transient ischemic attack or migraine and determine the effectiveness of transcatheter closure in these…
- Trial name
- IMPORT (NCT04686253)
- Testing
- not appliable
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Dysphagia, Aspiration
Effect of Afferent Oropharyngeal Pharmacological and Electrical Stimulation on Swallow Response and on Activation of Human Cortex in Stroke Patients With Oropharyngeal Dysphagia
Oropharyngeal dysphagia (OD) is a major complaint among many patients with stroke and causes severe complications. There is no specific treatment for these patients.
- Conditions
- Dysphagia, Aspiration, Stroke
- Trial name
- NCT01777672
- Testing
- Dietary and oral hygiene recommendations, oral TRPV1 agonist, pharyngeal electrical stimulation
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital de Mataró
Cerebrovascular Accident
Comparative Efficacy Research of Robot-Assisted Therapy With and Without Constraint-Induced Therapy in Stroke Rehabilitation
There are 3 specific study purposes. First, we will examine the treatment effects of RT combined with dCIT (RT + dCIT) compared to RT, dCIT, and a dose-matched control therapy (DMCT) in stroke patients.
- Trial name
- NCT01907139
- Testing
- Robot-assisted therapy, Distributed constraint-induced therapy, Dose-matched control therapy
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Ischemic Stroke
Combining Aspirin With Ticagrelor or Cilostazol in Large-vessel Minor Stroke or TIA
Along with the current clinical trial, the efficacy and safety of a 180 mg loading dose of ticagrelor administered within 24 hours of the first-ever large-vessel minor stroke or TIA compared to 200mg cilostazol were assessed…
- Trial name
- NCT06591377
- Testing
- Ticagrelor 90 MG, Cilostazol 100 MG, Aspirin 75mg
- Where
- 2 sites in Egypt
- Volunteers
- 900 people
- Sponsor
- Kafrelsheikh University
Ischemic Stroke, Chronic Stroke
Investigation of Neural Stem Cells in Ischemic Stroke
A study of stereotactic, intracerebral injection of CTX0E03 neural stem cells into patients with moderate to moderately severe disability as a result of an ischemic stroke.
- Conditions
- Ischemic Stroke, Chronic Stroke, Hemiparesis, Arm Paralysis
- Trial name
- PISCES III (NCT03629275)
- Testing
- CTX0E03 Drug Product and delivery device
- Where
- 23 sites in United States
- Volunteers
- 15 people
- Sponsor
- ReNeuron Limited
Stroke
Correlation Between Clinical Neurological Biomarkers and Rehabilitation Outcome
Our study purpose is to evaluate the predictive power of various clinical, neurophysiological, and neuroimaging biomarkers-acquired and analyzed using advanced and integrated techniques-on motor functional recovery and disability…
- Trial name
- PREVICTUS (NCT06805929)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele Roma
Sensorimotor Gait Disorder, Neurologic Ambulation Disorder
Clinical Study of the L300 Versus Ankle-foot Orthosis (AFO) on Post-Stroke Subjects With Foot Drop
The objective of this study is to determine the effectiveness of the NESS L300 (L300) in improving gait parameters, function, and quality of life among stroke subjects (greater than or equal to 3 months post stroke)with drop foot.
- Conditions
- Sensorimotor Gait Disorder, Neurologic Ambulation Disorder, Gait, Drop Foot, Poststroke Hemiparesis
- Trial name
- L300 (NCT01138995)
- Testing
- Ness L300, Ankle-foot orthosis
- Where
- 11 sites in United States
- Volunteers
- 197 people
- Sponsor
- Bioness Inc
Stroke
High-definition Transcranial Direct Current Stimulation for Facilitating Hand Function Recovery After Stroke
Transcranial direct current stimulation (tDCS) had recently been shown having feasibility in modulating cortical excitability transiently during motor training in a noninvasive way.
- Trial name
- NCT03875677
- Testing
- HD-tDCS group, Conventional tDCS group
- Where
- Hong Kong
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Rehabilitation, Stroke
Effects of Vibration Stimulation Combined With Task-oriented Training on Hand Motor Function in Chronic Stroke
There is a lack of effective therapies for hand and finger function recovery in people with chronic stroke. This study assessed the effects of combining vibration stimulation with task-oriented training on functional recovery…
- Conditions
- Rehabilitation, Stroke, Hand Grasp
- Trial name
- NCT06366477
- Testing
- Vibration stimulation combined with task-oriented training
- Volunteers
- 3 people
- Sponsor
- National Cheng-Kung University Hospital
Stroke, Motor Disorders
Functional Proprioceptive Stimulation of the Upper Limbs in Stroke Patients
Parallel-group, single-blinded controlled clinical trial. The study involved stroke patients (no more than 3 points on a scale Rankin) dived of the control group and experimental group.
- Conditions
- Stroke, Motor Disorders, Upper Extremity Paresis, Muscle Weakness
- Trial name
- NCT06143475
- Testing
- FPS group, Conventional therapy group
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Federal Center of Cerebrovascular Pathology and Stroke, Russian Federation Ministry of Health
Stroke, Acute Ischemic Stroke
Validation of Velocity Curvature Index as a Diagnostic Biomarker Tool for Assessment of Large Vessel Stroke
This study is a multi-center, multi-phase, multi-cohort, prospective, randomized, open, blinded endpoint (PROBE), non-significant risk (NSR) device study including up to 420 evaluable subjects measured with the study device(s)…
- Trial name
- VOICE (NCT05547412)
- Testing
- NovaGuide 2 Intelligent Ultrasound System
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- NeuraSignal Inc dba NovaSignal
Aquired Brain Injury, Traumatic Brain Injuries
Effectiveness of a Customized Digital Platform to Increase Coordination of Care and Uptake of Evidence-based Practices
Background: Cardiovascular and neurological conditions are major causes of disability worldwide. Early, intensive rehabilitation is essential but often challenging to access in current healthcare systems.
- Conditions
- Aquired Brain Injury, Traumatic Brain Injuries, Stroke, Cardiovascular Diseases
- Trial name
- NCT06867081
- Testing
- The intervention will be the BRILLIANT Platform, an online platform which provides five Modules aimed at increasing coordination of care and direct rehabilitation time
- Where
- 2 sites in Canada
- Volunteers
- 962 people, healthy volunteers welcome
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Stroke
The Effectiveness and Safety of Acupuncture for Elderly Patients of Stroke
Stroke and its sequelae are a major indication for acupuncture. The specific aims of this study are to assess the feasibility of pragmatic clinical trial on acupuncture in primary care setting and evaluate the effectiveness and…
- Trial name
- NCT04971603
- Testing
- Acupuncture
- Where
- Hong Kong
- Volunteers
- 500 people
- Sponsor
- Hong Kong Baptist University
Stroke, Frailty
Pilot of Cognitive Stimulation Therapy for Pre-frail Stroke Survivors
Frailty is described as a type of vulnerability where one can struggle to recover fully from things that can put stress on one\'s body, e.g., cold weather or bronchitis.
- Conditions
- Stroke, Frailty, Carers
- Trial name
- NCT06733103
- Testing
- Stroke Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Cerebrovascular Accident
A Study to Evaluate the Botulinum Toxin Type A for Injection(HengLi®) in Subjects With Post-stroke Upper Limb Spasticity
This is a multicenter, double-blind, randomized, placebo-controlled study designed to compare Botulinum Toxin Type A for Injection (HengLi®) with placebo on the efficacy and safety of treatment in post-stroke subjects with focal…
- Trial name
- NCT02280083
- Testing
- Botulinum Toxin Type A for Injection
- Volunteers
- 180 people
- Sponsor
- Lanzhou Institute of Biological Products Co., Ltd
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