Clinical trials: Brain Stroke
Stroke, Muscle Spasticity
The Movement of Botulinum Toxin Through the Lateral Gastrocnemius Muscle in Humans: An Expanded Examination
Despite the wide-spread use of botulinum toxin (BT) to treat spasticity (increased muscle tone) in central neurological disease, evidence-based guidance on dosing, dilution, and injection technique is limited.
- Trial name
- NCT03367429
- Testing
- Botox
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Weill Medical College of Cornell University
Stroke, Acute
Efficacy and Safety of Nerinetide in Participants With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy Excluding Thrombolysis
The primary purpose of this study is to determine if a single dose of nerinetide can reduce global disability in people who have had a stroke and are selected for endovascular therapy without the use of a tissue plasminogen…
- Trial name
- ESCAPE-NEXT (NCT04462536)
- Testing
- Nerinetide
- Where
- 81 sites in United States, Australia and 7 more
- Volunteers
- 850 people
- Sponsor
- NoNO Inc.
Stroke, Aphasia
Digital Interventions in Neurorehabilitation: iTALKbetter
iTALKBetter will provide an app-based therapy for people with word retrieval difficulties who have had a stroke. This study aims to test the therapy application for people with naming difficulties through a small scale…
- Conditions
- Stroke, Aphasia, Anomia
- Trial name
- NCT04566081
- Testing
- iTalkBetter Trained Items, iTalkBetter Untrained Items
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University College, London
Stroke, Shoulder Pain
Multimodal Treatment for Hemiplegic Shoulder Pain
Hemiplegic shoulder pain (HSP) affects up to 60% of moderate to severely impaired stroke survivors. HSP is associated with poor rehabilitation outcomes, including interference with activities of daily living (ADLs) and poor…
- Trial name
- NCT02893267
- Testing
- Peripheral Nerve Stimulation, Physical Therapy
- Where
- 3 sites in United States
- Volunteers
- 96 people
- Sponsor
- MetroHealth Medical Center
Post-stroke Spasticity, Spasticity Post-Traumatic Brain Injury
Dysport® Adult Lower Limb Spasticity Follow-on Study
The purpose of this research study is to assess the long term safety of Dysport® in hemiparetic subjects with lower limb spasticity due to stroke or traumatic brain injury over repeated treatment cycles.
- Trial name
- NCT01251367
- Testing
- Botulinum toxin type A
- Where
- 50 sites in United States, Australia and 9 more
- Volunteers
- 352 people
- Sponsor
- Ipsen
Stroke
Effects of Oropharyngeal Strengthening on Dysphagia in Patients Post-stroke
The overall goal of this randomized controlled pilot study is to characterize effects of SwallowSTRONG® Device-Facilitated Isometric Progressive Resistance Oropharyngeal (DF I-PRO) therapy in a dose response framework on…
- Trial name
- StrokeStrong (NCT02322411)
- Testing
- Isometric Progressive Resistance Oropharyngeal Therapy, Compensatory approaches
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Wisconsin, Madison
Stroke, Sensorimotor Impairment
Learning in Stroke
After a stroke, plasticity occurs in the brain from microscopic to network level with positive but also negative consequences for functional recovery.
- Trial name
- NCT05511467
- Testing
- Visuomotor learning task
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Brain Infarction, Brain Ischemia
Transcranial Direct Current Stimulation, Improve Functional Motor Recovery, Affected Arm
Overall goal of this study is to determine if transcranial direct current stimulation (tDCS) plus conventional occupational therapy improves functional motor recovery in the affected arm-hand in patients after an acute ischemic…
- Trial name
- NCT01201629
- Testing
- t DC stimulation, tDCStimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Oklahoma
Stroke
NewGait: A Low-Cost Rehabilitation System to Improve Post-Stroke Gait (Biomechanical Adaptations)
An affordable and easy to use gait-assistive device for stroke survivors to use at home is yet to be developed. This study is intended to modify the current design of the NewGait device to specifically work for stroke survivors…
- Trial name
- NCT06269367
- Testing
- NewGait, Control wearable limb orthotic device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Family Caregivers, Stroke
Caregiver Self-Management Needs Through Skill-Building
Caring for a family member after a stroke can be very difficult and worsen the physical and mental health of untrained caregivers.
- Trial name
- NCT03635151
- Testing
- Telephone Assessment and Skill-Building Kit (TASK III) Group, Information Support and Referral (ISR) Group
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Stroke, Brain Diseases
Spinal Cord Stimulation for Restoration of Arm and Hand Function in People With Subcortical Stroke
The goal of this study is to verify whether electrical stimulation of the cervical spinal cord can activate muscles of the arm and hand in people with hemiplegia following stroke.
- Conditions
- Stroke, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases
- Trial name
- NCT04512690
- Testing
- Epidural electrical stimulation (EES) of the cervical spinal cord
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Lee Fisher, PhD
Intracerebral Hemorrhage, Stroke
The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial
The purpose of this academic lead study is to determine if a treatment strategy of early intensive blood pressure (BP) lowering compared to conservative BP lowering policy in patients with elevated blood pressure within 6 hours…
- Conditions
- Intracerebral Hemorrhage, Stroke, Hypertension
- Trial name
- INTERACT2 (NCT00716079)
- Testing
- Blood pressure management policies
- Where
- 62 sites in United States, Argentina and 17 more
- Volunteers
- 2,839 people
- Sponsor
- The George Institute
Atrial Fibrillation, Thromboembolism
AMPLATZER™ LAA Occluder Post Approval Study (PAS)
The aim of this multicenter, non-randomized observational post-approval is to compile real world outcome data on the use of an AMPLATZER LAA Occluder in subjects with non-valvular atrial fibrillation (NVAF).
- Conditions
- Atrial Fibrillation, Thromboembolism, Stroke
- Trial name
- NCT02964208
- Testing
- AMPLATZER™ LAA Occluder
- Where
- 22 sites in Argentina, Belgium and 5 more
- Volunteers
- 520 people
- Sponsor
- Abbott Medical Devices
Myocardial Infarction, Stroke
Women's Health Initiative Strong and Healthy Study
The WHISH trial applies state-of-the science behavioral principles and currently available technologies to deliver a physical activity intervention without face-to-face contact to ~25,000 older U.S. women expected to consent.
- Conditions
- Myocardial Infarction, Stroke, Cardiovascular Mortality, Hip Fractures
- Trial name
- WHISH (NCT02425345)
- Testing
- Physical Activity
- Volunteers
- 49,331 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Stroke
Primed vs. Unprimed rTMS in Chronic Stroke
The goal of stroke rehabilitation is to restore function to the weak side of the body. However, this is often a difficult task to accomplish due to not only to damage from the stroke, but from increased excitability in the…
- Trial name
- NCT01757821
- Testing
- real 6-Hz primed low-frequency rTMS, real 1-Hz rTMS only
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Minnesota
Ischemic Stroke
Japan Statin Treatment Against Recurrent Stroke (J-STARS)
Although hyperlipidemia is not always the risk factor of stroke, inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A(HMG-CoA) reductase can decrease the incidence of stroke in the patient with ischemic heart disease.
- Trial name
- NCT00221104
- Testing
- Pravastatin
- Where
- Japan
- Volunteers
- 1,578 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Stroke
NMDA Receptors in Motor Learning in Humans
The purpose of this study is to focus on enhancing upper limb recovery in patients post-stroke by using robotic-assisted therapy in combination with a drug to improve learning new motor skills.
- Trial name
- NCT02082912
- Testing
- D-cycloserine, HandMentor Pro
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Emory University
Cerebrovascular Stroke
Noninvasive Brain Stimulation to Evaluate Neural Plasticity After Stroke
The purpose of this study is to examine how different areas in the brain interact with each other and how using brain imaging and brain stimulation approaches can influence these interactions.
- Trial name
- NCT02465034
- Testing
- Transcranial Magnetic Stimulation, Traditional Paired Associative Stimulation, Median Nerve Stimulation
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Emory University
Ischemic Stroke
Safety of Rt-PA + Transcranial Emission of Low-Energy Lasers for Acute Stroke Recovery
To assess the safety and preliminary efficacy of combining intravenous rt-PA with transcranial laser therapy (TLT) with the NeuroThera® Laser System (referred to hereafter as NTS) in subjects treated for acute ischemic stroke.
- Trial name
- StELLAR (NCT01220739)
- Testing
- Transcranial Laser Therapy
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Diego
Stroke
Comparison of Two High-intensity Gait Training Interventions on Contraversive Pushing Behaviors in Individuals Poststroke
The purpose of this study is to investigate the effect of two high-intensity gait training interventions on contraversive pushing behaviors in individuals poststroke in the acute inpatient rehabilitation setting.
- Trial name
- NCT04550039
- Testing
- Body-weight-supported treadmill, Ekso Bionics EksoNR exoskeleton
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Shirley Ryan AbilityLab