Clinical trials: Brain Stroke
Ischemic Stroke
Safety and Preliminary Efficacy of NXL-001 in Patients With Ischemic Stroke
This is a single-arm, open-label, single center, dose-escalation exploratory clinical study to evaluate the safety and tolerability of a single intracerebral injection of NXL-001, a NeuroD1 base gene therapy, in patients with…
- Trial name
- NXL-001 (NCT06761183)
- Testing
- intracerebral stereotactic injection of NXL-001
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Utilizing Gaming Mechanics to Optimize Telerehabilitation Adherence in Persons With Stroke
This trial studies the impact of motivational strategies designed by the gaming industry on adherence to a home tele-rehabilitation program designed to improve hand function in persons with stroke.
- Trial name
- NCT03985761
- Testing
- Home Telerehabilitation using HoVRS
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Rutgers, The State University of New Jersey
Fever, Ischemic Stroke
Impact of Fever Prevention in Brain Injured Patients
This study will assess the impact of fever prevention on fever burden and short- and long-term neurologic outcomes in brain injured patients.
- Conditions
- Fever, Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- INTREPID (NCT02996266)
- Testing
- Targeted Temperature Management, Standard Care
- Where
- 40 sites in United States, Australia and 4 more
- Volunteers
- 686 people
- Sponsor
- C. R. Bard
Transient Ischemic Attack, Stroke
Apixaban for Early Prevention of Recurrent Embolic Stroke and Hemorrhagic Transformation
The purpose of this study is to evaluate if Apixaban will decrease the complication of having another stroke for people who have atrial fibrillation if initiated earlier than standard of care.
- Conditions
- Transient Ischemic Attack, Stroke, Atrial Fibrillation
- Trial name
- AREST (NCT02283294)
- Testing
- Apixaban, Warfarin
- Where
- 5 sites in United States
- Volunteers
- 91 people
- Sponsor
- University of South Florida
Stroke, Post-Stroke Cognitive Impairment
Immune-Inflammatory Biomarkers in Predicting Early Cognitive Impairment in Adults With Acute Basal Ganglionic Stroke
Post-stroke cognitive impairment (PSCI) is a common and disabling complication that affects memory, thinking, and daily functioning after a stroke.
- Conditions
- Stroke, Post-Stroke Cognitive Impairment, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT07837466
- Volunteers
- 100 people
- Sponsor
- Assiut University
Constipation, Stroke
Auricular Acupuncture for Post-Stroke Constipation
The goal of this clinical trial is to learn if auricular acupuncture can improve constipation in hospitalized patients with post-stroke constipation.
- Conditions
- Constipation, Stroke, Post-stroke Constipation
- Trial name
- NCT07751224
- Testing
- Auricular Acupuncture
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Ho Chi Minh City Orthopedics and Rehabilitation Hospital
Stroke
Changes in Brain Activity Associated With Upper Limb Motor Recovery
This study is to investigate changes in brain activities in acute stroke patients , and to correlate findings with clinical outcome measures.
- Trial name
- NCT02325427
- Testing
- tDCS
- Where
- Singapore
- Volunteers
- 8 people
- Sponsor
- National University Hospital, Singapore
Intracerebral Infarcts, Ischemic Stroke
Discharge Educational Strategies for Reduction of Vascular Events
DESERVE is a discharge education study using health workers to enroll and randomly assign 800 subjects diagnosed with TIA, or mild stroke to either risk factor education or usual care.
- Conditions
- Intracerebral Infarcts, Ischemic Stroke, Hemorrhagic Strokes, TIA's
- Trial name
- DESERVE (NCT01836354)
- Testing
- DESERVE education
- Where
- 3 sites in United States
- Volunteers
- 552 people
- Sponsor
- NYU Langone Health
Fabry Disease
An Open-Label Maintenance Study of the Enzyme Replacement Therapy Replagal in Patients With Fabry Disease
This study will continue to evaluate the safety of using intravenous doses of Replagal for two patients with Fabry disease. Fabry disease is a genetic disorder inherited as an X-linked recessive trait.
- Trial name
- NCT00357786
- Testing
- Replagal agalsidase alfa, Replagal
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hemianopia, Stroke
Combined tDCS and Vision Restoration Training in Post-acute Stroke: an Exploratory Efficacy and Safety Study
The purpose of this Study is to determine whether non-invasive transcranial direct current stimulation (tDCS) is effective in increasing rehabilitation effects after stroke in visual Cortex.
- Trial name
- NCT02703870
- Testing
- verum tDCS, VRT
- Where
- 2 sites in Austria, Germany
- Volunteers
- 19 people
- Sponsor
- University of Magdeburg
Stroke
Tele BCI-FES for Upper -Limb Stoke Rehabilitation
The study aims to identify whether stroke survivors can intentionally modulate their brain signals for controlling an FES device to produce arm movements for home based rehabilitation.
- Trial name
- NCT05215522
- Testing
- The BCI-FES Intervention
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Sheffield
Congestive Heart Failure, Cancer
Team-based Versus Primary Care Clinician-led Advance Care Planning in Practice-based Research Networks
This project compares two models of the Serious Illness Care Program (SICP) in primary care: clinician-focused SICP and team-based SICP.
- Conditions
- Congestive Heart Failure, Cancer, Chronic Obstructive Pulmonary Disease, Cerebrovascular Accident
- Trial name
- NCT03577002
- Testing
- Serious Illness Care Program (SICP)
- Where
- 7 sites in United States, Canada
- Volunteers
- 1,120 people
- Sponsor
- Oregon Health and Science University
Acquired Brain Injury (Including Stroke), Caregivers
Nature in Harmony: Music and Nature-based Self-care for Individuals With Acquired Brain Injuries and Their Care Partners
The goal of this pilot study is to determine the initial impact on wellbeing for clients with acquired brain injury and their care partner after engaging in a nature \& music-based program facilitated by occupational therapy and…
- Trial name
- NCT07568301
- Testing
- Nature in Harmony
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Acute Ischemic Stroke
Efficacy and Safety of PCSK9 Inhibitors in Patients With Large-Artery Atherosclerosis (LAA) Ischemic Stroke
This prospective multicenter cohort study aims to evaluate the effectiveness and safety of early PCSK9 inhibitor therapy in patients with large-artery atherosclerotic ischemic stroke.
- Trial name
- NCT07540741
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
First Ever Clinical Stroke, Ischemic Stroke
Rehabilitation Combined With Bihemispherictranscranial Direct Current Stimulation in Subacute Ischemic Stroke
Rehabilitation after stroke improves motor functions by promoting plastic changes however, after completing standard rehabilitation, 50-60% of patients still exhibit some degree of motor impairment and require at least partial…
- Conditions
- First Ever Clinical Stroke, Ischemic Stroke, Subacute Phase, Persistent Hemiparesis of Upper Extremity
- Trial name
- RECOMBINE (NCT01644929)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- 3 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Dr. med. Carlo Cereda
Stroke
Reduction of Prehospital Delays in Stroke and Transient Ischaemic Attack (TIA)
In patients with acute stroke, systemic thrombolysis needs to be administered within three hours of symptom onset. The aim of the present study was to reduce prehospital delays in a population-based intervention.The intervention…
- Trial name
- BASS (NCT00744029)
- Testing
- educational material
- Where
- Germany
- Volunteers
- 1,388 people
- Sponsor
- Charite University, Berlin, Germany
Carotid Artery Stenosis
Enterprise Stent Implantation in the Treatment of Carotid Artery Stenosis With Ischemic Stroke
To investigate the long-term effects of intracranial implantation of Enterprise stent system versus antiplatelet medication on neurologic deficits, daily living abilities, and carotid artery stenosis in patients with…
- Trial name
- NCT02802072
- Testing
- Enterprise stent implantation, Only aspirin medication
- Volunteers
- 100 people
- Sponsor
- Beijing Chao Yang Hospital
Stroke
Perturbed-balance Training During Treadmill Walking for Stroke Subjects
A control and a post-stroke subject with right-side chronic hemiparesis were studied. The post-stroke subject underwent 30 sessions of balance-perturbed training while walking on an instrumented treadmill where the Balance…
- Trial name
- BALANCESI (NCT03285919)
- Testing
- Balance Assessment Robot (BAR™)
- Where
- Slovenia
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Acute Ischemic Stroke
Safety and Efficacy of Edaravone Dexborneol for Acute Ischemic Stroke
The purpose of this study is to determine the efficacy and safety of edaravone dexborneol in treating acute ischemic stroke.
- Trial name
- NCT06645522
- Testing
- Edaravone dexborneol
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Yi Yang
Acute Ischemic Stroke
Study to Assess the Efficacy and Safety of QHRD106 Injection in Acute Ischemic Stroke.
The purpose of this study is to determine the efficacy and safety of QHRD106 injection in treating acute ischemic stroke.
- Trial name
- NCT07396337
- Testing
- QHRD106 Injection (Low-dose group), QHRD106 Injection (Middle-dose group), QHRD106 Injection (High-dose group)
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Changzhou Qianhong Bio-pharma Co., Ltd.
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