Clinical trials: Brain Stroke
Dysphagia, Stroke
Changes in Sensitivity, Taste and Smell in Stroke Patients
This study evaluates changes in swallowing using endoscopic swallowing studies and measuring of pharyngeal sensitivity, taste and smell in stroke patients.
- Trial name
- 5S (NCT03240965)
- Testing
- FEES (flexible endoscopic evaluation of swallowing), Sensitivity threshold, Taste-/smell-test
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Ischemic Stroke
MultiStem® Administration for Stroke Treatment and Enhanced Recovery Study
A Phase 3 study to examine the safety and effectiveness of the allogeneic, adult stem cell investigational product, MultiStem, in adults who have suffered an acute ischemic stroke in the previous 18-36 hours.
- Trial name
- MASTERS-2 (NCT03545607)
- Testing
- MultiStem
- Where
- 26 sites in United States, Taiwan
- Volunteers
- 206 people
- Sponsor
- Healios K.K.
Stroke, Aphasia
Efficacy of Language Games as Therapy for Post Stroke Aphasia
Aphasia is a language impairment experienced by about one third of stroke patients. This often devastating condition is treated by speech and language therapists (SLTs).
- Trial name
- AphasiaGame (NCT02458222)
- Testing
- language game therapy, standard therapy
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Birmingham
Atrial Fibrillation
Belgian Real Life Non-interventional Study (NIS) on Xarelto in Non-valvular Atrial Fibrillation (AF) Patients Treated for the Prevention of Stroke and Systemic Embolism
The objective of this NIS is to assess in a real-life setting, usage patterns and associated outcomes in the management (healthcare resource utilisation and associated costs) of patients with non-valvular AF treated with Xarelto…
- Trial name
- BOX-AF (NCT01855139)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- Belgium
- Volunteers
- 106 people
- Sponsor
- Bayer
Stroke, Control
Exploring the Effect of Visual Feedback on Motion Trajectory in a Virtual Reality Environment.
The rehabilitation intensity and frequency of upper extremities of stroke patients is insufficient. Virtual reality technique may solved this problem.
- Trial name
- NCT04103957
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Stroke Rehabilitation
Effects of Local Vibrations Program of Dorsiflexor Muscles on Neuromotor Recovery in Subacute Stroke Patients.
The aim of the vibration intervention proposed in the current study is to allow a better neuromotor recovery in subacute stroke patients when compared with standard rehabilitation alone.
- Trial name
- NEUROVIB-AVC (NCT05945212)
- Testing
- Vibration, 10 meters Walk Test, 2 Minute Walk Test (2MWT)
- Where
- 7 sites in France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Ischemic Stroke, Haemorrhagic Stroke
The Effects of Posture on Cerebral Blood Flow Velocity During the Acute Phase of Stroke
After stroke, blood vessels in the brain can become damaged, and the brain's ability to control blood flow can be impaired. The brain therefore may be less able to maintain a healthy level of blood flow during challenges such as…
- Conditions
- Ischemic Stroke, Haemorrhagic Stroke, Cerebrovascular Accident, Acute Stroke
- Trial name
- NCT04972812
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Sheffield Hallam University
Stroke, Acute Ischemic Stroke
Extended Time Window Intravenous Tenecteplase Thrombolysis Registry for Acute Ischemic Stroke
The EXTEND-TNK Registry is a prospective, multicenter, observational cohort study designed to evaluate the effectiveness and safety of intravenous tenecteplase administered beyond 4.5 hours after last known well in patients with…
- Trial name
- EXTEND-TNK (NCT07536165)
- Testing
- Tenecteplase
- Where
- 2 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Stroke
Upper Limb Unilateral Strength Training and Mirror Therapy for Chronic Stroke Patients
This is a pilot randomised controlled trial investigating a combination of unilateral strength training (cross-education) and mirror therapy for the rehabilitation of upper limb impairment following a stroke.
- Trial name
- NCT03500705
- Testing
- Mirror Therapy, Cross-Education of Strengthening.
- Where
- Ireland
- Volunteers
- 35 people
- Sponsor
- Institute of Technology, Sligo
Stroke, Hemiparesis
Contralaterally Controlled FES of Arm & Hand for Subacute Stroke Rehabilitation
Impaired arm and hand function is one of the most disabling and most common consequences of stroke. The Investigators have developed Contralaterally Controlled Functional Electrical Stimulation (CCFES), an innovative…
- Conditions
- Stroke, Hemiparesis, Hemiplegia
- Trial name
- NCT01688856
- Testing
- Electrical Stimulator
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- MetroHealth Medical Center
Brain Ischemia With Non-valvular Atrial Fibrillation, Transient Ischemic Attack With Non-valvular Atrial Fibrillation
Prospective Record Of the Use of Dabigatran in Patients With Acute Stroke or TIA
The multi-center, prospective PRODAST study is investigating patients with non-valvular atrial fibrillation (AF) who experienced an ischemic stroke or a transient ischemic attack (TIA) recently (≤ 1 week) both with and without…
- Trial name
- PRODAST (NCT02507856)
- Where
- 90 sites in Germany
- Volunteers
- 10,044 people
- Sponsor
- University Hospital, Essen
Diabetes Mellitus, Cardiovascular Diseases
Improving Neurologic Outcomes in People With Diabetes Who Are Undergoing Heart Surgery
Preliminary studies have shown that people with diabetes who undergo heart surgery may have a higher risk of developing cognitive functioning problems, including memory problems, than people without diabetes who undergo heart…
- Trial name
- NCT00836329
- Testing
- Intensive Glucose Management, Traditional Glucose Management:
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Stroke
Interdisciplinary Home Rehabilitation of Patients With Stroke. A Randomised Controlled Intervention Trial.
Objective: To evaluate the effect of interdisciplinary home rehabilitation of patients with acute stroke. The trial seeks to evaluate: 1.
- Trial name
- NCT00626353
- Testing
- Home-based rehabilitation, Standard care
- Where
- Denmark
- Volunteers
- 71 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Internal Carotid Artery Dolichoarteriopathy, Carotid Artery Tortuosity
Clinical Significance of Internal Carotid Artery Dolichoarteriopathy
This observational study aims to investigate the clinical significance of internal carotid artery dolichoarteriopathy, including tortuosity, kinking, and coiling, and to identify factors associated with cerebral dysfunction and…
- Trial name
- DALISTA (NCT07882875)
- Where
- Russia
- Volunteers
- 560 people
- Sponsor
- Kuban State Medical University
Subarachnoid Hemorrhage, Aneurysmal, Cerebrovascular Disorders
Safety , Feasibility and Preliminary Efficacy of Remote Ischemic Conditioning in Patients With Aneurysmal Subarachnoid Hemorrhage After Aneurysm Clipping
This study was designed to evaluate the safety and efficacy of remote ischemic conditioning (RIC) in patients with aneurysmal subarachnoid hemorrhage (aSAH) following surgical clipping.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebrovascular Disorders, Brain Diseases, Stroke
- Trial name
- NCT06819657
- Testing
- Remote Ischemic Conditioning Treatment Instrument, Guideline-based therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Tiantan Hospital
Acute Stroke
Long-term Prognosis in Stroke Patients
A single-center cohort of patients with acute ischemic stroke and transient ischemic attack who admitted to the Severance hospital of Yonsei university and their long-term outcomes.
- Trial name
- NCT03510312
- Where
- South Korea
- Volunteers
- 9,000 people
- Sponsor
- Severance Hospital
Stroke
Skeletal Muscle Properties and the Metabolic Cost of Walking Post-stroke
Of the ~700,000 persons who suffer a stroke each year, only 50% recover the ability to perform unlimited community walking. One mechanism contributing to locomotor dysfunction post-stroke is an increased metabolic cost of walking…
- Trial name
- NCT00721357
- Testing
- Treadmill walking, Magnetic resonance spectroscopy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Stroke, Not Specified as Hemorrhage or Infarction, Angina Pectoris
Clinical Study of Medicinal Product Cardionat® Using in Health Athlete Volunteers
The objective of this study is to evaluate the long-term plasma and urine pharmacokinetic parameters of Cardionat®, capsules 250 mg, when used in healthy athlete volunteers. The study consists of four steps: Step 1.
- Trial name
- NCT02758912
- Testing
- оral intake of study drug capsules; study drug - Cardionat ® (trimethylhydrazinium propionate dihydrate), oral capsules 250 mg
- Where
- Russia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Burnasyan Federal Medical Biophysical Center
Sleep Apnea, Obstructive, Stroke
Stroke and CPAP Outcome Study 2
Obstructive sleep apnea (OSA) is associated with impaired stroke recovery. Treatment with continuous positive airway pressure (CPAP) may prevent this but is limited by poor adherence.
- Conditions
- Sleep Apnea, Obstructive, Stroke, Patient Adherence
- Trial name
- SCOUTS2 (NCT02809430)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Washington
Atrial Fibrillation, AFib
Stroke Feasibility Study
This is a feasibility study to assess the safety and efficacy of the AtriCure AtriClip when placed via Minimally Invasive Surgical Deployment to the Left Atrial Appendage.
- Trial name
- NCT01997905
- Testing
- AtriClip LAA Exclusion Device
- Where
- 7 sites in United States
- Volunteers
- 13 people
- Sponsor
- AtriCure, Inc.
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